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| 1 | 亚太地区慢性乙型肝炎治疗共识(2012最新版)显示文摘自2008年至今,有大量关于慢性HBV感染的自然史和治疗的最新数据不断涌现。其中包括慢性HBV感染的无症状感染者,以社区为基础的队列研究,HBV基因型的作用,非药物诱导的自然HBV变异型毒株,无创性肝纤维化评估方法的应用,HBsAg定量在临床中的应用,更有效的新治疗药物和新治疗方案等等。来自亚太地区的专家审查和评估了相关数据,并共同商讨了近年来报道的最有意义的发现,基于此,对2008年版的亚太地区慢性乙型肝炎治疗共识进行修订,同时对2008年版治疗指南定义的关键词组进行了修订。修订后的指南包括以下几方面内容:一般治疗,肝纤维化评价适应证,何时开始治疗或停药,初始抗病毒治疗药物的选择,如何监测治疗中和治疗后的患者。关于特殊人群的治疗建议中包括了对妊娠妇女,已发生耐药,合并其他病毒感染,肝功能失代偿,接受免疫抑制治疗、化疗,肝移植或肝细胞癌患者的具体治疗建议。 | 廖运范 Jia-HorngKao Teerha Piratvisuth Henry Lik Yuen Chan Rong-Nan Chien Chun-Jen Liu Ed Gane Stephen Locarnini Seng-Gee Lim Kwang-Hyub Han Deepak Amarapurkar Graham Cooksley Wasim Jafri Rosmawati Mohamed Wan-Long Chuang Laurentius A.Lesmana Jose D.Sollano Dong-Jin Suh Masao Omata 刘颖 徐莹 李芸 黄祖雄 樊蓉 李小溪 吕国涛 周彬 孙剑 侯金林 | 2012 | 临床肝胆病杂志2012，28，8： | 182 |
| 2 | A review of topology optimization for additive manufacturing:Status and challenges显示文摘Topology optimization was developed as an advanced structural design methodology to generate innovative lightweight and high-performance configurations that are difficult to obtain with conventional ideas.Additive manufacturing is an advanced manufacturing technique building asdesigned structures via layer-by-layer joining material,providing an alternative pattern for complex components.The integration of topology optimization and additive manufacturing can make the most of their advantages and potentials,and has wide application prospects in modern manufacturing.This article reviews the main content and applications of the research on the integration of topology optimization and additive manufacturing in recent years,including multi-scale or hierarchical structural optimization design and topology optimization considering additive manufacturing constraints.Meanwhile,some challenges of structural design approaches for additive manufacturing are discussed,such as the performance characterization and scale effects of additively manufactured lattice structures,the anisotropy and fatigue performance of additively manufactured material,and additively manufactured functionally graded material issues,etc.It is shown that in the research of topology optimization for additive manufacturing,the integration of material,structure,process and performance is important to pursue high-performance,multi-functional and lightweight production.This article provides a reference for further related research and aerospace applications. | Jihong ZHU Han ZHOU Chuang WANG Lu ZHOU Shangqin YUAN Weihong ZHANG | 2021 | Chinese Journal of Aeronautics2021，34，1： | 33 |
| 3 | Multi-scale design and optimization for solid-lattice hybrid structures and their application to aerospace vehicle components显示文摘By integrating topology optimization and lattice-based optimization,a novel multi-scale design method is proposed to create solid-lattice hybrid structures and thus to improve the mechanical performance as well as reduce the structural weight.To achieve this purpose,a two-step procedure is developed to design and optimize the innovative structures.Initially,the classical topology optimization is utilized to find the optimal material layout and primary load carrying paths.Afterwards,the solid-lattice hybrid structures are reconstructed using the finite element mesh based modeling method.And lattice-based optimization is performed to obtain the optimal crosssection area of the lattice structures.Finally,two typical aerospace structures are optimized to demonstrate the effectiveness of the proposed optimization framework.The numerical results are quite encouraging since the solid-lattice hybrid structures obtained by the presented approach show remarkably improved performance when compared with traditional designs. | Chuang WANG Jihong ZHU Manqiao WU Jie HOU Han ZHOU Lu MENG Chenyang LI Weihong ZHANG | 2021 | Chinese Journal of Aeronautics2021，34，5： | 14 |
| 4 | Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2012 update显示文摘 | Yun-Fan Liaw Jia-Horng Kao Teerha Piratvisuth Henry Chan Rong-Nan Chien Chun-Jen Liu Ed Gane Stephen Locarnini Seng-Gee Lim Kwang-Hyub Han Deepak Amarapurkar Graham Cooksley Wasim Jafri Rosmawati Mohamed Jin-Lin Hou Wan-Long Chuang Laurentius Lesmana Jose | 2012 | Hepatology International2012，，3： | 6 |
| 5 | Prognostic Value of Gai's Plaque Score and Agatston Coronary Artery Calcium Score for Functionally Significant Coronary Artery Stenosis显示文摘 | Chuang Zhang Shuang Yang Lu-Yue Gai Zhi-Qi Han Qian Xin Xiao-Bo Yang Jun-Jie Yang Qin-Hua Jin | 2016 | Chinese Medical Journal2016，，23： | 5 |
| 6 | PyWRKY26 and PybHLH3 cotargeted the PyMYB114 promoter to regulate anthocyanin biosynthesis and transport in red-skinned pears显示文摘Red pear is favored because of its bright appearance and abundant anthocyanins.Anthocyanin biosynthesis is controlled by transcription factors(TFs)forming regulatory complexes.In red-skinned pears,the WRKY TFs have a significant relationship with anthocyanin biosynthesis,but the molecular mechanism of the WRKY TFs involved in regulating color formation in red-skinned pear is unclear.In this study,the TFs PyWRKY31 and PyWRKY26 were screened as candidate genes for controlling anthocyanin biosynthesis by transcriptome data and bioinformatics analysis.The effect of anthocyanin accumulations after cotransformation of PyWRKY31 or PyWRKY26 with its partners PyMYB10,PyMYB114,and PybHLH3 was verified in tobacco leaves and strawberry receptacles by a transient expression system.RT-qPCR analysis and a dual-luciferase reporter system further confirmed that this cotransformation activated the expression of PyDFR,PyANS,and PyUFGT in anthocyanin biosynthesis and PyGST in anthocyanin transport instead of the PyABC transporter and PyAVP.Furthermore,the cotransformed PyWRKY26 and PybHLH3 could bind to the PyMYB114 promoter,and PyWRKY26 directly activated the transcription of PyMYB114.In addition,the TF PyWRKY26 could interact with PybHLH3,as confirmed by firefly luciferase complementation and yeast two-hybrid(Y2H)assays.These results showed that the interaction of PyWRKY26 and PybHLH3 could cotarget the PyMYB114 promoter,which resulted in anthocyanin accumulation in red-skinned pear.This study further strengthened the understanding of the regulatory mechanism of anthocyanin accumulation and contributed to improving the appearance of red-skinned pears. | Chuang Li Jun Wu Kang-Di Hu Shu-Wei Wei Hong-Ye Sun Lan-Ying Hu Zhuo Han Gai-Fang Yao Hua Zhang | 2020 | Horticulture Research2020，7，1： | 5 |
| 7 | Collaborative validation of GlobeLand30:Methodology and practices显示文摘30-m Global Land Cover(GLC)data products permit the detection of land cover changes at the scale of most human land activities,and are therefore used as fundamental information for sustainable development,environmental change studies,and many other societal benefit areas.In the past few years,increasing efforts have been devoted to the accuracy assessment of GlobeLand30 and other finer-resolution GLC data products.However,most of them were conducted either within a limited percentage of map sheets selected from a global scale or in some individual countries(areas),and there are still many areas where the uncertainty of 30-m resolution GLC data products remains to be validated and documented.In order to promote a comprehensive and collaborative validation of 30-m GLC data products,the GEO Global Land Cover Community Activity had organized a project from 2015 to 2017,to examine and explore its major problems,including the lack of international agreed validation guidelines and on-line tools for facilitating collaborative validation activities.With the joint effort of experts and users from 30 GEO member countries or participating organizations,a technical specification for 30-m GLC validation was developed based on the findings and experiences.An on-line validation tool,GLCVal,was developed by integrating land cover validation procedures with the service computing technologies.About 20 countries(regions)have completed the accuracy assessment of GlobeLand30 for their territories with the guidance of the technical specification and the support of GLCVal. | Jun Chen Lijun Chen Fei Chen Yifang Ban Songnian Li Gang Han Xiaohua Tong Chuang Liu Vanya Stamenova Stefan Stamenov | 2021 | Geo-Spatial Information Science2021，24，1： | 5 |
| 8 | Effects of Sb Content on Solidification Pathways and Grain Size of AZ91 Magnesium Alloy显示文摘The phase constitution and solidification pathways of AZ91+xSb(x = 0, 0.1, 0.5, 1, in wt%) alloys were investigated through ways of microstructure observation, thermal analysis technique, and thermodynamic calculation. It was found that the non-equilibrium solidification microstructure of AZ91+xSb(x = 0.1, 0.5, 1) is composed of a-Mg matrix, b-Mg17Al12 phase, and intermetallic compound Mg3Sb2. The grain size of the alloys with different Sb contents was quantitatively determined by electron backscattered diffraction technique which shows no grain refinement in Sb-containing AZ91 alloy. Thermodynamic calculations are in reasonable agreement with thermal analysis results, showing that the Mg3Sb2 phase forms after a-Mg nucleation, thus impossible acts as heterogeneous nucleus for a-Mg dendrite. Besides,the solid fraction at dendrite coherency point(fDCPs) determined from thermal analysis decreases slightly with increasing Sb content, which is consistent with the fact that Sb does not refine the grain size of AZ91 alloy. | Dan-Hui Hou Song-Mao Liang Rong-Shi Chen Chuang Dong En-Hou Han | 2015 | Acta Metallurgica Sinica(English Letters)2015，28，1： | 4 |
| 9 | A new ent-kaurane diterpenoid from Isodon japonica显示文摘One new ent-kaurane diterpenoid,named maoyecrystal L was isolated from the EtOAc extract of the dried leaves of lsodon japonica.Its structure was established by various spectroscopic means and confirmed by X-ray crystallographic analysis. | Di, Xue Mei Yan, Fu Lin Feng, Chuang Xie, Rui Jie Hou, Rui Jie Sun, Han Dong | 2010 | Chinese Chemical Letters2010，21，2： | 3 |
| 10 | Decrease in DNA methylation 1(DDM1) is required for the formation of ~mCHH islands in maize显示文摘DNA methylation plays a crucial role in suppressing mobilization of transposable elements and regulation of gene expression. A number of studies have indicated that DNA methylation pathways and patterns exhibit distinct properties in different species, including Arabidopsis, rice, and maize.Here, we characterized the function of DDM1 in regulating genome-wide DNA methylation in maize. Two homologs of Zm DDM1 are abundantly expressed in the embryo and their simultaneous disruption caused embryo lethality with abnormalities in cell proliferation from the early stage of kernel development. We establish that Zm DDM1 is critical for DNA methylation, at CHG sites, and to a lesser extent at CG sites, inheterochromatic regions, and unexpectedly, it is required for the formation ofmCHH islands. In addition, Zm DDM1 is indispensable for the presence of 24-nt si RNA, suggesting its involvement in the Rd DM pathway. Our results provide novel insight into the role of Zm DDM1 in regulating the formation of mCHH islands, via the Rd DM pathway maize, suggesting that,in comparison to Arabidopsis, maize may have adopted distinct mechanisms for regulating ~mCHH. | Jin Cheng Long Ai Ai Xia Jing Han Liu Ju Li Jing Ya Zhong Wang Chuang Ye Qi Yan He | 2019 | Journal of Integrative Plant Biology2019，61，6： | 2 |
| 11 | Erratum to: Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2012 update显示文摘 | Yun-Fan Liaw Jia-Horng Kao Teerha Piratvisuth Henry Lik Yuen Chan Rong-Nan Chien Chun-Jen Liu Ed Gane Stephen Locarnini Seng-Gee Lim Kwang-Hyub Han Deepak Amarapurkar Graham Cooksley Wasim Jafri Rosmawati Mohamed Jin-Lin Hou Wan-Long Chuang Laurentius A. | 2012 | Hepatology International2012，，4： | 2 |
| 12 | Hot Deformation Behavior and Workability of(SiC_p + Mg_2B_2O_(5w))/6061 Al Hybrid and SiC_p/6061 Al Composites显示文摘The hot deformation behavior of(3 vol%SiC_p + 3 vol%Mg_2B_2O_(5w))/6061 Al(W_3P_3) hybrid composite and6 vol%SiCp/6061 Al(P_6) composite have been characterized in the temperature range of 300-450 ℃ and strain rate range of 0.0001-0.1 s^(-1) using isothermal constant true strain rate tests.The flow behavior and processing maps have been investigated using the corrected data to eliminate the effect of friction.Under the same deformation conditions,the compressive resistance of the singular composite remains superior to that of the hybrid composites.The processing map of W_3P_3 hybrid composite exhibits a single hot working domain at the temperature between 350 and 450 ℃ with strain rate between 0.0001 and 0.003 s^(-1)(domain A).Two hot working domains exist for P_6 composite:(i) 300-400 ℃/0.0001-0.003 s^(-1)(domain Bl);(ii) 380-450 ℃/0.01-0.1 s^(-1)(domain B2).The processing maps also reveal the flow instability of the two composites,which is associated with whiskers breakage,whisker/matrix interfacial debonding,SiCp/matrix interfacial decohesion,adiabatic shear bands or flow localization,and wedge cracking in the corresponding regions.The estimated apparent activation energies are about 224 kJ mol^(-1) in domain A for W3P3 hybrid composite,177 kJ mol^(-1) in domain Bl and 263 kJ mol^(-1) in domain B2 for P_6 composite,respectively.These values are higher than that for self-diffusion in Al(142 kJ mol^(-1)),suggesting that there is a significant contribution from the back stress caused by the presence of particles and/or whiskers in the matrix.The deformation mechanisms corresponding to domain Bl and domain B2 are dislocation climb controlled creep and cross-slip for P_6 composite,respectively.For W_3P_3 hybrid composite,the deformation mechanisms contain dislocation climb controlled creep and grain boundary sliding caused by DRX in domain A. | Mingliang Wang Peipeng Jin Jinhui Wang Li Han Chuang Cui | 2014 | Acta Metallurgica Sinica(English Letters)2014，27，1： | 2 |
| 13 | Influence of Nitrogen Flow Rate on the Microstructure and Properties of N and Me (Me=Cr,Zr) Co-doped Diamond-like Carbon Films显示文摘In this paper,Me (Me=Cr,Zr) and N co-doped diamond like carbon (DLC-MeN) composite films were prepared on cemented carbide substrates by pulsed bias arc ion plating.The effect of nitrogen flow rates on the microstructure and properties of the films were investigated by X-ray photoelectron spectroscopy (XPS),Raman spectra,grazing incident X-ray diffraction (GIXRD),high resolution transmission electron microscopy (HRTEM) and nano-indentation.Raman,GIXRD and HRTEM results show that the deposited films are nanocomposite films with MeN nanocrystalline phase embedded within DLC amorphous matrix,which are vital for the mechanical properties of the films.The nitrogen flow rate has significant effect on the compositions and structures and hence on the hardness and elastic modulus of the films,and increasing nitrogen flow rate decreases drastically the hardness and elastic modulus of the films. | Zhiyun Han,Hongkai Li,Guoqiang Lin and Chuang Dong Key Laboratory for Material Modification by Laser,Ion and Electron Beams,Dalian University of Technology,Dalian 116085,China | 2010 | Journal of Materials Science & Technology2010，26，11： | 2 |
| 14 | A model of NSCLC microenvironment predicts optimal receptor targets显示文摘Background:Tumor microenvironment plays an essential role in the growth of malignancy.Understanding how tumor cells co-evolve with tumor-associated immune cells and stromal cells is important for tumor treatment.Methods:In this paper,we propose a logistic population dynamics model for quantifying the intercellular signaling nebvork in non-small-cell lung cancer (NSCLC).The model describes the evolutionary dynamics of cells and signaling proteins and was used to predict effective receptor targets through combination strategy analysis.Then,we optimized a multi-target strategy analysis algorithm that was verified by applying it to virtual patients with heterogeneous conditions.Furthermore,to deal with acquired resistance which was commonly observed in patients with NSCLC,we proposed a novel targeting strategy-tracking targeted therapy,to optimize the treatment by improving the therapeutic strategy periodically.Results:The synergistic effect when inhibiting multiple signaling pathways may help significantly retard carcinogenic processes associated with disease progression,compared with suppression of a single signaling pathway.While traditional treatment (surgery,radiotherapy and chemotherapy) tends to attack tumor cells directly,the multi-target therapy we suggested here is aimed to inhibit the development of tumor by emasculating the relative competitive advantages of tumor cells and promoting that of normal cells.Conclusion:The combination of traditional and targeted therapy,as an interesting experiment,was significantly more effective in treatment of virtual patients due to a clear complementary relationship between the two therapeutic schemes. | Chuang Han Yu Wu | 2019 | Frontiers of Electrical and Electronic Engineering in China2019，7，2： | 1 |
| 15 | NEPTUNE Study: On-treatment HBsAg level analysis confirms prediction of response observed in phase 3 study of peginterferon alfa-2a in HBeAg-positive patients 显示文摘 | Gane E Jia J Han K Tanwandee T Chuang WL Marcellin P Chan HL Piratvisuth T Wat C Martins E Liaw YF | 2011 | J Hepatol2011，54，： | 1 |
| 16 | The relationship between high-commitment HRM and knowledge-sharing behavior and its mediators 显示文摘 | CHIANG H H T S HAN J S CHUANG | 2011 | International Journal o{ Manpower2011，32，56： | 1 |
| 17 | An advanced quantum-inspiredevolutionary algorithm for unit commitment显示文摘 | CHUANG C Y HAN Yu KIT P W | 2011 | IEEE Trans onPower Systems2011，26，2： | 1 |
| 18 | Effects of music therapy on subjective sensations and heart rate variability in treated cancer survivors: A pilot study显示文摘 | Chuang CY Han WR Li PC | 2010 | Complement Ther Med2010，18，5： | 1 |
| 19 | Fluorobenzene diluted low-density electrolyte for high-energy density and high-performance lithium-sulfur batteries显示文摘The mass fraction of electrolytes is the crucial factor affecting the energy density of lithium-sulfur(Li-S)batteries. Due to the high porosity within the C/S cathode, high concentration of polysulfides, and side reaction in lithiun metal anode under lean electrolyte, it is extremely challenging to improve performance while reducing the electrolyte volume. Here, we report a novel electrolyte with relatively low density(1.16 g cm^(-2)), low viscosity(1.84 m Pa s), and high ionic conductivity, which significantly promotes energy density and cyclability of Li-S batteries under practical conditions. Moreover, such electrolyte enables a hybrid cathode electrolyte interphase(CEI) and solid electrolyte interface(SEI) layer with plentiful Li F, which leads to fast kinetics of ions transport and stable cyclability even under low temperatures.Compared to Li-S batteries in electrolyte employing 1,1,2,2-tetrafluoroethyl 2,2,3,3-tetrafluoropropyl ether(TTE) diluent, the ultra-thick cathode(20 mg cm^(-2)) shows a high capacity of 9.48 m Ah cm^(-2)and excellent capacity retention of 80.3% over 191 cycles at a low electrolyte-to-sulfur ratio(E/S = 2) and negative-to-positive capacity ratio(N/P = 2.5), realizing a 19.2% improvement in energy density in coin cells(from 370 to 441 Wh kg^(-1)) and a high energy density up to 467 Wh kg^(-1) in pouch cells. This study not only provides guidance for the electrolyte design but also paves the way for the development of high performance Li-S batteries under practical conditions. | Zhilong Han Shuping Li Mengjun Sun Renjie He Wei Zhong Chuang Yu Shijie Cheng Jia Xie | 2022 | Journal of Energy Chemistry2022，31，5： | 1 |
| 20 | From clusters to phase diagrams:composition rules of quasicrystals and bulk metallic glasses显示文摘 | DONG Chuang WANG Qing QIANG Jian-bing WANG Ying-min JIANG Nan HAN Guang LI Yan-hui WU Jiang XIA Jun-hai | | 0，，： | 1 |
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