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3篇 您的检索式:作者名="Christopher S.Chen"
    题名 作者 年代 出处 被引量
1Decreasing disparity in liver transplantation among white and Asian patients with hepatocellular carcinoma显示文摘Anthony S.Robbins Michael F.Daily Christopher A.Aoki Moon S.Chen ChristophTroppmann Richard V.Perez 2008Cancer2008,,8:1
2Feasibility of simultaneous bilateral carotid artery stenting显示文摘Michael S.Chen Deepak L.Bhatt DebabrataMukherjee Albert W.Chan MarcoRoffi Samir R.Kapadia Khaled M.Ziada Derek P.Chew Christopher T.Bajzer Jay S.Yadav 2004Cathet Cardiovasc Intervent2004,,4:1
3Probing the subcellular nanostructure of engineered human cardiomyocytes in 3D tissue显示文摘The structural and functional maturation of human induced pluripotent stem cell-derived cardiomyocytes(hiPSC-CMs)is essential for pharmaceutical testing,disease modeling,and ultimately therapeutic use.Multicellular 3D-tissue platforms have improved the functional maturation of hiPSC-CMs,but probing cardiac contractile properties in a 3D environment remains challenging,especially at depth and in live tissues.Using small-angle X-ray scattering(SAXS)imaging,we show that hiPSC-CMs matured and examined in a 3D environment exhibit a periodic spatial arrangement of the myofilament lattice,which has not been previously detected in hiPSC-CMs.The contractile force is found to correlate with both the scattering intensity(R^(2)=0.44)and lattice spacing(R^(2)=0.46).The scattering intensity also correlates with lattice spacing(R^(2)=0.81),suggestive of lower noise in our structural measurement than in the functional measurement.Notably,we observed decreased myofilament ordering in tissues with a myofilament mutation known to lead to hypertrophic cardiomyopathy(HCM).Our results highlight the progress of human cardiac tissue engineering and enable unprecedented study of structural maturation in hiPSC-CMs.Josh Javor Jourdan K.Ewoldt Paige E.Cloonan Anant Chopra Rebeccah J.Luu Guillaume Freychet Mikhail Zhernenkov Karl Ludwig Jonathan G.Seidman Christine E.Seidman Christopher S.Chen David J.Bishop 2021Microsystems & Nanoengineering2021,7,1:0
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