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| 1 | A critical role of IL-17 in modulating the B-cell response during H5N1 influenza virus infection显示文摘Interleukin-17(IL-17),a member of the IL-17 cytokine family,plays a crucial role in mediating the immune response against extracellular bacteria and fungi in the lung.Although there is increasing evidence that IL-17 is involved in protective immunity against H1 and H3 influenza virus infections,little is known about the role of IL-17 in the highly pathogenic H5N1 influenza virus infection.In this study,we show that H5N1-infected IL-17 knockout(KO)mice exhibit markedly increased weight loss,more pronounced lung immunopathology and significantly reduced survival rates as compared with infected wild-type controls.Moreover,the frequency of B cells in the lung were substantially decreased in IL-17 KO mice after virus infection,which correlated with reduced CXCR5 expression in B cells and decreased CXCL13 production in the lung tissue of IL-17 KO mice.Consistent with this observation,B cells from IL-17 KO mice exhibited a significant reduction in chemokine-mediated migration in culture.Taken together,these findings demonstrate a critical role for IL-17 in mediating the recruitment of B cells to the site of pulmonary influenza virus infection in mice. | Xiaohui Wang Chris CS Chan Min Yang Jun Deng Vincent KM Poon Virtual HC Leung King-Hung Ko Jie Zhou Kwok Yung Yuen Bo-Jian Zheng Liwei Lu | 2011 | Cellular & Molecular Immunology2011，8，6： | 2 |
| 2 | The dynamics and dilemma of workplace trade union reform in China:The case of the Honda workers’dtrike显示文摘 | Chan Chris King-Chi Hui Elaine Sio-Ieng | 2012 | Journal of Industrial Relations2012，54，5： | 1 |
| 3 | Femtosecond laser cataract surgery: technology and clinical practice显示文摘 | Timothy V Roberts Michael Lawless Colin CK Chan Mark Jacobs David Ng Shveta J Bali Chris Hodge Gerard Sutton | 2012 | Clinical & Experimental Ophthalmology2012，，2： | 1 |
| 4 | Dynamic cluster formation using level set methods显示文摘 | Yip Andy M Ding Chris Chan Tony F | 2006 | IEEE Trans on Pattern Analysis and Machine Intelligence2006，28，6： | 1 |
| 5 | Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial显示文摘 | Jeremy Chataway Nadine Schuerer Ali Alsanousi Dennis Chan David MacManus Kelvin Hunter Val Anderson Charles R M Bangham Shona Clegg Casper Nielsen Nick C Fox David Wilkie Jennifer M Nicholas Virginia L Calder John Greenwood Chris Frost Richard Nicholas | 2014 | The Lancet2014，，： | 1 |
| 6 | The behaviour of al in MSW incinerator fly ash during thermal treatment显示文摘 | Chris C Y Chan D W K Hilary M | 2000 | Journal of Hazardous Materials2000，76，1： | 1 |
| 7 | The behaviour of Al in MSW incinerator fly ash during thermal treatment显示文摘 | Chris C Y Chan Donald W Kirk Hilary Marsh | 2000 | J Hazard Materi2000，76，： | 1 |
| 8 | Chromium behavior during thermal treatment of MSW fly ash 显示文摘 | Donald W Kirk Chris Y Chan Hilary Marsh | 2002 | J Hazard Materi2002，90，： | 1 |
| 9 | Increasing prevalence of advanced colonic polyps in young patients undergoing colonoscopy in a referral academic hospital in Hong Kong显示文摘AIM: To investigate the distribution and frequency of advanced polyps over eight years. METHODS: 6424 colonoscopies were reviewed during the study period 1998 to 2005. The study period was subdivided into period Ⅰ: 1998 to 2001 and period Ⅱ: 2002-2005. RESULTS: 1856 polyps (33% advanced polyps) and 328 CRCs were detected. The mean ages of the patients with advanced polyps and cancer were 69.2 ± 12.0 and 71.6 ± 13.8 years, respectively. Advanced polyps were mainly left sided (59.5%). Advanced polyps were found in patients ≤ 60 years from 17.7% in periodⅠto 26.3% in period Ⅱ (P < 0.05), especially in male subjects ≤ 60 years (21.6% vs 31.6%, P < 0.05). Advanced tubulovillous polyps rose from 21.5% in period Ⅰto 29.5% in period Ⅱ (P < 0.05). Whereas cancers in male patients ≤ 60 years were similar in both periods: 23.2% vs 16.5% (P > 0.05). CONCLUSION: Advanced polyps increased significantly in the younger male group in the most recent period and there seems to be a shift towards a proximal location. | Tze Jui Lam Benjamin CY Wong Chris JJ Mulder A Salvador Pea Wai Mo Hui Shiu Kum Lam Annie On On Chan | 2007 | World Journal of Gastroenterology2007，13，28： | 1 |
| 10 | Behavior of metals under the conditions of roasting MSW incineration fly ash with chlorinating agents显示文摘 | CHAN CHRIS C Y KIRK DONALD W | 1999 | Journal of Hazardous Materials B1999，64，1： | 1 |
| 11 | The behavior of selected heavy metals in MSW incineration electrostatic precipitator ash during roasting with chlorination agent 显示文摘 | Chris Chan Charles Q Jia John W Graydon | 1996 | Journal of Hazardous Materials1996，50，： | 1 |
| 12 | Safety of thoracic pedicle screw application using the funnel technique in Asians : a cadaveric evaluation显示文摘 | Chris Yin Wei Chan Mun Keong Kwan Lim Beng Saw | 2010 | Eur Spine2010，19，： | 1 |
| 13 | The behavior of Al in MSW incinerator fly ash during thermal treatment 显示文摘 | Chris C Y Chan Donald W Kirk Hilayr Marsh | 2000 | Journal of hazardous materials2000，76，1： | 1 |
| 14 | The behavior of A1 in MSW incinerator fly ash during thermal treatment显示文摘 | Chris C Y Chan Donald W Kirk Hilary Marsh | 2000 | Journal of Hazardous Materials2000，76，1： | 1 |
| 15 | The behavior of selected heavy metal in MSW incineration electrostatic precipitator ash during roasting with chlorination agents显示文摘 | Chan Chris Jia Charles Q Graydon John W | 1996 | Journal of Hazardous Materials1996，50，1： | 1 |
| 16 | The Making of a New Working Class? A Study of Collective Actions of Migrant Workers in South China显示文摘 | Chris King-Chi Chan and PUN Ngai | 2009 | The China Quarterly2009，198，6： | 1 |
| 17 | Chromium behavior during thermal treatment of MSW fly ash显示文摘 | Kirk Donald W Chan Chris C Y Marsh Hilary | 2002 | Journal of Hazardous Materials2002，90，1： | 1 |
| 18 | Functional dissection of an IFN-α/β receptor 1 promoter variant that confers higher risk to chronic hepatitis B virus infection显示文摘 | Jie Zhou Jian-Dong Huang Vincent K.M. Poon Ding-Qiang Chen Chris C.S. Chan Fai Ng Xin-Yuan Guan Rory M. Watt Liwei Lu Kwok-Yung Yuen Bo-Jian Zheng | 2009 | Journal of Hepatology2009，，： | 1 |
| 19 | Behaviour of metal under tlle conditions of roasting M SW incinerator fly ash with chlorinating agents显示文摘 | Chris C Y Chan Donald W Kirk | 1999 | Journal of Hazardous Materials1999，7589，： | 1 |
| 20 | The behaviour of selected heavy metals in MSW incineration electrostatic precipitator ash during roasting with chlornation agents显示文摘 | Chan Chris Jia Charles Q Graydon John W | 1996 | Journal of Hazardous Materials1996，50，： | 1 |
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