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| 1 | 2008中西方BNP专家共识显示文摘1.前言
2008年6月,来自中国、美国、欧洲的急诊科、心血管科、实验室及内科临床专家相聚在中国上海。 | Alan Maise Christian Mueller W. Frank Peacock Gerasimos Filippatos Hu Dayi 胡大一(主译) 刘梅颜(主译) 吴寸草(翻译) 王博雅(翻译) 黄睿(翻译) | 2009 | 中国医药导刊2009，11，10： | 76 |
| 2 | Detection of disseminated pancreatic cells by amplification of cytokeratin-19 with quantitative RT-PCR in blood,bone marrow and peritoneal lavage of pancreatic carcinoma patients显示文摘AIM: To evaluate the diagnostic potential of cytokeratin-19 (CK-19) mRNA for the detection of disseminated tumor cells in blood, bone marrow and peritoneal lavage in patients with ductal adenocarcinoma of the pancreas. METHODS: Sixty-eight patients with pancreatic cancer (n = 37), chronic pancreatitis (n = 16), and non-pan- creatic benign surgical diseases (n = 15, control group) were included in the study. Venous blood was taken preoperatively, intraoperatively and at postoperative d 1 and 10. Preoperative bone marrow aspirates and peritoneal lavage taken before mobilization of the tumor were analyzed. All samples were evaluated for disseminated tumor cells by CK-19-specific nested-PCR and quantitative fluorogenic RT-PCR. RESULTS: CK-19 mRNA expression was increased in 24 (64%) blood samples and 11 (30%) of the peritoneal lavage samples in the patients with pancreatic cancer. In 15 (40%) of the patients with pancreatic cancer, disseminated tumor cells were detected in venous blood and bone marrow and/or peritoneal lavage. In the peritoneal lavage, the detection rates were correlated with the tumor size and the tumor differentiation. CK-19 levels were increased in pT3/T4 and moderately/poorly differentiated tumors (G2/G3). Pancreatic cancer patients with at least one CK-19 mRNA-positive sample showed a trend towards shorter survival. Pancreatic cancerpatients showed significantly increased detection rates of disseminated tumor cells in blood and peritoneal lavage compared to the controls and the patients with chronic pancreatitis. CONCLUSION: Disseminated tumor cells can be detected in patients with pancreatic ductal adenocar- cinoma by CK-19 fluorogenic RT-PCR. In peritoneal lavage, detection rate is correlated with tumor stage and differentiation. In the clinical use, CK-19 is suitable for the distinction between malignant and benign pancreatic disease in combination with other tumor-specific markers. | Katrin Hoffmann Christiane Kerner Wolfgang Wilfert Marc Mueller Joachim Thiery Johann Hauss Helmut Witzigmann | 2007 | World Journal of Gastroenterology2007，13，2： | 20 |
| 3 | VEGF-D expression correlates with colorectal cancer aggressiveness and is downregulated by cetuximab显示文摘AIM:To gain mechanistic insights into the role played by epidermal growth factor receptor (EGFR) in the regulation of vascular endothelial growth factors (VEGFs) in colorectal cancer (CRC). METHODS:The impact of high-level expression of the growth factor receptors EGFR and VEGF receptor (VEGFR)3 and the VEGFR3 ligands VEGF-C and VEGF-D on disease progression and prognosis in human CRC was investigated in 108 patients using immunohistochemistry. Furthermore, the expression of the lymphangiogenic factors in response to the modulation of EGFR signalling by the EGFR-targeted monoclonal antibody cetuximab was investigated at the mRNA and protein level in human SW480 and SW620 CRC cell lines and a mouse xenograft model. RESULTS: Human CRC specimens and cell lines displayed EGFR, VEGF-C and VEGF-D expression with varying intensities. VEGF-C expression was associated with histological grade. Strong expression of VEGF-D was significantly associated with lymph node metastases and linked to a trend for decreased survival in lymph node-positive patients. EGFR blockade with cetuximab resulted in a significant decrease of VEGF-D expression in vitro and in vivo. CONCLUSION:In conclusion, the expression of VEGF-D in colorectal tumours is significantly associated with lymphatic involvement in CRC patients and such expression might be blocked effectively by cetuximab. | Markus Moehler Christian Frings Annett Mueller Ines Gockel Carl C Schimanski Stefan Biesterfeld Institute of Pathology Johannes Gutenberg University Mainz 55101 Germany Peter R Galle Martin H Holtmann | 2008 | World Journal of Gastroenterology2008，14，26： | 15 |
| 4 | Risk stratification in patients with unstable angina using absolute serial changes of three high sensitive Troponin Assays显示文摘 | Tobias Reichlin Raphael Twerenbold Claudia Maushart Miriam Reiter Berit Moehring Nora Schaub Cathrin Balmelli Maria Rubini Gimenez Rebeca Hoeller Konstantin Sakarikos Beatrice Drexler Philip Haaf Stefan Osswald Christian Mueller | 2012 | American Heart Journal2012，，： | 2 |
| 5 | 3,5-二羟基-4-甲基己酸叔丁酯的合成显示文摘以 2 -甲基 - 3-羰基丁酸乙酯为原料 ,经 3-羟基 - 2 -甲基丁酸乙酯和 5 -羟基 - 4-甲基 - 3-羰基己酸叔丁酯合成了3,5 -二羟基 - 4-甲基己酸叔丁酯 ,总收率 38%。 | 吉爱国 Michael Mueller Michael Wolberg Christian Wandrey | 2003 | 中国医药工业杂志2003，34，2： | 2 |
| 6 | Injury patterns of seniors in traffic accidents: A technical and medical analysis显示文摘AIM:To investigate the actual injury situation of seniors in traffic accidents and to evaluate the different injury patterns.METHODS:Injury data,environmental circumstances and crash circumstances of accidents were collected shortly after the accident event at the scene.With these data,a technical and medical analysis was performed,including Injury Severity Score,Abbreviated Injury Scale and Maximum Abbreviated Injury Scale.The method of data collection is named the German InDepth Accident Study and can be seen as representative.RESULTS:A total of 4430 injured seniors in traffic accidents were evaluated.The incidence of sustaining severe injuries to extremities,head and maxillofacial region was significantly higher in the group of elderly people compared to a younger age(P<0.05).The number of accident-related injuries was higher in the group of seniors compared to other groups.CONCLUSION:Seniors are more likely to be involved in traffic injuries and to sustain serious to severe injuries compared to other groups. | Stephan Brand Dietmar Otte Christian Walter Mueller Maximilian Petri Philipp Haas Timo Stuebig Christian Krettek Carl Haasper | 2012 | World Journal of Orthopedics2012，3，9： | 2 |
| 7 | Do you want to participate in a clinical study as a healthy control?-Risk or benefit?显示文摘A healthy woman volunteered to participate as 'healthy control' in a study.An increased level of procalcitonin(PCT) was detected and remained elevated on follow-up measurements.As calcitonin levels were elevated as well,thyroid ultrasound was performed which revealed nodes in both thyroid lobes,one of them showing metabolic activity in positron emission tomography-computed tomography scan.To exclude a malignant thyroid cancer despite the negative findings in a fine needle aspiration the patient underwent thyroidectomy and a medullary thyroid carcinoma(MTC) was detected in the right lobe.MTC is a rare endocrine tumor with a poor prognosis once having spread,therefore early detection remains a priority for the outcome.Screening parameter is serum calcitonin,in absence of infection the pro-hormone PCT can be used as a screening parameter as well with high sensitivity. | Hanna Giessen Christian A Nebiker Matthias Bruehlmeier Stefan Spreitzer Beat Mueller Philipp Schuetz | 2017 | World Journal of Clinical Cases2017，5，12： | 2 |
| 8 | Utility of Absolute and Relative Changes in Cardiac Troponin Concentrations in the Early Diagnosis of Acute Myocardial Infarction显示文摘 | Tobias Reichlin Affan Irfan Raphael Twerenbold Miriam Reiter Willibald Hochholzer Hanna Burkhalter Stefano Bassetti Stephan Steuer Katrin Winkler Federico Peter Julia Meissner Philip Haaf Mihael Potocki Beatrice Drexler Stefan Osswald Christian Mueller | 2011 | Circulation2011，，2： | 2 |
| 9 | Altered Activation of Endothelial Anti- and Proapoptotic Pathways by High-Density Lipoprotein from Patients with Coronary Artery Disease: Role of High-Density Lipoprotein–Proteome Remodeling显示文摘 | Meliana Riwanto Lucia Rohrer Bernd Roschitzki Christian Besler Pavani Mocharla Maja Mueller Damir Perisa Kathrin Heinrich Lukas Altwegg Arnold von Eckardstein Thomas F. Lüscher Ulf Landmesser | 2013 | Circulation2013，，8： | 1 |
| 10 | Late Clinical Events After Clopidogrel Discontinuation May Limit the Benefit of Drug-Eluting Stents显示文摘 | Matthias Pfisterer Hans Peter Brunner-La Rocca Peter T. Buser Peter Rickenbacher Patrick Hunziker Christian Mueller Raban Jeger Franziska Bader Stefan Osswald Christoph Kaiser | 2006 | Journal of the American College of Cardiology2006，，12： | 1 |
| 11 | How to use high-sensitivity cardiac troponins in acute cardiac care?显示文摘 | Kristian Thygesen Johannes Mair Evangelos Giannitsis Christian Mueller Bertil Lindahl Stefan Blankenberg Kurt Huber Mario Plebani Luigi M. Biasucci Marco Tubaro Paul Collinson Per Venge Yonathan Hasin Marcello Galvani Wolfgang Koenig Christian Hamm Joseph | 2012 | European Heart Journal2012，，18： | 1 |
| 12 | Endothelial-Vasoprotective Effects of High-Density Lipoprotein Are Impaired in Patients With Type 2 Diabetes Mellitus but Are Improved After Extended-Release Niacin Therapy显示文摘 | Sajoscha A. Sorrentino Christian Besler Lucia Rohrer Martin Meyer Kathrin Heinrich Ferdinand H. Bahlmann Maja Mueller Tibor Horváth Carola Doerries Mariko Heinemann Stella Flemmer Andrea Markowski Costantina Manes Matthias J. Bahr Hermann Haller Arnold vo | 2010 | Circulation2010，，1： | 1 |
| 13 | Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease显示文摘 | Besler Christian Heinrich Kathrin Rohrer Lucia Doerries Carola Riwanto Meliana Shih Diana M Chroni Angeliki Yonekawa Keiko Stein Sokrates Schaefer Nicola Mueller Maja Akhmedov Alexander Daniil Georgios Manes Costantina Templin Christian Wys | 2011 | Journal of Clinical Investigation2011，，7： | 1 |
| 14 | Stem-cell-like glioma cells are resistant to TRAIL/Apo2L and exhibit down-regulation of caspase-8 by promoter methylation显示文摘 | David Capper Timo Gaiser Christian Hartmann Antje Habel Wolf Mueller Christel Herold-Mende Andreas Deimling Markus David Siegelin | 2009 | Acta Neuropathologica2009，，4： | 1 |
| 15 | Stem-cell-like glioma cells are resistant to TRAIL/Apo2L and exhibit down-regulation of caspase-8 by promoter methylation显示文摘 | David Capper Timo Gaiser Christian Hartmann Antje Habel Wolf Mueller Christel Herold-Mende Andreas Deimling Markus David Siegelin | 2009 | Acta Neuropathologica2009，，4： | 1 |
| 16 | One Hundred Thirty-Two Consecutive Pediatric Liver Transplants Without Hospital Mortality: Lessons Learned and Outlook for the Future显示文摘 | Dieter C. Broering Jong-Sun Kim Teresa Mueller Lutz Fischer Rainer Ganschow Turan Bicak Lars Mueller Christian Hillert Christian Wilms Bernd Hinrichs Knut Helmke Werner Pothmann Martin Burdelski Xavier Rogiers | 2004 | Annals of Surgery2004，，6： | 1 |
| 17 | Evaluation of chronic infectious interstitial pulmonary disease in children by low-dose CT-guided transthoracic lung biopsy显示文摘 | Christoph M. Heyer Stefan P. Lemburg Thomas Kagel Klaus-Michael Mueller Thomas G. Nuesslein Christian H. L. Rieger Volkmar Nicolas | 2005 | European Radiology2005，，7： | 1 |
| 18 | Comparative Study of Portal Vein Embolization Versus Portal Vein Ligation for Induction of Hypertrophy of the Future Liver Remnant Using a Mini-Pig Model显示文摘 | Christian Wilms Lars Mueller Christian Lenk Oliver Wittkugel Knut Helmke Gerrit Krupski-Berdien Xavier Rogiers Dieter C. Broering | 2008 | Annals of Surgery2008，，5： | 1 |
| 19 | Hepatocellular fat accumulation and low serum cholesterol in patients infected with HCV-3a显示文摘 | Harald Hofer Hans C Bankl Friedrich Wrba Petra Steindl-Munda Markus Peck-Radosavljevic Christoph ?sterreicher Christian Mueller Alfred Gangl Peter Ferenci | 2002 | The American Journal of Gastroenterology2002，，11： | 1 |
| 20 | Endothelial-Vasoprotective Effects of High-Density Lipoprotein Are Impaired in Patients With Type 2 Diabetes Mellitus but Are Improved After Extended-Release Niacin Therapy显示文摘 | Sajoscha A. Sorrentino Christian Besler Lucia Rohrer Martin Meyer Kathrin Heinrich Ferdinand H. Bahlmann Maja Mueller Tibor Horváth Carola Doerries Mariko Heinemann Stella Flemmer Andrea Markowski Costantina Manes Matthias J. Bahr Hermann Haller Arnold vo | 2010 | Circulation2010，，1： | 1 |
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