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| 1 | 欧洲血管外科学会指南:第二部分——颈动脉狭窄患者的诊断和检查显示文摘在此,我们呈献颈动脉狭窄患者脑血管事件二级预防的欧洲血管外科学会指南,包括降脂治疗、抗血小板治疗以及其他危险因素控制。这些推荐均基于现有的临床试验证据。对颈动脉病患者需要采取积极的预防性治疗。我们还讨论了颈动脉狭窄的诊断和分级。 | Christos D. Liapis Sir Peter F. Bell Dimitri P. Mikhailidis Juharli Sivenius Andrew Nicolaides Jose Femandes e Fernandes Giorgio Biasi Ears Norgrer 赵颖(译) 谭泽锋(译) 徐安定(译) | 2011 | 国际脑血管病杂志2011，19，7： | 9 |
| 2 | Effect of bombesin and neurotensin on gut barrier function in partially hepatectomized rats显示文摘AIM: To investigate the effect of regulatory peptides bombesin (BBS) and neurotensin (NT) on intestinal barrier function in partially hepatectomized rats.METHODS: Ninety male Wistar rats were randomly divided into five groups: Ⅰ (n = 10): controls, Ⅱ (n =20): sham operated, Ⅲ (n = 20): partial hepatectomy 70% (PHx), Ⅳ (n = 20): PHx+BBS (30 μg/kg/d), Ⅴ (n= 20): PHx+NT (300 μg/kg/d). Groups Ⅳ and Ⅴ were treated for 8 days before PHx and 48 h post surgery.At the end of the experiment, on day 10, intestinal barrier function was assessed by measuring endotoxin concentrations in portal and aortic blood. Tissue sections of the terminal ileum were examined histologically and villus density, mucosal thickness, mitotic activity and apoptosis in crypts were assessed. In addition, ileal mucosa was analyzed for DNA and protein content and microbiological analysis was performed in cecal contents.To estimate intestinal oxidative stress, lipid peroxidation was determined on tissue homogenates from terminal ileum.RESULTS: BBS or NT administration significantly reduced portal and systemic endotoxemia observed 48 h after partial hepatectomy. In hepatectomized rats (group Ⅲ), a trend towards induction of mucosal atrophy was observed, demonstrated by the reduction of villus density, mucosal thickness, protein content and significant reduction of DNA, while these alterations were reversed by regulatory peptides administration.This trophic effect of BBS and NT was accompanied by induction of mitoses above control levels and a significant reduction of apoptosis in intestinal crypts.Intestinal lipid peroxidation was found significantly lower in PHx group and regulatory peptides exerted an antioxidant action, further decreasing this parameter of oxidative stress. The bacterial population of E. coli and aerobic Gram (+) cocci was increased in cecal content of hepatectomized rats, while this parameter was not affected by the administration of BBS or NT.CONCLUSION: Gut regulatory peptides BBS and NT improve intestinal barrier function and reduce endotoxemia in experimental partial hepatectomy. This effect is, at least in part, mediated by their trophic,antiapoptotic, mitogenic, and antioxidant effect on the intestinal epithelium. This observation might be of potential value in patients undergoing liver resection. | Stelios F Assimakopoulos Ilias H Alexandris Chrisoula D Scopa Panagiotis G Mylonas Konstantinos C Thomopoulos Christos D Georgiou Vassiliki N Nikolopoulou Constantine E Vagianos | 2005 | World Journal of Gastroenterology2005，11，43： | 8 |
| 3 | 欧洲血管外科学会指南:第1部分——颈动脉狭窄患者的预防显示文摘在此,我们呈献颈动脉狭窄患者脑血管事件二级预防的欧洲血管外科学会指南,包括降脂治疗、抗血小板治疗以及其他危险因素控制。这些推荐均基于现有的临床试验证据。对颈动脉疾病患者需要采取积极的预防性治疗。我们还讨论了颈动脉狭窄的诊断和分级。 | Christos D. Liapis Sir Peter F. Bell Dimitri P. Mikhailidis Juhani Sivenius Andrew Nicolaides Jose Femandes e Fernandes Giorgio Biasi Lars Norgren 董大伟(译) 刘小艳(译) 徐安定(译) | 2011 | 国际脑血管病杂志2011，19，6： | 7 |
| 4 | Lipoma induced jejunojejunal intussusception显示文摘Intussusception in adults is rare. The clinical picture of intussusception in adults is subtle and the diagnosis is,therefore,elusive. The presence of a structural abnor- mality in the great majority of the adult cases mandates high clinical suspicion. Gastrointestinal lipomas are rare benign tumors and intussusception due to a gastrointes- tinal lipoma constitutes an infrequent clinical entity. The present report describes a case of jejunojejunal intus- susception in an adult with a history of severe episodes of hematochezia and colicky upper abdominal pain. The diagnosis was suspected preoperatively but computed tomography scan could not rule out malignancy. Explor- atory laparotomy revealed jejunojejunal intussusception secondary to a lipoma which was successfully treated with segmental intestinal resection. | Andreas Manouras Emmanuel E Lagoudianakis Dimitrios Dardamanis Dimitrios K Tsekouras Haridimos Markogiannakis Michael Genetzakis Nikolaos Pararas Artemisia Papadima Christos Triantafillou Vagelogiannis Katergiannakis | 2007 | World Journal of Gastroenterology2007，13，26： | 4 |
| 5 | Stimulation of oval cell and hepatocyte proliferation by exogenous bombesin and neurotensin in partially hepatectomized rats显示文摘AIM:To investigate the effect of the neuropeptides bombesin(BBS)and neurotensin(NT)on oval cell proliferation in partially hepatectomized rats not pretreated with a known hepatocyte inhibitor.METHODS:Seventy male Wistar rats were randomly divided into five groups:Ⅰ=controls,Ⅱ=sham operated,Ⅲ=partial hepatectomy 70%(PHx),Ⅳ=PHx+ BBS(30μg/kg per day),Ⅴ=PHx+NT(300μg/kg per day).Forty eight hours after liver resection,portal en-dotoxin levels and hepatic glutathione redox state were determined.α-fetoprotein(AFP)mRNA(in situ hybridisation),cytokeratin-19 and Ki67 antigen expression (immunohistochemistry)and apoptosis(TUNEL)were evaluated on liver tissue samples.Cells with morphological features of oval cells that were cytokeratin-19 (+)and AFP mRNA(+)were scored in morphometric analysis and their proliferation was recorded.In addition,the proliferation and apoptotic rates of hepatocytes were determined.RESULTS:In the control and sham operated groups,oval cells were significantly less compared to groups Ⅲ,ⅣandⅤ(P<0.001).The neuropeptides BBS and NT significantly increased the proliferation of oval cells compared to groupⅢ(P<0.001).In addition,BBS and NT induced a significant increase of hepatocyte proliferation(P<0.001),whereas it decreased their apoptotic activity(P<0.001)compared to groupⅢ.BBS and NT significantly decreased portal endotoxemia (P<0.001)and increased the hepatic GSH:GSSG ratio (P<0.05 and P<0.001,respectively)compared to groupⅢ.CONCLUSION:BBS and NT stimulated oval cell proliferation in a model of liver regeneration,without use of concomitant suppression of hepatocyte proliferation as oval cell activation stimuli,and improved the hepatocyte regenerative response.This peptides-induced combined stimulation of oval cell and hepatocyte proliferation might serve as a possible treatment modality for several liver diseases. | Stelios F Assimakopoulos Athanassios C Tsamandas Ilias H Alexandris Christos Georgiou Constantine E Vagianos Chrisoula D Scopa | 2011 | World Journal of Gastrointestinal Pathophysiology2011，2，6： | 2 |
| 6 | Circulating adiponectin levels are associated with better glycemic control,more favorable lipid profile,and reduced inflammation in women with type 2 diabetes显示文摘 | Christos SM Tricia L Joann E | 2005 | J Clin Endocrinol Metab2005，90，： | 1 |
| 7 | Erythromycin as aProkinetic A gent in Perterm Infants显示文摘 | Christos C Anthony G Evarhalo E | 2002 | J Pediatr Gastroen-terol Nutr2002，34，1： | 1 |
| 8 | Temozolomide for treating brain metastases显示文摘 | Lauren E Abrey Christos Christodoulou | 2001 | Seminars in Oncology2001，，： | 1 |
| 9 | The Phenomenology of Seitures and Epilepsy After Stroke显示文摘 | Lambrakis Marcelo E | 1998 | J Epilepsy1998，11，： | 1 |
| 10 | A license plate-recognition algorithm for intelligent transportation system applications 显示文摘 | Christos Nikolaos E Vassili Loumos | 2006 | IEEE Transactions on Intelligent Transportation System2006，7，3： | 1 |
| 11 | Variation in the blood supply of the sinus node显示文摘 | Christos E Nerantzis Hector Anninos | 2010 | Surgical and Radio logic Anatomy2010，，： | 1 |
| 12 | Phase Ⅰ trial of ixabepilone plus pegylated liposomal doxorubicin in patients with adenocarcinoma of breast or ovary dagger double dagger显示文摘 | Chuang E Wiener N Christos P | 2010 | Ann Oncol2010，21，10： | 1 |
| 13 | A mobile agent platform for distributed network and systems manage- ment 显示文摘 | DAMIANOS G GEORGE E T CHRISTOS A | 2009 | The Journal of Systems and Software2009，82，： | 1 |
| 14 | Improved Batch Fuzzy Learning Vector Quantization for Image Compression显示文摘 | George E T Mamalis A Christos A | 2008 | Information Sciences2008，178，20： | 1 |
| 15 | Phase I trial ofixabepilone plus pegylated liposomal doxorubicin inpatients with adenocarcinoma of breast or ovary daggerdouble dagger显示文摘 | Chuang E Wiener N Christos P | 2010 | Ann Oncol2010，21，10： | 1 |
| 16 | Ankle-brachial index as a predictor of the extent of coronary atherosclerosis and cardiovascular events in patients with coronary artery disease显示文摘 | Christos M Papamichael John P Lekakis Kimon S Stamatelopoulos Theodoros G Papaioannou Maria K Alevizaki Adriana T Cimponeriu John E Kanakakis Aggeliki Papapanagiotou Anastasios Th Kalofoutis Stamatios F Stamatelopoulos | 2000 | The American Journal of Cardiology2000，，6： | 1 |
| 17 | Predictive factors associated with axillary lymph node metastases in T1 a and T1 b breast carcinomas: analysis in more than 900 patients 显示文摘 | RIVADENEIRA D E SIMMONS R M CHRISTOS P J | 2000 | J Am Coll Surg2000，191，1： | 1 |
| 18 | Real time robotic tactile sensor system for the determination of the physical properties of biomaterials 显示文摘 | Sadao O Yoshinobu M Christos E C | 2004 | Sensors and Actuat9rs A : Physical2004，112，23： | 1 |
| 19 | Uncertainty estimation and monte carlo simulation method 显示文摘 | Christos E Papadopoulos Hoi Yeung | 2001 | Flow Measurement and Instrumentation2001，12，4： | 1 |
| 20 | Total nitrogen and ammonia removal prediction in horizontal subsurface flow constructed wetlands: Use of artificial neural networks and development of a design equation显示文摘 | Christos S A John N E Papaspyros V | 2009 | Bioresource Technology2009，100，2： | 1 |
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