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| 1 | Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase Ⅱ randomised placebo-controlled double-blind multicentre trial显示文摘Rationale Haematoma growth is common early after intracerebral haemorrhage(ICH),and is a key determinant of outcome.Tranexamic acid,a widely available antifibrinolytic agent with an excellent safety profile,may reduce haematoma growth.Methods and design Stopping intracerebral haemorrhage with tranexamic acid for hyperacute onset presentation including mobile stroke units(STOP-MSU)is a phase Ⅱ double-blind,randomised,placebo-controlled,multicentre,international investigator-led clinical trial,conducted within the estimand statistical framework.Hypothesis In patients with spontaneous ICH,treatment with tranexamic acid within 2 hours of onset will reduce haematoma expansion compared with placebo.Sample size estimates A sample size of 180 patients(90 in each arm)would be required to detect an absolute difference in the primary outcome of 20%(placebo 39%vs treatment 19%)under a two-tailed significance level of 0.05.An adaptive sample size re-estimation based on the outcomes of 144 patients will allow a possible increase to a prespecified maximum of 326 patients.Intervention Participants will receive 1 g intravenous tranexamic acid over 10 min,followed by 1 g intravenous tranexamic acid over 8 hours;or matching placebo.Primary efficacy measure The primary efficacy measure is the proportion of patients with haematoma growth by 24±6 hours,defined as either≥33%relative increase or≥6 mL absolute increase in haematoma volume between baseline and follow-up CT scan.Discussion We describe the rationale and protocol of STOP-MSU,a phase Ⅱ trial of tranexamic acid in patients with ICH within 2 hours from onset,based in participating mobile stroke units and emergency departments. | Nawaf Yassi Henry Zhao Leonid Churilov Bruce C V Campbell Teddy Wu Henry Ma Andrew Cheung Timothy Kleinig Helen Brown Philip Choi Jiann-Shing Jeng Annemarei Ranta Hao-Kuang Wang Geoffrey C Cloud Rohan Grimley Darshan Shah Neil Spratt Der-Yang Cho Karim Mahawish Lauren Sanders John Worthington Ben Clissold Atte Meretoja Vignan Yogendrakumar Mai Duy Ton Duc Phuc Dang Nguyen Thai My Phuong Huy-Thang Nguyen Chung Y Hsu Gagan Sharma Peter J Mitchell Bernard Yan Mark W Parsons Christopher Levi Geoffrey A Donnan Stephen M Davis | 2022 | Stroke & Vascular Neurology2022，7，2： | 1 |
| 2 | Hypothyroidism and hyperthyroidism in anxiety disorders revisited: new data and literature review显示文摘 | Naomi M Simon Deborah Blacker Nicole B Korbly Saumya G Sharma John J Worthington Michael W Otto Mark H Pollack | 2002 | Journal of Affective Disorders2002，，1： | 1 |
| 3 | Prevalence of positive syphilis serology and meningovascular neurosyphilis in patients admitted with stroke and TIA from a culturally diverse population (2005–09)显示文摘 | Dennis J. Cordato Sanja Djekic Sanjeev R. Taneja Michael Maley Roy G. Beran Cecilia Cappelen-Smith Neil C. Griffith Ibrahim Y. Hanna Suzanne J. Hodgkinson John M. Worthington Alan J. McDougall | 2013 | Journal of Clinical Neuroscience2013，，7： | 1 |
| 4 | Genes for rheumatoid arthritis offer new insights into disease mechanisms 显示文摘 | John S Davies N Worthington J | 2005 | Drug Discovery Today: Disease Mechanisms2005，，2： | 1 |
| 5 | Anxiety Symptoms Questionnaire(ASQ):development and validation显示文摘Background The Anxiety Symptoms Questionnaire(ASQ)is a brief self-report questionnaire which measures frequency and intensity of symptoms and was developed to improve assessment of anxiety symptoms in a clinical setting.We examined the reliability and validity of the ASQ in patients with anxiety disorders and/or depression,nonclinical control subjects and college students.Methods 240 outpatients with generalised anxiety disorder,social anxiety disorder,panic disorder or major depressive disorder were administered the ASQ and additional questionnaires measuring depression and anxiety,as were 111 non-clinical control subjects and 487 college students.Factor analysis,Pearson's correlation coefficients and logistic regression were used to assess reliability and validity.Test-retest reliability of the ASQ was measured using a subset who were re-administered the ASQ after 4 weeks.Results Factor analysis revealed measurement of a single dimension by the ASQ.Internal consistency and test-retest reliability were strong.The ASQ total score also significantly distinguished patients with an anxiety disorder from the clinical controls above and beyond the clinicianrated Hamilton Anxiety Scale.Conclusions The ASQ is a valid,reliable and effective self-rated measure of anxiety and may be a useful tool for screening and assessing anxiety symptoms in psychiatric as well as college settings. | Amanda Baker Naomi Simon Aparna Keshaviah Amy Farabaugh Thilo Deckersbach John J Worthington Elizabeth Hoge Maurizio Fava Mark P Pollack | 2019 | General Psychiatry2019，32，6： | 1 |
| 6 | Quetiapine augmentation of paroxetine CR for the treatment of refractory generalized anxiety disorder: preliminary findings显示文摘 | Naomi M. Simon Kathryn M. Connor Richard T. LeBeau Elizabeth A. Hoge John J. Worthington Wei Zhang Jonathan R. T. Davidson Mark H. Pollack | 2008 | Psychopharmacology2008，，4： | 1 |
| 7 | Hypothyroidism and hyperthyroidism in anxiety disorders revisited: new data and literature review显示文摘 | Naomi M Simon Deborah Blacker Nicole B Korbly Saumya G Sharma John J Worthington Michael W Otto Mark H Pollack | 2002 | Journal of Affective Disorders2002，，1： | 1 |
| 8 | Genes for rheumatoid arthritis offer new insights into disease mechanisms显示文摘 | John S Davies N Worthington J | 2005 | Drug Discovery Today: Disease Mechanisms2005，2，3： | 1 |
| 9 | Characterization of the oligomeric structure of the Ca(2+)-activated Cl- channel Ano1/TMEM16A 显示文摘 | John T Sheridan Erin N Worthington Yu Kuai | 2010 | J Biol Chem2010，286，2： | 1 |
| 10 | Genes for rheumatoid arthri-tis offer new insights into disease mechanisms显示文摘 | JOHN S DAVIES N WORTHINGTON J | 2005 | Drug Discovery Today:Disease Mechanisms2005，2，3： | 1 |
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