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| 1 | Indications for 5-aminosalicylate in inflammatory bowel disease:Is the body of evidence complete?显示文摘Mesalazine is a safe drug, although adverse events may be seen in a minority of patients. This applies also to pregnant women and children. The role of mesalazine in combination therapy to improve efficacy and con- comitant drug pharmacokinetics, or in chemoprevention against inflammatory bowel disease (IBD)-related co- lonic carcinoma has not yet been completely elucidated. Therapeutic success of mesalazine may be optimized by a combination of high dose and low frequency of dos- age to improve compliance. Therefore, due to its supe- rior safety profile and pharmacokinetic characteristics, mesalazine is preferable to sulphasalazine. This paper reviews the literature concerning mechanisms of action, indications and off-label use, pharmacokinetic properties and formulations, therapeutic efficacy, compliance, pae- diatric indications, chemoprevention, and safety issues and adverse event profile of mesalazine treatment versus sulphasalazine. It also highlights these controversies in order to clarify the potential benefits of mesalazines in IBD therapy and evidence for its use. | Ad A van Bodegraven Chris JJ Mulder | 2006 | World Journal of Gastroenterology2006，12，38： | 2 |
| 2 | Plasma leptin at the risk of cardiovascular disease in the West of Scotland Cor onary Prevention Study (WOSCPS) 显示文摘 | Wallace AM Me Mahon AD Chris JP | 2001 | Circulation2001，104，： | 1 |
| 3 | Plasma leptin at the risk of cardiovascular disease in the West of Scotland Coronary Prevention Study (WOSCPS) 显示文摘 | Wallace AM Mc Mahon AD Chris JP | 2001 | Ciroulation2001，104，21： | 1 |
| 4 | Lecithin:Cholesterol Acyltransferase Deficiency Protects against Cholesterol-induced Hepatic Endoplasmic Reticulum Stress in Mice显示文摘 | Lauren Hager Lixin Li Henry Pun Lu Liu Mohammad A. Hossain Graham F. Maguire Mark Naples Chris Baker Lilia Magomedova Jonathan Tam Khosrow Adeli Carolyn L. Cummins Philip W. Connelly Dominic S. Ng | 2012 | Journal of Biological Chemistry2012，，24： | 1 |
| 5 | Metabolic complications of total parenteral nutrition:effects of a nutrition support service显示文摘 | Chris AD Heimburger DC Morgan SL | 1996 | JPEN J Parenter Enteral Nutr1996，20，3： | 1 |
| 6 | Remote sensing and analysis of tropical cyclones:Current and emerging satellite sensors显示文摘This article describes recent advances in the capability of new satellite sensors for observing Tropical Cyclones(TC)fine structure,wind field,and temporal evolution.The article is based on a World Meteorological Organization(WMO)report prepared for the 10th International Workshop on Tropical Cyclones(IWTC),held in Bali in December 2022,and its objective is to present updates in TC research and operation every four years.Here we focus on updates regarding the most recent space-based TC observations,and we cover new methodologies and techniques using polar orbiting sensors,such as C-band synthetic aperture radars(SARs),L-band and combined C/X-band radiometers,scatterometers,and microwave imagers/sounders.We additionally address progress made with the new generation of geostationary and small satellites,and discuss future sensors planned to be launched in the next years.We then briefly describe some examples on how the newest sensors are used in operations and data assimilation for TC forecasting and research,and conclude the article with a discussion on the remaining challenges of TC space-based observations and possible ways to address them in the near future. | Lucrezia Ricciardulli Brian Howell Christopher R.Jackson Jeff Hawkins Joe Courtney Ad Stoffelen Sebastian Langlade Chris Fogarty Alexis Mouche William Blackwell Thomas Meissner Julian Heming Brett Candy Tony McNally Masahiro Kazumori Chinmay Khadke Maria Ana Glaiza Escullar | 2023 | Tropical Cyclone Research and Review2023，12，4： | 0 |
| 7 | The regenerative response of cardiac interstitial cells显示文摘Understanding how certain animals are capable of regenerating their hearts will provide much needed insights into how this process can be induced in humans in order to reverse the damage caused by myocardial infarction.Currently,it is becoming increasingly evident that cardiac interstitial cells play crucial roles during cardiac regeneration.To understand how interstitial cells behave during this process,we performed single-cell RNA sequencing of regenerating zebrafish hearts.Using a combination of immunohistochemistry,chemical inhibition,and novel transgenic animals,we were able to investigate the role of cell type-specific mechanisms during cardiac regeneration.This approach allowed us to identify a number of important regenerative processes within the interstitial cell populations.Here,we provide detailed insight into how interstitial cells behave during cardiac regeneration,which will serve to increase our understanding of how this process could eventually be induced in humans. | Laura Rolland Alenca Harrington Adèle Faucherre Jourdano Mancilla Abaroa Girisaran Gangatharan Laurent Gamba Dany Severac Marine Pratlong Thomas Moore-Morris Chris Jopling | 2022 | Journal of Molecular Cell Biology2022，14，10： | 0 |
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