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| 1 | Increased hepcidin expression in colorectal carcinogenesis显示文摘AIM:To investigate whether the iron stores regulator hepcidin is implicated in colon cancer-associated anae- mia and whether it might have a role in colorectal car- cinogenesis. METHODS: Mass spectrometry (MALDI-TOF MS and SELDI-TOF MS) was employed to measure hepcidin in urine collected from 56 patients with colorectal cancer. Quantitative Real Time RT-PCR was utilised to determine hepcidin mRNA expression in colorectal cancer tissue. Hepcidin cellular localisation was determined using im- munohistochemistry. RESULTS: We demonstrate that whilst urinary hepcidin expression was not correlated with anaemia it was posi- tively associated with increasing T-stage of colorectal cancer (P < 0.05). Furthermore, we report that hepcidin mRNA is expressed in 34% of colorectal cancer tissue specimens and was correlated with ferroportin repres- sion. This was supported by hepcidin immunoreactivity in colorectal cancer tissue. CONCLUSION: We demonstrate that systemic hepcidin expression is unlikely to be the cause of the systemic anaemia associated with colorectal cancer. However, we demonstrate for the first time that hepcidin is expressed by colorectal cancer tissue and that this may represent a novel oncogenic signalling mechanism. | Douglas G Ward Keith Roberts Matthew J Brookes Howard Joy Ashley Martin Tariq Ismail Robert Spychal Tariq Iqbal Chris Tselepis | 2008 | World Journal of Gastroenterology2008，14，9： | 12 |
| 2 | The GWmodel R package:further topics for exploring spatial heterogeneity using geographically weighted models显示文摘In this study,we present a collection of local models,termed geographically weighted(GW)models,which can be found within the GWmodel R package.A GW model suits situations when spatial data are poorly described by the global form,and for some regions the localized fit provides a better description.The approach uses a moving window weighting technique,where a collection of local models are estimated at target locations.Commonly,model parameters or outputs are mapped so that the nature of spatial heterogeneity can be explored and assessed.In particular,we present case studies using:(i)GW summary statistics and a GW principal components analysis;(ii)advanced GW regression fits and diagnostics;(iii)associated Monte Carlo significance tests for non-stationarity;(iv)a GW discriminant analysis;and(v)enhanced kernel bandwidth selection procedures.General Election data-sets from the Republic of Ireland and US are used for demonstration.This study is designed to complement a companion GWmodel study,which focuses on basic and robust GW models. | Binbin LU Paul HARRIS Martin CHARLTON Chris BRUNSDON | 2014 | Geo-Spatial Information Science2014，17，2： | 9 |
| 3 | Hardfacing steel with nanostructured coatings of Stellite-6 by supersonic laser deposition显示文摘The ability to manufacture coatings is critical to engineering design. Many components require the application of additional layers toenhance mechanical properties and protect against hostile environments. Supersonic laser deposition (SLD) is a novel coating methodbased on cold spray (CS) principles. In this technique, the deposition velocities can be significantly lower than those required foreffective bonding in CS applications. The addition of laser heat energy permits a change in the thermodynamic experience of impactingparticles, thereby offering a greater opportunity for efficient bonding at lower velocities as compared with the CS process. The workreported in this paper demonstrates the ability of the SLD process to deliver hardfacing materials to engineering surfaces. Stellite-6 hasbeen deposited on low-carbon steel tubes over a range of process parameters to establish the appropriate target power and traversespeeds for the coating formation. The coating properties and parameters were examined to determine the primary characteristics andgrain structure size. Their morphology and performance were studied through optical microscopy, scanning electron microscope(SEM), X-ray diffraction, hardness measurements and wear testing. The results have shown that SLD is capable of depositing layers ofStellite-6, with properties that are superior to those of their conventionally manufactured counterparts. | Rocco Lupoi Andrew Cockburn Chris Bryan Martin Sparkes Fang Luo William O’Neill | 2012 | Light(Science & Applications)2012，1，1： | 8 |
| 4 | Seasonal Rainfall Forecasts for the Yangtze River Basin of China in Summer 2019 from an Improved Climate Service显示文摘Rainfall forecasts for the summer monsoon season in the Yangtze River basin(YRB) allow decision-makers to plan for possible flooding, which can affect the lives and livelihoods of millions of people. A trial climate service was developed in 2016, producing a prototype seasonal forecast product for use by stakeholders in the region, based on rainfall forecasts directly from a dynamical model. Here, we describe an improved service based on a simple statistical downscaling approach. Through using dynamical forecast of an East Asian summer monsoon(EASM) index, seasonal mean rainfall for the upper and middle/lower reaches of YRB can be forecast separately by use of the statistical downscaling, with significant skills for lead times of up to at least three months. The skill in different sub-basin regions of YRB varies with the target season. The rainfall forecast skill in the middle/lower reaches of YRB is significant in May–June–July(MJJ), and the forecast skill for rainfall in the upper reaches of YRB is significant in June–July–August(JJA). The mean rainfall for the basin as a whole can be skillfully forecast in both MJJ and JJA. The forecasts issued in 2019 gave good guidance for the enhanced rainfall in the MJJ period and the near-average conditions in JJA. Initial feedback from users in the basin suggests that the improved forecasts better meet their needs and will enable more robust decision-making. | Philip E.BETT Nicola MARTIN Adam A.SCAIFE Nick DUNSTONE Gill M.MARTIN Nicola GOLDING Joanne CAMP Peiqun ZHANG Chris D.HEWITT Leon HERMANSON Chaofan LI Hong-Li REN Ying LIU Min LIU | 2020 | Journal of Meteorological Research2020，34，5： | 7 |
| 5 | A history of high-power laser research and development in the United Kingdom显示文摘The first demonstration of laser action in ruby was made in 1960 by T.H.Maiman of Hughes Research Laboratories,USA.Many laboratories worldwide began the search for lasers using different materials,operating at different wavelengths.In the UK,academia,industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of applications.This historical review looks at the contribution the UK has made to the advancement of the technology,the development of systems and components and their exploitation over the last 60 years. | Colin N.Danson Malcolm White John R.M.Barr Thomas Bett Peter Blyth David Bowley Ceri Brenner Robert J.Collins Neal Croxford A.E.Bucker Dangor Laurence Devereux Peter E.Dyer Anthony Dymoke-Bradshaw Christopher B.Edwards Paul Ewart Allister I.Ferguson John M.Girkin Denis R.Hall David C.Hanna Wayne Harris David I.Hillier Christopher J.Hooker Simon M.Hooker Nicholas Hopps Janet Hull David Hunt Dino A.Jaroszynski Mark Kempenaars Helmut Kessler Sir Peter L.Knight Steve Knight Adrian Knowles Ciaran L.S.Lewis Ken S.Lipton Abby Littlechild John Littlechild Peter Maggs Graeme P.A.Malcolm OBE Stuart P.D.Mangles William Martin Paul McKenna Richard O.Moore Clive Morrison Zulfikar Najmudin David Neely Geoff H.C.New Michael J.Norman Ted Paine Anthony W.Parker Rory R.Penman Geoff J.Pert Chris Pietraszewski Andrew Randewich Nadeem H.Rizvi Nigel Seddon MBE Zheng-Ming Sheng David Slater Roland A.Smith Christopher Spindloe Roy Taylor Gary Thomas John W.G.Tisch Justin S.Wark Colin Webb S.Mark Wiggins Dave Willford Trevor Winstone | 2021 | High Power Laser Science and Engineering2021，9，2： | 5 |
| 6 | A randomized trial of antioxidant therapy alone or with corticosteroids in acute alcoholic hepatitis显示文摘 | Stephen Stewart Martin Prince Margaret Bassendine Mark Hudson Oliver James David Jones Chris Record Christopher P. Day | 2007 | Journal of Hepatology2007，，2： | 3 |
| 7 | Association between early viral lower respiratory tract infections and subsequent asthma development显示文摘BACKGROUND The association between hospitalization for human respiratory syncytial virus(HRSV)bronchiolitis in early childhood and subsequent asthma is well established.The long-term prognosis for non-bronchiolitis lower respiratory tract infections(LRTI)caused by viruses different from HRSV and rhinovirus,on the other hand,has received less interest.AIM To investigate the relationship between infant LRTI and later asthma and examine the influence of confounding factors.METHODS The PubMed and Global Index Medicus bibliographic databases were used to search for articles published up to October 2021 for this systematic review.We included cohort studies comparing the incidence of asthma between patients with and without LRTI at≤2 years regardless of the virus responsible.The meta-analysis was performed using the random effects model.Sources of heterogeneity were assessed by stratified analyses.RESULTS This review included 15 articles(18 unique studies)that met the inclusion criteria.LRTIs at≤2 years were associated with an increased risk of subsequent asthma up to 20 years[odds ratio(OR)=5.0,95%CI:3.3-7.5],with doctor-diagnosed asthma(OR=5.3,95%CI:3.3-8.6),current asthma(OR=5.4,95%CI:2.7-10.6),and current medication for asthma(OR=1.2,95%CI:0.7-3.9).Our overall estimates were not affected by publication bias(P=0.671),but there was significant heterogeneity[I 2=58.8%(30.6-75.5)].Compared to studies with hospitalized controls without LRTI,those with ambulatory controls had a significantly higher strength of association between LRTIs and subsequent asthma.The strength of the association between LRTIs and later asthma varied significantly by country and age at the time of the interview.The sensitivity analyses including only studies with similar proportions of confounding factors(gender,age at LRTI development,age at interview,gestational age,birth weight,weight,height,smoking exposure,crowding,family history of atopy,and family history of asthma)between cases and controls did not alter the overall estimates.CONCLUSION Regardless of the causative virus and confounding factors,viral LRTIs in children<2 years are associated with an increased risk of developing a subsequent asthma.Parents and pediatricians should be informed of this risk. | Sebastien Kenmoe Etienne Atenguena Okobalemba Guy Roussel Takuissu Jean Thierry Ebogo-Belobo Martin Gael Oyono Jeannette Nina Magoudjou-Pekam Ginette Irma Kame-Ngasse Jean Bosco Taya-Fokou Chris Andre Mbongue Mikangue Raoul Kenfack-Momo Donatien Serge Mbaga Arnol Bowo-Ngandji Cyprien Kengne-Ndé Seraphine Nkie Esemu Richard Njouom Lucy Ndip | 2022 | World Journal of Critical Care Medicine2022，11，4： | 3 |
| 8 | Genomic resources for the brown planthopper, Nilaparvata lugens: Transcriptome pyrosequencing and microarray design显示文摘棕色的 planthopper, Nilaparvata lugens 是在整个亚洲的栽培米饭的一个害虫并且用杀虫药剂或抵抗米饭变化被控制。这种开发了抵抗到杀虫药剂的许多班,遗传因子型开发了那对先前是剧毒的抵抗米饭栽培变种。昆虫使用 detoxification 酶的一间套房,包括保卫自己对的细胞色素 P450s,谷胱甘肽 S-transferases 和 carboxyl/cholinesterases 种第二等的代谢物和杀虫剂。Roche 454-FLX 站台上的 Pyrosequencing 被用来生产补充存在 Sanger 的数据集定序的一个实质的表示顺序标签(EST ) 在 GenBank 的 EST。一个总数 78 959 读与 37 392 公开地可得到的 Sanger EST 被相结合;这些集合了进 8 911 contigs 和 10 620 单条。分发的分析试验有为生物进程和分子的函数的基因本体论的唯一的基因(拖船) 建议 454 并且 Sanger EST 汇编 N 是广泛地代表性的。lugens transcriptome。planthopper transcriptome 被发现包含编码 P450s,九个编码谷胱甘肽 S-transferases 和这些的 26 编码 carboxyl/cholinesterases 和许多的 31 条拖船的褐通常认为地涉及 xenobiotics 的 detoxification。Agilent eArray 站台被用来构造为 19 000 个 unigene 序列与探针占据的 oligonucleotide microarray,包括知道编码 detoxification 酶的所有那些。在这研究开发的 genomic 资源将对学习这个庄稼害虫的社区有用并且将帮助阐明位于杀虫药剂抵抗和 planthopper 改编下面到抵抗米饭栽培变种的分子的机制。 | Chris Bass Martin Bay Hebsgaard Joseph Hughes | 2012 | Insect Science2012，19，1： | 2 |
| 9 | Uncovering the Extent of the Phraseological Tendency: Towards a Systematic Analysis of Concgrams显示文摘 | Winnie Cheng Chris Greaves John McH. Sinclair Martin Warren | 2009 | Applied Linguistics2009，，2： | 2 |
| 10 | Intermittent Androgen Deprivation for Locally Advanced and Metastatic Prostate Cancer: Results from a Randomised Phase 3 Study of the South European Uroncological Group显示文摘 | Fernando E.C. Calais da Silva Aldo V. Bono Peter Whelan Maurizio Brausi Anton Marques Queimadelos Jose A. Portillo Martin Ziya Kirkali Fernando M.V. Calais da Silva Chris Robertson | 2009 | European Urology2009，，6： | 2 |
| 11 | On the dynamics of nitrite, nitrate and other biomarkers of nitric oxide production in inflammatory bowel disease显示文摘 | Fumito Saijo Alexandra B. Milsom Nathan S. Bryan Selena M. Bauer Thorsten Vowinkel Marina Ivanovic Chris Andry D. Neil Granger Juan Rodriguez Martin Feelisch | 2009 | Nitric Oxide2009，，2： | 2 |
| 12 | Application of near infrared spectroscopy in cotton fiber micronaire measurement显示文摘The term‘‘micronaire”describes an important cotton fiber property by characterizing both the fiber maturity and fineness.In practice,micronaire is regularly measured in laboratories with the well established high volume instrumentation(HVITM)protocol.In most scenarios,cotton breeders/geneticists sent cotton breeding line field trial samples to laboratories equipped to use the HVI^TM systems available for fiber micronaire determination.Researchers have previously investigated the use of NIR as an alternative means of measuring micronaire either at breeding sites or in standard laboratories.As a proof-of-concept investigation,this study collected both near infrared(NIR)spectra and HVI^TM micronaire from a total of 381 cottons harvested in the 2011 and 2012 crop years.Partial least square(PLS)calibration model relating NIR spectral information to fiber HVITM micronaire was developed and then applied to both a validation sample set from identical crop years and an independent test sample set from the 2014 crop year.Results indicated an acceptable bias(or differences between HVI^TM measured and NIR predicted micronaire)and an over 97%correctly predicted micronaire(within±0.30 micronaire unit)in an independent test set.Therefore,the development of a robust and effective NIR model for rapid laboratory micronaire assessment that would be applicable to remote/breeding locations is feasible. | Yongliang Liu Chris Delhom BTodd Campbell Vikki Martin | 2016 | Information Processing in Agriculture2016，3，1： | 2 |
| 13 | Generation and preservation of continental crust in the Grenville Orogeny显示文摘Detrital zircons from modern sediments display an episodic temporal distribution of U-Pb crystallization ages forming a series of 'peaks' and 'troughs'.The peaks are interpreted to represent either periods of enhanced generation of granitic magma perhaps associated with mantle overturn and superplume events,or preferential preservation of continental crust during global collisional orogenesis.The close association of those peaks with the assembly of supercontinents implies a causal relationship between collisional orogenesis and the presence of zircon age peaks.Here these two end-member models(episodic periodicity of increased magmatism versus selective preservation during collisional orogenesis) are assessed using U-Pb,Hf,and O analysis of detrital zircons from sedimentary successions deposited during the ~ 1.3-1.1Ca accretionary.~1.1-0.9 Ga collisional,and < 0.9 Ga extensional collapse phases of the Grenville orogenic cycle in Labrador and Scotland.The pre-collisional,accretionary stage provides a baseline of continental crust present prior to orogenesis and is dominated by Archean and Paleoproterozoic age peaks associated with pre-1300 Ma Laurentian geology.Strata deposited during the Grenville Orogeny display similar Archean and Paleoproterozoic detrital populations along with a series of broad muted peaks from~ 1500 to 1100 Ma.However,post-collisional sedimentary successions display a dominant age peak between 1085 and 985 Ma,similar to that observed in modern North American river sediments.Zircons within the post-orogenic sedimentary successions have progressively lower εHf and higherδ^(18)O values from ~ 1800 to ~ 1200 Ma whereupon they have higher εHf and δ^(18) within the dominant1085-985 Ma age peak.Furthermore,the Lu-Hf isotopic profile of the Grenville-related age peak is consistent with significant assimilation and contamination by older crustal material.The timing of this dominant age peak coincides with the peak of metamorphism and magmatism associated with the Crenville Orogeny,which is a typical collisional orogenic belt.The change from broad muted age peaks in the syn-orogenic strata to a single peak in the post-orogenic sedimentary successions and in the modern river sediments implies a significant shift in provenance following continental collision.This temporal change in provenance highlights that the source(s),from which detrital zircons within syn-orogenic strata were derived,was no longer available during the later stages of the accretionary and collisional stages of the orogenic cycle.This may reflect some combination of tectonic burial,erosion,or possibly recycling into the mantle by tectonic erosion of the source(s).During continental collision,the incorporated continental crust is isolated from crustal recycling processes operative at subduction margins.This tectonic isolation combined with sedimentaiy recycling likely controls the presence of the isotopic signature associated with the Grenville Orogeny in the modern Mississippi and Appalachian river sediments.These results imply that zircon age peaks,which developed in conjunction with supercontinents,are the product of selective crustal preservation resulting from collisional orogenesis. | Christopher J.Spencer Peter A.Cawood Chris J.Hawkesworth Anthony R.Prave Nick M.W.Roberts Matthew S.A.Horstwood Martin J.Whitehouse EIMF | 2015 | Geoscience Frontiers2015，6，3： | 1 |
| 14 | A phase I study of ZD0473 combined with paclitaxel for the treatment of solid malignancies显示文摘 | Chris Twelves Martin Reck Alan Anthoney Ulrich Gatzemeier Stan Kaye | 2003 | Cancer Chemotherapy and Pharmacology2003，，4： | 1 |
| 15 | Neuroanatomical Abnormalities and Cognitive Impairments Are Shared by Adults with Attention-Deficit/Hyperactivity Disorder and Their Unaffected First-Degree Relatives显示文摘 | Valentino Antonio Pironti Meng-Chuan Lai Ulrich Müller Chris Martin Dodds John Suckling Edward Thomas Bullmore Barbara Jacquelyn Sahakian | 2013 | Biological Psychiatry2013，，： | 1 |
| 16 | The influence of avatars on online consumer shopping behavior 显示文摘 | Martin Holzwarth Chris Janiszewski and Marcus M Neumann | 2006 | Journal of Marketing2006，70，10： | 1 |
| 17 | Organic matter accumulation during maturation of gravel-bed constructed wetlands treating farm dairy wastewater 显示文摘 | Chris C T M James P S S Martin P U | 1998 | WaterRes1998，32，10： | 1 |
| 18 | Perceptual hashing of video con-tent based on differential block similarity显示文摘 | Zhou X B Martin S Chris B | | 0，，： | 1 |
| 19 | Improved understanding of the petroleum systems of the Niger Delta Basin, Nigeria显示文摘 | OluKayode J. Samuel Chris Cornford Martin Jones Olabisi A. Adekeye Samuel O. Akande | 2009 | Organic Geochemistry2009，，4： | 1 |
| 20 | Oxaliplatin Pharmacoki- netics and Pharmacodynamies in Adult Cancer Patients with Im- paired Renal Function 显示文摘 | Chris HT Martin AG Graham L | 2007 | Clic Cancer Res2007，13，16： | 1 |
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