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| 1 | Interventional radiology in the management of malignant biliary obstruction显示文摘Malignant biliary obstruction is commonly due to pancreatic carcinoma,cholangiocarcinoma and metastatic disease which are often inoperable at presentation and carry a poor prognosis.Percutaneous biliary drainage and stenting provides a safe and effective method of palliation in such patients,thereby improving their quality of life.It may also be an adjunct to surgical management by improving hepatic and,indirectly,renal function before resection of the tumor. | Cherian George Oliver Richard Byass James Edmund Ian Cast | 2010 | World Journal of Gastrointestinal Oncology2010，2，3： | 15 |
| 2 | Sperm membrane modulation by Sapindus mukorossi during sperm maturation显示文摘Aim:TO observe the alterations in the biochemical and biophysical changes in the sperm membrane during sperm maturation in male rats treated with the water extract of the fruit pericarp of S.mukorossi.Methods:Adult male Sprague-Dawley rats were gavaged the aqueous extract of the fruit pericarp of S.mukorossi at a dose of 50mg/kg/dfor45days.On day46,the sperm parameters were observed in idfferent sections of the epididymis and the sperm superoxide dismutase and the lipid peroxidation was edtermined and compared with the controls.The testis and epidiymis were routinely prepared for histological examination under the light microscope.Results:No significant differences in the sperm number and morphology were observed between the control and reated groups.However,a significant inhibition(P<0.05-0.01)of sperm motility in the caput,corpus and cauda regions of the epididymis was seen in the treated group.No significant histopathological changes were found in the testis and epididymis.Theimportant finding was that in the treated animals,the spermatozoa showed an abnormal distribution of the superoxide dismutase activity,being minimum in the caput and maximum in the corpus,which was just opposite to that of the controls.Conclusion:The study provides a unique observation where the plant extract alters the sperm membrane physiology without change the testicular and epididymal morphology. | Manish Nivsarkar Neeta Shrivastava Manoj Patel Harish Padh Cherian Bapu | 2002 | Asian Journal of Andrology2002，4，3： | 14 |
| 3 | Anatomy and physiology of cisternostomy显示文摘 | lype Cherian Giovanni Grasso Antonio Bernardo Sunil Munakomi | 2016 | Chinese Journal of Traumatology2016，19，1： | 9 |
| 4 | MnO_2纳米粒子固载纤维素酶用于高效水解农业废弃物制备生物乙醇(英文)显示文摘纤维素酶是一种有效的纤维质类物质水解催化剂,工业应用时可通过固定化纤维素酶来降低其成本.本文将烟曲霉原变种JCF产生的纤维素酶固定在Mn O2纳米颗粒上.MnO2可提高纤维素酶的活性,并充当一个更好的载体.采用扫描电镜表征了所制MnO2纳米粒子及其负载纤维素酶的表面性质,以傅里叶变换红外光谱分析了固定在MnO2纳米粒子上纤维素酶的官能团性质.纤维素酶在MnO2纳米粒子上最大的固定化效率为75%.考察了固定化纤维素酶的活性、操作pH值、温度、热稳定性和重复使用性等性质.结果表明,所制固定化酶的稳定性比游离酶更高.固定于MnO2纳米粒子上的纤维素酶可用于纤维质类物质的水解反应,且能在较宽的温度和pH值范围内使用.表征结果证实了该催化剂具有非常高的催化纤维素类物质水解的活性. | Elsa Cherian Mahendradas Dharmendirakumar Gurunathan Baskar | 2015 | 催化学报2015，36，8： | 7 |
| 5 | Egg quality, fatty acid composition and immunoglobulin Y content in eggs from laying hens fed full fat camelina or flax seed显示文摘Background: The current study was conducted to evaluate egg quality and egg yolk fatty acids and immunoglobulin(Ig Y) content from laying hens fed full fat camelina or flax seed.Methods: A total of 75, 48-week-old Lohman brown hens were randomly allocated to 3 treatments, with 5replicates containing 5 laying hens each replicate. The hens were fed corn-soybean basal diet(Control), or Control diet with 10 % of full fat camelina(Camelina) or flax seed(Flax) for a period of 16 wk. Hen production performance egg quality, egg yolk lipids, fatty acids and Ig Y were determined every 28 d during the experimental period.Results: Egg production was higher in hens fed Camelina and Flax than in Control hens(P < 0.05). Egg weight and albumen weight was lowest in eggs from hens fed Camelina(P < 0.05). Shell weight relative to egg weight(shell weight %), and shell thickness was lowest in eggs from hens fed Flax(P < 0.05). No difference was noted in Haugh unit, yolk:albumen ratio, and yolk weight. Significant increase in α-linolenic(18:3 n-3), docosapentaenoic(22:5 n-3)and docoshexaenoic(22:6 n-3) acids were observed in egg yolk from hens fed Camelina and Flax. Total n-3 fatty acids constituted 1.19 % in Control eggs compared to 3.12 and 3.09 % in Camelina and Flax eggs, respectively(P < 0.05). Eggs from hens fed Camelina and Flax had the higher Ig Y concentration than those hens fed Control diet when expressed on a mg/g of yolk basis(P < 0.05). Although the egg weight was significantly lower in Camelina-fed hens, the total egg content of Ig Y was highest in eggs from hens fed Camelina(P < 0.05).Conclusions: The egg n-3 fatty acid and Ig Y enhancing effect of dietary camelina seed warrants further attention into the potential of using camelina as a functional feed ingredient in poultry feeding. | Gita Cherian Nathalie Quezada | 2016 | Journal of Animal Science and Biotechnology2016，7，3： | 4 |
| 6 | Laparoscopic liver resection:Wedge resections to living donor hepatectomy, are we heading in the right direction?显示文摘Despite inception over 15 years ago and over 3000 completed procedures, laparoscopic liver resection has remained mainly in the domain of selected centers and enthusiasts. Requirement of extensive open liver resection(OLR) experience, in-depth understanding of anatomy and considerable laparoscopic technical expertise may have delayed wide application. However healthy scepticism of its actual benefits and presence of a potential publication bias; concern about its safety and technical learning curve, are probably equally responsible. Given that a large proportion of our work, at least in transplantation is still OLR, we have attempted to provide an entirely unbiased, mature opinion of its pros and cons in the current invited review. We have dividedthis review into two sections as we believe they merit separate attention on technical and ethical grounds. The first part deals with laparoscopic liver resection(LLR) in patients who present with benign or malignant liver pathology, wherein we have discussed its overall outcomes; its feasibility based on type of pathology and type of resection and included a small section on application of LLR in special scenarios like cirrhosis. The second part deals with the laparoscopic living donor hepatectomy(LDH) experience to date, including its potential impact on transplantation in general. Donor safety, graft outcomes after LDH and criterion to select ideal donors for LLR are discussed. Within each section we have provided practical points to improve safety in LLR and attempted to reach reasonable recommendations on the utilization of LLR for units that wish to develop such a service. | P Thomas Cherian Ashish Kumar Mishra Palaniappen Kumar Vijayant Kumar Sachan Anand Bharathan Gadiyaram Srikanth Baiju Senadhipan Mohamad S Rela | 2014 | World Journal of Gastroenterology2014，20，37： | 4 |
| 7 | Nutrition and metabolism in poultry: role of lipids in early diet显示文摘Modern strains of broiler chickens are selected for fast growth and are marketed anywhere from 36 to 49 days after a21-day incubational period. For a viable healthy chick, all the necessary nutrients required for growth and development must be provided by the hen through the fertilized egg. The current feeding strategies for improved growth, health and productivity are targeted towards chicks after hatching. Considering the fact that developing chick embryo spends over 30 % of its total life span inside the hatching egg relying on nutrients deposited by the breeder hen, investigations on nutritional needs during pre-hatch period will improve embryonic health, hatchability and chick viability. In this context, investigations on hatching egg lipid quality is of utmost importance because, during incubation, egg fat is the major source of energy and sole source of essential omega-6(n-6) and omega-3(n-3) fatty acids to the chick embryo.Due to the unique roles of n-3 and n-6 fatty acids in growth, immune health, and development of central nervous system, this review will focus on the role of early exposure to essential fatty acids through maternal diet and hatching egg and its impact on progeny in meat-type broiler chickens. | Gita Cherian | 2016 | Journal of Animal Science and Biotechnology2016，7，3： | 4 |
| 8 | 印度喀拉拉邦出土的孔雀蓝釉陶器标本显示文摘2014年,故宫博物院与印度喀拉拉邦历史研究委员会合作,在印度帕特南遗址、奎隆港口遗址进行联合考古发掘工作,相继发现有孔雀蓝釉陶器标本出土。本文对这两处遗址中孔雀蓝釉陶器标本的出土情况作简要报告,结合国内同类标本出土情况及相关文献资料,判断这些标本是9至10世纪自古阿拉伯帝国远航中国途中的遗物,同类器物在进入中国之后,其性质发生了转变。 | 无 冀洛源 PJ Cherian | 2022 | 故宫博物院院刊2022，，6： | 3 |
| 9 | 排放削减活动和清洁发展机制:关键的未解决问题显示文摘《京都议定书》的清洁发展机制(CDM)使得工业化国家和过渡经济国家能使用经认证的,因CDM活动而自然形成的排放量削减来履行其限制和减少排放量的承诺的某一部分.本文侧重于关于在CDM范围内开展的排放削减活动的实施的未解决问题(例如,有歧义的语言,各种排放削减活动的实施手段上的不一致). | Anilla Cherian | 1999 | 产业与环境1999，21，1： | 3 |
| 10 | A 10-miRNA risk score-based prediction model for pathological complete response to neoadjuvant chemotherapy in hormone receptor-positive breast cancer显示文摘Patients with hormone receptor(HR)-positive tumors breast cancer usually experience a relatively low pathological complete response(p CR)to neoadjuvant chemotherapy(NAC).Here,we derived a 10-micro RNA risk score(10-mi RNA RS)-based model with better performance in the prediction of p CR and validated its relation with the disease-free survival(DFS)in 755 HRpositive breast cancer patients(273,265,and 217 in the training,internal,and external validation sets,respectively).This model,presented as a nomogram,included four parameters:the 10-mi RNA RS found in our previous study,progesterone receptor(PR),human epidermal growth factor receptor 2(HER2)status,and volume transfer constant(K).Favorable calibration and discrimination of 10-mi RNA RS-based model with areas under the curve(AUC)of 0.865,0.811,and 0.804 were shown in the training,internal,and external validation sets,respectively.Patients who have higher nomogram score(>92.2)with NAC treatment would have longer DFS(hazard ratio=0.57;95%CI:0.39–0.83;P=0.004).In summary,our data showed the 10-mi RNA RS-based model could precisely identify more patients who can attain p CR to NAC,which may help clinicians formulate the personalized initial treatment strategy and consequently achieves better clinical prognosis for patients with HRpositive breast cancer. | Chang Gong Ziliang Cheng Yaping Yang Jun Shen Yingying Zhu Li Ling Wanyi Lin Zhigang Yu Zhihua Li Weige Tan Chushan Zheng Wenbo Zheng Jiajie Zhong Xiang Zhang Yunjie Zeng Qiang Liu RStephanie Huang Andrzej LKomorowski Eddy SYang François Bertucci Francesco Ricci Armando Orlandi Gianluca Franceschini Kazuaki Takabe Suzanne Klimberg Naohiro Ishii Angela Toss Mona PTan Mathew A Cherian Erwei Song | 2022 | Science China(Life Sciences)2022，65，11： | 3 |
| 11 | Liver transplantation for acute intermittent porphyria:a viable treatment?显示文摘BACKGROUND:Acute intermittent porphyria (AIP) is the most common hepatic porphyria.Its clinical presentation includes severe disabling and life-threatening neurovisceral symptoms and acute psychiatric symptoms.These symptoms result from the overproduction and accumulation of porphyrin precursors,5-aminoleuvulinic acid (ALA) and porphobilinogen (PBG).The effect of medical treatment is transient and is not effective once irreversible neurological damage has occurred.Liver transplantation (LT) replaces hepatic enzymes and can restore normal excretion of ALA and PBG and prevent acute attacks.METHOD:Two cases of LT for AIP were identified retrospectively from a prospectively maintained LT database.RESULT:LT was successful with resolution of AIP in two patients who suffered from repeated acute attacks.CONCLUSION:LT can correct the underlying metabolic abnormality in AIP and improves quality of life significantly. | Faisal S Dar Koji Asai Ali Raza Haque Thomas Cherian Mohamed Rela Nigel Heaton | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，1： | 2 |
| 12 | A modified Murashige and Skoog media for efficient multipleshoot induction in G. arborea Roxb.显示文摘This paper reports on the effect of various micropropagation factors of Gmelina arborea Roxb. through multiple shoot induction. Factors like the source and age of explants, plant growth regulators(PGRs), media composition, and carbon source affected multiple shooting in the present study. Among all the explants used, only shoot tips derived from one, two, and three week old seedlings could form multiple shoots. Besides, the formation of multiple shoots depended on the concentration and combination of PGRs. Among all the PGRs, BAP(6-benzylaminopurine) alone gave the highest regeneration efficiency. Similarly, IBA(Indole-3-butyric acid) was the most efficient PGR in inducing root formation in the microshoots. Media composition and carbon source also affected the regeneration efficiency. MS(Murashige and Skoog medium) proved to be the best media for regeneration followed by B5, SH(Schenk and Hilderbrandt medium) and WPM(Woody plant medium) in that order. Similarly, among sugars, only sucrose and glucose supported induction of microshoots. Based on this study we recommend the use of glucose in place of sucrose in MS medium for maximum regeneration efficiency. | Shilpa S. Madke Konglanth J. Cherian Rupesh S. Badere | 2014 | Journal of Forestry Research2014，25，3： | 2 |
| 13 | Epoxy-modified, unsaturated polyester hybrid networks显示文摘 | A. Benny Cherian Lity Alen Varghese Eby Thomas Thachil | 2007 | European Polymer Journal2007，，4： | 2 |
| 14 | The utility of a novel narrow band imaging endoscopy system in patients with Barrett’s esophagus显示文摘 | Prateek Sharma Ajay Bansal Sharad Mathur Sachin Wani Rachel Cherian Douglas McGregor April Higbee Sandra Hall Allan Weston | 2006 | Gastrointestinal Endoscopy2006，，： | 2 |
| 15 | p53 protein overexpression in low grade dysplasia (LGD) in barrett’s esophagus: Immunohistochemical marker predictive of progression显示文摘 | Allan P Weston Sushanta K Banerjee Prateek Sharma Trang M Tran Robert Richards Rachel Cherian | 2001 | The American Journal of Gastroenterology2001，，5： | 2 |
| 16 | 不同距离观看3D影像后视光学参数和视力疲劳症状分析(英文)显示文摘目的:不同距离观看3D影像后调节幅度、集合近点(NPC)及近隐斜视和视力疲劳的症状分析。方法:前瞻性研究,包括30例青年。每人每天三次分别在特定距离和不同距离观看3D影像,并连续三天进行观察,每一距离使用相同视频,相同的时间和不同的屏幕大小。使用K-multimedia player 3D播放器。观看3D影响后立即记录立体视觉、调节幅度、调节近点及近隐斜视和视力疲劳症状等相关变量。分别使用TNO测量视功能,RAF尺测量调节幅度和集合近点,棱镜杆测量近隐斜视,封闭式问卷调查视力疲劳症状的发生情况。用描述性统计和配对t检验进行数据分析,定性数据采用卡方检测。结果:在40 cm,3 m和6 m处调节幅度分别减少了0.66 D,1.12 D和1.44 D,集合近点显著降低了0.63 cm,0.93 cm和1.23 cm,近隐斜视分别增加了0.87,2.74和2.2棱镜度。结果发现,大多数受试者在每一距离处都出现眼周疼痛,头痛和刺激等反应。在家庭环境中,头痛、盗汗、疲劳、刺激和恶心等症状会显著增加,此外,通过使用笔记本电脑观看3D可能会引起头痛和盗汗等相关不适症状。结论:观看3D前后、在三种不同距离处,调节幅度、集合近点及近隐斜视和视力疲劳的症状显著不同。在不同距离观看3D影像后,视力疲劳为主要症状。 | Oleeviya Joseph Lavanya Kalikivayi Sajeev Cherian Jacob Venkataramana Kalikivayi | 2018 | 国际眼科杂志2018，18，5： | 2 |
| 17 | The Global Alliance against Chronic Respiratory Diseases:journey so far and way ahead显示文摘The Global Alliance Against Chronic Respiratory Diseases(GARD)is a voluntary alliance of national and international organizations,institutions,and agencies committed to the vision of 'a world where all people breathe freely'Its goal is to reduce the global burden of chronic respiratory disease(CRD).The GARD initiative was set up to respond to a resolution of the World Health Assembly in May 2000(Resolution WHA53.17)that emphasized the need to increase awareness of the growing epidemic of CRDs worldwide.A program was begun to design a comprehensive approach to the prevention and control of CRDs.11,21 The resolution was approved by the General Assembly of World Health Organization(WHO)in 2004. | Arzu Yorgancioglu Nikolai Khaltaev Jean Bousquet Cherian Varghese | 2020 | Chinese Medical Journal2020，，13： | 2 |
| 18 | Metallothioneins in human tumors and potential roles in carcinogenesis显示文摘 | M.George Cherian A. Jayasurya Boon-Huat Bay | 2003 | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis2003，，1： | 2 |
| 19 | Down-regulation of transcription factor peroxisome proliferator-activated receptor in programmed hepatic lipid dysregulation and inflammation in intrauterine growth-restricted offspring显示文摘 | Magee TR Han G Cherian B | 2008 | Am J Obstet Gynecol2008，199，3： | 1 |
| 20 | Canalith repositioning for benign paroxysmal positional vertigo显示文摘 | White J Savvides P Cherian N | 2005 | Otol Neurotol2005，26，： | 1 |
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