6篇
您的检索式：作者名="Christopher WT"
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| 1 | Indications and surgical options for small bowel, large bowel and perianal Crohn's disease显示文摘Despite advancements in medical therapy of Crohn's disease(CD), majority of patients with CD will eventually require surgical intervention, with at least a third of patients requiring multiple surgeries. It is important to understand the role and timing of surgery, with the goals of therapy to reduce the need for surgery without increasing the odds of emergency surgery and its associated morbidity, as well as to limit surgical recurrence and avoid intestinal failure. The profile of CD patients requiring surgical intervention has changed over the decades with improvements in medical therapy with immunomodulators and biological agents. The most common indication for surgery is obstruction from stricturing disease, followed by abscesses and fistulae. The risk of gastrointestinal bleeding in CD is high but the likelihood of needing surgery for bleeding is low. Most major gastrointestinal bleeding episodes resolve spontaneously, albeit the risk of re-bleeding is high. The risk of colorectal cancer associated with CD is low. While current surgical guidelines recommend a total proctocolectomy for colorectal cancer associated with CD, subtotal colectomy or segmental colectomy with endoscopic surveillance may be a reasonable option. Approximately 20%-40% of CD patients will need perianal surgery during their lifetime. This review assesses the practice parameters and guidelines in the surgical management of CD, with a focus on the indications for surgery in CD(and when not to operate), and a critical evaluation of the timing and surgical options available to improve outcomes and reduce recurrence rates. | James WT Toh Peter Stewart Matthew JFX Rickard Rupert Leong Nelson Wang Christopher J Young | 2016 | World Journal of Gastroenterology2016，22，40： | 2 |
| 2 | Retroperitoneal Sarcomas 显示文摘 | Christopher WT Peter WT | 2005 | Cancer Control2005，1，： | 1 |
| 3 | Retroperitoneal Sarcomas 显示文摘 | Christopher WT Peter WT Pisters | 2005 | Cancer Control2005，1，： | 1 |
| 4 | From 3D to 2D : A review of the molecular imprinting of proteins 显示文摘 | Nicholas WT Christopher WJ Keith RB | 2006 | Biotechnol Prog2006，22，6： | 1 |
| 5 | 显示文摘 | Richard WT Christopher MF Yandle TG | 2000 | Lancet2000，355，： | 1 |
| 6 | Retroperitoneal Sarcomas显示文摘 | Christopher WT Peter WT Pisters | 2005 | Cancer Contro2005，1，： | 1 |
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