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| 1 | Effect of Nimesulide on proliferation and apoptosis of human hepatoma SMMC-7721 cells显示文摘AIM: Cyclooxygenase-2 (COX-2) has been suggested to beassociated with carcinogenesis. We sought to investigatethe effect of the selective COX-2 inhibitor, Nimesulide onproliferation and apoptosis of SMMC-7721 human hepatomacells.METHODS: This study was carried out on the culture ofhepatic carcinoma SMMC-7721 cell line. Variousconcentrations of Nimesulide (0、200 μmol/L、300 μmol/L、400μmol/L) were added and incubated. Cell proliferation wasdetected with MTT colorimetric assay, cell apoptosis byelectron microscopy, flow cytometry and TUNEL.RESULTS: Nimesulide could significantly inhibit SMMC-7721cells proliferation dose-dependent and in a dependentmanner compared with that of the control group. Theduration lowest inhibition rate produced by Nimesulide inSMMC-7721 cells was 19.06 %, the highest inhibition ratewas 58.49 %. After incubation with Nimesulide for 72 h, themost highest apoptosis rate and apoptosis index of SMMC-7721 cells comparing with those of the control were 21. 20 %+1.62% vs2.24% +0.26% and21.23+ 1.78 vs2.01+0.23(p<0.05).CONCLUSION: The selective COX-2 inhibitor, Nimesulide caninhibit the proliferation of SMMC-7721 cells and increaseapoptssis rate and apoptosis index of SMMC-7721 cells. Theapoptoois rate and the apoptosis index are dose-dependent.Under electron microscope SMMC-7721 cells incubated with 300μmol and 400 μmol Nimesulide show apoptotic characteristics.With the clarification of the mechanism of selective COX-2inhibitors, These COX-2 selective inhibitors can become thechoice of prevention and treatment of cancers. | Geng Tian Jie-Ping Yu He-Sheng Luo Bao-Ping Yu Hui Yue Jian-Ying Li Oiao Mei,Gastroenterology department,Renmin hospital of Wuhan university,Wuhan 430060,Hubei Province,China | 2002 | World Journal of Gastroenterology2002，8，3： | 51 |
| 2 | Galangin induces apoptosis of hepatocellular carcinoma cells via the mitochondrial pathway显示文摘AIM:To investigate the mechanism by which galangin,a polyphenolic compound derived from medicinal herbs,induces apoptosis of hepatocellular carcinoma(HCC) cells.METHODS:The 3-(4,5-Dimethyl-thiazol-2-yl)-2,5-diphenyl-tetrazolium bromide assay was used to measure cell viability.Apoptosis was evaluated by in situ uptake of propidium iodide and Hoechst 33258 and was then detected by fluorescence microscopy.Protein expressions were detected by Western blotting.To confirm the apoptotic pathway mediated by galangin,cells were transfected by bcl-2 gene to overexpress Bcl-2 or siRNA to down-regulate Bcl-2 expression.RESULTS:Galangin(46.25-370.0 μmol/L) exerted an anti-proliferative effect,induced apoptosis,and decreased mitochondrial membrane potential in a dose and time-dependent manner.Treatment with galangin induced apoptosis by translocating the pro-apoptotic protein Bax to the mitochondria,which released apoptosis-inducing factor and cytochrome c into the cytosol.Overexpression of Bcl-2 attenuated galangin-induced HepG2 cell apoptosis,while decreasing Bcl-2 expression enhanced galangin-induced cell apoptosis.CONCLUSION:Our data suggests that galangin mediates apoptosis through a mitochondrial pathway,and may be a potential chemotherapeutic drug for the treatment of HCC. | Hai-Tao Zhang Liu-Bo Lan Da-Hua Fan Kai-Dan Zhu Xiao-Yi Chen Min Wen Hui-Ming Liu Guangdong Province China Hui Luo | 2010 | World Journal of Gastroenterology2010，16，27： | 32 |
| 3 | A novel gene delivery system targeting cells expressing VEGF receptors显示文摘Two ligand oligopeptides GV1 and GV2 were designed according to the putative binding region of VEGF to its receptors. GV1, GV2 and endosome releasing oligopeptide HA20 were conjugated with poly-L-lysine or protamine and the resulting conjugates could interact with DNA in a noncovalent bond to form a complex. Using pSV2-β-galactosidase as a reporter gene, it has been demonstrated that exogenous gene was transferred into bovine aortic arch-derived endothelial cells (ABAE) andhuman malignant melanoma cell lines (A375) in vitro. In vivo experiments, exogenous gene was transferred into tumor vascular endothelial cells and tumor cells of subcutaneously transplanted human colon cancer LOVO, human malignant melanoma A375 and human hepatoma graft in nude mice. This system could also target gene to intrahepatically transplanted human hepatoma injected via portal vein in nude mice. These results are correlated with theGene delivery system targeting VEGF receptors relevant receptors (flt-1, flk-1/KDR) expression on the targeted cells and tissues. | LI JUN MIN JUN SONG HAN YI HUANG PEI KUN TIAN SHU MIN QU MIN YAO HUI QIU JIANG DA FANG WAN JING CHU LUO CHENG XIAO GU JIAN REN GU( National Labomtory for Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai 200032,China)(National Laboratory of | 1999 | Cell Research1999，9，1： | 22 |
| 4 | Grey GM(1,1) Model with Function-Transfer Method for Wear Trend Prediction and its Application显示文摘Trend forecasting is an important aspect in fault diagnosis and work state supervision. The principle, where Grey theory is applied in fault forecasting, is that the forecast system is considered as a Grey system; the existing known information is used to infer the unknown information’s character, state and development trend in a fault pattern, and to make possible forecasting and decisions for future development. It involves the whitenization of a Grey process. But the traditional equal time interval Grey GM (1,1) model requires equal interval data and needs to bring about accumulating addition generation and reversion calculations. Its calculation is very complex. However, the non equal interval Grey GM (1,1) model decreases the condition of the primitive data when establishing a model, but its requirement is still higher and the data were pre processed. The abrasion primitive data of plant could not always satisfy these modeling requirements. Therefore, it establishes a division method suited for general data modeling and estimating parameters of GM (1,1), the standard error coefficient that was applied to judge accuracy height of the model was put forward; further, the function transform to forecast plant abrasion trend and assess GM (1,1) parameter was established. These two models need not pre process the primitive data. It is not only suited for equal interval data modeling, but also for non equal interval data modeling. Its calculation is simple and convenient to use. The oil spectrum analysis acted as an example. The two GM (1,1) models put forward in this paper and the new information model and its comprehensive usage were investigated. The example shows that the two models are simple and practical, and worth expanding and applying in plant fault diagnosis. | LUO You xin 1 , PENG Zhu 2 , ZHANG Long ting 1 , GUO Hui xin 1 , CAI An hui 1 1Department of Mechanical Engineering, Changde Teachers University, Changde 415003, P.R. China 2 Engineering Technology Board, Changsha Cigare | 2001 | International Journal of Plant Engineering and Management2001，6，4： | 11 |
| 5 | Research status of key techniques for shock-induced combustion ramjet(shcramjet) engine显示文摘As one of the most promising propulsion systems in the future,shock-induced combustion ramjet engine can remedy the disadvantages in the integrated design of scramjet engine and airframe.It can shorten the length of the combustor,lighten the structure weight of the engine and keep better performance in a broad range of flight Mach number.The elementary principle of shock-induced combustion ramjet engine is introduced.The key technologies of this kind of propulsion system are described,while their research status is presented in detail.Suggestion on the development of shcramjet engine in China is put forward. | HUANG Wei,QIN Hui,LUO ShiBin & WANG ZhenGuo Institute of Aerospace & Materials Engineering,National University of Defense Technology,Changsha 410073,China | 2010 | Science China(Technological Sciences)2010，53，1： | 9 |
| 6 | Endoscopic sphincterotomy associated cholangitis in patients receiving proximal biliary self-expanding metal stents显示文摘BACKGROUND: Endoscopic biliary stent placement during the procedure of endoscopic retrograde cholangiopancreatography (ERCP) is preferred to provide biliary drainage for unresectable malignant biliary obstruction. There is considerable controversy over the use of endoscopic sphincterotomy (ES) prior to stent placement. This study aimed to determine whether ES before intraductal self-expanding metal stent (SEMS) placement affects the clinical outcome and complications in patients with proximal malignant obstructive biliary diseases. METHODS: In a prospective randomized controlled trial, 82 patients with inoperable malignant biliary strictures were randomly assigned to biliary stenting groups with or without ES. Resolution of jaundice and the incidence of complications including acute cholangitis, pancreatitis and stent occlusion within 6 months were evaluated. RESULTS: SEMSs were successfully deployed in all patients, resulting in clinical and biochemical improvement of obstructive symptoms in both groups. The incidence of cholangitis was higher in the ES group than in the non-ES group (58.5% vs 31.7%, P=0.015). The interval between stent placement and the first acute cholangitis was much shorter in the ES group than in the non-ES group (P=0.024). The use of ES increased the incidence of cholangitis (P=0.004, risk ratio, 8.196). The rate of post-ERCP pancreatitis after stent placement was greater in the non-ES group than in the ES group (31.7% vs 9.8%, P=0.014). No significant differences were found in the rate of restenosis and the mortality rate between the two groups.CONCLUSIONS: ES prior to intraductal SEMS placement was associated with an increased incidence of acute cholangitis. ES should be carefully evaluated prior to its use in patients with proximal malignant obstructive biliary diseases. | Hui Zhou, Lei Li, Feng Zhu, Sheng-Zheng Luo, Xiao-Bo Cai,Xin-Jian Wan Department of Gastroenterology, Shanghai First People’s Hospital, Shanghai Jiaotong University, Shanghai 200080, China | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，6： | 8 |
| 7 | Spatial patterns in temperature sensitivity of soil respiration in China: Estimation with inverse modeling显示文摘Temperature sensitivity of soil respiration (Q10) is an important parameter in modeling the effects of global warming on ecosystem carbon release. Experimental studies of soil respiration have ubiquitously indicated that Q10 has high spatial heterogeneity. However, most biogeochemical models still use a constant Q10 in projecting future climate change and no spatial pattern of Q10 values at large scales has been derived. In this study, we conducted an inverse modeling analysis to retrieve the spatial pattern of Q10 in China at 8 km spatial resolution by assimilating data of soil organic carbon into a proc-ess-based terrestrial carbon model (CASA model). The results indicate that the optimized Q10 values are spatially heterogeneous and consistent to the values derived from soil respiration observations. The mean Q10 values of different soil types range from 1.09 to 2.38, with the highest value in volcanic soil, and the lowest value in cold brown calcic soil. The spatial pattern of Q10 is related to environmental factors, especially precipitation and top soil organic carbon content. This study demonstrates that inverse modeling is a useful tool in deriving the spatial pattern of Q10 at large scales, with which being incorporated into biogeochemical models, uncertainty in the projection of future carbon dynamics could be potentially reduced. | ZHOU Tao1,2, SHI PeiJun1,2, HUI DaFeng3 & LUO YiQi4 1 State Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University, Beijing 100875, China 2 Academy of Disaster Reduction and Emergency Management, Ministry of Civil Affairs & Ministry of Education, Beijing 100875, China 3 Department of Biological Sciences, Tennessee State University, Nashville, TN 37209, USA 4 Department of Botany and Microbiology, University of Oklahoma, Norman, OK 73019, USA | 2009 | Science China(Life Sciences)2009，52，10： | 4 |
| 8 | THE SIGNIFICANCE OF TESTING PREOPERATIVE VISUAL FUNCTION IN CATARACT USING LASER INTERFEROMETRIC VISUAL ACUITY AND ERG显示文摘Tests of preoperative visual function and prediction of postoperative E chart visual acuity(ECVA) using laser interferometric visual acuity(LIVA) and electroretinogram(ERG) were performed in 16 cases(19 eyes) of cataract. The results showed that the coincident rate between preoperative LIVA and postoperative ECVA was 63.2%, and there was a parallel correlation between preoperative amplitude of photopic ERG b-wave and postoperative ECVA in 79.0% of the eyes. Comparing these two methods, the test of LIVA ... | De-Zheng Wu Lezheng Wu Xijing Xu Hui Chen Taiqing Luo Zhongshan Ophthalmic Center Sun Yat-sen University of Medical Sciences Guangzhou 510060, China | 1991 | 眼科学报1991，7，1： | 2 |
| 9 | Blood flow activation in rat somatosensory cortex under sciatic nerve stimulation revealed by laser speckle imaging显示文摘In many functional neuroimaging research the change of local cerebral blood flow (CBF) induced by sensory stimulation is regarded as an indicator of the change in cortical neuronal activity although a precise and full spatio-temporal description of local CBF response coupled to neural activity has still not been laid out. Using the laser speckle imaging technique a relatively large exposed area in somatosensory cortex of rat was imaged for the observation of the variations of CBF during sciatic nerve stimulation. The results showed that cerebral blood flow activation was spatially localized and discretely distributed in the targeted microvasculature. Individual arteries, veins and capillaries in different diameters were activated with the time going. The response pattern of CBF related to the function of brain activity and energy metabolism is delineated exactly. | WANG Zheng, LUO Qingming, CHENG Haiying, LUO Weihua, GONG Hui and LU Qiang(The Key Laboratory of Biomedical Photonics of Ministry of Education of China, Huazhong University of Science and Technology, Wuhan 430074, China) | 2003 | Progress in Natural Science:Materials International2003，13，7： | 2 |
| 10 | Strongly Zero-Dimensional Locales | KOU Hui LUO Mao Kang Department of Mathematics. Sichuan University, Chengdu 610064. P. R. China | 2002 | Acta Mathematica Sinica,English Series2002，18，1： | 1 |
| 11 | Identification and functional analysis of a novel box C/D snoRNA from Schizosaccharomyces pombe显示文摘By constructing and screening the Schizosac-charomyces pombe nuclear cDNA library, a novel small nu-cleolar RNAs (snoRNA) was identified. The novel snoRNAdisplays structural features typical of C/D box snoRNA fam-ily and possesses a 10-nt-long rRNA antisense element whichis predicted to guide the 2’-O-methylation of the fission yeast 25S rRNA at G940. As expected, the rRNA ribose-methyla-tion site predicted by the novel snoRNA was preciselymapped by a deoxynucleoside triphosphate concentration-dependent primer extension assay. The comparison of func-tional element of guide snoRNAs among eukaryotes reveals that the novel snoRNA is a partial counterpart of the bud-ding yeast snR60 and was termed snR60-II. snR60-II genenested in the intron of a non-coding RNA gene with an un-known function, which is the first example of a yeastsnoRNA encoded in an intron of a non-coding RNA gene.Furthermore, a number of yeast snR60 homologues were also identified from other fungi and fly. Our results reveal thatsnR60 exhibits diverse genomic organization in eukaryotes, implying the high mobility of snR60 gene in the course ofevolution. | LUO Yuping, ZHUO Hui, LI Siguang & QU Lianghu Key Laboratory of Gene Engineering of the Ministry of Education, Bio-technology Research Center Zhongshan University, Guangzhou 510275, China Correspondence should be addressed to Qu Lianghu (e-mil: lsbrc04@zsu.edu.cn) | 2004 | Chinese Science Bulletin2004，49，18： | 1 |
| 12 | A Study of the Driving Force for Inclusion Complexation of α- and β-Cyclodextrin with Substituted Benzene显示文摘Introductionα-Cyclodextrinandβ-cyclodextrin(α-andβ-CD)aremacrocyclicoligomersofsixandsevenglucoseunits,respectively.Theyhaveb... | ZHANG Hai ming, LUO Shuang hui, CHEN Chao, LIU Lei GUO Qing xiang ** and LIU You cheng (Department of Chemistry, University of Science and Technology of China, Hefei, 230026 National Laboratory of Applied Organic Chemistry, Lanzhou Universi | 1999 | Chemical Research in Chinese Universities1999，15，1： | 1 |
| 13 | WATER-SOLUBLE FULLERENE DERIVATIVES, SYNTHESIS AND CHARACTERIZA显示文摘WATER-SOLUBLE FULLERENE DERIVATIVES,SYNTHESIS AND CHARACTERIZATION OF β-ALANINE C_(60) ADDUCTSWATER-SOLUBLEFULLERENEDERIVATIV... | Liang Bing GAN Chu Ring LUO Lian Bin XU De Jing ZHOU Chun Hui HUANG(Department of Chemistry, Peking University, Beijing, 100871, China)Shan Kai ZHAO(Instrumentation Analysis and Research Center, Zhong Shan University, Guangzhou. 510275) | 1994 | Chinese Chemical Letters1994，5，4： | 1 |
| 14 | A Study on the Driving Force for Binding of Benzene Derivatives by α-and β-Cyclodextrin显示文摘A three-dimensional diagram shows that the association constants (Ka) for the inclusionof a- and 6-CD with substitUted benzene are mainly correIated with the molar refraction (R.) andhydrophobic constant (%) of the substitUents of guest compounds. It reveals that the inclusion ofcyclodextrin with the substitUted benzene is dondnantly driYen by van der Waals forces andhydrophobic interactions. | Shuang Hui LUO Hui Ming JMNG You Cheng LIU(National Laboratory of Applied organic Chemistry, Lanzhou University, Lanzhou 730000)Qing Xiang GUO (Department of Chemistry, University of Science and Technology of China, Hefei 230026) | 1998 | Chinese Chemical Letters1998，9，5： | 0 |
| 15 | AN ALGORITHM OF EDGE DETECTION IN ULTRASONEC MEDICINE IMAGING BASED ON ENTROPY OPERATOR显示文摘ANALGORITHMOFEDGEDETECTIONINULTRASONECMEDICINEIMAGINGBASEDONENTROPYOPERATORANALGORITHMOFEDGEDETECTIONINULTRASONECMEDICINEIMAG... | WANG Hui BIAN zhengzhong LUO Jing(Department of Biomedical Engineering of Xi’an Jiaotong Univ.Xi’an, Shaanxi, 710049,China) | 1995 | Chinese Journal of Biomedical Engineering(English Edition)1995，4，3： | 0 |
| 16 | STUDY OF APPLICATION OF FUZZY SYNTHETICAL JUDGMENT IN CLASSIFYING THE LOWING INDEX OF BLOOD显示文摘STUDYOFAPPLICATIONOFFUZZYSYNTHETICALJUDGMENTINCLASSIFYINGTHELOWINGINDEXOFBLOODSTUDYOFAPPLICATIONOFFUZZYSYNTHETICALJUDGMENTINC... | WANG Hui LUO Jing BIAN Zhengzhong(Department of Biomedical Engineering of Xi’an Jiaotong UniversityXi’an, Shaanxi, 710049 China)’ | 1995 | Chinese Journal of Biomedical Engineering(English Edition)1995，4，3： | 0 |
| 17 | Ultrafast photo-induced turning of magnetization and its relaxation dynamics in GaMnAs显示文摘We report that,by linearly polarized pumping of different wavelengths,Kerr transients appear at zero magnetic field only in the case when GaMnAs samples are initialized at 3 K by first applying a 0.8 Tesla field and then returning to zero field.We find that,instead of magnetization precession,the near-band gap excitation induces a coherent out-of-plane turning of magnetization,which shows very long relaxation dynamics with no precession.When photon energy increases,the peak value of the Kerr transient increases,but it decays rapidly to the original slow transient seen under the near-band-gap excitation. | LUO Jing,ZHENG HouZhi,SHEN Chao,ZHANG Hao,ZHU Ke,ZHU Hui,LIU Jian,LI GuiRong,JI Yang & ZHAO JianHua State Key Laboratory for Superlattices and Microstructures,Institute of Semiconductors,Chinese Academy of Sciences,Beijing 100083,China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，5： | 0 |
| 18 | ENTHALPY-ENTROPY COMPENSATION IN THE INCLUSION OF 1-SUBSTITUTED NAPHTHALENES BY β-CYCLODEXTRIN IN WATER显示文摘ENTHALPY-ENTROPYCOMPENSATIONINTHEINCLUSIONOF1-SUBSTITUTEDNAPHTHALENESBYβ-CYCLODEXTRININWATER￥QingXiangGUO;XiaoQiZHENG;ShuangH... | Qing Xiang GUO Xiao Qi ZHENG Shuang Hui LUO You Cheng LIU(a Department of Modern Chemistry, University of Science andTechnology of China, Hefei 230026)(b National Laboratory of Applied Organic Chemistry. Lanzhou University, Lanzhou 730000) | 1996 | Chinese Chemical Letters1996，7，4： | 0 |
| 19 | A REGRESSION STUDY ON THE INCLUSION OF CYCLODEXTRIN WITH BENZENE DERIVATIVES显示文摘A REGRESSION STUDY ON THE INCLUSION OF CYCLODEXTRIN WITH BENZENE DERIVATIVESAREGRESSIONSTUDYONTHEINCLUSIONOFCYCLODEXTRINWITHB... | Qing Xiang GUO Shuang Hui LUO Xiao Qi ZHENG and You Cheng LIU(Department of Modern Chemistry. University of Science andTechnology of China, Hefei 230026)(National Laboratory of Applied Organic Chemistry. LanzhouUniversity. Lanzhou 730000) | 1996 | Chinese Chemical Letters1996，7，8： | 0 |
| 20 | THE COKING PROPERTIES AND STATES OF AN INDUSTRIAL W-Ni USED CATALYST显示文摘PASCA, ESR and Microreactor, have been used to study the states and properties of coking deposits on catalyst. The results indicate that the C exists as three types of states on catalyst surface. The first and second types of carbon are the main reason of the catalyst deactivation, but the third type has a promoting role in n-C7 hydrocracking reaction. The Ss-C interacts strongly with catalyst, forming metal-carbon-support interaction (MCSI). | Ji Gang LUO~* AND Chen Lie LI (Chemical and Technology University of East China, Shanghai, 200237) Ming Shi LI, Yan ZHO, Xi Hui LUO (Fushun Research Institute of Petroleum and Petrochemicals, Fushun, Lianing, 113001) | 1991 | Chinese Chemical Letters1991，2，12： | 0 |
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