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| 1 | Far lateral lumbar disc herniation part 1: Imaging, neurophysiology and clinical features显示文摘Far lateral lumbar disc herniations(FLLDH)represent a separate category of disc pathology which includes both intraforaminal and extraforaminal lumbar disc herniations,that are characterized by a peculiar clinical presentation,diagnostic and treatment modalities as compared to the more frequent median and paramedian disc hernias.Surgical treatment often represents the only effective weapon for the cure of this disease and over the years different approaches have been developed that can reach the region of the foramen or external to it,with different degrees of invasiveness.The diagnosis is more demanding and still underestimated as it requires a more detailed knowledge in the spine anatomy and dedicated radiological studies.Computerized tomography and in particular magnetic resonance imaging are the appropriate tools for the diagnosis of FLLDH.Despite the widespread use of these diagnostic tests,many cases of FLLDH are overlooked due to insufficiently detailed radiological examinations or due to the execution of exams not focused to the foraminal or the extraforaminal region.Neurophysiological studies represent a valid aid in the diagnostic classification of this pathology and in some cases they can facilitate the differential diagnosis with other types of radiculopathies.In the present study,a comprehensive review of the clinical presentation,epidemiology,radiological study and the neurophysiological aspects is presented. | Luigi Valentino Berra Andrea Di Rita Federico Longhitano Enrico Mailland Paolo Reganati Alessandro Frati Antonio Santoro | 2021 | World Journal of Orthopedics2021，12，12： | 14 |
| 2 | Orthopedic disorders of the knee in hemophilia:A current concept review显示文摘The knee is frequently affected by severe orthopedic changes known as hemophilic arthropathy(HA) in patients with deficiency of coagulation factor Ⅷ or Ⅸ and thus this manuscript seeks to present a current perspective of the role of the orthopedic surgeon in the management of these problems.Lifelong factor replacement therapy(FRT) is optimal to prevent HA,however adherence to this regerous treatment is challenging leading to breakthrough bleeding.In patients with chronic hemophilic synovitis,the prelude to HA,radiosynovectomy(RS) is the optimal to ameliorate bleeding.Surgery in people with hemophilia(PWH) is associated with a high risk of bleeding and infection,and must be performed with FRT.A coordinated effort including orthopedic surgeons,hematologists,physical medicine and rehabilitation physicians,physiotherapists and other team members is key to optimal outcomes.Ideally,orthopedic procedures should be performed in specialized hospitals with experienced teams.Until we are able to prevent orthopedic problems of the knee in PWH will have to continue performing orthopedic procedures(arthrocentesis,RS,arthroscopic synovectomy,hamstring release,arthroscopic debridement,alignment osteotomy,and total knee arthroplasty).By using the aforementioned procedures,the quality of life of PWH will be improved. | E Carlos Rodriguez-Merchan Leonard A Valentino | 2016 | World Journal of Orthopedics2016，7，6： | 9 |
| 3 | Evolution of Microstructure and Mechanical Property during Long-Term Aging in Udimet 720Li显示文摘Thermal stabilities of microstructure and mechanical property have been investigated on super- alloy U72OLi, which is of great interest of application for jet engine and land-based turbine disc. The results showed that, the primary and secondary γ’?particles maintain good thermal stability at 650 and 7000C with aging time up to 3000 h, while the tertiary γ’?is apparently dependent on aging temperature and time. The tertiary γ’?particles undergo a procedure of coarsening, dissolution and eventually complete disappearance with the increasing of aging time and temper- ature. They exhibit unusual high sensibility upon aging temperature, which is attributed to the lattice misfit between the γ’?precipitates and the matrix in the alloy. The grain boundary phase M23C6 remains stable without forming of sigma phase even with aging time up to 3000 h at 700℃. Microhardness decreases apparently with increasing aging time and aging temperature. Theoretical analysis based on dislocation mechanism indicates that the change of microhardness should be attributed to the evolution of the tertiary γ’?during aging. | Lanzhang ZHOU and Valentino LUPINC CNR-TeMPE, Via R. Cozzi 53, 20125 Milano, Italy Jianting GUO Institute of Metal Research, CAS, 72 Wenhua Road, Shenyang 110016, China | 2001 | Journal of Materials Science & Technology2001，17，6： | 6 |
| 4 | Acute alcoholic hepatitis, end stage alcoholic liver disease and liver transplantation: An Italian position statement显示文摘Alcoholic liver disease encompasses a broad spectrum of diseases ranging from steatosis steatohepatitis,fibrosis,and cirrhosis to hepatocellular carcinoma.Forty-four per cent of all deaths from cirrhosis are attributed to alcohol.Alcoholic liver disease is the second most common diagnosis among patients undergoing liver transplantation(LT).The vast majority of transplant programmes(85%)require 6 mo of abstinence prior to transplantation;commonly referred to as the'6-mo rule'.Both in the case of progressive end-stage liver disease(ESLD)and in the case of severe acute alcoholic hepatitis(AAH),not responding to medical therapy,there is a lack of evidence to support a 6-mo sobriety period.It is necessary to identify other risk factors that could be associated with the resumption of alcohol drinking.The'Group of Italian Regions'suggests that:in a case of ESLD with model for end-stage liver disease<19 a 6-mo abstinence period is required;in a case of ESLD,a 3-mo sober period before LT may be more ideal than a 6-mo period,in selected patients;and in a case of severe AAH,not respond-ing to medical therapies(up to 70%of patients die within 6 mo),LT is mandatory,even without achieving abstinence.The multidisciplinary transplant team must include an addiction specialist/hepato-alcohologist.Patients have to participate in self-help groups. | Gianni Testino Patrizia Burra Ferruccio Bonino Francesco Piani Alessandro Sumberaz Roberto Peressutti Andrea Giannelli Castiglione Valentino Patussi Tiziana Fanucchi Ornella Ancarani Giovanna De Cerce Anna Teresa Iannini Giovanni Greco Antonio Mosti Marilena Durante Paola Babocci Mariano Quartini Davide Mioni Sarino Aricò Aniello Baselice Silvia Leone Fabiola Lozer Emanuele Scafato Paolo Borro | 2014 | World Journal of Gastroenterology2014，20，40： | 5 |
| 5 | Seed-mediated synthesis of dendritic platinum nanostructures with high catalytic activity for aqueous-phase hydrogenation of acetophenone显示文摘This work reports a facile and efficient seed-mediated method for the synthesis of dendritic platinum(Pt)nanoparticles(NPs) at low temperatures of 55–60 °C in water, using L-ascorbic acid as a reducing agent and sodium citrate as a capping agent. It is found that the dendritic Pt NPs(10–150 nm) are composed of tiny Pt nanocrystals, which nucleate and grow through the introduced smaller Pt seeds with diameters of 3–5 nm.Further investigation shows that the dendritic Pt nanostructures display excellent catalytic performance in an aqueous-phase aromatic ketone hydrogenation reaction, including:(i) acetophenone conversion rate of> 90%, with smaller dendritic Pt NPs(10–46 nm) offering a higher conversion efficiency;(ii) high chemoselectivity toward carbonyl group(90.6%–91.5%), e.g., the selectivity to 1-phenylethanol is ~90.1% with nearly100% acetophenone conversion for 10 nm dendritic Pt NPs within 60 min, under mild reaction conditions(20 °C, 1.5 bar H2 pressure, and 1.5 mol% catalyst). The high catalytic activity, selectivity and stability of the dendritic Pt nanostructures under the organic solvent-free conditions make them promising for many potential applications in green catalytic conversion of hydrophilic biomass derived compounds. | Yuan Yuan Yusuf Valentino Kaneti Minsu Liu Fangzhu Jin Danielle Frances Kennedy Xuchuan Jiang Jun Huang Aibing Yu | 2015 | Journal of Energy Chemistry2015，24，5： | 3 |
| 6 | Optical and Structural Properties of Carbon Nanotube-Rutile Heterostructures显示文摘 | Marianna Barbeno Pasquale Barone Alessandra Imbrogno Fang Xu Valentino Pingitore Assunta Bonanno | 2012 | Journal of Chemistry and Chemical Engineering2012，6，10： | 3 |
| 7 | Ultrafast response of harmonic modelocked THz lasers显示文摘The use of fundamental modelocking to generate short terahertz(THz)pulses and THz frequency combs from semiconductor lasers has become a routine affair,using quantum cascade lasers(QCLs)as a gain medium.However,unlike classic laser diodes,no demonstrations of harmonic modelocking,active or passive,have been shown in THz QCLs,where multiple pulses per round trip are generated when the laser is modulated at the harmonics of the cavity’s fundamental round-trip frequency.Here,using time-resolved THz techniques,we show for the first time harmonic injection and mode-locking in which THz QCLs are modulated at the harmonics of the round-trip frequency.We demonstrate the generation of the harmonic electrical beatnote within a QCL,its injection locking to an active modulation and its direct translation to harmonic pulse generation using the unique ultrafast nature of our approach.Finally,we show indications of self-starting harmonic emission,i.e.,without external modulation,where the QCL operates exclusively on a harmonic(up to its 15th harmonic)of the round-trip frequency.This behaviour is supported by time-resolved simulations of induced gain and loss in the system and shows the importance of the electronic,as well as photonic,nature of QCLs.These results open up the prospect of passive harmonic modelocking and THz pulse generation,as well as the generation of low-noise microwave generation in the hundreds of GHz region. | Feihu Wang Valentino Pistore Michael Riesch Hanond Nong Pierre-Baptiste Vigneron Raffaele Colombelli Olivier Parillaud Juliette Mangeney Jerome Tignon Christian Jirauschek Sukhdeep S.Dhillon | 2020 | Light(Science & Applications)2020，9，1： | 3 |
| 8 | Human polymorphonuclear leukocyte chemotaxis as a tool in detecting biological early effects in workers occupationally exposed to low levels of n-hexane显示文摘 | Governa M Valentino M Visona I | 1994 | Hum Exp Toxicol1994，13，10： | 2 |
| 9 | Biosynthesis of the avermectins by Streptomyces avermitilis 显示文摘 | Schulman M D Valentino D Hensens O | 1986 | J Antibiot1986，44，4： | 2 |
| 10 | Coronal plane deformity around the knee in the skeletally immature population:A review of principles of evaluation and treatment显示文摘Coronal plane deformity around the knee,also known as genu varum or genu valgum,is a common finding in clinical practice for pediatricians and orthopedists.These deformities can be physiological or pathological.If untreated,pathological deformities can lead to abnormal joint loading and a consequent risk of premature osteoarthritis.The aim of this review is to provide a framework for the diagnosis and management of genu varum and genu valgum in skeletally immature patients. | Valentino Coppa Mario Marinelli Roberto Procaccini Danya Falcioni Luca Farinelli Antonio Gigante | 2022 | World Journal of Orthopedics2022，13，5： | 2 |
| 11 | CXCR4-mediated adhesion and MMP-9 secretion in head and neck squamous cell carcinoma显示文摘 | Ghassan J. Samara Diana M. Lawrence Christian J. Chiarelli Michael D. Valentino Sergey Lyubsky Stanley Zucker Gayle G. Vaday | 2004 | Cancer Letters2004，，2： | 2 |
| 12 | Acetaldehyde Inhibits PPARγ via H 2 O 2 -Mediated c-Abl Activation in Human Hepatic Stellate Cells显示文摘 | Elisabetta Ceni David W. Crabb Marco Foschi Tommaso Mello Mirko Tarocchi Valentino Patussi Luca Moraldi Renato Moretti Stefano Milani Calogero Surrenti Andrea Galli | 2006 | Gastroenterology2006，，4： | 2 |
| 13 | Experimental study on performance and emissions of a high speed diesel engine fuelled with n-butanol diesel blends under premixed low temperature combustion显示文摘 | Gerardo Valentino Felice E. Corcione Stefano E. Iannuzzi Simone Serra | 2011 | Fuel2011，，1： | 2 |
| 14 | The results of radiosurgical management of 72 middle fossa meningiomas显示文摘 | V. Valentino G. Schinaia A. J. Raimondi | 1993 | Acta Neurochirurgica (-)1993，，1： | 2 |
| 15 | Factors affecting membrane-controlled drug release for an osmotic pump tablet (OPT) utilizing (SBE) 7 m -β-CD as both a solubilizer and osmotic agent显示文摘 | Kazuto Okimoto Atsuo Ohike Rinta Ibuki Osamu Aoki Norio Ohnishi Roger A. Rajewski Valentino J. Stella Tetsumi Irie Kaneto Uekama | 1999 | Journal of Controlled Release1999，，2： | 2 |
| 16 | Laparoscopy versus laparotomy for the surgical management of apparent early stage ovarian cancer显示文摘 | Fabio Ghezzi Antonella Cromi Stefano Uccella Valentino Bergamini Silvia Tomera Massimo Franchi Pierfrancesco Bolis | 2006 | Gynecologic Oncology2006，，2： | 2 |
| 17 | The multifaceted PDCD10/CCM3 gene显示文摘The programmed cell death 10(PDCD10)gene was originally identified as an apoptosis-related gene,although it is now usually known as CCM3,as the third causative gene of cerebral cavernous malformation(CCM).CCM is a neurovascular disease that is characterized by vascular malformations and is associated with headaches,seizures,focal neurological deficits,and cerebral hemorrhage.The PDCD10/CCM3 protein has multiple subcellular localizations and interacts with several multi-protein complexes and signaling pathways.Thus PDCD10/CCM3 governs many cellular functions,which include cell-to-cell junctions and cytoskeleton organization,cell proliferation and apoptosis,and exocytosis and angiogenesis.Given its central role in the maintenance of homeostasis of the cell,dysregulation of PDCD10/CCM3 can result in a wide range of altered cell functions.This can lead to severe diseases,including CCM,cognitive disability,and several types of cancers.Here,we review the multifaceted roles of PDCD10/CCM3 in physiology and pathology,with a focus on its functions beyond CCM. | Mariaelena Valentino Elisabetta Dejana Matteo Malinverno | 2021 | Genes & Diseases2021，8，6： | 2 |
| 18 | Integrin-targeting with peptide-bioconjugated semiconductor-magnetic nanocrystalline heterostructures显示文摘二进制不对称的 nanocrystals (BNC ) ,加入的光敏的 TiO 2 nanorod 填写了 superparamagnetic -Fe2O3 球形的领域,在聚乙烯乙二醇被嵌入修改 phospholipid micelle 并且成功地 bioconjugated 到包含一个 RGD 主题的合适设计的肽。BNC 表示由于在一个粒子的二个不同领域的共存,相关多功能的 nanomaterial 由高 photoactivity 和磁性描绘了,那特别地在生物成像用作光线疗法和过高热代理人以及一根磁性的探针被适合。我们选择了 RGD 主题以便指向在激活的 endothelial 房间和癌症房间的几种类型上表示的 integrin。准备 RGD-peptide/BNC 结合,包括地由使用互补光、结构的技术监视了,在生物媒介表明了高稳定性和一致可分散性。RGD-peptide/BNC 的 cytotoxicity 结合在 vitro 被学习。RGD 肽的细胞的举起在房间结合,在房间 lysates 借助于二条不同途径,也就是共焦的显微镜学分析和排放光谱学决心估计了, RGD-peptide-BNC 的显示的选择为 v3 integrin 结合。这些 RGD-peptide-BNC 结合为癌症的 theranostic 治疗有一个高潜力。 | Gianpiero Valente Nicoletta Depalo Ivan de Paola Rosa Maria lacobazzi Nunzio Denora Valentino Laquintana Roberto Comparelli Emiliano Altamura Tiziana Latronico Michele Altomare Elisabetta Fanizza Marinella Striccoli Angela Agostiano Michele Saviano Annarita Del Gatto Laura Zaccaro Maria Lucia Curri | 2016 | Nano Research2016，9，3： | 2 |
| 19 | 光学相干断层扫描评估未发病的Leber遗传性视神经病变基因突变携带者的视网膜神经纤维层厚度 | Savini G. Barboni P. Valentino M.L. 张少娟 | 2005 | 世界核心医学期刊文摘(眼科学分册)2005，0，5： | 2 |
| 20 | Prognostic value of cy- cle exercise testing prior to and after outpatient cardiac rehabilita- tion显示文摘 | Di Valentino M Maeder MT Jaggi S | 2010 | Int J Cardio]2010，140，1： | 1 |
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