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| 1 | Homeopathic potencies of Arnica montana L. change gene expression in a Tamm-Horsfall protein-1 cell line in vitro model: the role of ethanol as a possible confounder and statistical bias显示文摘Marzotto et al. showed that homeopathic preparations of Arnica montana L. acted directly on gene expression of Tamm-Horsfall protein-1(THP-1) monocyte/macrophage cell lines activated with phorbol12-myristate13-acetate and interleukin-4(IL-4). A. montana homeopathic dilutions are used in complementary and alternative medicine to treat inflammation disorders and post-traumatic events as well as for wound repair. The French Pharmacopoeia of these remedies uses 0.3% ethanol in each centesimal dilution. In this paper, we discuss how ethanol-containing A. montana homeopathic centesimal dilutions can change gene expression in IL-4-treated monocyte/macrophage THP-1. We assessed the role of ethanol in the Arnica homeopathic dilutions containing this alcohol by investigating its action on gene expression of THP-1 cell. Evidence would strongly suggest that the presence of ethanol in these remedies might play a fundamental role in the dilutions ability to affect gene expression, particularly for doses from 5c to 15 c. Where, rather than playing a major role in the mesoscopic structure of water, the ethanol might have a chemical-physical role in the induction of THP-1 gene expression, apoptosis, and deoxyribonucleic acid function. This evidence generates a debate about the suggestion that the use of a binary-mixed solvent in homeopathic chemistry, used by Hahnemann since 1810, may be fundamental to explain the activity of homeopathy on cell models. | Salvatore Chirumbolo Geir Bj?rklund | 2017 | Journal of Integrative Medicine2017，15，4： | 2 |
| 2 | Job Insecurity,Union Support and Intentions to Resign Membership:A Psychological Contract Perspective显示文摘 | De Witte H Sverke M Van Ruysseveldt J Goslinga S Chirumbolo A Hellgren J Naswall K | | 0，，1： | 1 |
| 3 | Basophil Activation Test in Allergy:Time for an Up- date 显示文摘 | Chirumbolo S | 2012 | Int Arch Allergy Immunol2012，158，2： | 1 |
| 4 | Quercetin in cancer prevention and therapy 显示文摘 | Chirumbolo Salvatore/S | 2013 | Integr Cancer Ther2013，12，2： | 1 |
| 5 | Individual and organizational consequences of job insecurity: A European study 显示文摘 | CHIRUMBOLO A HETLGREN J | 2003 | Economical and Industrial Democracy2003，24，2： | 1 |
| 6 | Monitoring of CD63 in basophil activation test and suggested new parameters for allergy diagnosis显示文摘 | Chirumbolo S | | 0，，02： | 1 |
| 7 | The use of IL-3 in basophil activation tests is the real pitfall 显示文摘 | Chirumbolo S | 2011 | Cytometry B Clin Cytom2011，80，2： | 1 |
| 8 | In vivo anti-diabetic potential of chlorogenic acid as a consequence of synergism with other phenolic compounds?显示文摘 | Chirumbolo S | 2015 | British Journal of Nutrition2015，113，3： | 1 |
| 9 | Moti- vated elosed-mindedness and creativity in small groups显示文摘 | CHIRUMBOLO A MANNETTI L PIERRO A | 2005 | Small Group Researeh2005，36，1： | 1 |
| 10 | Enhancement ofT cell activation by immobilized hu5C8(anti-CD40L)monoclonal antibody显示文摘 | Arpinati M Chirumbolo G Rondelli D | 2008 | European Journal Haematology2008，80，4： | 1 |
| 11 | Effects of need for closure on creativity in small group interactions 显示文摘 | Chirumbolo A | 2004 | European Journal of Personality2004，18，4： | 1 |
| 12 | Basophil activation test in allergy: time for an update?显示文摘 | Chirumbolo S | 2012 | Int Arch Allergy Immunol2012，158，2： | 1 |
| 13 | Acute graft-versus-host disease and steroid treatment impair CD11c+and CD123+dendritic cell reconstitution after allogeneic peripheral blood stem cell transplantation显示文摘 | Arpinati M Chirumbolo G Urbini B | 2004 | Biol Blood Marrow Transplant2004，10，2： | 1 |
| 14 | Role of plasmacytoid dendritic cells in immunhy and tolerance after allogeneic hematopoietie stem cell transplantation显示文摘 | Arpinatl M Chirumbolo G Uribini B | 2003 | Transpl Immunol2003，11，： | 1 |
| 15 | The role of quercetin, flavonols and flavones in modulating inflammatory cell function 显示文摘 | Chirumbolo Salvatore | 2010 | lnflamm Allergy Drug Targets2010，9，4： | 1 |
| 16 | The role of quercetin, flavonols and flavones in modulating inflammatory cell function显示文摘 | Chirumbolo S | 2010 | Inflammation & Allergy-Drug Targets2010，9，4： | 1 |
| 17 | State-of-the-art review about basophil research in im- munology and allergy: is the time right to treat these cells with the re- spect they deserve? 显示文摘 | Chirumbolo S | 2012 | Blood Transfus2012，10，2： | 1 |
| 18 | Iron primes 3T3-L1 adipocytes to a TLR4-mediated inflammatory response显示文摘 | Salvatore Chirumbolo Andrea P. Rossi Vanni Rizzatti Elena Zoico Guido Franceschetti Domenico Girelli Mauro Zamboni | 2015 | Nutrition2015，，10： | 1 |
| 19 | Flavonoids in propolis acting on mast cell-mediated wound healing显示文摘 | Chirumbolo S | 2012 | Inflammopharmacology2012，20，2： | 1 |
| 20 | Role of plasmacytoid dendritic cells in immunity and tolerance after allogeneic hematopoietic stem cell transplantation显示文摘 | Arpinati M Chirumbolo G Urbini B | 2003 | Transplant Immunol2003，11，34： | 1 |
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