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| 1 | Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms显示文摘协调的子宫胚胎的轴形成并且蜕膜的改变是哺乳动物的培植以后的胚胎开发的特点。胚胎子宫的取向在起始的培植被决定并且与蜕膜的开发同步。然而,控制这些事件的分子的机制留下尽管有它的发现逃犯很长时间以前。在现在的学习,我们发现了 Rbpj 的那子宫特定的删除,槽口发信号的原子变换器,在培植以后的阶段导致了反常胚胎子宫的取向和蜕膜的 patterning,导致实质的胚胎损失。我们进一步表明在胚胎附件以前, Rbpj 授与在时间上经由身体上与子宫的雌激素受体交往的子宫的腔形状转变(ERα) 以一种槽口小径无关的方式,它为在有子宫的轴的排列的胚胎取向的起始的建立是必要的。当时在培植以后的阶段, Rbpj 直接以一种槽口小径依赖者方式调整子宫的矩阵 metalloproteinase 的表示,它为正常被要求培植以后的蜕膜的改变。这些结果证明子宫的 Rbpj 为经由指示起始的胚胎子宫的取向并且以一种阶段特定的方式保证正常蜕膜的 patterning 的正常胚胎开发是必要的。我们的数据也证实正常哺乳动物的胚胎子宫的取向要求的概念合适的指导从发展地控制了子宫的发信号。 | Shuang Zhang Shuangbo Kong Bingyan Wang Xiaohong Cheng Yongjie Chen Weiwei Wu Qiang Wang Junchao Shi Ying Zhang Shumin Wang Jinhua Lu John P Lydon Francesco DeMayo Warren S Pear Hua Han Haiyan Lin Lei Li Hongmei Wang Yan-ling Wang Bing Li Qi Chen Enkui Duan Haibin Wang | 2014 | Cell Research2014，24，8： | 12 |
| 2 | A bioactive injectable self-healing anti-inflammatory hydrogel with ultralong extracellular vesicles release synergistically enhances motor functional recovery of spinal cord injury显示文摘The repair and motor functional recovery after spinal cord injury(SCI)remains a worldwide challenge.The inflammatory microenvironment is one of main obstacles on inhibiting the recovery of SCI.Using mesenchymal stem cells(MSCs)derived extracellular vesicles to replace MSCs transplantation and mimic cell paracrine secretions provides a potential strategy for microenvironment regulation.However,the effective preservation and controlled release of extracellular vesicles in the injured spinal cord tissue are still not satisfied.Herein,we fabricated an injectable adhesive anti-inflammatory F127-polycitrate-polyethyleneimine hydrogel(FE)with sustainable and long term extracellular vesicle release(FE@EVs)for improving motor functional recovery after SCI.The orthotopic injection of FE@EVs hydrogel could encapsulate extracellular vesicles on the injured spinal cord,thereby synergistically induce efficient integrated regulation through suppressing fibrotic scar formation,reducing inflammatory reaction,promoting remyelination and axonal regeneration.This study showed that combining extracellular vesicles into bioactive multifunctional hydrogel should have great potential in achieving satisfactory locomotor recovery of central nervous system diseases. | Chenggui Wang Min Wang Kaishun Xia Jingkai Wang Feng Cheng Kesi Shi Liwei Ying Chao Yu Haibin Xu Shining Xiao Chengzhen Liang Fangcai Li Bo Lei Qixin Chen | 2021 | Bioactive Materials2021，6，8： | 9 |
| 3 | Interferon-armed RBD dimer enhances the immunogenicity of RBD for sterilizing immunity against SARS-CoV-2显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused a global crisis,urgently necessitating the development of safe,efficacious,convenient-to-store,and low-cost vaccine options.A major challenge is that the receptor-binding domain(RBD)-only vaccine fails to trigger long-lasting protective immunity if used alone for vaccination. | Shiyu Sun Yueqi Cai Tian-Zhang Song Yang Pu Lin Cheng Hairong Xu Jing Sun Chaoyang Meng Yifan Lin Haibin Huang Fang Zhao Silin Zhang Yu Gao Jian-Bao Han Xiao-Li Feng Dan-Dan Yu Yalan Zhu Pu Gao Haidong Tang Jincun Zhao Zheng Zhang Jiaming Yang Zhenxiang Hu Yang-Xin Fu Yong-Tang Zheng Hua Peng | 2021 | Cell Research2021，31，9： | 7 |
| 4 | Effects of different biochars on antibiotic resistance genes during swine manure thermophilic composting显示文摘Elimination of antibiotic resistance genes(ARGs)in animal manure from concentrated animal feeding operations by thermophilic composting has drawn increasing attention.This study investigated the effects of sawdust biochar,corn stover biochar and peanut hull biochar with three spiked levels on ARGs in swine manure during thermophilic composting.Thirteen ARGs corresponding to four classes of antibiotics(tetracyclines,sulfonamides,macrolides and quinolones)were determined in the composting piles.Results indicated that the ten tested composting groups became fully mature after 30-day thermophilic composting process.tetM,tetO and ermB were reduced in all tested groups;tetC and tetG,tetX,sul1,sul2,ermF,qnrD and aac(6’)-Ib were mostly reduced under low level biochar addition but increased under higher level biochar addition;gyrA increased under medium biochar addition and reduced in other groups;oqxB remained comparatively stable throughout the composting process.The addition levels of spiked biochar are more important than types of spiked biochar on the removal of ARGs in the composting pile.The average removal rates of ARGs in the control group,low,medium and high level biochar addition groups were 0.24 logs,0.52-0.72 logs,-0.52-0.18 logs and-0.19-0.21 logs,respectively.In summary,low level biochar addition could enhance the elimination of studied ARGs in swine manure during the composting process,while medium level biochar addition to the composting piles would increase the risk of ARGs’propagation. | Jian Wang Bin Sui Yujun Shen Haibo Meng Lixin Zhao Haibin Zhou Ran Li Jingtao Ding Hongsheng Cheng Xi Zhang | 2018 | International Journal of Agricultural and Biological Engineering2018，11，6： | 5 |
| 5 | Investigation and analysis of the linkage mechanism and whole process cost of livestock manure organic fertilizer显示文摘In recent years,the utilization of manure resources for livestock and poultry farming has attracted a widespread attention,and manure resources utilization models suitable for different regional characteristics have formed gradually.Among them,the production of organic fertilizer from animal manure is a vital utilization method.However,there are still some problems such as high production costs,difficult sales,and the unwillingness of farmers to use organic fertilizers which have affected the breeding cycle and the sustainability of manure treatment in livestock and poultry breeding.This article selected 371 organic fertilizer plants,related farms and farmers in China,focusing on the main links of the entire process of livestock manure-organic fertilizer-farm application,and studied the mode of animal manure collection by organic fertilizer plants.The costs of organic fertilizer production and farmland application were discussed.Moreover,suggestions were made for the promotion and implementation of large-scale organic fertilizers to make good utilization of manure resources in livestock and poultry farming. | Shanshan Dong Bin Sui Yujun Shen Haibo Meng Lixin Zhao Jingtao Ding Haibin Zhou Xi Zhang Hongsheng Cheng Jian Wang Ran Li Liqiu Song Pengxiang Xu Ji Li | 2020 | International Journal of Agricultural and Biological Engineering2020，13，2： | 2 |
| 6 | P2P traffic optimization显示文摘Peer-to-peer (P2P) based content distribution systems have emerged as the main form for content distribution on the Internet,which can greatly reduce the distribution cost of content providers and improve the overall system scalability.However,the mismatch between the overlay and underlay networks causes large volume of redundant traffic,which intensifies the tension between P2P content providers and ISPs.Therefore,how to efficiently use network resources to reduce the traffic burden on the ISPs is crucial for the sustainable development of P2P systems.This paper surveys the state-of-art P2P traffic optimization technologies from three perspectives:P2P cache,locality-awareness and data scheduling.Technological details,comparison between these technologies and their applicabilities are presented,followed by a discussion of the issues that remain to be addressed and the direction of future content distribution research. | ZHANG GuoQiang TANG MingDong CHENG SuQi ZHANG GuoQing SONG HaiBin CAO JiGuang YANG Jing | 2012 | Science China(Information Sciences)2012，55，7： | 2 |
| 7 | Differentiation transforming system显示文摘The differentiation transforming (DFT) system is developed to produce the tangent linear codes, which is used to calculate the Jaco- bian- and the Hessian-vector products with no truncation errors. This paper first gives the introduction of the functionality and features of the DFT system, and then discusses several techniques for the implementation of automatic differentiation tools, including data depen- dence analysis, singular differentiation and code optimization. Finally, the codes generated with DFT used in several applications have been demonstrated. | Qiang Cheng Haibin Zhang Bin Wang Yonghua Zhao | 2009 | Progress in Natural Science:Materials International2009，19，3： | 2 |
| 8 | Nucleocapsid Protein of SARS Coronavirus Tightly Binds to Human Cyclophilin A显示文摘 | Luo Haibin Zheng Suxin | 2004 | Biochemical and Biophysical Research Communications2004，321，3： | 1 |
| 9 | Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe显示文摘 | SHI Haibin CHENG Xiamin SZE S K | 2011 | Chemical Communications2011，47，11： | 1 |
| 10 | A survey of workflow management显示文摘 | Haibin L Yushun F Cheng W | 2000 | Journal of Software2000，11，7： | 1 |
| 11 | Investigation of Model Ensemble for Fine-Grained Air Quality Prediction显示文摘Air pollution which is detrimental to people’s health is a wide spread problem across many countries around the world.Developing better air quality prediction approaches is an important research issue.Existing methods often focus on the prediction of air pollution concentrations,which is not as intuitive to the public as the air quality levels.In this paper,near future fine-grained air quality level prediction task is explored with a series of machine learning ensemble methods.Included ensemble methods are majority voting,averaging,weighted averaging and 16 different stacking tactics.To investigate the performances of these ensemble methods,comprehensive comparative experiments are conducted.Included contrast models are classical Autoregressive Integrated Moving Average(ARIMA),popular deep learning model Long Short-Term Memory(LSTM)neural network,and nine of the base-level models such as Support Vector Machine(SVM),Random Forest(RF),Logistic Regression(LR)and several boosting models.Datasets acquired from a coastal city Hong Kong and an inland city Beijing are used to train and validate all the models.Experiments show that performances of the ensemble methods outperform most of the individual models,especially when stacking with probability distributions together with engineered original features,which demonstrates the best performance. | Hong Zheng Yunhui Cheng Haibin Li | 2020 | China Communications2020，17，7： | 1 |
| 12 | Ion-exchange properties of mildiomycin on HZ110? resin显示文摘 | Yong Chen Haibin Qu Zhinan Xu Yiyu Cheng | 2006 | Korean Journal of Chemical Engineering2006，，6： | 1 |
| 13 | Heavy metals and community structure of microorganism changes during livestock manure composting with inoculation of effective microorganisms显示文摘Effective microorganisms(EM)is usually used in composting to improve the composting process.However,the effect of EM on heavy metals evolution was still unclear.This study was performed to illustrate the microbial community changes that occur during composting with the addition of EM and to determine the evolution of heavy metal speciation during this process.The requirement of harmlessness for pig manure was met after the addition of EM at a dosage of 0.5%,with a germination index of 96.42%.The bacterial and fungal diversity were both found to decrease during the composting process.Additionally,the bioavailability of Cu and Pb decreased significantly during composting.Significant correlations were observed between the microbial composition and the percentage of different heavy metals fractions;however,the mechanism responsible for this correlation requires further investigation.This study has the potential to contribute to control of heavy metal contamination during the process of recycling pig manure through the controlled addition of EM. | Haibin Zhou Yujun Shen Ran Li Haibo Meng Xi Zhang Jian Wang Hongsheng Cheng Shanshan Dong Liqiu Song Jingtao Ding Qiongyi Cheng | 2020 | International Journal of Agricultural and Biological Engineering2020，13，6： | 1 |
| 14 | Development and Validation of a Column-Switching LC–ESI–MS Assay for Determination of Huperzine?A in Rat Plasma and Cerebrospinal Fluid显示文摘 | Jianyang Pan Qiao Wang Qing Shao Yiyu Cheng Haibin Qu | 2009 | Chromatographia (-)2009，，5： | 1 |
| 15 | Efficient algorithm for localized support vector machine显示文摘 | Cheng Haibin Tan Pangning Jin Rong | 2010 | IEEE Transactions on Knowledge and Data Engineering2010，，： | 1 |
| 16 | A formal structure for symbolic reachability analysis of rectangular hybrid systems显示文摘For symbolic reachability analysis of rectangular hybrid systems, the basic issue is finding a formal structure to represent and manipulate its infinite state spaces. Firstly, this structure must be closed to the reachability operation which means that reachable states from states expressed by this structure can be presented by it too. Secondly, the operation of finding reachable states with this structure should take as less computation as possible. To this end, a constraint system called rectangular zone is formalized, which is a conjunction of fixed amount of inequalities that compare fixed types of linear expressions with two variables to rational numbers. It is proved that the rectangular zone is closed to those reachability operations-intersection, elapsing of time and edge transition. Since the number of inequalities and the linear expression of each inequality is fixed in rectangular zones, so to obtain reachable rectangular zones, it just needs to change the rational numbers to which these linear expressions need to compare. To represent rectangular zones and unions of rectangular zones, a data structure called three dimensional constraint matrix(TDCM) and a BDD-like structure rectangular hybrid diagram(RHD) are introduced. | ZHANG HaiBin ZHAO Cheng LI Rong | 2016 | Science China(Technological Sciences)2016，59，2： | 0 |
| 17 | The dynamic arms race during the early invasion of woodland strawberry by Botrytis cinerea revealed by dual dense high-resolution RNA-seq analyses显示文摘Necrotrophic pathogens replicate massively upon colonizing plants,causing large-scale wilting and death of plant tissues.Under-standing both mechanisms of pathogen invasion and host response processes prior to symptom appearance and their key regulatory networks is therefore important for defense against pathogen attack.Here,we investigated the mechanisms of interaction between woodland strawberry(Fragaria vesca)leaves and gray mold pathogen(Botrytis cinerea)at 14 infection time points during the first 12 hours of the infection period using a dense,high-resolution time series dual transcriptomic analysis,characterizing the arms race between strawberry F.vesca and B.cinerea before the appearance of localized lesions.Strawberry leaves rapidly initiated strong systemic defenses at the first sign of external stimulation and showed lower levels of transcriptomic change later in the infection process.Unlike the host plants,B.cinerea showed larger-scale transcriptomic changes that persisted throughout the infection process.Weighted gene co-expression network analysis identified highly correlated genes in 32 gene expression modules between B.cinerea and strawberry.Yeast two-hybrid and bimolecular fluorescence complementation assays revealed that the disease response protein FvRLP2 from woodland strawberry interacted with the cell death inducing proteins BcXYG1 and BcPG3 from B.cinerea.Overexpression of FvRLP2 in both strawberry and Arabidopsis inhibited B.cinerea infection,confirming these genes’respective functions.These findings shed light on the arms race process by which B.cinerea invades host plants and strawberry to defend against pathogen infection. | Yibo Bai Haibin Wang Kaikai Zhu Zong-Ming Cheng | 2023 | Horticulture Research2023，10，12： | 0 |
| 18 | Effect of Bath pH on the Squareness of Electroless CoNiWP Magnetic Films显示文摘Electroless CoNiWP magnetic films were prepared by varying the bath pH and then characterized by energy dispersive X-ray analysis,X-ray diffraction and magnetic force microscopy.It has been found that the mi- crostructure and the magnetic properties of films were influenced greatly by the bath pH.At the bath pH 8.06, the grain size and coercivity of the films reach maximum,while the squareness(M_r/M_s)of MH curves reaches minimum.The Henkel plots indicates that the exchange-coupling interaction is very weak at this pH,which may be caused by phase-separation and large grain size,and then results in the lowest squareness.At pH above 8.5,obvious exchange-coupling interaction is observed because of the inexistence of phase-separation and the refinement of grain size. | Haibin CHENG Shuai XU Wenyu ZHAO Suling ZHAO Pengcheng ZHAI Zhigang SUNand Qingjie ZHANGt Pengcheng ZHAI Zhigang SUN Qingjie ZHANG | 2008 | Journal of Materials Science & Technology2008，24，5： | 0 |
| 19 | Adjoint code generator显示文摘The adjoint code generator (ADG) is developed to produce the adjoint codes, which are used to analytically calculate gradients and the Hessian-vector products with the costs independent of the number of the independent variables. Different from other automatic differentiation tools, the implementation of ADG has advantages of using the least program behavior decomposition method and several static dependence analysis techniques. In this paper we first address the concerned concepts and fundamentals, and then introduce the functionality and the features of ADG. In particular, we also discuss the design architecture of ADG and implementation details including the recomputation and storing strategy and several techniques for code optimization. Some experimental results in several applications are presented at the end. | CHENG Qiang CAO JianWen WANG Bin ZHANG HaiBin | 2009 | Science in China(Series F)2009，52，6： | 0 |
| 20 | Computational Investigations about the Effects of Heteromolecular Aggregation on Bioactivities:a Case of Neonicotinoids and Water显示文摘Molecular aggregation state of bioactive compounds plays a key role in bio-interactive procedure.Diverse ag-gregation states of bioactive compounds contribute to different biological or chemical properties.Water-bridge,as the simple hetero-molecular aggregation,has been found bridging the binding between many bioactive compounds and their targets through hydrogen bonding network,e.g.in the recognition of neonicotinoids with insect nAChRs.To better understanding the roles of water-bridge on bioactivities of compounds,an approach of hetero-dimeric ag-gregation with water was proposed.Quantitative structure-activity relationship(QSAR)and pharmacophore mod-eling investigations were applied on 19 neonicotinoids,as well as their aggregates with water.The aggregate-based CoMSIA,PHASE and linear QSAR models presented better statistical significance and predictabilities than the monomer ones,which indicated that the bioactivities correlated with the aggregate properties and water bridged hy-drogen bond of the active site.All results revealed the essential roles of water-bridge in ligand recognition,which should be considered in future ligand design and optimization. | Shuang Xia Jiagao Cheng Yue Feng Xusheng Shao Haibin Luo Zhiping Xu Xiaoyong Xu Zhong Li | 2014 | Chinese Journal of Chemistry2014，32，4： | 0 |
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