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| 1 | Yellow light dilemma zone researches: a review显示文摘The yellow light dilemma zone is widely known as an area on the high-speed intersection approach,where vehicles neither safely stop before the stop line nor proceed through the intersection during amber interval. Within such an area,a vehicle might be involved in a right-angle crash or rear-end collision. This issue has been extensively discussed over five decades in traffic engineering field,covering fromtheory to practice. However,fewcomprehensive reviewliteratures on the amber signal dilemma zone problems can be found. The objective of this paper is to summarize the evolution of yellow light dilemma zone researches. Basic definition and boundary of dilemma zone followed by driver behavior and dilemma zone hazard measurement are depicted. At last,the future directions of yellow light dilemma zone research are discussed. | Yaping Zhang Chuanyun Fu Liwei Hu | 2014 | Journal of Traffic and Transportation Engineering(English Edition)2014，1，5： | 5 |
| 2 | Preparation and evaluation of a new releasable PEGylated tumor necrosis factor-α(TNF-α) conjugate for therapeutic application显示文摘To design a releasable PEGylated TNF-α(rPEG-TNF-α ), a cathepsin B-sensitive dipeptide (Val-Cit moiety) was inserted into conventional PEG-modified TNF- (PEG-TNF- ), facilitating its clinical use for anti-tumor therapy. Comparative pharmaco- kinetic and pharmacodynamic studies showed that the half-lives of both PEGylated forms of TNF-α were ~60-fold greater than that of unmodified TNF-α . In addition, the in vitro bioactivity of rPEG-TNF-α was greater than that of PEG-TNF-α with the same degree of PEG modification. Release of TNF-α from rPEG-TNF-α in vitro was dependent on the presence of cathepsin B and was inhibited by a cathepsin B inhibitor. Despite the potent cytotoxicity of unmodified TNF-α against normal cells, its PEGylated forms at higher TNF-α concentrations showed low cytotoxic activity against these cells. In contrast, both forms of PEGylated TNF-α showed potent cytotoxic activity against the B16 and L929 cell lines, with rPEG-TNF-α being 5- and 9- fold more potent, respectively, than PEG-TNF-α . Moreover, rPEG-TNF-α was a more potent in vivo antitumor agent than PEG-TNF-α . | DAI ChuanYun FU Ya CHEN ShaoCheng LI Biao YAO Bo LIU WanHong ZHU LiQing CHEN Nan CHEN Ji ZHANG Qiang | 2013 | Science China(Life Sciences)2013，56，1： | 4 |
| 3 | Linkage with cathepsin B-sensitive dipeptide promotes the in vitro and in vivo anticancer activity of PEGylated tumor necrosis factor-alpha(TNF-α) against murine fibrosarcoma显示文摘To improve the pharmacological profile of tumor necrosis factor alpha(TNF-α),we have synthesized a new PEGylated prodrug,PEG-vcTNF-α,using a cathepsin B-sensitive dipeptide(valine-citrulline,vc) to link branched PEG and TNF-α.PEG-modified TNF-α without the dipeptide linker(PEG-TNF-α) and unconjugated TNF-α were also tested as controls.It was found for the first time that TNF-α released from PEG-vcTNF-α was specifically dependent on the presence of cathepsin B.PEG-vcTNF-α induced higher cytotoxicity and greater apoptosis against L929 murine fibrosarcoma cells than PEG-TNF-α.Reversal of these effects by a cathepsin-B inhibitor confirmed that these effects were mediated by cathepsin B-specific release of TNF-α.In vivo pharmacokinetics studies demonstrated that the plasma stability of PEG-vcTNF-α was significantly increased compared to TNF-α.Finally,the improved anticancer efficacy of PEG-vcTNF-α and the distinct activities among the three formulations confirmed the positive contribution of both PEGylation and the dipeptide linkage to the improved drug-like properties of PEG-vcTNF-α.The results here indicate that linking proteins and PEG via the cathepsin B-sensitive dipeptide may be a promising strategy for developing protein therapeutics. | DAI ChuanYun FU Ya LI Biao WANG YiGuang ZHANG Xuan WANG JianCheng ZHANG Qiang | 2011 | Science China(Life Sciences)2011，54，2： | 4 |
| 4 | Investigating crash injury severity at unsignalized intersections in Heilongjiang Province,China显示文摘Many studies suggest that more crashes occur due to mixed traffic flow at unsignalized intersections.However,very little is known about the injury severity of these crashes.The objective of this study is therefore to investigate how contributory factors affect crash injury severity at unsignalized intersections.The dataset used for this analysis derived from police crash reports from Dec.2006 to Apr.2009 in Heilongjiang Province,China.An ordered probit model was developed to predict the probability that the injury severity of a crash will be one of four levels:no injury,slight injury,severe injury,and fatal injury.The injury severity of a crash was evaluated in terms of the most severe injury sustained by any person involved in the crash.Results from the present study showed that different factors had varying effects on crash injury severity.Factors found to result in the increased probability of serious injuries include adverse weather,sideswiping with pedestrians on poor surface,the interaction of rear-ends and the third-class highway,winter night without illumination,and the interaction between traffic signs or markings and the third-class highway.Although there are some limitations in the current study,this study provides more insights into crash injury severity at unsignalized intersections. | Yulong Pei Chuanyun Fu | 2014 | Journal of Traffic and Transportation Engineering(English Edition)2014，1，4： | 3 |
| 5 | Effectiveness of Xiaoyao capsule(逍遥丸)on sleep disorders and mood disturbance in patients in recovery from coronavirus disease 2019:a randomized controlled trial显示文摘OBJECTIVE:To study the efficacy of Xiaoyao capsule(逍遥丸)in improving the clinical symptoms of sleep and mood disorders during recovery from coronavirus disease 2019(COVID-19).METHODS:The study cohort comprised 200 patients with sleep and mood disorders during recovery from COVID-19.Patients were randomized into the control group and the experimental group in a 1:1 ratio by blocked randomization.The patients received either Xiaoyao capsule(experimental group)or a placebo Xiaoyao capsule(control group)for 2 weeks.The improvements in the Traditional Chinese Medicine(TCM)syndrome scales,total effective rates,and disappearance rates of irritability,anxiety,and poor sleep were compared between the two groups.RESULTS:The TCM syndrome pattern scales,total effective rates,and disappearance rates of irritability,anxiety,and poor sleep did not significantly differ between the experimental group versus the control group in the full analysis set and the per protocol set after 1 and 2 weeks of treatment(P>0.05).CONCLUSIONS:Xiaoyao capsule do not significantly improve the clinical symptoms of sleep and mood disorders in patients in recovery from COVID-19. | YANG Cunqing LIAN Fengmei YANG Guiping HUANG Yufeng ZHANG Shuangbin WANG Jianghua ZHOU Jing GUO Dongqing SHEN Chuanyun YE Tiansong FU Aojie LI Xiaoli CHEN Le ZHANG Huifeng TU Qiyin WANG Ying YANG Wenzhe TONG Xiaolin BA Yuanming | 2023 | Journal of Traditional Chinese Medicine2023，43，2： | 0 |
| 6 | Investigating distance halo effect of fixed automated speed camera based on taxi GPS trajectory data显示文摘Background:The deterrence effect of automated speed camera(ASC)is still inconclusive.Moreover,it is pointed out that ASC may have varying deterrence effects on different types of road users(e.g.,taxis).Objective:This study intends to investigate the distance halo effect of fixed ASC(hereafter called ASC)on taxis.Method:More than 1.34 million taxis’GPS trajectory data were collected.A novel indicator,the delta speed(defined as the difference between the traveling speed and the speed limit),was proposed to continuously describe the variations in traveling speeds.The upstream and downstream critical delta speeds during each time period on weekdays and weekends were obtained by using K-means clustering method,respectively.Based on the critical delta speeds,the ranges of upstream and downstream distance halo effects of ASC during different time periods on weekdays and weekends were determined separately and compared.Results:The downstream critical delta speed is smaller than the upstream one.The upstream and downstream distance halo effects of ASC on taxis are within a range of 8-2180 m and an area of 10-580 m to the ASC location,respectively.There are no obvious difference in the ranges of upstream and downstream distance halo effects of ASC on taxis between different time periods or between weekdays and weekends.Conclusion:The present study confirms that the upstream and downstream distance halo effects of ASC on taxis have different ranges and the stabilities of time-of-day and day-of-week.Practical application:The findings of this study can provide a basic reference for reasonably deploying ASCs within a region. | Chuanyun Fu Hua Liu | 2023 | Journal of Traffic and Transportation Engineering(English Edition)2023，10，1： | 0 |
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