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| 1 | 3D assessment of intervertebral disc degeneration in zebrafish identifies changes in bone density that prime disc disease显示文摘Back pain is a common condition with a high social impact and represents a global health burden.Intervertebral disc disease(IVDD)is one of the major causes of back pain;no therapeutics are currently available to reverse this disease.The impact of bone mineral density(BMD)on IVDD has been controversial,with some studies suggesting osteoporosis as causative for IVDD and others suggesting it as protective for IVDD.Functional studies to evaluate the influence of genetic components of BMD in IVDD could highlight opportunities for drug development and repurposing.By taking a holistic 3D approach,we established an aging zebrafish model for spontaneous IVDD.Increased BMD in aging,detected by automated computational analysis,is caused by bone deformities at the endplates.However,aged zebrafish spines showed changes in bone morphology,microstructure,mineral heterogeneity,and increased fragility that resembled osteoporosis.Elements of the discs recapitulated IVDD symptoms found in humans:the intervertebral ligament(equivalent to the annulus fibrosus)showed disorganized collagen fibers and herniation,while the disc center(nucleus pulposus equivalent)showed dehydration and cellular abnormalities.We manipulated BMD in young zebrafish by mutating sp7 and cathepsin K,leading to low and high BMD,respectively.Remarkably,we detected IVDD in both groups,demonstrating that low BMD does not protect against IVDD,and we found a strong correlation between high BMD and IVDD.Deep learning was applied to high-resolution synchrotron\iCJ image data to analyze osteocyte 3D lacunar distribution and morphology,revealing a role of sp7 in controlling the osteocyte lacunar 3D profile.Our findings suggest potential avenues through which bone quality can be targeted to identify beneficial therapeutics for IVDD. | Erika Kague Francesco Turci Elis Newman Yushi Yang Kate Robson Brown Mona S.Aglan Ghada A.Otaify Sarnia A.Temtamy Victor L.Ruiz-Perez Stephen Cross C.Patrick Royall P.Eckhard Witten Chrissy L.Hammond | 2021 | Bone Research2021，9，4： | 2 |
| 2 | Capability Maturity Model for Software显示文摘 | CURTIS B CHRISSIS M B | 1991 | Software Engineering Institute1991，，8： | 1 |
| 3 | A hybrid algorithm for solving polynomial zero-one mathematical programming problem显示文摘 | Snyder W S Chrissis J W | 1990 | IIE Transactions1990，22，2： | 1 |
| 4 | Low magnitude mechanical loading is osteogenic in children with disabling conditions 显示文摘 | Kate W Chrissie A Janette C | 2004 | Journal of Bone and Mineral Research2004，19，3： | 1 |
| 5 | Food Fight: Eating and Identity in Japan during the Second World War显示文摘 | Chrissie Tate Reilly | 2010 | International Journal of Arts and Sciences2010，3，8： | 1 |
| 6 | Capability maturity model显示文摘 | Paulk M Curtis B Chrissis M | 1993 | IEEE Software1993，10，4： | 1 |
| 7 | Grass overseeding gives tired leys lift显示文摘 | Chrissie L | 2005 | Farmers Weekly2005，143，3： | 1 |
| 8 | Low magnitude mechanical loading is osteogenic in children with disabling conditions 显示文摘 | Kate W Chrissie A Janette C | 2004 | Journal of Bone and Mineral Research2004，19，3： | 1 |
| 9 | Capability maturity model,Version 1,1显示文摘 | Paulk M C B Curtis M B Chrissis C V Weber | 1993 | IEEE Software1993，，4： | 1 |
| 10 | Correlates of depressive symptoms among women undergoing the menopausal transition显示文摘 | Lisa Gallicchio Chrissy Schilling Susan R. Miller Howard Zacur Jodi A. Flaws | 2007 | Journal of Psychosomatic Research2007，，3： | 1 |
| 11 | Ecological and Human Health Risk Assessment显示文摘 | Biksey Thomas M Schultz Amy Couch Bernhardt Aaron M Marion Brett Peterson Chrissy Smith Preston | 2011 | EN2011，，10： | 1 |
| 12 | Endogenous hor- mones, participant characteristics, and symptoms among midlife women显示文摘 | Lisa Gallicchio Chrissy Schilling Wiliam A | 2008 | Maturitas2008，59，2： | 1 |
| 13 | Grass overseeding gives tired leys lift 显示文摘 | Chrissie L | 2005 | Farmers Weekly2005，143，3： | 1 |
| 14 | Osteomodulin downregulation is associated with osteoarthritis development显示文摘Abnormal subchondral bone remodeling leading to sclerosis is a main feature of osteoarthritis(OA), and osteomodulin(OMD), a proteoglycan involved in extracellular matrix mineralization, is associated with the sclerotic phenotype. However, the functions of OMD remain poorly understood, specifically in vivo. We used Omd knockout and overexpressing male mice and mutant zebrafish to study its roles in bone and cartilage metabolism and in the development of OA. The expression of Omd is deeply correlated with bone and cartilage microarchitectures affecting the bone volume and the onset of subchondral bone sclerosis and spontaneous cartilage lesions. Mechanistically, OMD binds to RANKL and inhibits osteoclastogenesis, thus controlling the balance of bone remodeling. In conclusion, OMD is a key factor in subchondral bone sclerosis associated with OA. It participates in bone and cartilage homeostasis by acting on the regulation of osteoclastogenesis. Targeting OMD may be a promising new and personalized approach for OA. | Jérémie Zappia Qiao Tong Renée Van der Cruyssen Frederique MFCornelis Cécile Lambert Tiago Pinto Coelho Juliane Grisart Erika Kague Rik JLories Marc Muller Dirk Elewaut Chrissy LHammond Christelle Sanchez Yves Henrotin | 2023 | Bone Research2023，11，4： | 0 |
| 15 | 爱情,在校园开花结果显示文摘2005年9月1日,我国教育部新颁布的《普通高等学校学生管理规定》正式实施,取代沿用了15年的旧规定。新规定有一条特别引人注目,那就是取消了旧规定中的第30条:“在校期间擅自结婚而未办理退学手续的学生,作退学处理。”教育部学生司林司长这样强调:“教育部不禁止在校学生结婚,但并不提倡。”据统计,自新规定颁布以来,在70所大学里,申请结婚的学生只有万分之一。大学生结婚,离现实究竟还有多远?禁令取消后,现实会是如何呢?是像打开了“潘多拉盒子”,情况变得复杂起来,还是实际影响相当有限呢?大家见仁见智,也许这个问题还需要交由时间来回答。在外国许多国家,大学生结婚不会被禁止,以下这篇报道讲的就是美国哈佛大学和乔治敦大学校园里把爱情进行到底的学生。编者之所以挑这篇文章,出发点很简单,就是希望大家读着别人的故事,能感受到另一种不同的人生选择和生活体验。 | Chrissy A.Balz 杰拉德 | 2005 | 疯狂英语(阅读版)2005，0，11： | 0 |
| 16 | 五种工作习惯让你看起来像菜鸟(英文)显示文摘Regardless of who you are or what you do, it's probably a safe bet that you want to look like a pro) When you exhibit a professional image, you increase your own confidence while simultaneously boosting the confidence others have in you and your capabilities. It's a win-win. | Chrissy Scivicque 孟一馨 | 2013 | 大学英语2013，，6： | 0 |
| 17 | Stature and Body Weight Estimations from Footprint Dimensions among Asante and Fante Females in Ghana显示文摘Background:Footprints recovered from crime scenes can assist in establishing the identity(stature,body weight,and sex)of a person.Due to variations(genetic and environmental factors)in the morphology of the foot,several authors have derived populationspecific regression equations for stature and weight estimations.Aims and Objectives:Tribal differences in the footprint dimensions of Ghanaians have not been established.Hence,this study was done to determine if they were tribal differences in footprint dimensions.Materials and Methods:The footprints of Ghanaian females,aged 19-35 years,and belonging to two tribal groups(72 Asante and 73 Fante)were recovered using an ink pad method.Height,body weight,and footprint measurements were obtained following standard procedures.Results:Although Fante females had longer foot lengths and shorter foot breadths than Asante females,the difference was significant(P<0.001)only in the left big toe-pad length(eta squared=0.496).Height correlated better with footprint dimensions of Fante(r=0.246-0.809)than Asante(r=0.214-0.660)females.Body weight correlated weakly with footprint dimensions.Unlike in Asante females,foot length measurements did not correlate significantly with body weight among Fante females.Conclusion:The use of mixed population in deriving stature,weight and sex equations is cautioned especially when there is increased genetic diversity.The findings of this study have important applications in forensic anthropometric investigations. | Samuel Kwaku Dwomoh Atta Kusi Appiah Nancy Darkoa Kusi Appiah Chrissie Stansie Abaidoo | 2023 | Journal of Forensic Science and Medicine2023，9，1： | 0 |
| 18 | 怎样改善与老板的关系显示文摘如果你在寻找改善与老板关系的方法,请忘记谄媚,也不要费心寻找精致的礼物。你可以使用以下8个简单易行的策略。 | Chrissy Scivicque 韦华明 | 2014 | 报刊荟萃2014，，6： | 0 |
| 19 | 绘制经典的童话场景显示文摘Chrissie Zullo用iPad Pro中价廉物美的软件Procreate,绘制出童话故事中的标志性片段Chrissie Zullo居住地:美国Chrissie是一名居住在康涅狄格州的插画家,她为漫画书、海报以及玩具设计进行艺术创作。她还有个奇特的爱好,就是收藏所有带有雪人模样的东西。 | Chrissie Zullo | 2018 | 艺术教育2018，，10： | 0 |
| 20 | 冰与火的缠绵——NAFA2006北京裘皮发布显示文摘热烈,像火灼烧着一切,寒冷,让一切也随之冻结,这就是NAFA(北美裘皮协会)2006裘皮发布带给我们的终极体验,作为新一季的潮流趋势之一,皮草显得比往年更有创意,简约的轮廓设计,丰富的色彩变化,多种面料的混搭,皮草依然是奢华与摩登的混合体,带给女人一生难以抗拒的诱惑。 | Chrissy NAFA(图) | 2006 | 服装设计师2006，，10： | 0 |
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