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| 1 | 儿童期肥胖、成年期肥胖和心血管风险因子显示文摘过去30年,儿童超重或肥胖的发生率明显增加[1]。儿童期肥胖是死亡率增加的预测因子,这主要是由于儿童期肥胖可导致心血管疾病发生率增加。相关的预测研究提示"肥胖流行症"可能改变目前心血管疾病死亡率下降的趋势,使现今儿童的寿命缩短。 | Juonala M Magnussen CG Berenson GS Venn A Burns TL Sabin MA Srinivasan SR Daniels SR Davis PH Chen W Sun C Cheung M Viikari JS Dwyer T Raitakari OT 叶鹏 | 2012 | 中华高血压杂志2012，20，1： | 6 |
| 2 | T wave altemans threshold in normal children 显示文摘 | Cheung MM Davis AM Cohen RJ | 2001 | J Cardiovasc Electrophysiol2001，12，4： | 1 |
| 3 | 显示文摘 | Schmuhl N Davis E Cheung H M | 1998 | Langmuir1998，14，： | 1 |
| 4 | Methylation of an intronic region regulates miR-199a in testicular tumor malignancy显示文摘 | Cheung HH Davis AJ Lee TL | 2011 | Oncogene2011，30，31： | 1 |
| 5 | Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding显示文摘 | Cheung P C Salt I P Davies S P | 2000 | Biochem2000，346，： | 1 |
| 6 | Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase Ⅱ randomised placebo-controlled double-blind multicentre trial显示文摘Rationale Haematoma growth is common early after intracerebral haemorrhage(ICH),and is a key determinant of outcome.Tranexamic acid,a widely available antifibrinolytic agent with an excellent safety profile,may reduce haematoma growth.Methods and design Stopping intracerebral haemorrhage with tranexamic acid for hyperacute onset presentation including mobile stroke units(STOP-MSU)is a phase Ⅱ double-blind,randomised,placebo-controlled,multicentre,international investigator-led clinical trial,conducted within the estimand statistical framework.Hypothesis In patients with spontaneous ICH,treatment with tranexamic acid within 2 hours of onset will reduce haematoma expansion compared with placebo.Sample size estimates A sample size of 180 patients(90 in each arm)would be required to detect an absolute difference in the primary outcome of 20%(placebo 39%vs treatment 19%)under a two-tailed significance level of 0.05.An adaptive sample size re-estimation based on the outcomes of 144 patients will allow a possible increase to a prespecified maximum of 326 patients.Intervention Participants will receive 1 g intravenous tranexamic acid over 10 min,followed by 1 g intravenous tranexamic acid over 8 hours;or matching placebo.Primary efficacy measure The primary efficacy measure is the proportion of patients with haematoma growth by 24±6 hours,defined as either≥33%relative increase or≥6 mL absolute increase in haematoma volume between baseline and follow-up CT scan.Discussion We describe the rationale and protocol of STOP-MSU,a phase Ⅱ trial of tranexamic acid in patients with ICH within 2 hours from onset,based in participating mobile stroke units and emergency departments. | Nawaf Yassi Henry Zhao Leonid Churilov Bruce C V Campbell Teddy Wu Henry Ma Andrew Cheung Timothy Kleinig Helen Brown Philip Choi Jiann-Shing Jeng Annemarei Ranta Hao-Kuang Wang Geoffrey C Cloud Rohan Grimley Darshan Shah Neil Spratt Der-Yang Cho Karim Mahawish Lauren Sanders John Worthington Ben Clissold Atte Meretoja Vignan Yogendrakumar Mai Duy Ton Duc Phuc Dang Nguyen Thai My Phuong Huy-Thang Nguyen Chung Y Hsu Gagan Sharma Peter J Mitchell Bernard Yan Mark W Parsons Christopher Levi Geoffrey A Donnan Stephen M Davis | 2022 | Stroke & Vascular Neurology2022，7，2： | 1 |
| 7 | Methylation of an intronic region regulates miR-199a in testicular tumor malignancy显示文摘 | Cheung H H Davis A J Lee T L | 2011 | Oncogene2011，30，31： | 1 |
| 8 | Characterization of AMP-activated protein kinase γ subunit isoforms and their role in AMP binding显示文摘 | Cheung P C Salt I P Davies S P | 2000 | Biochem J2000，346，： | 1 |
| 9 | Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding显示文摘 | CHEUNG P C SALT I P DAVIES S P | 2000 | Biochem2000，346，： | 1 |
| 10 | Characterization of AMPactivated protein kinase gamma-subunit isoforms and their role in AMP binding显示文摘 | Cheung P C Salt I P Davies S P | 2000 | Biochem2000，346，3： | 1 |
| 11 | Morphology of thermally polymerized microporous polymer materials from methyl methacrylate and 2 -hydroxyethyl methacrylate microemulsions显示文摘 | Schmuhl N Davis E Cheung H M | 1998 | Langmuir1998，14，4： | 1 |
| 12 | T wave alter- naris threshold in normal children 显示文摘 | Cheung MM Davis AM Cohen RJ | 2002 | J Cardiovasc Electro- physiol2002，12，4： | 1 |
| 13 | Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding显示文摘 | Cheung P C Salt I P Davies S P | 2000 | J Biochem2000，346，3： | 1 |
| 14 | Genome-wide DNA methylation profiling reveals novel epigenetically regulated genes and non coding RNAs in human testicular cancer显示文摘 | Cheung H H Lee T L Davis A J | 2010 | Br J Cancer2010，102，： | 1 |
| 15 | Characterization of AMP-activated protein kinase y-subunit isoforms and their role in AMP binding 显示文摘 | Cheung PC Salt IP Davies SP | 2000 | Biochem J2000，346，3： | 1 |
| 16 | Characterization of AMP activated protein kinase gamma subunit isoforms and their role in AMP binding显示文摘 | Cheung P C Salt I P Davies S P | 2000 | Bio Chem2000，346，： | 1 |
| 17 | The potential of fire assay and inductively coupled plasma source mass spectrometry for the determination of platinum group elements in geological materials 显示文摘 | Ddte A R Davis A E Cheung Y Y | 1987 | Analyst1987，112，9： | 1 |
| 18 | Methylation of an intronic region regulates miR-199a in testieular tumor malignancy显示文摘 | Cheung HH Davis AJ Lee TL | 2011 | On- cogene2011，30，31： | 1 |
| 19 | A Relation- al-XML Data Warehouse for Data Aggregation with SQL and XQuery 显示文摘 | Fong Joseph Shiu Herbert Cheung Davy | 2008 | Software-practice & Experience2008，38，11： | 1 |
| 20 | Morphology of thermally polymefized microporous polymer materials prepared from methyl methacrylate and 2-hydroxyethyl methaerylate microemulsions 显示文摘 | Schmuhl N Davis E Michael Cheung H | 1998 | Langmuir1998，14，： | 1 |
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