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| 1 | YPED: An Integrated Bioinformatics Suite and Database for Mass Spectrometry-based Proteomics Research显示文摘We report a significantly-enhanced bioinformatics suite and database for proteomics research called Yale Protein Expression Database(YPED) that is used by investigators at more than 300 institutions worldwide. YPED meets the data management, archival, and analysis needs of a high-throughput mass spectrometry-based proteomics research ranging from a singlelaboratory, group of laboratories within and beyond an institution, to the entire proteomics community. The current version is a significant improvement over the first version in that it contains new modules for liquid chromatography–tandem mass spectrometry(LC–MS/MS) database search results, label and label-free quantitative proteomic analysis, and several scoring outputs for phosphopeptide site localization. In addition, we have added both peptide and protein comparative analysis tools to enable pairwise analysis of distinct peptides/proteins in each sample and of overlapping peptides/proteins between all samples in multiple datasets. We have also implemented a targeted proteomics module for automated multiple reaction monitoring(MRM)/selective reaction monitoring(SRM) assay development. We have linked YPED's database search results and both label-based and label-free fold-change analysis to the Skyline Panorama repository for online spectra visualization. In addition, we have built enhanced functionality to curate peptide identifications into an MS/MS peptide spectral library for all of our protein database search identification results. | Christopher M.Colangelo Mark Shifman Kei-Hoi Cheung Kathryn L.Stone Nicholas J.Carriero Erol E.Gulcicek TuKiet T.Lam Terence Wu Robert D.Bjornson Can Bruce Angus C.Nairn Jesse Rinehart Perry L.Miller Kenneth R.Williams | 2015 | Genomics, Proteomics & Bioinformatics2015，13，1： | 3 |
| 2 | Relationship between Myopia and Optical Components - A Study among Chinese Hong Kong Student Population显示文摘Purpose: To establish the prevalence and severity of myopia among the Chinese Hong Kong students and to study the relationship between myopia and optical components.Methods;One thousand and seventy-five freshmen of the 1993-1994 academic year in the Chinese University of Hong Kong underwent the eye examination including evaluation of refractive error, keratometry, and A-scan ultrasonic biometry. The data were analyzed with the SPSS/PC+4. 01 statistical package. Results: The prevalence of myopia was 91. 7% with the mean refraction being -4. 00 ± 2. 64D in this young adult population. The statistical analyses demonstrated a significant correlation between refractive value and axial length of the globe (r=-0. 78), vitreous length (r=-0. 76), anterior chamber depth (r=-0. 33), lens thickness (r = 0. 13) and corneal curvature (r = 0. 19). Conclusion: The refractive status is mainly dependent on the axial length. In general, the higher the myopia was, the longer the eyeball, the deeper the anterior chamber, | Peng Iob Lo Patrick CP Ho Joseph TF Lau Albert YK Cheung Ernst Goldschmidt Mark OM Tso | 1996 | Eye Science1996，16，3： | 2 |
| 3 | ASPP2 Binds Par-3 and Controls the Polarity and Proliferation of Neural Progenitors during CNS Development显示文摘 | Roberta Sottocornola Christophe Royer Virginie Vives Luca Tordella Shan Zhong Yihua Wang Indrika Ratnayaka Mark Shipman Amanda Cheung Carles Gaston-Massuet Patrizia Ferretti Zoltán Molnár Xin Lu | 2010 | Developmental Cell2010，，1： | 1 |
| 4 | Antecedents and sex/gender differences in youth suicidal behavior显示文摘Suicide is the second leading cause of death in youth globally; however, there is uncertainty about how best to intervene. Suicide rates are typically higher in males than females, while the converse is true for suicide attempts. We review this 'gender paradox' in youth, and in particular, the age-dependency of these sex/gender differences and the developmental mechanisms that may explain them. Epidemiologic, genetic,neurodevelopmental and psychopathological research have identified suicidal behaviour risks arising from genetic vulnerabilities and sex/gender differences in early adverse environments, neurodevelopment, mental disorder and their complex interconnections. Further, evolving sex-/gender-defined social expectations and norms have been thought to influence suicide risk. In particular, how youth perceive and cope with threats and losses(including conforming to others' or one's own expectations of sex/gender identity) and adapt to pain(through substance use and helpseeking behaviours). Taken together, considering brain plasticity over the lifespan, these proposed antecedents to youth suicide highlight the importance of interventions that alter early environment(s)(e.g., childhood maltreatment) and/or one's ability to adapt to them. Further, such interventions may have more enduring protective effects, for the individual and for future generations, if implemented in youth. | Anne E Rhodes Michael H Boyle Jeffrey A Bridge Mark Sinyor Paul S Links Lil Tonmyr Robin Skinner Jennifer M Bethell Corine Carlisle Sarah Goodday Travis Salway Hottes Amanda Newton Kathryn Bennett Purnima Sundar Amy H Cheung Peter Szatmari | 2014 | World Journal of Psychiatry2014，4，4： | 1 |
| 5 | Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase Ⅱ randomised placebo-controlled double-blind multicentre trial显示文摘Rationale Haematoma growth is common early after intracerebral haemorrhage(ICH),and is a key determinant of outcome.Tranexamic acid,a widely available antifibrinolytic agent with an excellent safety profile,may reduce haematoma growth.Methods and design Stopping intracerebral haemorrhage with tranexamic acid for hyperacute onset presentation including mobile stroke units(STOP-MSU)is a phase Ⅱ double-blind,randomised,placebo-controlled,multicentre,international investigator-led clinical trial,conducted within the estimand statistical framework.Hypothesis In patients with spontaneous ICH,treatment with tranexamic acid within 2 hours of onset will reduce haematoma expansion compared with placebo.Sample size estimates A sample size of 180 patients(90 in each arm)would be required to detect an absolute difference in the primary outcome of 20%(placebo 39%vs treatment 19%)under a two-tailed significance level of 0.05.An adaptive sample size re-estimation based on the outcomes of 144 patients will allow a possible increase to a prespecified maximum of 326 patients.Intervention Participants will receive 1 g intravenous tranexamic acid over 10 min,followed by 1 g intravenous tranexamic acid over 8 hours;or matching placebo.Primary efficacy measure The primary efficacy measure is the proportion of patients with haematoma growth by 24±6 hours,defined as either≥33%relative increase or≥6 mL absolute increase in haematoma volume between baseline and follow-up CT scan.Discussion We describe the rationale and protocol of STOP-MSU,a phase Ⅱ trial of tranexamic acid in patients with ICH within 2 hours from onset,based in participating mobile stroke units and emergency departments. | Nawaf Yassi Henry Zhao Leonid Churilov Bruce C V Campbell Teddy Wu Henry Ma Andrew Cheung Timothy Kleinig Helen Brown Philip Choi Jiann-Shing Jeng Annemarei Ranta Hao-Kuang Wang Geoffrey C Cloud Rohan Grimley Darshan Shah Neil Spratt Der-Yang Cho Karim Mahawish Lauren Sanders John Worthington Ben Clissold Atte Meretoja Vignan Yogendrakumar Mai Duy Ton Duc Phuc Dang Nguyen Thai My Phuong Huy-Thang Nguyen Chung Y Hsu Gagan Sharma Peter J Mitchell Bernard Yan Mark W Parsons Christopher Levi Geoffrey A Donnan Stephen M Davis | 2022 | Stroke & Vascular Neurology2022，7，2： | 1 |
| 6 | Comparative cytotoxicity and pharmacokinetics of antimelanoma immunotoxins containing either natural or recombinant gelonin显示文摘 | Rosenblum M G Marks J W Cheung L H | 1999 | Cancer Chemother Pharmacol1999，44，4： | 1 |
| 7 | Deep hypothermic circulatory arrest: I. Effects of cooling on electroencephalogram and evoked potentials显示文摘 | Mark M Stecker Albert T Cheung Alberto Pochettino Glenn P Kent Terry Patterson Stuart J Weiss Joseph E Bavaria | 2001 | The Annals of Thoracic Surgery2001，，1： | 1 |
| 8 | In vitro and in vivo studies of a VEGF121/r Oelonin chimeric fusion toxin targeting the neovas culature of solid tumors显示文摘 | Veenndaal L M Jin H Ran S Cheung L Navone N Marks J W | 2002 | Proc Natl Aead Sci USA2002，99，： | 1 |
| 9 | Agglomerative Fuzzy K-Means Clustering Algorithm with Selection of Number of Cluster显示文摘 | Mark Junjie Li Michael K Ng Yiu-ming Cheung | 2008 | IEEE Transactions on Knowledge and Data Engineering2008，20，11： | 1 |
| 10 | The role of leptin and melanocortin signaling inuremia-associated cachexia显示文摘 | Cheung W Marks DL Yu X | 2005 | J Clin Invest2005，115，6： | 1 |
| 11 | Mode-locked pulsed fiber array sealable to high power显示文摘 | Eric Cheung Mark Weber David Mordaunt | 2004 | SPIE2004，5335，： | 1 |
| 12 | The role of leptin and melano- cortin signaling in uremia-associated caehexia 显示文摘 | Cheung W Marks DL Yu X | 2005 | Clin Invest2005，115，： | 1 |
| 13 | Radial immunodiffusion of apolipoprotein: Factor contributory to assay workshop on apolipoprotein quantification显示文摘 | Cheung Mark Albers JJ | 1983 | Bethesda: Maryland1983，，： | 1 |
| 14 | Cervical cancer risk for women undergoing concurrent testing for human papillomavirus and cervical cytology: a population-based study in routine clinical practice显示文摘 | Hormuzd A Katki Walter K Kinney Barbara Fetterman Thomas Lorey Nancy E Poitras Li Cheung Franklin Demuth Mark Schiffman Sholom Wacholder Philip E Castle | 2011 | Lancet Oncology2011，，7： | 1 |
| 15 | Orexigenic and anorexigenlc mechanism in the control of nutrition in chronic kidney disease显示文摘 | MARK R H CHEUNG W CONE R D | 2005 | Pediatr Nephrol2005，20，： | 1 |
| 16 | Cervical cancer risk for women undergoing concurrent testing for human papillomavirus and cervical cytology: a population-based study in routine clinical practice显示文摘 | Hormuzd A Katki Walter K Kinney Barbara Fetterman Thomas Lorey Nancy E Poitras Li Cheung Franklin Demuth Mark Schiffman Sholom Wacholder Philip E Castle | 2011 | Lancet Oncology2011，，7： | 1 |
| 17 | Managerial Flexibility in Capital Investment Decision : Insights from the Real - Options Literature显示文摘 | Cheung Joseph Kland Mark Rubinstein | 1993 | Journal of Account- ing Literature1993，，： | 1 |
| 18 | The ECLIPSE Trials: Comparative Studies of Clevidipine to Nitroglycerin, Sodium Nitroprusside, and Nicardipine for Acute Hypertension Treatment in Cardiac Surgery Patients显示文摘 | Solomon Aronson Cornelius M. Dyke Kevin A. Stierer Jerrold H. Levy Albert T. Cheung Philip D. Lumb Dean J. Kereiakes Mark F. Newman | 2008 | Anesthesia & Analgesia2008，，： | 1 |
| 19 | A comparison of detection performance for several track-before- detect algorithms 显示文摘 | Davey Samuuel J Rutten Mark G Brian Cheung | 2008 | Eurasip Journal on Advances in Signal Processing2008，41，： | 1 |
| 20 | A pilot study to develop a prediction instrument for endocarditis in injection drug users admitted with fever显示文摘 | Robert Rodriguez Harrison Alter Kaija-Leena Romero Bory Kea William Chiang Jonathan Fortman Christina Marks Paul Cheung Simon Conti | 2011 | American Journal of Emergency Medicine2011，，8： | 1 |
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