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| 1 | LONG-TERM CREEP ASSESSMENT OF VISCOELASTIC POLYMER BY TIME-TEMPERATURE-STRESS SUPERPOSITION显示文摘Nonlinear viscoelastic creep properties of poly (methyl methacrylate) at various temperatures and stress levels were measured in short-term tests to check the applicability of time-temperature-stress superposition principle, which is the combined form of time-temperature superposition principle and time-stress superposition principle. A unified master creep compliance curve was constructed from the short-term tests by joint application of time-temperature superposition and time-stress superposition. The unified master curve establishes the creep compliance over two years, which is 4.2 decades longer than the test duration. Moreover, it is verified that in nonlinear viscoelastic cases, the time-temperature shift factors are dependent on stresses at which the shifts are applied, while the time-stress shift factors are dependent on temperatures. | Wenbo Luo Chuhong Wang Xiaoling Hu Tingqing Yang | 2012 | Acta Mechanica Solida Sinica2012，25，6： | 8 |
| 2 | Construction of a small-caliber tissue-engineered blood vessel using icariin-loaded β-cyclodextrin sulfate for in situ anticoagulation and endothelialization显示文摘The rapid endothelialization of tissue-engineered blood vessels(TEBVs) can effectively prevent thrombosis and inhibit intimal hyperplasia. The traditional Chinese medicine ingredient icariin is highly promising for the treatment of cardiovascular diseases.β-cyclodextrin sulfate is a type of hollow molecule that has good biocompatibility and anticoagulation properties and exhibits a sustained release of icariin. We studied whether icariin-loaded β-cyclodextrin sulfate can promote the endothelialization of TEBVs. The experimental results showed that icariin could significantly promote the proliferation and migration of endothelial progenitor cells; at the same time, icariin could promote the migration of rat vascular endothelial cells(RAVECs). Subsequently,we used an electrostatic force to modify the surface of the TEBVs with icariin-loaded β-cyclodextrin sulfate, and these vessels were implanted into the rat common carotid artery. After 3 months, micro-CT results showed that the TEBVs modified using icariin-loaded β-cyclodextrin sulfate had a greater patency rate. Scanning electron microscopy(SEM) and CD31 immunofluorescence results showed a better degree of endothelialization. Taken together, icariin-loaded β-cyclodextrin sulfate can achieve anticoagulation and rapid endothelialization of TEBVs to ensure their long-term patency. | Jingyuan Yang Keyu Wei Yeqin Wang Yanzhao Li Ning Ding Da Huo Tianran Wang Guanyuan Yang Mingcan Yang Tan Ju Wen Zeng Chuhong Zhu | 2018 | Science China(Life Sciences)2018，61，10： | 5 |
| 3 | 3D hierarchically porous NiO/Graphene hybrid paper anode for long-life and high rate cycling flexible Li-ion batteries显示文摘With the rapid emergence of wearable devices, flexible lithium-ion batteries(LIBs) are much more needed than ever. Free-standing graphene-based composite paper electrodes with various active materials have appealed wide applications in flexible LIBs. However, due to the prone-to-restacking feature of graphene layers, a long cycle life at high current densities is rather difficult to be achieved. Herein, a unique threedimensional(3D) hierarchically porous NiO micro-flowers/graphene paper(fNiO/GP) electrode is successfully fabricated. The resulting fNiO/GP electrode shows superior long-term cycling stability at high rates(e.g., storage capacity of 359 mAh/g after 600 cycles at a high current density of 1 A/g). The facile 3D porous structure combines both the advantages of the graphene that is highly conductive and flexible to ensure rapid electrons/ions transfer and buffer the volume expansion of NiO during charge/discharge,and of the micro-sized NiO flowers that induces hierarchical between-layer pores ranging from nanomicro meters to promote the penetration of the electrolyte and prevent the re-stacking of graphene layers. Such structural design will inspire future manufacture of a wide range of active materials/graphene composite electrodes for high performance flexible LIBs. | Ju Fu Wenbin Kang Xiaodong Guo Hao Wen Tianbiao Zeng Ruoxin Yuan Chuhong Zhang | 2020 | Journal of Energy Chemistry2020，29，8： | 5 |
| 4 | The potential value of microRNA-4463 in the prognosis evaluation in hepatocellular carcinoma显示文摘The purpose of this study is to measure the expression of microRNA-4463 and microRNA-6087 between normal persons and patients with hepatocellular carcinoma(HCC),and to clarify the meaning of them in the prognosis evaluation in HCC.Forty-five samples from healthy people and patients,who had been diagnosed with hepatocellular carcinoma before any treatment,were collected to study respectively.Real-time PCR was used to detect the expression of miRNA-4463 and miRNA-6087 in the serum of control group and hepatocellular carcinoma patients.The expression of miR-4463 in the serum of HCC patients was significantly higher than that in control group(P<0.05),and the expression level was independent of gender,tumor size,cell types,stages,alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL)and HBsAg status(P>0.05).But there was a significant difference of different level of AFP in HCC(P<0.05),and the difference between the group of AFP lower than 400 ug/l and the control group is statistically significant(P<0.05).Besides,the survival time had showed a significant difference at the high and low expression levels(P<0.05).But the expression level of miRNA-6087 was no difference in HCC and control group.The disorder of miRNA-4463 occurred in HCC,even the AFP level doesn’t rises.What’s more,patients who get the high level of miRNA-4463 seem to have a shorter survival time.And it contributes great to the prognostic evaluation.This is the first study to illustrate the potential significance of miRNA-4463 in the prognosis in HCC. | Tian Hu Jincheng Li Chuhong Zhang Xiu lv Sai Li Sha He Hanxing Yan Yixi Tan Mingsheng Lei Meiling Wen Jianhong Zuo | 2017 | Genes & Diseases2017，4，2： | 3 |
| 5 | Highly concentrated graphene oxide ink for facile 3D printing of supercapacitors显示文摘3D printing of functional energy storage devices is receiving escalating attention over the years due to the customizable manufacturing flexibility and imparted high areal and gravimetric energy density of three-dimensional structured devices, which contribute to the creation of numerous new opportunities for futuristic electronics. Graphene-based inks are ideal elements for the realization of 3D printed energy storage devices if the attractive intrinsic physiochemical properties of graphene could be preserved. However, it is still a great challenge to prepare uniformly dispersed graphene-based materials with desired rheological properties for 3D printing. Here we report a facile strategy for 3D printing of supercapacitors from a highly concentrated graphene oxide (GO) ink. The GO is properly dispersed and the ink fulfills the stringent rheological specifications for 3D printing. The printed GO electrode is functionalized with enhanced structural stability for proper reduction to graphene. The printed supercapacitors deliver the potential to linearly scale up in areal capacitance without jeopardizing the gravimetric capacitance when increasing printed layers. The results hold great promise for the construction of 3D structured energy storage devices that cater to the challenges from next-generation electronics. | Shangwen Ling Wenbin Kang Shanwen Tao Chuhong Zhang | 2019 | Nano Materials Science2019，1，2： | 3 |
| 6 | Hexagonally arranged arrays of urchin-like Ag hemispheres decorated with Ag nanoparticles for surface-enhanced Raman scattering substrates显示文摘The surface topography of noble metal particles is a significant factor in tailoring surface-enhanced Raman scattering (SERS) properties. Here, we present a simple fabrication route to hexagonally arranged arrays of surface-roughened urchin- like Ag hemispheres (Ag-HSs) decorated with Ag nanoparticles (Ag-NPs) for highly active and reproducible SERS substrates. The urchin-like Ag-HS arrays are achieved by sputtering Ag onto the top surface of a highly ordered porous anodic aluminum oxide (AAO) template to form ordered arrays of smooth Ag-HSs and then by electrodepositing Ag-NPs onto the surface of each Ag-HS. Owing to the ordered arrangement of the Ag-HSs and the improved surface roughness, the urchin-like hierarchical Ag-HS arrays can provide sufficient and uniform "hot spots" for reproducible and highly active SERS effects. Using the urchin-like Ag-HS arrays as SERS substrates, 10-7 M dibutyl phthalate (a member of plasticizers family) and 1.5 × 10-5 M PCB-77 (one congener of polychlorinated biphenyl, a notorious class of pollutants) are identified, showing promising potential for these substrates in the rapid recognition of organic pollutants. | Haibin Tang Guowen Meng Zhongbo Li Chuhong Zhu Zhulin Huang Zhaoming Wang Fadi Li | 2015 | Nano Research2015，8，7： | 3 |
| 7 | COVID-19-associated monocytic encephalitis(CAME):histological and proteomic evidence from autopsy显示文摘Severe neurological symptoms are associated with Coronavirus disease 2019(COVID-19).However,the morphologic features,pathological nature and their potential mechanisms in patient brains have not been revealed despite evidence of neurotropic infection.In this study,neuropathological damages and infiltrating inflammatory cells were quantitatively evaluated by immunohistochemical staining,ultrastructural examination under electron microscopy,and an image threshold method,in postmortem brains from nine critically ill COVID-19 patients and nine age-matched cadavers of healthy individuals.Differentially expressed proteins were identified by quantitative proteomic assays.Histopathological findings included neurophagocytosis,microglia nodules,satellite phenomena,extensive edema,focal hemorrhage,and infarction,as well as infiltrating mononuclear cells.Immunostaining of COVID-19 brains revealed extensive activation of both microglia and astrocytes,severe damage of the blood-brain barrier(BBB)and various degrees of perivascular infiltration by predominantly CD14+/CD16+/CD141+/CCR7+/CD11c+monocytes and occasionally CD4+/CD8+T lymphocytes.Quantitative proteomic assays combined with bioinformatics analysis identified upregulated proteins predominantly involved in immune responses,autophagy and cellular metabolism in COVID-19 patient brains compared with control brains.Proteins involved in brain development,neuroprotection,and extracellular matrix proteins of the basement membrane were downregulated,potentially caused by the activation of transforming growth factorβreceptor and vascular endothelial growth factor signaling pathways.Thus,our results define histopathological and molecular profiles of COVID-19-associated monocytic encephalitis(CAME)and suggest potential therapeutic targets. | Pei-Pei Zhang Zhi-Cheng He Xiao-Hong Yao Rui Tang Jie Ma Tao Luo Chuhong Zhu Tian-Ran Li Xindong Liu Dingyu Zhang Shuyang Zhang Yi-Fang Ping Ling Leng Xiu-Wu Bian | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 3 |
| 8 | ZnO-nanotaper array sacrificial templated synthesis of noble-metal building-block assembled nanotube arrays as 3D SERS-substrates显示文摘这份报纸描述一个 ZnO-nanotaper 数组为有试管墙的 nanotubes 的数组的制造的合成途径由 Ag-nanoplates, Au-nanorods, Pt-nanothorns 或 Pd-nanopyramids 的大楼块装配了的牺牲的 templated,因此拥有高密度的 3D 在有 nano 尖端,角落或边的附近的积木的 sub-10-nm 差距的热点。另外,这些层次 nanostructure 数组与富有的表面化学拥有高表面区域,对捕获 analyte 有益。Ag-nanoplateassembled nanotube 数组能被用作散布的敏感提高表面的拉曼(重量的单位) 有好信号一致性和重制度的底层。用如此的 Ag ,层次 nanostructure 作为重量的单位底层穿,不是仅仅有 10 <啜class=“ a-plus-plus ”> 14 M 玫瑰精 6G 识别,而且 10 <啜class=“ a-plus-plus ”> 7 M polychlorinated 联本基(印刷电路板,坚持的器官的污染物质的一个臭名昭著的班)被认出,并且甚至印刷电路板的二同种的物能在混合物被识别,在环境器官的污染物质的基于重量的单位的快速的察觉显示出材料的潜在的应用。 | Chuhong Zhu Guowen Meng Qing Huang Xiujuan Wang Yiwu Qian Xiaoye Hu Haibin Tang Nianqiang Wu | 2015 | Nano Research2015，8，3： | 3 |
| 9 | The role of hypoxia-inducible factors in tumor angiogenesis and cell metabolism显示文摘Hypoxia-inducible factor(HIF)is a main heterodimeric transcription factor that regulates the cellular adaptive response to hypoxia by stimulating the transcription of a series of hypoxia-inducible genes.HIF is frequently upregulated in solid tumors,and the overexpression of HIF can promote tumor progression or aggressiveness by blood vessel architecture and altering cellular metabolism.In this review,we focused on the pivotal role of HIF in tumor angiogenesis and energy metabolism.Furthermore,we also emphasized the possibility of HIF pathway as a potential therapeutic target in cancer. | Xiu Lv Jincheng Li Chuhong Zhang Tian Hu Sai Li Sha He Hanxing Yan Yixi Tan Mingsheng Lei Meiling Wen Jianhong Zuo | 2017 | Genes & Diseases2017，4，1： | 3 |
| 10 | Current advances and future perspectives of additive manufacturing for functional polymeric materials and devices显示文摘Three-dimensional(3D)printing has received extensive attention due to its unique multidimensional functionality and customizability and has been recognized as one of the most revolutionary manufacturing technologies.Functional 3D printed products represent an important orientation for next-generationmanufacturing and attract a great spotlight for the application in sensors,actuators,robots,electronics,and medical devices.However,the lack of functions of printing polymeric materials dramatically limits the development of functional 3D printing.Different from traditional processing,the physical properties,such as geometry and rheological behavior,of the polymericmaterialsmust match the printing process,making the selection of printable materials limited.More importantly,challenges in large-scale production of such materials further stifle the development of functional 3D printing industry.In this review,we aim to outline recent advances in polymeric materials and methodologies for the functional 3D printing technology.The reports are classified based on functionalities,including electronic conductive,thermally conductive,electromagnetic interference shielding,energy storage,and energy harvesting materials.This study attempts to provide a comprehensive overview of the challenges and opportunities for 3D printing functional polymeric materials/devices,also seeks to enlighten the orientation of future research in this field. | Chuhong Zhang Yijun Li Wenbin Kang Xingang Liu Qi Wang | 2021 | SusMat2021，1，1： | 2 |
| 11 | Engineering hiPSC-CM and hiPSC-EC laden 3D nanofibrous splenic hydrogel for improving cardiac function through revascularization and remuscularization in infarcted heart显示文摘Cell therapy has been a promising strategy for cardiac repair after myocardial infarction(MI),but a poor ischemic environment and low cell delivery efficiency remain significant challenges.The spleen serves as a hematopoietic stem cell niche and secretes cardioprotective factors after MI,but it is unclear whether it could be used for human pluripotent stem cell(hiPSC)cultivation and provide a proper microenvironment for cell grafts against the ischemic environment.Herein,we developed a splenic extracellular matrix derived thermoresponsive hydrogel(SpGel).Proteomics analysis indicated that SpGel is enriched with proteins known to modulate the Wnt signaling pathway,cell-substrate adhesion,cardiac muscle contraction and oxidation-reduction processes.In vitro studies demonstrated that hiPSCs could be efficiently induced into endothelial cells(iECs)and cardiomyocytes(iCMs)with enhanced function on SpGel.The cytoprotective effect of SpGel on iECs/iCMs against oxidative stress damage was also proven.Furthermore,in vivo studies revealed that iEC/iCM-laden SpGel improved cardiac function and inhibited cardiac fibrosis of infarcted hearts by improving cell survival,revascularization and remuscularization.In conclusion,we successfully established a novel platform for the efficient generation and delivery of autologous cell grafts,which could be a promising clinical therapeutic strategy for cardiac repair and regeneration after MI. | Ge Guan Da Huo Yanzhao Li Xiaolin Zhao Yinghao Li Zhongliang Qin Dayu Sun Guanyuan Yang Mingcan Yang Ju Tan Wen Zeng Chuhong Zhu | 2021 | Bioactive Materials2021，6，12： | 2 |
| 12 | An expert system for fault diagnosis in internal combustion engines using wavelet packet transform and neural network显示文摘 | WU JIANDA LIU CHUHONG | 2009 | Expert Systems with Applications2009，36，3： | 1 |
| 13 | A hypothesis testing approach to semifragile watermark-based authentication显示文摘 | Chuhong Fei Raymond H Kwong Deepa Kundur | | 0，，2： | 1 |
| 14 | The promotion of endothelial progenitor cells recruitment by nerve growth factors in tissue-engineered blood vessels显示文摘 | Wen Zeng Wei Yuan Li Li Jianhong Mi Shangcheng Xu Can Wen Zhenhua Zhou Jiaqiang xiong Jiansen Sun Dajun Ying Mingcan Yang Xiaosong Li Chuhong Zhu | 2009 | Biomaterials2009，，7： | 1 |
| 15 | Study on ultrasonic induced encapsulation emulsion polymerization in the presence of nanoparticles 显示文摘 | Xia Hesheng Zhang Chuhong Wang Qi | 2001 | J Appl Polym Sci2001，80，8： | 1 |
| 16 | Preparation of pol- ymer/inorganic nanoparticles composites through ultrasonic irradiation 显示文摘 | Wang Qi Xia Hesheng Zhang Chuhong | 2001 | Journal of Applied Polymer Science2001，80，9： | 1 |
| 17 | Study on ultrason- ic induced encapsulating emulsion polymerization in the pres-ence of nanoparticles 显示文摘 | Xia Hesheng Zhang Chuhong Wang Qi | 2001 | Journal of Applied Polymer Sci- ence2001，80，8： | 1 |
| 18 | Programming of Regulatory T Cells In Situ for Nerve Regeneration and Long-Term Patency of Vascular Grafts显示文摘Rapid integration into the host tissue is critical for long-term patency after small diameter tissue engineering vascular grafts(sdTEVGs)transplantation.Neural recognition may be required for host integration and functionalization of the graft.However,immune rejection and inflammation hinder nerve regeneration of sdTEVGs.Here,a CRISPR/dCas9-nanocarrier was used for targeted programming of regulatory T cells(Treg cells)in situ to promote nerve regeneration of sdTEVGs by preventing excessive inflammation.Treg cells and(C-C chemokine receptor)CCR2+macrophage recruitment occurred after transplantation.The nanodelivery system upregulated ten eleven translocation(TET2)in Treg cells in vitro.Reprogrammed Treg cells upregulated anti-inflammatory cytokines and decreased the proportion of CCR2+macrophages.IL-6 concentrations decreased to the levels required for nerve regeneration.Implantation of CRISPR/dCas9 nanodelivery system-modified sdTEVGs in rats resulted in Treg cell editing,control of excessive inflammation,and promoted nerve regeneration.After 3 months,nerve regeneration was similar to that observed in normal blood vessels;good immune homeostasis,consistency of hemodynamics,and matrix regeneration were observed.Neural recognition promotes further integration of the graft into the host,with unobstructed blood vessels without intimal hyperplasia.Our findings provide new insights into vascular implant functionalization by the host. | Yanhong Wang Fangchao Xue Yanzhao Li Lin Lin Yeqin Wang Shanlan Zhao Xingli Zhao Yong Liu Ju Tan Gang Li Haoran Xiao Juan Yan Hao Tian Min Liu Qiao Zhang Zhaojing Ba Lang He Wenyan Zhao Chuhong Zhu Wen Zeng | 2022 | Research2022，，4： | 1 |
| 19 | The power line carrier eommunieation channel modeling teehnology re- view 显示文摘 | Cai Wei Le Jian Jin Chao Huang Chuhong Zheng Xue | | Department of eleetrieal engineering0，，： | 1 |
| 20 | A study of suicidal ideation in acute ischemic stroke patients显示文摘 | DOU Jin TANG Jie LU Chuhong | 2015 | Health Quality Life Outcomes2015，13，7： | 1 |
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