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| 1 | New insights into the roles of CHOP-induced apoptosis in ER stress显示文摘Endoplasmic 蜂窝胃应力(嗯应力) 在 ER 由于动态平衡的损失被触发,在 ER 腔导致累积 ofmisfolded 蛋白质。嗯因为 ER 的展开的蛋白质 response.Perturbation 是抄写因素 C/EBP 相应蛋白质(砍) 的强大的 inducer,应力激活知道的一系列适应机制。尽管它过时的人或物证明到 ER 的过多或不利的应力触发 apoptosis,由砍位于这些 processesinduced 下面的特定的机制仍然保持不清楚。现在,导致砍的 apoptosis 在嗯应力在众多的人的疾病被含有例如 neurodegenerative 疾病,糖尿病, ischemic 疾病,肿瘤等等。在这评论,我们从实验室在几疾病的发展总结了砍的角色的 currentunderstanding 到诊所。 | Yiming Li Yunshan Guo Juan Tang Jianli Jiang Zhinan Chen | 2014 | Acta Biochimica et Biophysica Sinica2014，46，8： | 45 |
| 2 | Development of and Perspective on High-Performance Nanostructured Bainitic Bearing Steel显示文摘Bearings are the most important component of nearly all mechanical equipment, as they guarantee the steady running of the equipment, which is especially important for high-end equipment such as highspeed trains and shield tunneling machines. Requirements regarding the quality of bearings are increasing with the rapid development in technology. A country’s bearings manufacturing level directly reflects the level of that country’s steel metallurgy and machinery manufacturing. The performance of the bearing steel is the critical factor that determines the quality of a bearing. The development of new bearing steel with higher performance is the ambition of material researchers and the expectation of the manufacturing industry. Many famous bearing manufacturing enterprises are competing to develop the new generation of bearing steel. Nanostructured bainitic bearing steel (NBBS), which is a newly developed bearing steel, not only possesses high strength and toughness, but also exhibits excellent wear resistance and rolling contact fatigue (RCF) resistance. In recent years, relevant achievements in NBBS in China have led to significant progress in this field. NBBS was first used in China to manufacture large bearings for wind turbines and heavy-duty bearings, with excellent performance. As a result, NBBS and its corresponding heat-treatment process have been included in the national and industry standards for the first time. The bearing industry considers the exploitation of NBBS to be epoch-making, and has termed this kind of bearing as the second generation of bainitic bearing. In this paper, the development of NBBS is reviewed in detail, including its advantages and disadvantages. Further research directions for NBBS are also proposed. | Fucheng Zhang Zhinan Yang | 2019 | Engineering2019，5，2： | 29 |
| 3 | IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (HIN1) Virus显示文摘 | Chenggang Li Penghui Yang Yang Sun Taisheng Li Chen Wang Zhong Wang Zhen Zou Yiwu Yan Wei Wang Chen Wang Zhongwei Chen Li Xing Chong Tang Xiangwu Ju Feng Guo Jiejie Deng Yan Zhao Peng Yang Jun Tang Huanling Wang Zhongpeng Zhao Zhinan Yin Bin Cao Xiliang Wang Chengyu Jiang | 2012 | Cell Research2012，22，3： | 22 |
| 4 | Adoptive cell transfer therapy for hepatocellular carcinoma显示文摘Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. This malignancy is associated with poor prognosis and high mortality. Novel approaches for prolonging the overall survival of patients with advanced HCC are urgently needed. The antitumor activities of adoptive cell transfer therapy (ACT), such as strategies based on tumor-infiltrating lymphocytes and cytokine-induced killer cells, are more effective than those of traditional strategies. Currently, chimeric antigen receptor T-cell (CAR-T) immunotherapy has achieved numerous breakthroughs in the treatment of hematological malignancies, including relapsed or refractory lymphoblastic leukemia and refractory large B-cell lymphoma? Nevertheless, this approach only provides a modest benefit in the treatment of solid tumors. The clinical results of CAR-T immunotherapy for HCC that could be obtained at present are limited. Some published studies have demonstrated that CAR-T could inhibit tumor growth and cause severe side effects. In this review, we summarized the current application of ACT, the challenges encountered by CAR-T technology in HCC treatment, and some possible strategies for the future direction of immunotherapeutic research. | Renyu Zhang Zhao Zhang Zekun Liu Ding Wei Xiaodong Wu Huijie Bian Zhinan Chen | 2019 | Frontiers of Medicine2019，13，1： | 17 |
| 5 | Meiofauna distributions at the oxygen minimum zone in Changjiang (Yangtze) River Estuary waters显示文摘A quantitative study on meiofauna was carried out along a transect throughout the Changjiang Estuary’s oxygen minimum zone (OMZ) in the East China Sea. There exist two distinct station groups in the OMZ: the fine-grained hypoxic area and the more fine-grained anoxic area. Meiofauna abundance ranged from (101.5±31.0) ind./cm2 (hypoxic area) to (369.9±123.9) ind./cm2 (anoxic area) along the transect. Free-living marine nematodes were the numerically dominant meiofauna at every station. The anoxic area differed significantly in meiofauna abundance and vertical distribution pattern from the hypoxic area. Within the anoxic area, nematodes abundance increased and amounted to over 90% of the total meiofauna; about 50% of nematodes were found in the 25 and 58 cm layers. At hypoxic stations, about over 85% were restricted to the top 2 cm. Benthic copepod abundance and dominance decreased consistently with the oxygen gradient. The pattern of meiofauna biomass was similar to that of abundance. The correlation analysis of the meiofauna numbers and environmental parameters indicated that abundance and biomass of total meiofauna and nematodes had significant or highly significant (P<0.05 or P<0.01) correlations with Chl a and Pha a, but no significant (P>0.05) correlations with bottom-water oxygen (BWO2). On the other hand, there was a highly significant positive correlation between benthic copepod abundance and bottom-water oxygen (P<0.05). The investigation on the nematode community structure indicated that two different nematode communities existed in hypoxic and anoxic areas. In certain way, the shift in nematode species composition distinguishes the anoxia to hypoxia. Nematode diversity was generally lower within the anoxic stations than the hypoxic ones, but the difference was not significant. Indices of the nematode community structure varied in relation to the bottom-water oxygen together with bottom-water temperature, Chl a concentration and median grain size of sediment. | HUA Er ZHANG Zhinan ZHANG Yan | 2006 | Acta Oceanologica Sinica2006，25，5： | 11 |
| 6 | Chimeric antigen receptor T cell targeting EGFRvIII for metastatic lung cancer therapy显示文摘Lung cancer is the most common incident cancer and the leading cause of cancer death. In recent years, the development of tumor immunotherapy especially chimeric antigen receptor T (CAR-T) cell has shown a promising future. Epidermal growth factor receptor variant III (EGFRvlll) is a tumor-specific mutation expressed in various types of tumors and has been detected in non-small cell lung cancer with a mutation rate of 10%. Thus, EGFRvIII is a potential antigen for targeted lung cancer therapy. In this study, CAR vectors were constructed and transfected into virus-packaging cells. Then, activated T cells were infected with retrovirus harvested from stable virus-producing single clone cell lines. CAR expression on the surfaces of the T cells was detected by flow cytometry and Western blot. The function of CAR-T targeting EGFRvIII was then evaluated. The EGFRvIII-CAR vector was successfully constructed and confirmed by DNA sequencing. A stable virus-producing cell line was produced from a single clone by limited dilution. The culture conditions for the cell line, including cell density, temperature, and culture medium were optimized. After infection with retrovirus, CAR was expressed on more than 90% of the T cells. The proliferation of CAR-T cells were induced by cytokine and specific antigen in vitro. More importantly, EGFRvIII-CART specifically and efficiently recognized and killed A549-EGFRvIII cells with an effector/target ratio of 10:1 by expressing and releasing cytokines, including perforin, granzyme B, IFN-γ, and TNF-α. The in vivo study indicated that the metastasis of A549-EGFRvIII cells in mice were inhibited by EGFRvIII-CART cells, and the survival of the mice was significantly prolonged with no serious side effects. EGFRvIII-CART showed significantly efficient antitumor activity against lung cancer cells expressing EGFRvlll in vivo and in vitro. Therefore, CAR-T targeting EGFRvIII is a potential therapeutic strategy in preventing recurrence and metastasis of lung cancer after surgery. | Zhao Zhang Jun Jiang Xiaodong Wu Mengyao Zhang Dan Luo Renyu Zhang Shiyou Li Youwen He Huijie Bian Zhinan Chen | 2019 | Frontiers of Medicine2019，13，1： | 11 |
| 7 | Global Dynamic Molecular Profiling of Stomatal Lineage Cell Development by Single-Cell RNA Sequencing显示文摘The regulation of stomatal lineage cell development has been extensively investigated.However,a comprehensive characterization of this biological process based on single-cell transcriptome analysis has not yet been reported.In this study,we performed RNA sequencing on 12844 individual cells from the cotyledons of 5-day-old Arabidopsis seedlings.We identified 11 cell clusters corresponding mostly to cells at specific stomatal developmental stages using a series of marker genes.Comparative analysis of genes with the highest variable expression among these cell clusters revealed transcriptional networks that regulate development from meristemoid mother cells to guard mother cells.Examination of the developmental dynamics of marker genes via pseudo-time analysis revealed potential interactions between these genes.Collectively,our study opens the door for understanding how the identified novel marker genes participate in the regulation of stomatal lineage cell development. | Zhixin Liu Yaping Zhou Jinggong Guo Jiaoai Li Zixia Tian Zhinan Zhu Jiajing Wang Rui Wu Bo Zhang Yongjian Hu Yijing Sun Yan Shangguan Weiqiang Li Tao Li Yunhe Hu Chenxi Guo Jean-David Rochaix Yuchen Miao Xuwu Sun | 2020 | Molecular Plant2020，13，8： | 11 |
| 8 | Influence of fault slip on mining-induced pressure and optimization ofroadway support design in fault-influenced zone显示文摘This paper presents an investigation on the characteristics of overlying strata collapse and mininginduced pressure in fault-influenced zone by employing the physical modeling in consideration of fault structure.The precursory information of fault slip during the underground mining activities is studied as well.Based on the physical modeling,the optimization of roadway support design and the field verification in fault-influenced zone are conducted.Physical modeling results show that,due to the combined effect of mining activities and fault slip,the mining-induced pressure and the extent of damaged rock masses in the fault-influenced zone are greater than those in the uninfluenced zone.The sharp increase and the succeeding stabilization of stress or steady increase in displacement can be identified as the precursory information of fault slip.Considering the larger mining-induced pressure in the fault-influenced zone,the new support design utilizing cables is proposed.The optimization of roadway support design suggests that the cables can be anchored in the stable surrounding rocks and can effectively mobilize the load bearing capacity of the stable surrounding rocks.The field observation indicates that the roadway is in good condition with the optimized roadway support design. | Hongwei Wang Yaodong Jiang Sheng Xue Lingtao Mao Zhinan Lin Daixin Deng Dengqiang Zhang | 2016 | Journal of Rock Mechanics and Geotechnical Engineering2016，8，5： | 10 |
| 9 | Microbial production of natural poly amino acid显示文摘Three kinds of poly amino acids, poly-γ-glutamic acid, poly(ε-L-lysine) and multi-L-arginyl-poly (L-aspartic acid) can be synthesized by enzymatic process independently from ribosomal protein biosynthesis pathways in microorganism. These biosynthesized polymers have attracted more and more attentions because of their unique properties and various applications. In this review, the current knowledge on the biosynthesis, biodegradations and applications of these three poly amino acids are summarized. | SHI Feng XU ZhiNan CEN PeiLin | 2007 | Science China Chemistry2007，50，3： | 9 |
| 10 | reatment of allergic inflammation and hyperresponsiveness by a simple compound, Bavachinin, isolated from Chinese herbs显示文摘气喘的发炎被一种类型调停 2 助手 T 房间(Th2 ) cytokine 反应,和堵住的 Th2 cytokine 生产被证明有一个有势力治疗学对气喘的发炎的效果。用 IL-4-green 荧光灯蛋白质(GFP ) 记者老鼠,我们表明了那 Bavachinin,从中国植物孤立的单个混合物,显著地禁止的 Th2 cytokine 生产包括 IL-4, IL-5 和 IL-13。尤其是,在 ovalbumin (卵) 的这复合几乎完全堵住的发炎敏化动物气喘模型。而且,我们证明这化学药品有选择地影响 GATA-3 的水平,由影响 GATA-3 mRNA 的稳定性最可能。第一次,我们的结果证明这单个混合物的潜在的治疗学的价值源于中国植物。 | Xi Chen Ti Wen Jun Wei Zhenzhou Wu Puyue Wang Zhangyong Hong Liqing Zhao Bin Wang Richard Flavell Shumei Gao Min Wang Zhinan Yin | 2013 | Cellular & Molecular Immunology2013，10，6： | 9 |
| 11 | Taxonomic Distinctness of Macrofauna as an Ecological Indicator in Laizhou Bay and Adjacent Waters显示文摘In this paper, we assessed the ecological and biodiversity status in the Bohai Sea through a quantitative survey on mac-rofaunal community at 25 stations in Laizhou Bay and adjacent waters in the autumn of 2006.We tested the robustness and effectiveness of taxonomic distinctness as an ecological indictor by analyzing its correlation with species richness and natural environmental variables and by analyzing other ecological indicators (Shannon-Wiener H' and W statistics from Abundance Biomass Comparison curve).Results so obtained indicated that the benthic environment of the study waters in general is not under major impact of anthropogenic disturbance, but some stations in Laizhou Bay and along the coast of the Shandong Peninsula and even in the central Bohai Sea might be moderately disturbed and showed signs of ecological degradation.The taxonomic distinctness measures △+ and Λ+ were independent of sampling effort and natural environment factors and were compliant to other ecological indicators.Further application of the taxonomic distinctness indicator to assess marine biodiversity and ecosystem health on a larger regional scale with historical data seems promising. | ZHOU Hong HUA Er ZHANG Zhinan | 2010 | Journal of Ocean University of China2010，9，4： | 9 |
| 12 | Allogeneic Vγ9Vδ2 T-cell immunotherapy exhibits promising clinical safety and prolongs the survival of patients with late-stage lung or liver cancer显示文摘Vγ9Vδ2 T cells are promising candidates for cellular tumor immunotherapy.Due to their HLA-independent mode of action,allogeneic Vγ9Vδ2 T cells can be considered for clinical application.To apply allogeneic Vγ9Vδ2 T cells in adoptive immunotherapy,the methodology used to obtain adequate cell numbers with optimal effector function in vitro needs to be optimized,and clinical safety and efficacy also need to be proven.Therefore,we developed a novel formula to improve the expansion of peripheralγδT cells from healthy donors.Then,we used a humanized mouse model to validate the therapeutic efficacy of expandedγδT cells in vivo;furthermore,the expandedγδT cells were adoptively transferred into late-stage liver and lung cancer patients.We found that the expanded cells possessed significantly improved immune effector functions,including proliferation,differentiation,and cancer cell killing,both in vitro and in the humanized mouse model.Furthermore,a phase I clinical trial in 132 late-stage cancer patients with a total of 414 cell infusions unequivocally validated the clinical safety of allogeneic Vγ9Vδ2 T cells.Among these 132 patients,8 liver cancer patients and 10 lung cancer patients who received≥5 cell infusions showed greatly prolonged survival,which preliminarily verified the efficacy of allogeneic Vγ9Vδ2 T-cell therapy.Our clinical studies underscore the safety and efficacy of allogeneic Vγ9Vδ2 T-cell immunotherapy,which will inspire further clinical investigations and eventually benefit cancer patients. | Yan Xu Zheng Xiang Mohammed Alnaggar Léonce Kouakanou Jiawei Li Junyi He Jiashuang Yang Yi Hu Yan Chen Li Lin Jianlei Hao Jingxia Li Jibing Chen Man Li Qingling Wu Christian Peters Qinghua Zhou Jianshuang Li Yingqing Liang Xiaohua Wang Baohui Han Meili Ma Dieter Kabelitz Kecheng Xu Wenwei Tu Yangzhe Wu Zhinan Yin | 2021 | Cellular & Molecular Immunology2021，18，2： | 8 |
| 13 | Two-Dimensional Tellurium:Progress,Challenges,and Prospects显示文摘Since the successful fabrication of two-dimensional(2D)tellurium(Te)in 2017,its fascinating properties including a thickness dependence bandgap,environmental stability,piezoelectric effect,high carrier mobility,and photoresponse among others show great potential for various applications.These include photodetectors,field-effect transistors,piezoelectric devices,modulators,and energy harvesting devices.However,as a new member of the 2D material family,much less known is about 2D Te compared to other 2D materials.Motivated by this lack of knowledge,we review the recent progress of research into 2D Te nanoflakes.Firstly,we introduce the background and motivation of this review.Then,the crystal structures and synthesis methods are presented,followed by an introduction to their physical properties and applications.Finally,the challenges and further development directions are summarized.We believe that milestone investigations of 2D Te nanoflakes will emerge soon,which will bring about great industrial revelations in 2D materials-based nanodevice commercialization. | Zhe Shi Rui Cao Karim Khan Ayesha Khan Tareen Xiaosong Liu Weiyuan Liang Ye Zhang Chunyang Ma Zhinan Guo Xiaoling Luo Han Zhang | 2020 | Nano-Micro Letters2020，12，8： | 8 |
| 14 | One new species and two new records of free-living marine nematodes from the Huanghai Sea显示文摘One new species of free-living marine nematode of the genus Curvolaimus, Curvolaimus filiformis sp. nov. from the Huanghai Sea isdescribed and illustrated. This new species is characterized by the buccal cavity teeth, large amphids and two ventral seta at the conicalpart of tail. Meanwhile, two new records of genus Halalaimus, Halalaimus longicaudatus and H. isaitshikovi are first reported in China.Types are deposited in the College of Marine Life Sciences, Ocean University of China. | ZHANG Zhinan HUANG Yong | 2005 | Acta Oceanologica Sinica2005，24，4： | 7 |
| 15 | Meiofauna Distribution in Intertidal Sandy Beaches Along China Shoreline(18?–40?N)显示文摘In this study,the distribution pattern of meiofauna from nine sandy beaches at six latitudinal gradients along Chinese coast between 18 and 40?N was studied on their meiofauna abundance to examine the effect of latitudinal gradients.In general,meiofauna abundance was lower in four subtropical beaches in Xiamen(24?N) and Zhoushan(29?N) than that in other beaches.Meiofauna abundance differed little between tropical and temperate beaches.The taxonomic structure of meiofauna showed a dominance of nematode in colder area.The relative composition of turbellarians and polychaetes increased in warmer area.In addition to latitudinal gradient,salinity,oxygenation,sediment grain size affect also the meiofauna latitudinal distribution.As for horizontal distribution,the highest meiofauna abundance was found in low tidal zone at tropical beaches,and in middle tidal zone at temperate beaches.The horizontal distribution of meiofauna was controlled by both physical and biotic factors including feeding and anthropogenic activities.Although meiofauna abundance exhibited a horizontal difference,the composition of meiofaunal main taxa was unanimous horizontally at all beaches at the same sampling latitude. | HUA Er ZHANG Zhinan ZHOU Hong MU Fanghong LI Jia ZHANG Ting CONG Bingqing LIU Xiaoshou | 2016 | Journal of Ocean University of China2016，15，1： | 7 |
| 16 | Seasonal variability in free-living marine nematode community structure in a sandy beach of the Taiping Bay of Qingdao,China显示文摘Nematode assemblage composition, trophic structure and biodiversity were followed over an annual cycle in a sandy beach of the Taiping Bay of Qingdao, China. Nematode assemblage in the sandy beach maintained a high genus diversity (75 genera). Microlaimus and Bathylaimus were the dominant genus of the nematode assemblage, accounting for 66% of the total nematode abundance. The nematodes' dominant trophic structure changed seasonally as a response to the seasonal changes in food quality. Epigrowth-feeder nematodes (2A) were the dominant trophic groups in the trophic structure with the highest abundance in spring because of phytoplankton bloom, while the feeding type (1B) showed higher abundance in summer that was due to the increasing of sediment detritus after spring bloom. Furthermore, species diversity and evenness calculated on nematodes identified to the genus level displayed significant temporal changes, which was also reflected by the index of trophic diversity. According to the cluster analysis, the nematode community structure of the whole year was clearly separated into two periods (A and B). Biota-Environment matching (BIOENV) results showed that seawater temperature,sediment Chl a and grain size were responsible for the nematode community structure variation in spring and summer period (Period A). However, seawater/interstitial water temperature, interstitial water dissolved oxygen concentration,interstitial water salinity, and sediment Ph a a were more important in constructing the autumn and winter period (Period B) nematode community structure. | LIU Haibin ZHANG Zhinan FAN Shiliang HUA Er DENG Ke | 2008 | Acta Oceanologica Sinica2008，27，2： | 7 |
| 17 | Biomass of meiobenthic in the Bohai Sea, China显示文摘A grid of 22 stations, giving a broad geographic coverage of the Bohai Sea and the Bohai Strait was selected. Undisturbed sediments were collected from sampling stations during cruises in June 1997, in September/October 1998 and again in April/May 1999. Based on the results of Juario (1975), the average biomass, 0.404 g/(m2a) of meiofauna (including nematode, harpacticoida, bivalve larvae, polycheata and kinorhyncha) in the Bohai Sea is given and accounts for 4.5 percent of the macrofauna in the Bohai Sea. The horizontal distribution of the biomass of meiofauna showed that it was higher at the stations of middle east part of the Bohai Sea and the strait in 1998 and 1999 cruises and it decreased at the stations near to the strait mouth and increased at Station B1 in 1999 cruise. The annual average production in the Bohai Sea is 3.636 g/m2 calculated in term of the formula P = 9B. Compared with the biomass of other sea areas in the world, the biomass of the Bohai Sea is similar but slightly lower. The individual average dry weight of nematodes given by different authors is analyzed. | Guo Yuqing, Zhang Zhinan, Mu Fanghong 1. Department of Life Science, Ocean University of Qingdao, Qingdao 266003, China 2. Agricultural College, jimei University, Xiamen 361021, China | 2001 | Acta Oceanologica Sinica2001，20，3： | 6 |
| 18 | Fundamental theories and basic principles of triboelectric effect: A review显示文摘Long-term observation of the triboelectric effect has not only proved the feasibility of many novel and useful tribo-devices(e.g., triboelectric nanogenerators), but also constantly motivated the exploration of its mysterious nature. In the pursuit of a comprehensive understanding of how the triboelectric process works, a more accurate description of the triboelectric effect and its related parameters and factors is urgently required. This review critically goes through the fundamental theories and basic principles governing the triboelectric process. By investigating the difference between each charging media, the electron, ion, and material transfer is discussed and the theoretical deduction in the past decades is provided. With the information from the triboelectric series, interesting phenomena including cyclic triboelectric sequence and asymmetric triboelectrification are precisely analyzed. Then, the interaction between the tribo-system and its operational environment is analyzed, and a fundamental description of its effects on the triboelectric process and results is summarized. In brief, this review is expected to provide a strong understanding of the triboelectric effect in a more rigorous mathematical and physical sense. | Shuaihang PAN Zhinan ZHANG | 2019 | Friction2019，7，1： | 6 |
| 19 | Analysis of high-frequency local coupling instability induced by multi- transmitting formula - P-SV wave simulation in a 2D waveguide显示文摘Local coupling instability will occur when the numerical scheme of absorbing boundary condition and that of the field wave equation allow energies to spontaneously enter into the computational domain.That is, the two schemes support common wave solutions with group velocity pointed into the computation domain.The key to eliminate local coupling instability is to avoid such wave solutions.For lumped-mass finite element simulation of P-SV wave motion in a 2D waveguide, an approach for stable implementation of high order multi-transmitting formula is provided.With a uniform rectangular mesh, it is proven and validated that high-frequency local coupling instability can be eliminated by setting the ratio of the element size equal to or greater than 2^(1/2) times the ratio of the P wave velocity to the S wave velocity.These results can be valuable for dealing instability problems induced by other absorbing boundary conditions. | Xie Zhinan Zhang Xubin | 2017 | Earthquake Engineering and Engineering Vibration2017，16，1： | 6 |
| 20 | A critical epitope in CD147 facilitates memory CD4^(+) T-cell hyper-activation in rheumatoid arthritis显示文摘The abnormal activation of CD4^(+)CD45RO+memory T(Tm)cells plays an important role in the pathogenesis of rheumatoid arthritis(RA).Previous studies have shown that CD147 participates in T-cell activation.However,it remains unclear whether CD147 is involved in abnormal Tm-cell activation in RA patients.In this study,we demonstrated that CD147 was predominantly upregulated in Tm cells derived from RA patients.The anti-CD147 mAb 5A12 specifically inhibited Tm-cell activation and proliferation and further restrained osteoclastogenesis.Using a structural–functional approach,we depicted the interface between 5A12 and CD147.This allowed us to identify two critical residues,Lys63 and Asp65,as potential targets for RA treatment,as the double mutation K63A/D65A inhibited Tm-cell activation,mimicking the neutralization by 5A12.This study provides not only a theoretical basis for a“CD147-Tm/Osteoclast-RA chain”for the potential prevention and treatment of RA or other T-cell-mediated autoimmune diseases but also a new target for related drug design and development. | Na Guo Sheng Ye Kui Zhang Xiaoling Yu Hongyong Cui Xiangmin Yang Peng lin Minghua Lv Jinlin Miao Yang Zhang Qing Han Rongguang Zhang Zhinan Chen Ping Zhu | 2019 | Cellular & Molecular Immunology2019，16，6： | 6 |
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