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| 1 | Changing patterns and survival improvements of young breast cancer in China and SEER database, 1999-2017显示文摘Objective: Breast cancer in young females was usually considered more aggressive and requires aggressive therapy. We investigated whether early detection and improved treatments changed the patterns of characteristics,management and outcomes of young breast cancer patients over time.Methods: Females under 40 years of age diagnosed with breast cancer during the periods 1999-2017 and1999-2015 were identified in the Fudan University Shanghai Cancer Center(FUSCC) and the population-based Surveillance, Epidemiology, and End Results(SEER) registry, respectively. Clinicopathologic characteristics and treatment information were collected. Patients diagnosed before 2013 were followed up.Results: The proportions of young breast cancer patients were 15.0% and 5.3% in the FUSCC and SEER cohorts, respectively. In the FUSCC cohort, there was a significant increase in the proportion of ductal carcinoma in situ(DCIS)(from 8.8% to 16.9%;P<0.0001) and it remained stable in SEER cohort. The proportion of T1-stage tumors increased dramatically in the FUSCC cohort(from 35.3% to 41.9%;P=0.008), whereas it decreased in SEER cohort(from 42.4% to 33.0%;P<0.0001). The percentage of estrogen receptor(ER)-positive cancers was consistently increased in both the invasive ductal carcinoma(IDC) and DCIS patients in the two cohorts. Breastconserving surgery and immediate implant reconstruction after mastectomy both exhibited increased use over time in the FUSCC cohort. Both the FUSCC and SEER cohorts showed a significantly better prognosis in the recent time period.Conclusions: With the increased early-stage and ER-positive diseases in young patients as well as better systemic treatment strategies, improved survival has been observed in recent years. There has been a substantial deescalation in surgical therapies in young breast cancer patients. | Rong Guo Jing Si Jingyan Xue Yonghui Su Miao Mo Benlong Yang Qi Zhang Weiru Chi Yayun Chi Jiong Wu | 2019 | Chinese Journal of Cancer Research2019，31，4： | 24 |
| 2 | Effects of hydrocarbon generation on fluid flow in the Ordos Basin and its relationship to uranium mineralization显示文摘诺思中国的 Ordos 盆是不仅一个重要的铀矿化作用省,而且在中国的油,气体和煤的一个主要制片人。在铀矿化作用和烃之间的基因关系被认出了由很多以前的研究,而是它很好没以盆液体的水动力学被理解流动。我们在以前的研究证明了在 Ordos 侏罗记节的上面的部分的白垩纪铀矿化作用的优先的本地化可能与在向上的流动之间的接口有关,减少液体并且向下流动,氧化液体。这个接口可能被在与不平衡沉积压缩有关的液体过压之间的相互影响控制了并且它驾驶了向上的流动,和地志的地势,它开车了向下流动。在这研究,我们执行了为对液体过压的发展的油和煤气的产生的贡献的数字建模,除了沉积压缩并且加热。当烃产生没被考虑时,我们的结果显示当烃产生被考虑时,液体过压非常与模拟比较在白垩纪期间被加倍。而且,在沉积的结束的液体过压驱散相对没有烃产生盒子慢下来。这些结果建议烃产生可能在铀矿化作用,不是仅仅在规定减少为矿化作用要求的代理人,而且在贡献驱动力维持向上的流动起了一个重要作用。 | Chunji Xue Guoxiang Chi Wei Xue | 2011 | Geoscience Frontiers2011，2，3： | 12 |
| 3 | Occurrence and Diversity of Marine Yeasts in Antarctica Environments显示文摘A total of 28 yeast strains were obtained from the sea sediment of Antarctica.According to the results of routine identi-fication and molecular characterization,the strains belonged to species of Yarrowia lipolytica,Debaryomyces hansenii,Rhodotorula slooffiae,Rhodotorula mucilaginosa,Sporidiobolus salmonicolor,Aureobasidium pullulans,Mrakia frigida and Guehomyces pullu-lans,respectively.The Antarctica yeasts have wide potential applications in biotechnology,for some of them can produce b-galactosidase and killer toxins. | ZHANG Xue HUA Mingxia SONG Chunli CHI Zhenming | 2012 | Journal of Ocean University of China2012，11，1： | 11 |
| 4 | An overview of hydrodynamic studies of mineralization显示文摘液体流动是热水的矿化作用的不可分的部分,并且它的分析和描述组成一个矿化作用模型的重要部分。矿化作用的水动力学学习处理分析驱动力,液体压力政体,液体流动率和方向,并且他们与矿化作用的本地化的关系。这份报纸考察矿化作用的水动力学研究的原则和方法,并且为矿石沉积物研究和矿物质探索讨论他们的意义和限制。流动可能与液体过压,地志的消除,构造变丑,和液体密度有关的液体的驱动力由于加热或咸度变化变化,取决于特定的地质的环境和矿化作用过程。学习方法可以被分类进三种类型,放大了(领域) 观察,显微镜的分析,并且数字建模。放大了的特征陈述语气显著地 overpressured (特别 lithostatic 或 supralithostatic ) 液体系统包括水平静脉,沙注射堤,和水力的角砾岩。显微镜的研究,特别液体包括的 microthermometry 和液体包括飞机(联邦信息处理标准) 的 microthermometry 能关于液体温度,压力,和液体结构的关系提供重要信息,因此抑制液体流动模型。数字建模能被执行解决管理液体流动,热转移,岩石变丑和化学反应的部分微分方程,以便模仿液体的分发在 2D 或 3D 空间并且整个时间的压力,温度,液体流动率和方向,和矿物质降水或溶解。矿化作用的水动力学研究的结果能提高我们热水的沉积物的形成过程的理解,并且能在矿物质探索直接或间接地被使用。 | Guoxiang Chi Chunji Xue | 2011 | Geoscience Frontiers2011，2，3： | 11 |
| 5 | The effect of hematoma puncture drainage before decompressive craniectomy on the prognosis of hypertensive intracerebral hemorrhage with cerebral hernia at a high altitude显示文摘Purpose:Rapid decompressive craniectomy(DC)was the most effective method for the treatment of hypertensive intracerebral hemorrhage(HICH)with cerebral hernia,but the mortality and disability rate is still high.We suspected that hematoma puncture drainage(PD)+DC may improve the therapeutic effect and thus compared the combined surgery with DC alone.Methods:From December 2013 to July 2019,patients with HICH from Linzhi,Tibet and Honghe,Yunnan Province were retrospectively analyzed.The selection criteria were as follows:(1)altitude≥1500 m;(2)HICH patients with cerebral hernia;(3)Glascow coma scale score of 4-8 and time from onset to admission≤3 h;(4)good liver and kidney function;and(5)complete case data.The included patients were divided into DC group and PD+DC group.The patients were followed up for 6 months.The outcome was assessed by Glasgow outcome scale(GOS)score,Kaplan-Meier survival curve and correlation between time from admission to operation and prognosis.A good outcome was defined as independent(GOS score,4-5)and poor outcome defined as dependent(GOS score,3-1).All data analyses were performed using SPSS 19,and comparison between two groups was conducted using separatet-tests or Chi-square tests.Results:A total of 65 patients was included.The age ranged 34-90 years(mean,63.00±14.04 years).Among them,31 patients had the operation of PD+DC,whereas 34 patients underwent DC.The two groups had no significant difference in the basic characteristics.After 6 months of follow-up,in the PD+DC group there were 8 death,4 vegetative state,4 severe disability(GOS score 1-3,poor outcome 51.6%);8 moderate disability,and 7 good recovery(GOS score 4-5,good outcome 48.4%);while in the DC group the result was 15 death,6 vegetative state,5 severe disability(poor outcome 76.5%),4 moderate disability and 4 good recovery(good outcome 23.5%).The GOS score and good outcome were significantly less in DC group than in PD+DC group(Z=-1.993,p=0.046;χ2=4.38,p=0.043).However,there was no significant difference regarding the survival curve between PD+DC group and DC group.The correlation between the time from admission to operation and GOS at 6 months(r=-0.41,R2=0.002,p=0.829)was not significant in the PD+DC group,but significant in the DC group(r=-0.357,R2=0.128,p=0.038).Conclusion:PD+DC treatment can improve the good outcomes better than DC treatment for HICH with cerebral hernia at a high altitude. | Lin-Jie Wei Chi Lin Xing-Sen Xue Guo-Dong Dun Jian-Bo Zhang Yan-Xiang Tong Jia-Xiong Wang Shi-Ji Yang Ling Wang Zhi Chen Hua Feng Gang Zhu | 2021 | Chinese Journal of Traumatology2021，24，6： | 11 |
| 6 | Brown adipose tissue transplantation improves whole-body energy metabolism显示文摘 | Qingsheng Chi Dehua Wang Zhaoyun Zhang Chenzhong Li Yiming Li Yaoming Xue John R Speakma Wanzhu Jin Xiaomeng Liu Zongji Zhen Xiaoming Zhu Minghui Meng Lan Li Yanyan Shen | 2013 | Cell Research2013，23，6： | 11 |
| 7 | Chinese Herbal Medicine Combined with Entecavir for HBeAg Positive Chronic Hepatitis B:Study Protocol for a Multi-Center,Double-Blind Randomized-Controlled Trial显示文摘Background: The domestic prevalence of chronic hepatitis B(CHB) in China is 7.18% in 2006, imposing great societal healthcare burdens. Nucleot(s)ide analogues(NUCs) anti-hepatitis B virus(HBV) therapies are widely applied despite the relatively low rate of seroconversion and high risk of drug-resistant mutation. More effective treatments for CHB deserve further explorations. Combined therapy of NUCs plus Chinese herbal medicine(CHM) is widely accepted in China, which is recognized as a prospective alternative approach. The study was primarily designed to confirm the hypothesis that Tiaogan-Yipi Granule(调肝益脾颗粒, TGYP) or Tiaogan-Jianpi-Jiedu Granule(调肝健脾解毒颗粒, TGJPJD) plus entecavir tablet(ETV) was superior over ETV monotherapy in enhancing HBeA g loss rate. Methods: The study was a nationwide, large-scale, multi-center, double-blind, randomized, placebo-control ed trial with a designed duration of 108 weeks. A total of 16 hospitals and 596 eligible Chinese HBeA g positive CHB patients were enrolled from November 2012 to September 2013 and randomly allocated into 2 groups in 1:1 ratio via central randomization system: experimental group(EG) and control group(CG). Subjects in EG received CM formulae(TGYP or TGJPJD, 50 g per dose, twice daily) plus ETV tablet(or ETV placebo) 0.5 mg per day in the first 24 weeks(stage 1), and CHM granule plus ETV tablet(0.5 mg per day) from week 25 to 108(stage 2). Subjects in CG received CHM Granule placebo plus ETV tablet(0.5 mg per day) for 108 weeks throughout the trial. The assessments of primary outcomes(HBV serum markers and HBV-DNA) were conducted by a third-party College of American Pathologists(CAP) qualified laboratory. Adverse effects were observed in the hospitals of recruitment. Discussion: The study was designed to compare the curative effect of CM plus ETV and ETV monotherapy in respect of HBe Ag loss, which is recognized by the European Association for the Study of the Liver as 'a valuable endpoint'. We believe this trial could provide a reliable status for patients' 'journey' towards durable responses after treatment discontinuation. The trial was registered before recruitment on Chinese Clinical trial registry(No. ChiC TR-TRC-12002784, Version 1.0, 2015/12/23). | YE Yong-an LI Xiao-ke ZHOU Da-qiao CHI Xiao-ling LI Qin WANG Li LU Bing-jiu MAO De-wen WU Qi-kai WANG Xian-bo ZHANG Ming-xiang XUE Jing-dong LI Yong LU Wei GUO Jian-chun JIANG Feng ZHANG Xin-wei DU Hong-bo YANG Xian-zhao GUO Hui GAN Da-nan LI Zhi-guo | 2018 | Chinese Journal of Integrative Medicine2018，24，9： | 10 |
| 8 | Multilayered electret films based triboelectric nanogenerator显示文摘摩擦电 nanogenerator (TENG ) 是基于薄电影的表面接触充电把周围的机械精力变换成电的一台简单、合算的设备。有限表面费用密度可以影响 TENG 的全面表演。在这份报纸,基于的 TENG (E-TENG ) 由日冕制作了收费的一部新奇驻极体电影被建议那极大地作为与使遭到联系充电的那些相比提高薄电影的有效表面费用密度。E-TENG 的电线走火电流,转移电的费用密度,和开电路的电压被调查了,用控告电压,针尖距离和时间以便探索最佳的不同日冕试验性的条件。E-TENG 的电线走火电流,转移电的费用密度,和开电路的电压比那些平常的 polytetrafluoroethylene (PTFE ) 拍摄基于的 TENG 的被发现是大约七大倍。基于日冕收费,几 multilayered E-TENGs 被制作了,并且有层的不同数字的 E-TENGs 的电线走火电流,转移电的费用密度,和开电路的电压为完成最佳的表演被学习。这个工作为改进有效表面费用密度并且从而增加 TENG 的输出能力提供一条有效途径,它将极大地在自我动力的便携式的电子学和传感器网络支持 TENG 应用程序。 | Tao Zhou Limin Zhang Fei Xue Wei Tang Chi Zhang Zhong Lin wang | 2016 | Nano Research2016，9，5： | 10 |
| 9 | Adefovir Dipivoxil plus Chinese Medicine in HBeAg-Positive Chronic Hepatitis B Patients:A Randomized Controlled 48-Week Trial显示文摘Objective:To evaluate the effects of a 48-week course of adefovir dipivoxil(ADV)plus Chinese medicine(CM)therapy,namely Tiaogan Jianpi Hexue(调肝健脾和血)and Tiaogan Jiedu Huashi(调肝解毒化湿)fomulae,in hepatitis B e antigen(HBeAg)-positive Chinese patients.Methods:A total of 605 HBeAg-positive Chinese CHB patients were screened and 590 eligible participants were randomly assigned to 2 groups in 1:1 ratio including experimental group(EG,received ADV plus CM)and control group(CG,received ADV plus CM-placebo)for 48 weeks.The major study outcomes were the rates of HBeAg and HBV-DNA loss on week 12,24,36,48,respectively.Secondary endpoints including liver functions(enzymes and bilirubin readings)were evaluated every 4 weeks at the beginning of week 24,36,and 48.Routine blood,urine,and stool analyses in addition to electrocardiogram and abdominal B scan were monitored as safety evaluations.Adverse events(AEs)were documented.Results:The combination therapy demonstrated superior HBeAg loss at 48 weeks,without additional AEs.The full analysis population was 560 and 280 in each group.In the EG,population achieved HBeAg loss on week 12,24,36,and 48 were 25(8.90%),34(12.14%),52(18.57%),and 83(29.64%),respectively;the equivalent numbers in the CG were 20(7.14%),41(14.64%),54(19.29%),and 50(17.86%),respectively.There was a statistically significant difference between two groups on week 48(P<0.01).No additional AEs were found in EG.Subgroup analysis suggested different outcomes among treatment patterns.Conclusion:Combination of CM and ADV therapy demonstrated superior HBeAg clearance compared with ADV monotherapy.The finding indicates that this combination therapy may provide an improved therapeutic effect and safety profile(ChiCTR-TRC-11001263). | LI Xiao-ke ZHANG Ming-xiang SHAO Feng-zhen ZHOU Da-qiao XUE Jing-dong LIU Tie-jun CHI Xiao-ling LU Bing-jiu WANG Xian-bo LI Qin LI Jun MAO De-wen YANG Hua-sheng YANG Hong-zhi ZHAO Wen-xia LI Yong ZHANG Guo-liang ZHAO Yi-ming ZOU Jian-dong LIU Meng-yang ZHANG Ke-ke YANG Xian-zhao GAN Da-nan LI Ying ZHANG Peng LI Zhi-guo LI Shuo YE Yong-an | 2020 | Chinese Journal of Integrative Medicine2020，26，5： | 9 |
| 10 | Olivine-norite rock detected by the lunar rover Yutu-2 likely crystallized from the SPA-impact melt pool显示文摘Chang’E-4 landed in the South Pole-Aitken(SPA)basin,providing a unique chance to probe the composition of the lunar interior.Its landing site is located on ejecta strips in Von Karm´an crater that´possibly originate from the neighboring Finsen crater.A surface rock and the lunar regolith at 10 sites along the rover Yutu-2 track were measured by the onboard Visible and Near-Infrared Imaging Spectrometer in the first three lunar days of mission operations.In situ spectra of the regolith have peak band positions at 1 and 2μm,similar to the spectral data of Finsen ejecta from the Moon Mineralogy Mapper,which confirms that the regolith’s composition of the landing area is mostly similar to that of Finsen ejecta.The rock spectrum shows similar band peak positions,but stronger absorptions,suggesting relatively fresh exposure.The rock may consist of 38.1±5.4%low-Ca pyroxene,13.9±5.1%olivine and 48.0±3.1%plagioclase,referred to as olivine-norite.The plagioclase-abundant and olivine-poor modal composition of the rock is inconsistent with the origin of the mantle,but representative of the lunar lower crust.Alternatively,the rock crystallized from the impact-derived melt pool formed by the SPA-impact event via mixing the lunar crust and mantle materials.This scenario is consistent with fast-cooling thermal conditions of a shallow melt pool,indicated by the fine to medium-sized texture(<3 mm)of the rock and the SPA-impact melting model[Icarus 2012;220:730–43]. | Honglei Lin Zhiping He Wei Yang Yangting Lin Rui Xu Chi Zhang Meng-Hua Zhu Rui Chang Jinhai Zhang Chunlai Li Hongyu Lin Yang Liu Sheng Gou Yong Wei Sen Hu Changbin Xue Jianfeng Yang Jie Zhong Xiaohui Fu Weixing Wan Yongliao Zou | 2020 | National Science Review2020，7，5： | 9 |
| 11 | Features of a Chinese family with cerebral cavernous malformation induced by a novel CCM1 gene mutation显示文摘 | WANG Xue LIU Xue-wu Nora Lee LIU Qi-ji LI Wen-na HAN Tao WEI Kun-kun QIAO Shan CHI Zhao-fu | 2013 | Chinese Medical Journal2013，，18： | 7 |
| 12 | Prognostic factors and therapeutic effects of different treatment modalities for colorectal cancer liver metastases显示文摘BACKGROUND Colorectal cancer(CRC)is one of the most common malignant tumors in China,and the liver is the most common metastatic site in patients with advanced CRC.Hepatectomy is the gold standard treatment for colorectal liver metastases.For patients who cannot undergo radical resection of liver metastases for various reasons,ablation therapy,interventional therapy,and systemic chemotherapy can be used to improve their quality of life and prolong their survival time.AIM To explore the prognostic factors and treatments of liver metastases of CRC.METHODS A retrospective analysis was conducted on 87 patients with liver metastases from CRC treated at the Liaoning Cancer Hospital and Institute between January 2005 and March 2011.According to different treatments,the patients were divided into the following four groups:Surgical resection group(36 patients);ablation group(23 patients);intervention group(15 patients);and drug group(13 patients).The clinicopathological data and postoperative survival of the four groups were analyzed.The Kaplan-Meier method was used for survival analysis,and the Cox proportional hazards regression model was used for multivariate analysis.RESULTS The median survival time of the 87 patients was 38.747±3.062 mo,and the 1-and 3-year survival rates were 87.5%and 53.1%,respectively.The Cox proportional hazards model showed that the following factors were independent factors affecting prognosis:The degree of tumor differentiation,the number of metastases,the size of metastases,and whether the metastases are close to great vessels.The results of treatment factor analysis showed that the effect of surgical treatment was better than that of drugs,intervention,or ablation alone,and the median survival time was 48.83±4.36 mo.The drug group had the worst prognosis,with a median survival time of only 13.5±0.7 mo(P<0.05).For patients with liver metastases of CRC near the great vessels,the median survival time(27.3 mo)of patients undergoing surgical resection was better than that of patients using other treatments(20.6 mo)(P<0.05).CONCLUSION Patients with a low degree of primary tumor differentiation,multiple liver metastases(number of tumors>4),and maximum diameter of liver metastases>5 cm have a poor prognosis.Among drug therapy,intervention,ablation,and surgical treatment options,surgical treatment is the first choice for liver metastases.When liver metastases are close to great vessels,surgical treatment is significantly better than drug therapy,intervention,and ablation alone. | Zuo-Hong Ma Yong-Peng Wang Wen-Heng Zheng Ji Ma Xue Bai Yong Zhang Yuan-He Wang Da Chi Xi-Bo Fu Xiang-Dong Hua | 2020 | World Journal of Gastrointestinal Oncology2020，12，10： | 7 |
| 13 | Prediction and safety analysis of additional vertical stress within a shaft wall in an extra-thick alluvium显示文摘An alluvium with a sandy aquifer at the bottom,but lacking an effective impermeable layer between the sandy aquifer and bedrock is referred to as a special alluvial stratum.Impacted by the drainage of the aquifer due to mining activities,a shaft wall in this special alluvial stratum will be subject to a downward load by an additional vertical force which must be taken into consideration in the design of the shaft wall.The complexity of interaction between shaft wall and the surrounding walls makes it extremely difficult to determine this additional vertical force.For a particular shaft wall in an extra-thick alluvium and assuming that the friction coefficient between shaft wall and stratum does not change with depth,an analysis of a numerical simulation of the stress within the shaft wall has been carried out.Growth and size of the additional vertical stress have been obtained,based on specific values of the friction coefficient,the modulus of elasticity of the drainage layer and the thickness of the drainage layer.Subsequently, the safety of shaft walls with different structural types was studied and a more suitable structural design,providing an important basis for the design of shaft walls,is promoted. | WANG Yansen ZHANG Chi XUE Libing HUANG Xinggen | 2010 | Mining Science and Technology2010，20，3： | 7 |
| 14 | MicroRNA-29a attenuates angiotensin-Ⅱ induced-left ventricular remodeling by inhibiting collagen,TGF-β and SMAD2/3 expression显示文摘Background Left ventricular(LV)remodeling is the most common target organ damage in hypertension.Previously,our study found that plasma microRNA-29a(miR-29a)level was associated with the LV remodeling in hypertensive patients.However,the causal relationship between miR-29a and LV remodeling remains unknown.Thus,the aim of this study was to investigate the regulation mechanism of miR-29a in LV remodeling.Methods&Results Overexpression and knockdown miR-29a mice were generated by tail-intravenous injection of miR-29a-mimic and inhibitor lentivirus for one week respectively.Then the mice were subjected to angiotensin-II(AngII)induced LV remodeling by subcutaneous AngII capsule osmotic pumping into AngII for four weeks.AngII-induced LV remodeling mice as the model group(n=9).Age-matched male SPF C57/BL6J mice(6–8 weeks old)were treated with the pumping of saline as a vehicle(n=6).In vivo,overexpression miR-29a ameliorated AngII-induced LV remodeling,while knockdown miR-29a deteriorated LV remodeling.Simultaneously,we observed that overexpression miR-29a mice inhibited but knockdown miR-29a mice increased cardiac cross-sectional area,indicating that miR-29a has an antagonistic effect on cardiac hypertrophy.Further studies found that overexpression miR-29a inhibited the content of the LV collagen including collagen I and III.Moreover,the expression of transforming growth factor-β(TGF-β)and phosphorylated SMAD2/3 decreased with the down-regulation of collagen I and III in overexpression miR-29a mice.Conclusions Our finding indicates that overexpression miR-29a attenuates LV remodeling by inhibiting collagen deposition,TGF-β,and phosphorylated SMAD2/3 expression.Thus,intervention miR-29a may be a therapeutic target for attenuating LV remodeling. | Si-Jin ZHANG Cui-Juan YUN Jie LIU Si-Yu YAO Yao LI Miao WANG Chi WANG Yong-Yi BAI Hao XUE | 2020 | Journal of Geriatric Cardiology2020，17，2： | 7 |
| 15 | Transparent paper-based triboelectric nanogenerator as a page mark and anti-theft sensor显示文摘基于著名摩擦电效果和静电的正式就职效果,摩擦电 nanogenerator (TENG ) 被证明了是一条简单、合算的途径让自我动力的系统把周围的机械精力变换成电。我们报导由当摩擦电出现,电影和聚乙烯 terephthalate (宠物) 拍摄的铟听氧化物(ITO ) 组成的灵活、透明的基于纸的摩擦电 nanogenerator (PTENG ) ,它充当精力供应而且作为一个自我动力的活跃传感器不仅。当纸的表进入接触时,它能相对由垂直接触分离模式和侧面的滑动模式的联合的对方收获动能,弯曲或滑动。另外,我们也作为一个自我动力的反偷窃传感器把组织栅栏的 PTENG 集成到一本书。在处理期间,这本书分页的机械焦虑能有效地被变换成电的产量驾驶一台商业电子设备或触发警告 buzzer。而且,每页上的不同栅栏结构由相对对方滑动生产产量山峰的不同数字,它能精确地充当页的数字转了的一个页标记和记录。这个工作在自我动力的基于纸的设备向前是重要的步。 | Limin Zhang Fei Xue Weiming Du Changbao Han Chi Zhang Zhonglin Wang | 2014 | Nano Research2014，7，8： | 7 |
| 16 | Untreated Prior Pulmonary Tuberculosis Adversely Affects Pregnancy Outcomes in Infertile Women Undergoing in vitro Fertilization and Embryo Transfer: A Large Retrospective Cohort Study显示文摘Objective Prior pulmonary tuberculosis(PTB) on chest X-ray(CXR) was commonly found in infertile patients receiving examinations before in vitro fertilization and embryo transfer(IVF-ET). It was unclear whether untreated PTB would affect pregnancy outcomes after IVF-ET.Method We conducted a retrospective cohort study of 14,254 infertile patients who had received IVFET at Peking University Third Hospital in 2017. Prior PTB was defined as the presence of signs suggestive of old or inactive PTB on CXR, with or without a clinical TB history. Patients who had prior PTB on CXR but had not received a clinical diagnosis and anti-TB therapy were included for analysis. Live birth,clinical pregnancy, and miscarriage rates were compared between the untreated PTB and non-PTB groups.Results The untreated PTB group had significantly lower clinical pregnancy(31.7% vs. 38.1%) and live birth(23.8% vs. 30.6%) rates than the non-PTB group(both P < 0.001). Multivariate analysis revealed that untreated PTB was a risk factor for decreased live birth rate [odds ratio(OR), 0.80;95% confidence interval(CI), 0.66–0.98;P = 0.028] in all patients and for increased miscarriage(OR, 4.19;95% CI,1.69–10.39;P = 0.002) and decreased live birth(OR, 0.45;95% CI, 0.24–0.83;P = 0.011) rates in patients with unexplained infertility.Conclusions Untreated PTB was associated with adverse pregnancy outcomes after IVF-ET, especially in patients with unexplained infertility, highlighting the clinical significance of PTB in this specific patient population. | GAI Xiao Yan CHI Hong Bin ZENG Lin CAO Wen Li CHEN Li Xue ZHANG Chen LU Ming NING Lan Ding CHANG Chun ZHANG Wei Xia LIU Ping LI Rong SUN Yong Chang QIAO Jie | 2021 | Biomedical and Environmental Sciences2021，34，2： | 6 |
| 17 | Acute and Chronic Changes and Predictive Value of Tpeak-Tend lor Ventricular Arrhythmia Risk in Cardiac Resynchronization Therapy Patients显示文摘 | Cong Xue Wei Hua Chi Cai Li-Gang Ding Zhi-Min Liu Xiao-Han Fan Yun-Zi Zhao Shu Zhang | 2016 | Chinese Medical Journal2016，，18： | 6 |
| 18 | Hydrodynamic regime as a major control on localization of uranium mineralization in sedimentary basins显示文摘Uranium deposits in sedimentary basins can be formed at various depths,from near surface to the basement.While many factors may have played a role in controlling the location of mineralization,examination of various examples in the world,coupled with numerical modeling of fluid flow,indicates that the hydrodynamic regime of a basin may have exerted a major control on the localization of uranium deposits.If a basin is strongly overpressured,due to rapid sedimentation,abundance of low-permeability sediments or generation of hydrocarbons,fluid flow is dominantly upward and uranium mineralization is likely limited at shallow depths.If a basin is moderately overpressured,upward moving fluids carrying reducing agents may meet downward moving,oxidizing,uranium-bearing fluids in the middle of the basin,forming uranium deposits at moderate depths.If a basin is weakly or not overpressured,either due to slow sedimentation or dominance of high-permeability lithologies,minor topographic disturbance or density variation may drive oxidizing fluids to the bottom of the basin,leaching uranium either from the basin or the basement,forming unconformity-type uranium deposits.It is therefore important to analyze the hydrodynamic regime of a basin in order to predict the most likely type and location of uranium deposits in the basin. | CHI GuoXiang XUE ChunJi | 2014 | Science China Earth Sciences2014，57，12： | 6 |
| 19 | Effect of HIV-1 Tat on Secretion of TNF-α and IL-1β by U87 Cells in AIDS Patients with or without AIDS Dementia Complex显示文摘Objective To explore the role of HIV-1 tat gene variations in AIDS dementia complex(ADC) pathogenesis.Methods HIV-1 tat genes derived from peripheral spleen and central basal ganglia of an AIDS patient with ADC and an AIDS patient without ADC were cloned for sequence analysis. HIV-1 tat gene sequence alignment was performed by using CLUSTAL W and the phylogentic analysis was conducted by using Neighbor-joining with MEGA4 software. All tat genes were used to construct recombinant retroviral expressing vector MSCV-IRES-GFP/tat. The MSCV-IRES-GFP/tat was cotransfected into 293T cells with pCMV-VSV-G and pUMVC vectors to assemble the recombinant retrovirus. After infection of gliomas U87 cells with equal amount of the recombinant retrovirus, TNF-α, and IL-1β concentrations in the supernatant of U87 cells were determined with ELISA. Results HIV-1 tat genes derived from peripheral spleen and central basal ganglia of the AIDS patient with ADC and the other one without ADC exhibited genetic variations. Tat variations and amino acid mutation sites existed mainly at Tat protein core functional area(38-47aa). All Tat proteins could induce U87 cells to produce TNF-α and IL-1β, but the level of IL-1β production was different among Tat proteins derived from the ADC patient's spleen, basal ganglia, and the non-ADC patient's spleen. The level of Tat proteins derived from the ADC patient's spleen, basal ganglia, and the non-ADC patient's spleen were obviously higher than that from the non-ADC patient's basal ganglia. Conclusion Tat protein core functional area(38-47aa) may serve as the key area of enhancing the secretion of IL-1β. This may be related with the neurotoxicity of HIV-1 Tat. | ZHAO Li PU Shuang Shuang GAO Wen Hua CHI Yuan Yuan WEN Hong Ling WANG Zhi Yu SONG Yan Yan YU Xue Jie | 2014 | Biomedical and Environmental Sciences2014，27，2： | 5 |
| 20 | Hydrodynamic analysis of clastic injection and hydraulic fracturing structures in the Jinding Zn-Pb deposit,Yunnan,China显示文摘Jinding Zn-Pb 存款通常被考虑了以一个相对被动的方法从传播 basinal 液体形成了,与液体流动被结构和沉积外形正在控制,类似于许多另外的招待沉积的底金属存款。然而,几最近的研究在 Jinding 存款的开的坑揭示了沙注射结构,恼人的角砾岩,和水力的破裂的存在并且建议存款从 overpressured 液体的爆炸版本被形成。这研究报导液体的新观察过压相关从地下的活动方式(Paomaping 和 Fengzishan ) 组织,它比在开的坑显示出更清楚的横切的关系。观察结构包括:1 ) 沙(楳湧晩捩湡汴 ? 潣瑮楲畢整琠? 桴 ? 潴慴? 票牤 ' 夷典? | Guoxiang Chi Chunji Xue Hairuo Qing Wei Xue Jiangwei Zhang Yunqiang Sun | 2012 | Geoscience Frontiers2012，3，1： | 5 |
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