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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | High-resolution microendoscopy for esophageal cancer screening in China: A cost-effectiveness analysis显示文摘AIM:To study the cost-effectiveness of high-resolution microendoscopy(HRME)in an esophageal squamous cell carcinoma(ESCC)screening program in China.METHODS:A decision analytic Markov model of ESCC was developed.Separate model analyses were conducted for cohorts consisting of an averagerisk population or a high-risk population in China.Hypothetical 50-year-old individuals were followed until age 80 or death.We compared three different strategies for both cohorts:(1)no screening;(2)standard endoscopic screening with Lugol’s iodine staining;and(3)endoscopic screening with Lugol’s iodine staining and an HRME.Model parameters were estimated from the literature as well as from GLOBOCAN,the Cancer Incidence and Mortality Worldwide cancer database.Health states in the model included non-neoplasia,mild dysplasia,moderate dysplasia,high-grade dysplasia,intramucosal carcinoma,operable cancer,inoperable cancer,and death.Separate ESCC incidence transition rates were generated for the average-risk and high-risk populations.Costs in Chinese currency were converted to international dollars(I$)and were adjusted to 2012dollars using the Consumer Price Index.RESULTS:The main outcome measurements for this study were quality-adjusted life years(QALYs)and incremental cost-effectiveness ratio(ICER).For the average-risk population,the HRME screening strategy produced 0.043 more QALYs than the no screening strategy at an additional cost of I$646,resulting in an ICER of I$11808 per QALY gained.Standard endoscopic screening was weakly dominated.Among the high-risk population,when the HRME screening strategy was compared with the standard screening strategy,the ICER was I$8173 per QALY.For both the high-risk and average-risk screening populations,the HRME screening strategy appeared to be the most cost-effective strategy,producing ICERs below the willingness-topay threshold,I$23500 per QALY.One-way sensitivity analysis showed that,for the average-risk population,higher specificity of Lugol’s iodine(>40%)and lower specificity of HRME(<70%)could make Lugol’s iodine screening cost-effective.For the high-risk population,the results of the model were not substantially affected by varying the follow-up rate after Lugol’s iodine screening,Lugol’s iodine test characteristics(sensitivity and specificity),or HRME specificity.CONCLUSION:The incorporation of HRME into an ESCC screening program could be cost-effective in China.Larger studies of HRME performance are needed to confirm these findings. | Chin Hur Sung Eun Choi Chung Yin Kong Gui-Qi Wang Hong Xu Alexandros D Polydorides Li-Yan Xue Katherine E Perzan Angela C Tramontano Rebecca R Richards-Kortum Sharmila Anandasabapathy | 2015 | World Journal of Gastroenterology2015，21，18： | 8 |
| 3 | Adult metaplastic hutch diverticulum with robotic-assisted diverticulectomy and reconstruction:A case report显示文摘BACKGROUND Hutch diverticulum arises from the compromised muscular development at the ureteral orifice.It is a congenital disease and extremely rare in adult,only accounting for about 3%occurrence worldwide.It can be either symptomatic or asymptomatic,and relies on image tools for diagnosis and preoperative planning.Indications for surgery are dependent on the complications from the diverticulum.Metaplasia is about 10%among those with hutch diverticulum,and it still has chances turning into malignancy,especially urothelial cell carcinoma.CASE SUMMARY A 27-year-old man was presented with frequently recurrent urinary tract infection for one year,and had suffered from intermittent right flank pain for 3 mo.No past medical histories were recorded before.No obvious abnormalities on laboratory data and urine examination were found.Under ultrasound,right hydronephrosis was seen and an anatomical abnormality was observed on intravenous pyelography.Further computed tomography urogram showed one diverticulum seated at superolateral side of right ureteral orifice.Cystoscopy was done and biopsy results showed focal metaplasia.After discussing with him,roboticassisted diverticulectomy with reconstruction was performed.Right hydronephrosis was greatly improved after surgery.He has completed his 1.5-year follow-ups,and no malignancies were seen from urine cytology and image of intravenous pyelography.CONCLUSION Robotic-assisted diverticulectomy and reconstruction to hutch diverticulum is a safe and efficient operation,providing several advantages over open and laparoscopic ones. | Che H Yang Yi S Lin Yen C Ou Wei C Weng Li H Huang Chin H Lu Chao Y Hsu Min C Tung | 2020 | World Journal of Clinical Cases2020，8，20： | 2 |
| 4 | On image analysis by the method of moments 显示文摘 | The C H Chin R T | 1988 | IEEE Trans PAMI1988，10，4： | 2 |
| 5 | On image analysis by the methods of moments显示文摘 | The C H Chin R T | 1988 | IEEE Transaction on Pattern Analysis and Machine Intelligence1988，10，： | 1 |
| 6 | Evaluation of surface compo- nents of Brucella ovis as antigens for the detection of preeipitin antibody in serums from artificially exposed rams显示文摘 | Chin J C Plant J W Claxton P D | 1983 | Aust Vet J1983，60，： | 1 |
| 7 | New Generation NSAIDs: The Benefit Without the Risk显示文摘 | WALLACE J L CHIN B C | 1997 | Drugs Today1997，33，： | 1 |
| 8 | Sensitive Detection of Cold Cesium Molecules Formed on Feshbach Resonances显示文摘 | CHIN C VULETIC V KERMAN A J | 2003 | Phys Rev Lett2003，90，03： | 1 |
| 9 | Traffic responsive signal timing forsystem - wide traffic control显示文摘 | Spall J C Chin D C | 1997 | Transportation ResearchPart C :Emerging Technologies1997，5，3： | 1 |
| 10 | Thetwo-component sensor kinase KdpD is required forSalmonella typhimurium colonization ofCaenorhabditis elegans and survival in macrophages显示文摘 | Alegado R A Chin C Y Monack D M | 2011 | Cellular Microbiology2011，13，10： | 1 |
| 11 | Fahrieation of carbon nano-tuhes decorated with ultra fine superparamagnetic nano-particles under continuous flow conditions显示文摘 | CHIN S F IYER K S TASTON C L | 2008 | Lab on a Chip2008，8，3： | 1 |
| 12 | The effect of innova- tive activity on firm performance: the experience ofTaiwan 显示文摘 | ANANDARAJAN A CHIN C - L CHI H - Y | 2007 | Ad- vances in Accounting2007，23，1： | 1 |
| 13 | Restoring de novo coenzyme Q biosynthesis in Caenorhabditis elegans coq-3 mutants yields profound rescue compared to exogenous coenzyme Q supplementation显示文摘 | Gomez F Saiki R Chin R Srinivasan C Clarke CF | 2012 | Gene2012，506，： | 1 |
| 14 | Metal distribution in jet plating显示文摘 | Karakur C Chin D T | | J Electrochem Soc0，141，3： | 1 |
| 15 | New ternary Ni-Ta-Sn bulk metallic glasses显示文摘 | TIEN H Y LIN C Y CHIN T S | 2006 | Intermetallies2006，14，： | 1 |
| 16 | The effect of static in vivo bending on the murine intervertebral diac显示文摘 | Collion OK Chin JR | 2001 | Spine J2001，1，4： | 1 |
| 17 | Arsenic-implanted HfON charge-trapping flash memory with large memory window and good retention显示文摘 | TSAI C T LEE T H CHIN A | 2011 | IEEE Electron Device Letter2011，32，3： | 1 |
| 18 | Inclusion degree:a perspective on measures for rough set data analysis显示文摘 | Xu Z B Liang J Y Dang C Y Chin K S | 2002 | Information Sciences2002，141，： | 1 |
| 19 | Application of bifurcation theory to subsynchronous resonance in power systems 显示文摘 | Nayfeh A M Harb A M Chin C M | 1998 | International Journal of Bifurcation and Chaos1998，8，1： | 1 |
| 20 | Modification of fatty acids changes the flavor volatiles in tomato leaves 显示文摘 | Wang G C Xing J Chin C K | 2001 | Phytochemistry2001，58，： | 1 |
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