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| 1 | Differential Scanning Calorimetry as a Tool to Investigate the Transfer of Anticancer Drugs to Biomembrane Model显示文摘 | Maria Grazia Sarpietro Maria Lorena Accolla Christian Celia Alessandro Grattoni Francesco Castelli Massimo Fresta Mauro Ferrari Donatella Paolino | 2013 | Current Drug Targets2013，，9： | 1 |
| 2 | Operative Safety and Oncologic Outcome of Laparoscopic Radical Nephrectomy for Renal Cell Carcinoma >7 cm: A Multicenter Study of 222 Patients显示文摘 | Lorenzo G. Luciani Francesco Porpiglia Tommaso Cai Carolina D’Elia Valentino Vattovani Guido Giusti Daniele Tiscione Stefano Chiodini Roberto Peschechera Christian Fiori Rosa Spina Paolo Parma Antonio Celia Gianni Malossini | 2013 | Urology2013，，： | 1 |
| 3 | Interaction of pH-sensitive non-phospholipid liposomes with cellular mimetic membranes显示文摘 | Carlotta Marianecci Federica Rinaldi Luisa Marzio Daniela Pozzi Giulio Caracciolo Daniela Manno Luciana Dini Donatella Paolino Christian Celia Maria Carafa | 2013 | Biomedical Microdevices2013，，2： | 1 |
| 4 | Mechanisms of Mitotic Cell Death Induced by Chemotherapy-Mediated G2 Checkpoint Abrogation显示文摘 | Celia Vogel Christian Hager Holger Bastians | 2007 | Cancer Res2007，67，1： | 1 |
| 5 | Neonatal Fc receptor-targeted lignin-encapsulated porous silicon nanoparticles for enhanced cellular interactions and insulin permeation across the intestinal epithelium显示文摘Oral insulin delivery could change the life of millions of diabetic patients as an effective,safe,easy-to-use,and affordable alternative to insulin injections,known by an inherently thwarted patient compliance.Here,we designed a multistage nanoparticle(NP)system capable of circumventing the biological barriers that lead to poor drug absorption and bioavailability after oral administration.The nanosystem consists of an insulin-loaded porous silicon NP encapsulated into a pH-responsive lignin matrix,and surface-functionalized with the Fc fragment of immunoglobulin G,which acts as a targeting ligand for the neonatal Fc receptor(FcRn).The developed NPs presented small size(211±1 nm)and narrow size distribution.The NPs remained intact in stomach and intestinal pH conditions,releasing the drug exclusively at pH 7.4,which mimics blood circulation.This formulation showed to be highly cytocompatible,and surface plasmon resonance studies demonstrated that FcRn-targeted NPs present higher capacity to interact and being internalized by the Caco-2 cells,which express FcRn,as demonstrated by Western blot.Ultimately,in vitro permeability studies showed that Fc-functionalized NPs induced an increase in the amount of insulin that permeated across a Caco-2/HT29-MTX co-culture model,showing apparent permeability coefficients(Papp)of 2.37×106 cm/s,over the 1.66×106 cm/s observed for their non-functionalized counterparts.Overall,these results demonstrate the potential of these NPs for oral delivery of anti-diabetic drugs. | Joao P.Martins Patrícia Figueiredo Shiqi Wang Erika Espo Elena Celi Beatriz Martins Marianna Kemell Karina Moslova Ermei Makil Jarno Salonen Mauri A.Kostiainen Christian Celia Vincenzo Cerullo Tapani Viitala Bruno Sarmento Jouni Hirvonen Helder A.Santos | 2022 | Bioactive Materials2022，7，3： | 0 |
| 6 | How 'Sustainable' are Post-disaster Measures? Lessons to Be Learned a Decade After the 2004 Tsunami in the Indian Ocean显示文摘This article addresses the sustainability implications of post-disaster measures in the context of the 2004 Indian Ocean Tsunami by presenting an analysis of the current situations and changes in some of the affected regions. Sustainability implications of measures are captured by investigating the persistence of the social and economic living conditions in relation to post-disaster measures, and the alignment of the measures with basic environmental aspects. Based on major concepts relevant in disaster science and sustainability research, the study explored sustainability aspects of post-disaster measures implemented after the 2004 tsunami, by conducting selected interviews among the participants of the 2015 international seminar ‘‘11 Years after the Indian Ocean Tsunami 2004'' and a broader online survey. Information was sought about(1) the current state of vulnerability of the local population in the regions affected;(2) the main lessons that have been identified to improve project design and management of recovery and vulnerability reduction;and(3) project sustainability implications with respect to the state of today's vulnerability. Based on the analysis of the information on these three priority areas, selected tasks for future disaster risk management are identified, such as more integrative planning and improved coordination with international organizations and local people. | Christiane Stephan Celia Norf Alexander Fekete | 2017 | International Journal of Disaster Risk Science2017，8，1： | 0 |
| 7 | The apple REFPOP—a reference population for genomics-assisted breeding in apple显示文摘Breeding of apple is a long-term and costly process due to the time and space requirements for screening selection candidates.Genomics-assisted breeding utilizes genomic and phenotypic information to increase the selection efficiency in breeding programs,and measurements of phenotypes in different environments can facilitate the application of the approach under various climatic conditions.Here we present an apple reference population:the apple REFPOP,a large collection formed of 534 genotypes planted in six European countries,as a unique tool to accelerate apple breeding.The population consisted of 269 accessions and 265 progeny from 27 parental combinations,representing the diversity in cultivated apple and current European breeding material,respectively.A high-density genome-wide dataset of 303,239 SNPs was produced as a combined output of two SNP arrays of different densities using marker imputation with an imputation accuracy of 0.95.Based on the genotypic data,linkage disequilibrium was low and population structure was weak.Two well-studied phenological traits of horticultural importance were measured.We found marker–trait associations in several previously identified genomic regions and maximum predictive abilities of 0.57 and 0.75 for floral emergence and harvest date,respectively.With decreasing SNP density,the detection of significant marker–trait associations varied depending on trait architecture.Regardless of the trait,10,000 SNPs sufficed to maximize genomic prediction ability.We confirm the suitability of the apple REFPOP design for genomics-assisted breeding,especially for breeding programs using related germplasm,and emphasize the advantages of a coordinated and multinational effort for customizing apple breeding methods in the genomics era. | Michaela Jung Morgane Roth Maria JoséAranzana Annemarie Auwerkerken Marco Bink Caroline Denancé Christian Dujak Charles-Eric Durel Carolina Font i Forcada Celia M.Cantin Walter Guerra Nicholas P.Howard Beat Keller Mariusz Lewandowski Matthew Ordidge Marijn Rymenants Nadia Sanin Bruno Studer Edward Zurawicz François Laurens Andrea Patocchi Hélène Muranty | 2020 | Horticulture Research2020，7，1： | 0 |
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