|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 2010年台湾心脏病学会高血压管理指南显示文摘高血压是心血管疾病和心血管死亡的重要危险因素。从2003年美国高血压预防、检测、评价和治疗全国联合委员会第7次报告(the seventh report of the joint national committee on prevention,detection,evaluation,and treatment of high blood pressure,JNC7)和2007年欧洲高血压协会/欧洲心脏病学会高血压防治指南发布以来, | Chern-En Chiang Tzung-Dau Wang Yi-Heng Li Tsung-Hsien Lin Kuo-Liong Chien Hung-I Yeh Kou-Gi Shyu Wei-Chuen Tsai Ting-Hsing Chao Juey-Jen Hwang Fu-Tien Chiang Jyh-Hong Chen | 2011 | 中华高血压杂志2011，19，1： | 20 |
| 2 | Driving vascular endothelial cell fate of human multipotent Isl1 heart progenitors with VEGF modified mRNA显示文摘multipotent 心祖先的不同家庭在哺乳动物的 cardiogenesis 期间在多样的心脏的、光滑的肌肉和 endothelial 房间系的产生起一个中央作用。驾驶这些 multipotent 祖先的房间命运决定的精确 paracrine 信号的鉴定,和小说的开发来临在 vivo 交付这些信号,是向开他们的再生治疗学的潜力的关键步。此处,我们识别了位于早人的胎儿的心(OFT-ECs ) 的流出道的人的心脏的 endothelial 中介的一个家庭,由 Isl1 和 CD144/vWF 的 coexpression 描绘了。由比较人的 OFT-ECs 和非心脏的 EC 表示的 angiocrine 因素,脉管的 endothelial 生长因素( VEGF ) A 作为最富有地表示的因素被识别,并且同种细胞的试金记录了它的能力驱使人的胚胎的干细胞(转换字符)的 endothelial 说明以一种 VEGF 受体依赖者方式导出 Isl1 +祖先。人的 Isl1-ECs (区分开来与导出 hESC 的 ISL1 + 祖先的 endothelial 房间) 以心脏的 endothelial 祖先的表示类似于 OFT-ECs -- 并且 endocardial 房间特定的基因,证实他们的机关特性。决定是否 VEGF -- A 可能是服务一在里面为人的导出转换字符的 Isl1-ECs 的 vivo 房间命运开关,我们证实化学上使用的一条新奇途径作为一个平台修改了 mRNA 为短暂,还在心血管的祖先的 paracrine 因素的高度有效的表示。VEGF 的 Overexpression -- A 支持在 vivo 的人的 Isl1 + 祖先的不仅 endothelial 说明而且嫁接,增长和幸存(减少的 apoptosis ) 。从人的 pluripotent 干细胞的心脏特定的人的 Isl1-ECs 的大规模推导,结合了能力驾驶跟随移植的 endothelial 说明,嫁接,和幸存,在心为脉管的新生建议新奇策略。 | Kathy O Lui Llor Lang Eduardo A Silva Lei Bu Makoto Sahara Ronald A Li David J Mooney Kenneth R Chien | 2013 | Cell Research2013，23，10： | 6 |
| 3 | The Arabidopsis B-box protein BZS1/BBX20 interacts with HY5 and mediates strigolactone regulation of photomorphogenesis显示文摘Plant growth is controlled by integration of hormonal and light-signaling pathways. BZS1 is a B-box zinc finger protein previously characterized as a negative regulator in the brassinosteroid(BR)-signaling pathway and a positive regulator in the light-signaling pathway. However, the mechanisms by which BZS1/BBX20 integrates light and hormonal pathways are not fully understood. Here, using a quantitative proteomic workflow, we identified several BZS1-associated proteins, including light-signaling components COP1 and HY5. Direct interactions of BZS1 with COP1 and HY5 were verified by yeast two-hybrid and co-immunoprecipitation assays. Overexpression of BZS1 causes a dwarf phenotype that is suppressed by the hy5 mutation, while overexpression of BZS1 fused with the SRDX transcription repressor domain(BZS1-SRDX) causes a long-hypocotyl phenotype similar to hy5, indicating that BZS1's function requires HY5. BZS1 positively regulates HY5 expression, whereas HY5 negatively regulates BZS1 protein level, forming a feedback loop that potentially contributes to signaling dynamics. In contrast to BR,strigolactone(SL) increases BZS1 level, whereas the SL responses of hypocotyl elongation, chlorophyll and HY5 accumulation are diminished in the BZS1-SRDX seedlings, indicating that BZS1 is involved in these SL responses. These results demonstrate that BZS1 interacts with HY5 and plays a central role in integrating light and multiple hormone signals for photomorphogenesis in Arabidopsis. | Chuang-Qi Wei Chih-Wei Chien Lian-Feng Ai Jun Zhao Zhenzhen Zhang Kathy H. Li Alma L. Burlingame Yu Sun Zhi-Yong Wang | 2016 | Journal of Genetics and Genomics2016，43，9： | 5 |
| 4 | Changes in Serum Levels of HBV DNA and Alanine Aminotransferase Determine Risk for Hepatocellular Carcinoma显示文摘 | Chuen–Fei Chen Wen–Chung Lee Hwai–I. Yang Hung–Chuen Chang Chin–Lan Jen Uchenna H. Iloeje Jun Su Chuhsing K. Hsiao Li–Yu Wang San–Lin You Sheng–Nan Lu Chien–Jen Chen | 2011 | Gastroenterology2011，，4： | 3 |
| 5 | Metabolic Factors and Risk of Hepatocellular Carcinoma by Chronic Hepatitis B/C Infection: A Follow-up Study in Taiwan显示文摘 | Chi–Ling Chen Hwai–I. Yang Wei–Shiung Yang Chun–Jen Liu Pei–Jer Chen San–Lin You Li–Yu Wang Chien–An Sun Sheng–Nan Lu Ding–Shin Chen Chien–Jen Chen | 2008 | Gastroenterology2008，，1： | 3 |
| 6 | PECS: Towards Personalized Edge Caching for Future Service-Centric Networks显示文摘Mobile operators face the challenge of how to best design a service-centric network that can effectively process the rapidly increasing number of bandwidth-intensive user requests while providing a higher quality of experience(QoE). Existing content distribution networks(CDN) and mobile content distribution networks(mCDN) have both latency and throughput limitations due to being multiple network hops away from end-users. Here, we first propose a new Personalized Edge Caching System(PECS) architecture that employs big data analytics and mobile edge caching to provide personalized service access at the edge of the mobile network. Based on the proposed system architecture, the edge caching strategy based on user behavior and trajectory is analyzed. Employing our proposed PECS strategies, we use data mining algorithms to analyze the personalized trajectory and service usage patterns. Our findings provide guidance on how key technologies of PECS can be employed for current and future networks. Finally, we highlight the challenges associated with realizing such a system in 5G and beyond. | Ming Yan Wenwen Li Chien Aun Chan Sen Bian Chih-Lin I André F. Gygax | 2019 | China Communications2019，16，8： | 3 |
| 7 | Prediction models of long‐term Cirrhosis and hepatocellular carcinoma risk in chronic hepatitis B patients: Risk scores integrating host and virus profiles显示文摘 | Mei‐Hsuan Lee Hwai‐I. Yang Jessica Liu Richard Batrla‐Utermann Chin‐Lan Jen Uchenna H. Iloeje Sheng‐Nan Lu San‐Lin You Li‐Yu Wang Chien‐Jen Chen | 2013 | Hepatology2013，，2： | 3 |
| 8 | Carriers of Inactive Hepatitis B Virus Are Still at Risk for Hepatocellular Carcinoma and Liver-Related Death显示文摘 | Jin–De Chen Hwai–I. Yang Uchenna H. Iloeje San–Lin You Sheng–Nan Lu Li–Yu Wang Jun Su Chien–An Sun Yun–Fan Liaw Chien–Jen Chen | 2010 | Gastroenterology2010，，5： | 2 |
| 9 | Risk of pancreatic cancer in chronic hepatitis B virus infection: data from the REVEAL‐HBV cohort study显示文摘 | Uchenna H.Iloeje Hwai‐IYang Chin‐LanJen JunSu Li‐YuWang San‐LinYou Sheng‐NanLu Chien‐JenChen | 2010 | Liver International2010，，3： | 2 |
| 10 | Molecular basis of the effects of shear stress on vascular endothelial cells显示文摘 | Yi-Shuan J. Li Jason H. Haga Shu Chien | 2004 | Journal of Biomechanics2004，，10： | 2 |
| 11 | Notch2‐induced COX‐2 expression enhancing gastric cancer progression显示文摘 | Yun‐Chien Tseng Yu‐Hui Tsai Min‐Jen Tseng Kai‐Wen Hsu Min‐Chieh Yang Kuo‐Hung Huang Anna Fen‐Yau Li Chin‐Wen Chi Rong‐Hong Hsieh Hung‐Hai Ku Tien‐Shun Yeh | 2011 | Mol Carcinog2011，，12： | 2 |
| 12 | A comparion of the chemical composition and bioactive ingredients of the Chinese medicinal mushroom dongchongxiacao, its counterfeit and mimic, and fermented mycelium of Cordyceps sinensis 显示文摘 | TAI H H LI H S Chien Y H | 2002 | Food Chemistry2002，78，： | 1 |
| 13 | Control of mineral scale deposition in cooling systems using secondary-treated municipal wastewater显示文摘 | LI H HSIEH M K CHIEN S H | 2011 | Water Research2011，45，2： | 1 |
| 14 | Simultaneous absorption of SO2 and NO from flue gas with KMnO4/NaOH solutions显示文摘 | CHU H CHIEN T W LI S Y | 2001 | The Science of the Total Environment2001，275，13： | 1 |
| 15 | Variable mold temperature to improve surface quality of microcellular injection molded parts using induction heating technology 显示文摘 | CHEN S C LIU Y W CHIEN R D LI H M | 2008 | Advances in Polymer Technology2008，27，4： | 1 |
| 16 | Synthesis and seectroscopic properties of finite Ph2N-containing oligo (arylenevinulene) derivatives that emit blue to red fluoreseenee显示文摘 | Li Chien Le Shieh S J Lin Shien Chang | 2003 | Org Lett2003，5，7： | 1 |
| 17 | Carriers of Inactive Hepatitis B Virus Are Still at Risk for Hepatocellular Carcinoma and Liver-Related Death显示文摘 | Jin–De Chen Hwai–I. Yang Uchenna H. Iloeje San–Lin You Sheng–Nan Lu Li–Yu Wang Jun Su Chien–An Sun Yun–Fan Liaw Chien–Jen Chen | 2010 | Gastroenterology2010，，5： | 1 |
| 18 | Escalating water de- mand for energy production and the potential for use of treated municipal wastewater显示文摘 | Li H Chien S H Hsieh M K | 2011 | Environ Sci Technol2011，45，10： | 1 |
| 19 | Simultaneous absorption of SO2 and NO from flue gas with KMnO4/NaOH solutions显示文摘 | Chu H Chien T W Li S Y | 2001 | The Science of the Total Environment2001，，275： | 1 |
| 20 | Fast magnetic resonance diffusion weighted imaging of acute human stroke 显示文摘 | Warach S Chien D Li W | 1992 | Neurology1992，42，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员