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| 1 | Clinical Management of Hepatocellular Carcinoma. Conclusions of the Barcelona-2000 EASL Conference显示文摘 | Jordi Bruix Morris Sherman Josep M Llovet Michel Beaugrand Riccardo Lencioni Andrew K Burroughs Erik Christensen Luigi Pagliaro Massimo Colombo Juan Rodés | 2001 | Journal of Hepatology2001，，3： | 11 |
| 2 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 3 | Targeting Dexamethasone to Macrophages in a Porcine Endotoxemic Model显示文摘 | Asger Granfeldt Christine Lodberg Hvas Jonas Heilskov Graversen Peter Astrup Christensen Mikkel Due Petersen Gabriela Anton Pia Svendsen Christoffer S?lling Anders Etzerodt Else T?nnesen S?ren Kragh Moestrup Holger Jon M?ller | 2013 | Critical Care Medicine2013，，11： | 2 |
| 4 | Chronic hepatitis C:Treat or wait? Medical decision making in clinical practice显示文摘AIM:To analyzes the decision whether patients with chronic hepatitis C virus (HCV) infection are treated or not.METHODS:This prospective cohort study included 7658 untreated patients and 6341 patients receiving pegylated interferon α2 a/ribavirin,involving 434 physicians/institutions throughout Germany (377 in private practice and 57 in hospital settings).A structured questionnaire had to be answered prior to the treatment decision,which included demographic data,information about the personal life situation of the patients,anamnesis and symptomatology of hepatitis C,virological data,laboratory data and data on concomitant diseases.A second part of the study analyzes patients treated with pegylated interferon α2a.All questionnaires included reasons against treatment mentioned by the physician.RESULTS:Overall treatment uptake was 45%.By multivariate analysis,genotype 1/4/5/6,HCV-RNA ≤ 520 000 IU/mL,normal alanine aminotransferase (ALT),platelets ≤ 142 500/μL,age > 56 years,female gender,infection length > 12.5 years,concomitant diseases,human immunodeficiency virus co-infection,liver biopsy not performed,care in private practice,asymptomatic disease,and unemployment were factors associated with reduced treatment rate.Treatment and sustained viral response rates in migrants (1/3 of cohort) were higher than in German natives although 1/3 of migrants had language problems.Treatment rate and liver biopsy were higher in clinical settings when compared to private practice and were low when ALT and HCV-RNA were low.CONCLUSION:Some reasons against treatment were medically based whereas others were related to fears,socio-economical problems,and information deficits both on the side of physicians and patients. | Claus Niederau Dietrich Hüppe Elmar Zehnter Bernd Mller Renate Heyne Stefan Christensen Rainer Pfaff Arno Theilmeier Ulrich Alshuth Stefan Mauss | 2012 | World Journal of Gastroenterology2012，18，12： | 2 |
| 5 | Variation within isolates of Acremonium endophytes from perennial ryegrass显示文摘 | Christensen M J Latch G C M Tapper B A | 1991 | Mycology Research1991，95，： | 1 |
| 6 | Pneumocystis murina infection and cigarette smoke exposure interact to cause increased organism burden,development of airspace enlargement,and pulmonary Inflammation in mice显示文摘 | Christensen P J Preston A M Ling T | 2008 | Infect Immun2008，76，8： | 1 |
| 7 | Neutron stars,trace anomalies and the Hawking effect显示文摘 | Fulling S A | 1977 | Phys Rev D1977，15，： | 1 |
| 8 | MicroRNA expression in the adult mouse central nervous system 显示文摘 | Bak M Silahtaroglu A Moiler M Christensen M Rath MF Skry- abin B | 2008 | RNA2008，14，3： | 1 |
| 9 | Primary culture of Caenorhabditis elegans developing embryo cells for electrophysiological, cell biological and molecular studies显示文摘 | Strange K Christensen M Morrison R | 2007 | Nat Protoc2007，2，： | 1 |
| 10 | Recent developments in inductively coupled plasma magnetic sector multiple collector mass spectrometry 显示文摘 | Halliday A N Lee D C Christensen J N Walder A J Freedman P A Jones C E Hall C M Yi W Teagle D | 1995 | Int J Mass Spec Ion Proc1995，，： | 1 |
| 11 | The role of taurine in infant nutrition显示文摘 | Chesny RW Helms RA Christensen M | 1998 | Adv Exp Med Biol1998，，： | 1 |
| 12 | Pharmacokinetics of terbinafine after single oral doseadministration in red-tailed hawks ( Buieo jamaicensis )显示文摘 | BECHERT U CHRISTENSEN J M POPPENGA R etal | 2010 | J Avian Med Surg2010，24，2： | 1 |
| 13 | Carbon footprint-a catalyst for life cycle assessment 显示文摘 | WEIDEMA B P THRANE M CHRISTENSEN P | 2008 | Journal of Industrial Ecology2008，12，1： | 1 |
| 14 | MicroRNA expres- sion ratio is predictive of head and neck squamous cell carcinoma 显示文摘 | Avissar M Christensen BC Kelsey KT | 2009 | Clin Cancer Res2009，15，8： | 1 |
| 15 | The rules of innovation显示文摘 | Christensen C M | 2002 | MIT Technology Review2002，21，： | 1 |
| 16 | Preadmis-sion Use of Systemic Glucocorticoids and 30-Day Mortality Following Bleeding Peptic Ulcer: A Pop-ulation-Based Cohort Study显示文摘 | Olsen M Christensen S Riis A | 2010 | Am 1 Ther2010，17，1： | 1 |
| 17 | Lysine deacety-lases are produced in pancreatic beta cells and are differentially regulatedby proinilammatory cytokines 显示文摘 | Lundh M Christensen DP Rasmussen DN | 2010 | Diabetologia y2010，53，12： | 1 |
| 18 | Polybrominated diphenyl ethers (PBDEs) in marine fish and blue mussels from southern Greenland 显示文摘 | Christensen J H Glasius M Pecseli M | 2002 | Chemosphere2002，47，6： | 1 |
| 19 | Occurrence of chalk brood (Ascosphaera apis) in honey bees in the United States 显示文摘 | Hitchcock JD Christensen M | 1972 | Mycologia1972，64，5： | 1 |
| 20 | Customer power, strate- gic investment, and the failure of leading firms 显示文摘 | Christensen C M Bower J L | 1996 | Strategic Management Journal1996，17，3： | 1 |
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