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6篇 您的检索式：作者名="Christopher Gondi"

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		题名	作者	年代	出处	被引量
	1	Therapeutic options for the management of pancreatic cancer显示文摘Since its initial characterization, pancreatic ductal adenocarcinoma has remained one of the most devastating and difficult cancers to treat. Pancreatic cancer is the fourth leading cause of death in the United States, resulting in an estimated 38460 deaths annually. With few screening tools available to detect this disease at an early stage, 94% of patients will die within five years of diagnosis. Despite decades of research that have led to a better understanding of the molecular and cellular signaling pathways in pancreatic cancer cells, few effective therapies have been developed to target these pathways. Other treatment options have included more sophisticated pancreatic cancer surgeries and combination therapies. While outcomes have improved modestly for these patients, more effective treatmentsare desperately needed. One of the greatest challenges in the future of treating this malignancy will be to develop therapies that target the tumor microenvironment and surrounding pancreatic cancer stem cells in addition to pancreatic cancer cells. Recent advances in targeting pancreatic stellate cells and the stroma have encouraged researchers to shift their focus to the role of desmoplasia in pancreatic cancer pathobiology in the hopes of developing newer-generation therapies. By combining novel agents with current cytotoxic chemotherapies and radiation therapy and personalizing them to each patient based on specific biomarkers, the goal of prolonging a patient's life could be achieved. Here we review the most effective therapies that have been used for the treatment of pancreatic cancer and discuss the future potential of therapeutic options.	Maria L Rossi Azeem A Rehman Christopher S Gondi	2014	World Journal of Gastroenterology2014，20，32：	13
	2	Inhibition of invasion, angiogenesis, tumor growth and metastasis by adenovirus-mediated transfer of antisense uPAR and MMP-9 in non - small cell lung cancer ceils 显示文摘	Jasti S Rao Christopher Gondi Chandramu Chetty	2005	Mol Cancer Ther2005，4，9：	1
	3	Specific knockdown of uPA/uPAR attenuates invasion in glioblastorna ceils and xenografts by inhibition of cleavage and trafficking of Notch -1 receptor显示文摘	Raghu Hari Gondi Christopher Dinh Dzung	2011	Molecular Cancer2011，10，1：	1
	4	MMP-9 induces CD44 cleavage and CD44 mediated cell migration in glioblastoma xenograft cells显示文摘	Chandramu Chetty Sravan K. Vanamala Christopher S. Gondi Dzung H. Dinh Meena Gujrati Jasti S. Rao	2011	Cellular Signalling2011，，2：	1
	5	RNA interference-mediated simultaneous down-regulation of urokinase-type plasminogen activator receptor and eathepsin B induces caspase-8-mediated apoptosis in SNB19 human glioma cells显示文摘	Christopher S Gondi NK Shakuntala K	2006	Mol Cancer Ther2006，5，12：	1
	6	Specific knockdown of uPA/uPAR attenuates invasion in glioblastoma cells and xenografts by inhibition of cleavage and trafficking of notch-1 receptor显示文摘	Raghu Hari Gondi Christopher Dinh Dzung	2011	Molecular Cancer2011，10，：	1

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