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| 1 | Enhanced efficiency of generating induced pluripotent stem (iPS) cells from human somatic cells by a combination of six transcription factors显示文摘 | Jing Liao Zhao Wu Ying Wang Lu Cheng Chun Cui Yuan Gao Taotao Chen Lingjun Rao Siye Chen Nannan Jia Huiming Dai Shunmei Xin Jiuhong Kang Gang Pei Lei Xiao | 2008 | Cell Research2008，18，5： | 61 |
| 2 | Reprogramming of ovine adult fibroblasts to pluripotency via drug-inducible expression of defined factors显示文摘在 enucleated 鸡蛋的体的房间的 Reprogramming 做了多丽,绵羊,在 1996 的第一个成功地克隆的哺乳动物。然而,绵羊的机制体的房间 reprogramming 还没被探讨了。而且,绵羊胚胎的茎(ES ) 细胞仍然不是可得到的,它限制精确修改基因的绵羊的产生。在这研究,我们报导体的房间能是的那只绵羊直接 reprogrammed 到导致的 pluripotent 用定义因素(Oct4, Sox2, c-Myc, Klf4, Nanog, Lin28, SV40 大 T 和 hTERT ) 的茎(iPS ) 房间。我们的观察显示从绵羊的体的细胞比从另外的种,在 iPS,细胞被报导了的体的细胞对改编更困难。我们证明绵羊 iPS 房间表示 ES 房间标记,包括碱的磷酸酶, Oct4, Nanog, Sox2, Rex1,阶段特定的胚胎的 antigen-1, TRA-1-60, TRA-1-81 和 E-cadherin。绵羊 iPS 房间展出了正常 karyotypes 并且能在 vitro 并且在 teratomas 区分进所有三细菌层。我们的学习可以帮助在绵羊揭示体的房间 reprogramming 的机制并且提供一个平台为绵羊 ES 房间探索文化条件。而且,绵羊 iPS 房间可以直接被用来产生精确修改基因的绵羊。 | Lei Bao Lixiazi He Jijun Chen Zhao Wu Jing Liao Lmgdun Rao Jiangtao Ren Hui Li Hui Zhu Lei Qian Yijun Gu Huimin Dai Xun Xu Jinqiu Zhou Wen Wang Chun Cui Lei Xiao | 2011 | Cell Research2011，21，4： | 32 |
| 3 | In vitro differentiation of rat embryonic stem cells into functional cardiomyocytes显示文摘在老鼠的产生的最近的突破胚胎的干细胞(rESCs ) 打开门到基因指向为人的疾病的学习创造模型的申请。另外,在里面从进三细菌层的衍生物的 rESCs 的 vitro 区别系统将为哺乳动物的开发,房间函数,织物修理,和药发现的调查用作一个强大的工具和资源。然而,这些使用被困难限制了在 vitro 区别。这研究的目的是建立一在里面从 rESCs 并且到的 vitro 区别系统调查 rESCs 是否能够形成区分终端的 cardiomyocytes。用最新确定的 rESCs,我们发现那胚胎植物或动物身体(EB ) 基于在没能为没有浆液的栽培 rESCs 工作的老鼠转换字符(mESC ) 区别使用的方法。我们然后由三个化学禁止者和喂调节媒介的联合开发了一个协议。在这个条件下面, rESCs 变成了 EB,宣传并且区分三胚胎的细菌层。而且,形成 rESC 的 EB 能区分进自发地在 plating 以后打败 cardiomyocytes。分子、结构、功能的性质的分析表明导出 rESC 的 cardiomyocytes 类似于从胎儿的老鼠心和 mESCs 导出的那些。在结论,我们成功地发展了一在里面为功能的 myocytes 通过被产生并且显示老鼠的显型的 rESCs 的 vitro 区别系统胎儿的 cardiomyocytes。这个唯一的细胞的系统将提供一条新途径学习早开发和心脏的功能,并且在测试的药理学和房间治疗用作一个重要工具。 | Nan Cao Jing Liao Zumei Liu Wenmin Zhu Jia Wang Lijun Liu Lili Yu Ping Xu Chun Cui Lei Xiao Huang-Tian Yang | 2011 | Cell Research2011，21，9： | 13 |
| 4 | Generation of hircine-induced pluripotent stem cells by somatic cell reprogramming显示文摘 | Jiangtao Ren Yongjun Pak Lixiazi He Lei Qian Yijun Gu Hui Li Lingjun Rao Jing Liao Chun Cui Xun Xu Jinqiu Zhou Hakchol Ri Lei Xiao | 2011 | Cell Research2011，21，5： | 10 |
| 5 | Clinical Characteristics of Children with Coronavirus Disease 2019 in Hubei, China显示文摘Since December 2019,COVID-19 has occurred unexpectedly and emerged as a health problem worldw ide.Despite the rapidly increasing number of cases in subsequent weeks,the clinical characteristics of pediatric cases are rarely described.A cross-sectional multicenter study was carried out in 10 hospitals across Hubei province.A total of 25 confirmed pediatric cases of COVID-19 were collected.The demographic data,epidemiological history,underlying discascs,clinical mani festations,laboratory and radiological data,treatments,and outcomes were analyzcd.Of 25 hospitalized patients with COVID-19,the boy to girl ratio was 1.27:1.The median age was 3 years.COVID-19 cases in children aged<3 years,3-6 years,and≥6-years patients were 10(40%),6(24%),and 9(36%),respectively.The most common symptoms at onset of ilness were fever(13[52%]),and dry cough(11[44%]).Chest CT images showed essential normal in 8 cases(33.3%),unilateral involvement of lungs in 5 cases(20.8%),and bilateral involvement in 11 cases(45.8%).Clinical diagnoses included upper respiratory tract infection(n=8),mild pneumonia(n=15),and critical cases(n=2).Two critical cases(8%)were given invasive mechanical ventilation,corticosteroids,and immunoglobulin.The symptoms in 24(96%)of 25 patients were alleviated and one patient had been discharged.It was concluded that children were susceptible to COVID-19 like adults,while the clinical presentations and outcomes were more favorable in children.However,children less than 3 years old accounted for majority cases and critical cases lied in this age group,which demanded extra attentions during home caring and hospitalization treatment. | Fang ZHENG Chun LIAO Qi-hong FAN Hong-bo CHEN Xue-gong ZHAO Zhong-guo XIE Xi-lin LI Chun-xi CHEN Xiao-xia LU Zhi-sheng LIU Wei LU Chun-bao CHEN Rong JIAO Ai-ming ZHANG Jin-tang WANG Xi-wei DING Yao-guang ZENG Li-ping CHENG Qing-feng HUANG Jiang WU Xi-chang LUO Zhu-jun WANG Yan-yan ZHONG Yan BAI Xiao-yan WU Run-ming JIN | 2020 | Current Medical Science2020，40，2： | 10 |
| 6 | Morphologies of Al_4Sr Intermetallic Phase and Its Modification Property upon A356 Alloys显示文摘In general,the modification performance of Al-Sr master alloys is primarily dependent upon the morphologies and sizes of the Al_4Sr intermetallic phase.In this paper,the crystal structure,morphologies,sizes,hardness and elastic modulus of Al_4Sr in Al-Sr master alloys prepared from variant processes were studied by means of optical metallurgical microscope,X-ray diffraction(XRD),scanning electron microscopy(SEM),and nanoindentation system.The results revealed that the microstructures and modification performance of the Al_4Sr phase were related to the preparation processes.That is to say,when a 'direct reaction-hot extrusion' process was used,the Al_4Sr phase exhibited a homogeneous distribution in the Al matrix with small size and roundish shapes,which ensured the Al-Sr master alloy wire advantages involving high recovery,good reproducibility,no delitescence of modification,no corrosion on equipments,and good workability.However,in the case of the traditional 'direct reaction' process,the Al4Sr phase was in large size with shapes of rectangular stripe and plates,which limited the Sr content increasing due to the brittleness of the Al-Sr alloy.It was also found that the morphology and size of the Al_4Sr phases changed during heat treatment at high temperature up to 600 ℃. | Chengwei Liao Jianchun Chun Yang Li Rui Tu Chunxu Pan | 2012 | Journal of Materials Science & Technology2012，28，6： | 7 |
| 7 | Preparation and characterization O-lauroyl chitosan/poly (L-lactic acid) blend membranes by solution-casting approach显示文摘O-Lauroyl chitosan/poly(L-lactide) (OCS/PLLA) blend membranes with different compositions were prepared by solution-casting approach using chloroform as common solvent. The experimental results of FT-IR, DSC and WAXD indicated that inter-association hydrogen-bond interactions existed between OCS and PLLA in the blend membranes. And SEM observation confirmed that the blend membranes with suitable compositions were compatible. | Yao Zu Liao Mei Hua Xin Ming Chun Li Sheng Su | 2007 | Chinese Chemical Letters2007，18，2： | 4 |
| 8 | Abrogation of Hn RNP L enhances anti-PD-1 therapy efficacy via diminishing PD-L1 and promoting CD8^(+) T cell-mediated ferroptosis in castration-resistant prostate cancer显示文摘Owing to incurable castration-resistant prostate cancer(CRPC)ultimately developing after treating with androgen deprivation therapy(ADT),it is vital to devise new therapeutic strategies to treat CRPC.Treatments that target programmed cell death protein 1(PD-1)and programmed death ligand-1(PD-L1)have been approved for human cancers with clinical benefit.However,many patients,especially prostate cancer,fail to respond to anti-PD-1/PD-L1 treatment,so it is an urgent need to seek a support strategy for improving the traditional PD-1/PD-L1 targeting immunotherapy.In the present study,analyzing the data from our prostate cancer tissue microarray,we found that PD-L1 expression was positively correlated with the expression of heterogeneous nuclear ribonucleoprotein L(Hn RNP L).Hence,we further investigated the potential role of Hn RNP L on the PD-L1 expression,the sensitivity of cancer cells to T-cell killing and the synergistic effect with anti-PD-1 therapy in CRPC.Indeed,Hn RNP L knockdown effectively decreased PD-L1 expression and recovered the sensitivity of cancer cells to T-cell killing in vitro and in vivo,on the contrary,Hn RNP L overexpression led to the opposite effect in CRPC cells.In addition,consistent with the previous study,we revealed that ferroptosis played a critical role in T-cell-induced cancer cell death,and Hn RNP L promoted the cancer immune escape partly through targeting YY1/PD-L1 axis and inhibiting ferroptosis in CRPC cells.Furthermore,Hn RNP L knockdown enhanced antitumor immunity by recruiting infiltrating CD8^(+)T cells and synergized with anti-PD-1 therapy in CRPC tumors.This study provided biological evidence that Hn RNP L knockdown might be a novel therapeutic agent in PD-L1/PD-1 blockade strategy that enhanced anti-tumor immune response in CRPC. | Xumin Zhou Libin Zou Hangyu Liao Junqi Luo Taowei Yang Jun Wu Wenbin Chen Kaihui Wu Shengren Cen Daojun Lv Fangpeng Shu Yu Yang Chun Li Bingkun Li Xiangming Mao | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 4 |
| 9 | Outcomes of percutaneous coronary intervention in patients ≥ 75 years: one-center study in a Chinese patient group显示文摘ObjectiveTo 调查临床并且病人 ≥ 的 perioperative 特征;75 经历经皮的冠的干预(一种总线标准) 并且从 2011 年 12 月经历了一种总线标准到 2013 年 11 月的连续题目被划分在这特定的病人 group.Methods1,035 评估与短期的一种总线标准以后的死亡有关的风险因素成四个范畴:(1 ) 有稳定的咽峡炎(SA ) 的病人 ≥75 年(n = 58 ) ;(2 ) 有 SA < 的病人;75 年(n = 218 ) ;(3 ) 有急性冠的症候群(交流) 的病人 ≥75 年(n = 155 ) ;(4 ) 有交流 < 的病人;75 年(n = 604 ) 。multivariable 逻辑回归分析被进行在病人 ≥ 检测六月的死亡的风险因素;75 年经历了一种总线标准。临床的 comorbidities,在里面医院生物化学的指示物, perioperative 数据,在里面医院和六月的结果与更年轻的组,一起在四 groups.ResultsCompared 之中被分析并且比较病人 ≥75 年是更可能的有高血压,中风的历史,长期的妨碍的肺的疾病,外部脉管的疾病,心脏性的吃惊和恶意的心律不齐,并且他们与相对更低的重量,血红素,白朊, triglyceride,更高的 creatinine,尿酸,脲氮和 pro-BNP 进入医院。左主要动脉损害,多容器,钙化的损害,长期完全吸藏也是更可能的在老组被看。Univariate 分析揭示了那年龄 ≥在承认,紧急情况一种总线标准,优先的击和长期的肾疾病的 85 年,心脏性的吃惊或严重心律不齐与在老病人 ≥ 的六月的死亡有关;75 年经历了一种总线标准。Multivariable 逻辑回归证明在承认,长期的肾疾病和优先的击的心脏性的吃惊或严重心律不齐是在老病人 ≥ 预言六月的死亡的独立风险因素;75 年经历了 PCI.ConclusionsOur 数据的人,显示出那与在 75 年下面的病人相比,老病人(≥75 年) 经历了一种总线标准的人,有经常伴有 multi-comorbidities, severer 承认条件和复杂冠的损害的死亡,和更多的相对更高的风险。因素和更多强烈地在乎的风险的更好的评估应该被带去病人 ≥75 年经历了一种总线标准治疗减少复杂并发症。 | Peng-Fei CHEN Dan-Ning WANG Kan CHEN Chun LIANG Yu-Sheng RENG Jing YANG Ru DING Jacob Blackwell De-Ning LIAO | 2015 | Journal of Geriatric Cardiology2015，12，6： | 4 |
| 10 | Highly dispersed Co-Mo sulfide nanoparticles on reduced graphene oxide for lithium and sodium ion storage显示文摘A novel hybrid,highly dispersed spinel Co-Mo sulfide nanoparticles on reduced graphene oxide(Co3S4/CoMo2S4@rGO),is reported as anode for lithium and sodium ion storage.The hybrid is synthesized by one-step hydrothermal method but exhibits excellent lithium and sodium storage performances.The as-synthesized Co3S4/CoMo2S4@rGO presents reversible capacity of 595.4 mA·h·g^−1 and 408.8 mA·h·g^−1 after 100 cycles at a current density of 0.2 A·g^−1 for lithium and sodium ion storages,respectively.Such superior performances are attributed to the unique composition and structure of Co3S4/CoMo2S4@rGO.The rGO provides a good electronically conductive network and ensures the formation of spinel Co3S4/CoMo2S4 nanoparticles,the Co3S4/CoMo2S4 nanoparticles provide large reaction surface for lithium and sodium intercalation/deintercalation,and the spinel structure allows fast lithium and sodium ion diffusion in three dimensions. | Yuqing Liao Chun Wu Yaotang Zhong Min Chen Luyang Cai Huirong Wang Xiang Liu Guozhong Cao Weishan Li | 2020 | Nano Research2020，13，1： | 4 |
| 11 | Erlotinib versus gemcitabine plus cisplatin as neoadjuvant treatment of stage IIIA-N2 EGFR-mutant non-small-cell lung cancer:final overall survival analysis of the EMERGING-CTONG 1103 randomised phase II trial显示文摘EMERGING-CTONG 1103 showed improved progression-free survival(PFS)with neoadjuvant erlotinib vs.chemotherapy for patients harbouring EGFR sensibility mutations and R0 resected stage IIIA-N2 non-small cell lung cancer(NSCLC)(NCT01407822).Herein,we report the final results.Recruited patients were randomly allocated 1:1 to the erlotinib group(150 mg/day orally;neoadjuvant phase for 42 days and adjuvant phase to 12 months)or to the GC group(gemcitabine 1250 mg/m2 plus cisplatin 75 mg/m2 intravenously;2 cycles in neoadjuvant phase and 2 cycles in adjuvant phase).Objective response rate(ORR),complete pathologic response(pCR),PFS,and overall survival(OS)were assessed along with safety.Post hoc analysis was performed for subsequent treatments after disease recurrence.Among investigated 72 patients(erlotinib,n=37;GC,n=35),the median follow-up was 62.5 months.The median OS was 42.2 months(erlotinib)and 36.9 months(GC)(hazard ratio[HR],0.83;95%confidence interval[CI],0.47-1.47;p=0.513).The 3-and_(5-y)ear OS rates were 58.6%and 40.8%with erlotinib and 55.9%and 27.6%with GC(p_(3-y)=0.819,p_(5-y)=0.252).Subsequent treatment was administered in 71.9%and 81.8%of patients receiving erlotinib and GC,respectively;targeted therapy contributed mostly to OS(HR,0.35;95%CI,0.18-0.70).After disease progression,the ORR was 53.3%,and the median PFS was 10.9 months during the EGFR-TKI rechallenge.During postoperative therapy,grade 3 or 4 adverse events(AEs)were 13.5%in the erlotinib group and 29.4%in the GC group.No serious adverse events were observed.Erlotinib exhibited clinical feasibility for resectable IIIA-N2 NSCLC over chemotherapy in the neoadjuvant setting. | Wen-Zhao Zhong Hong-Hong Yan Ke-Neng Chen Chun Chen Chun-Dong Gu Jun Wang Xue-Ning Yang Wei-Min Mao Qun Wang Gui-Bin Qiao Ying Cheng Lin Xu Chang-Li Wang Ming-Wei Chen Xiao-Zheng Kang Wan-Pu Yan Ri-Qiang Liao Jin-Ji Yang Xu-Chao Zhang Si-Yang Liu Qing Zhou Yi-Long Wu | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 4 |
| 12 | A Hybrid Method of Domain Lexicon Construction for Opinion Targets Extraction Using Syntax and Semantics显示文摘中国 microblogs 的意见目标抽取在意见采矿起一个重要作用。最近在这个区域有重要进步,特别方法基于有条件的随机的地(CRF ) 。然而,这个方法仅仅考虑词典相关的特征并且不挖掘暗示了语法、语义的知识。我们建议与一些句法、语义的特征一起合并领域词典的一条新奇途径。途径通过基于词嵌入通过 Partof 讲话,相关性结构,短语结构,语义角色和语义类似探索语法、语义的信息的一个新奇方法获得领域词典。然后我们把领域词典与意见目标为意见目标抽取与一些特征一起从 CRF 提取了相结合。COAE2014 数据集上的试验性的结果在意见目标抽取的任务与另外的著名方法相比显示出途径的 outperformance。 | Chun Liao Chong Feng Sen Yang He-Yan Huang | 2016 | Journal of Computer Science & Technology2016，31，3： | 4 |
| 13 | Prognostic Factors for Luminal B-like Breast Cancer显示文摘This study aimed to examine the prognostic factors of luminal B-like breast cancer.Clinical data of 695 luminal B-like breast cancer patients who had been treated in our hospital during the period of past 4.5 years were collected and analyzed. Estrogen receptor (ER), progesterone receptor (PgR), antigen identified by monoclonal antibody Ki-67 (Ki67) were immunohistochemically detected. Different cutoffs of ER, PgR, and Ki67 were evaluated. Pearson X test was performed to compare categorical parameters. Univariate and multivariate models were used to evaluate predictors of disease free survival (DFS). The results showed that patients who were younger, and had larger tumors, and more positive lymph nodes were more likely to receive neo-adjuvent chemotherapy (NAC). Patients with ER-positive tumors having <10% positive cells received more anthracycline- and taxane-based chemotherapy and less endocrine therapy than those with ER-positive tumors having >10% positive cells (P=0.004 and P=0.007, respectively);however, patients with ER-positive tumors having <10% positive cells experienced more recurrence (P<0.001). PgR expression levels were not associated with therapeutic schedule and DFS. Patients with tumor tissue Ki67 score >30% received more anthracycline- and taxane-based chemotherapy and had worse DFS than those with tumor tissue Ki67 score <30%. Univariate and multivariate analysis showed that clinical T stage, lymph nodes, ER, Ki67, and HER2 status were independent prognostic factors. In conclusion, ER-positive rate <10% and Ki67 score >30%, similar to higher clinical T stage, more metastatic lymph nodes, and HER2 positive status, may indicate a worse prognosis for luminal B-like breast cancer patients. Multi-center prospective trials with larger sample sizes are necessary for the continued perfection of our work. | Nian-hua DING Cong-fan LIU Chun HU Jia-qi YUAN Wei-hua LIAO Zhi XIAO | 2019 | Current Medical Science2019，39，3： | 4 |
| 14 | Peginterferon Alfa-2a Plus Ribavirin for the Treatment of Dual Chronic Infection With Hepatitis B and C Viruses显示文摘 | Chun–Jen Liu Wan–Long Chuang Chuan–Mo Lee Ming–Lung Yu Sheng–Nan Lu Shun–Sheng Wu Li–Ying Liao Chi–Ling Chen Hsing–Tao Kuo You–Chen Chao Shui–Yi Tung Sien–Sing Yang Jia–Horng Kao Chen–Hua Liu Wei–Wen Su Chih–Lin Lin Yung–Ming Jeng Pei–Jer Chen Ding–Shinn | 2009 | Gastroenterology2009，，2： | 3 |
| 15 | Derivation and characterization of human embryonic stem cell lines from the Chinese population显示文摘人的胚胎的干细胞(hESCs ) 无止境地装自我更新并且在人的身体区分进所有房间类型。因此,他们在再生药,人的发展生物学和药发现是珍贵的。很多根 hESC 线从中国人口被导出,但是他们限制了为研究目的是可得到的。这里,我们报导线从中国起源的人的胚囊导出的二 hESC 的推导和描述。这些 hESCs 快车碱的磷酸酶和 hESC 特定的标记,包括的 Oct4, Nanog, SSEA-3, SSEA-4, TRA-1-60 和 TRA-1-81。他们也有 telomerase 活动和正常 karyotypes 的高水平。这些房间能在 vitro 形成胚胎植物或动物身体并且能被 teratoma 形成在 vivo 区分进所有三细菌层。最新确定的 hESCs 将为研究目的被散布。从中国人口的 hESC 线的可获得性将从不同的种族组在 hESCs 在差别上便于研究。 | Zhao Wu Hui Li Lingjun Rao Lixiaz iHe Lei Bao Jing Liao Chun Cui Zhenyu Zuo Qiao Li Huimin Dai Lei Qian Qing Tian Lei Xiao Xiao junTan | 2011 | Journal of Genetics and Genomics2011，38，1： | 3 |
| 16 | Homocysteine aggravates cerebral hemorrhage in rats: Correlation with oxygen-free radical production and cell apoptosis in tissue surrounding hematoma显示文摘BACKGROUND:Previous studies have demonstrated that homocysteine is an independent risk factor for ischemic stroke,as determined by detection of apoptosis and oxygen-free radical scavengers following cerebral ischemia.However,the mechanisms of homocysteine remain unclear.Several reports have addressed the effects of homocysteine on ischemic stroke.OBJECTIVE:To analyze the effects of homocysteine on apoptosis,intracellular superoxide dismutase(SOD) activity,and malondialdehyde content in tissue surrounding hematoma in rats with cerebral hemorrhage,and to determine the action pathway of malondialdehyde following cerebral hemorrhage.DESIGN,TIME AND SETTING:The randomized,controlled,animal experiment was performed at the Laboratory of Molecular Biology,Hospital Affiliated to Luzhou Medical College,China from April 2007 to April 2008.MATERIALS:In situ apoptosis detection kit(Roche,Mannheim,Germany),SOD detection kit and malondialdehyde detection kit(Nanjing Jiancheng Bioengineering Institute,China),and homocysteine(Sigma,St Louis,MO,USA) were used in the present study.METHODS:A total of 75 Sprague Dawley rats were equally and randomly assigned to sham surgery,model,and homocysteine groups.Autologous blood was infused into the caudate putamen of rats to establish models of cerebral hemorrhage in model and homocysteine groups.Homocysteine was injected directly into the brain through the skull at the hematoma hemisphere at 30 minutes after model induction in the homocysteine group.MAIN OUTCOME MEASURES:At 6,12,24,and 72 hours,as well as 1 week,post-surgery,neurological deficits were observed in each group.Brain water content was measured using the dry-wet weight method.Cell apoptosis in tissue surrounding the hematoma was detected utilizing terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling(TUNEL).SOD activity and malondialdehyde content in tissue surrounding the hematoma were respectively measured using the xanthine oxidase and thiobarbituric acid methods.RESULTS:Neurological function was similar between model and homocysteine groups following cerebral hemorrhage(P > 0.05).Brain water content was increased at 12 hours post-surgery,peaked at 3 days,and remained unchanged at 7 days in the model group.Brain edema was not significantly aggravated following homocysteine intervention(P > 0.05),but SOD activity significantly decreased and malondialdehyde content significantly increased(P < 0.05).The number of apoptotic cells increased in rats with cerebral hemorrhage at 12 hours(P < 0.05),and numbers peaked at 72 hours following model establishment(P < 0.05).The time of peak value was identical between model and homocysteine groups.Brain water content was negatively associated with SOD activity(rmodel group =-0.448,P < 0.05;rhomocysteine group =-0.612,P < 0.05),but was positively associated with malondialdehyde content(rmodel group = 0.542,P < 0.05;rhomocysteine group = 0.684,P < 0.05) in brain tissues surrounding the hematoma following surgery in model and homocysteine groups.CONCLUSION:Homocysteine aggravates neurological dysfunction and brain edema in rats with cerebral hemorrhage.The mechanisms of action are likely associated with production of oxygen-free radical and cellular apoptosis following cerebral hemorrhage. | Yingying Liu Xinjun Li Chun Wang Chun Chen Ping Liu Qin Feng Duanxiu Liao Xiaogang Li | 2010 | Neural Regeneration Research2010，5，13： | 3 |
| 17 | Investigation of PM_(2.5) pollution during COVID-19 pandemic in Guangzhou,China显示文摘The COVID-19 pandemic has raised awareness about various environmental issues,includ-ing PM_(2.5) pollution.Here,PM_(2.5) pollution during the COVID-19 lockdown was traced and an-alyzed to clarify the sources and factors influencing PM_(2.5) in Guangzhou,with an emphasis on heavy pollution.The lockdown led to large reductions in industrial and traffic emissions,which significantly reduced PM_(2.5) concentrations in Guangzhou.Interestingly,the trend of PM_(2.5) concentrations was not consistent with traffic and industrial emissions,as minimum concentrations were observed in the fourth period(3/01-3/31,22.45 μg/m^(3))of the lockdown.However,the concentrations of other gaseous pollutants,e.g.,SO_(2),NO_(2) and CO,were corre-lated with industrial and traffic emissions,and the lowest values were noticed in the sec-ond period(1/24-2/0_(3))of the lockdown.Meteorological correlation analysis revealed that the decreased PM_(2.5) concentrations during COVID-19 can be mainly attributed to decreased in-dustrial and traffic emissions rather than meteorological conditions.When meteorological factors were included in the PM_(2.5) composition and backward trajectory analyses,we found that long-distance transportation and secondary pollution offset the reduction of primary emissions in the second and third stages of the pandemic.Notably,industrial PM_(2.5) emis-sions from western,southern and southeastern Guangzhou play an important role in the formation of heavy pollution events.Our results not only verify the importance of control-ling traffic and industrial emissions,but also provide targets for further improvements in PM_(2.5) pollution. | Luyao Wen Chun Yang Xiaoliang Liao Yanhao Zhang Xuyang Chai Wenjun Gao Shulin Guo Yinglei Bi Suk-Ying Tsang Zhi-Feng Chen Zenghua Qi Zongwei Cai | 2022 | Journal of Environmental Sciences2022，34，5： | 2 |
| 18 | Performance Evaluation of Memory-Centric ARMv8 Many-Core Architectures:A Case Study with Phytium 2000+显示文摘This article presents a comprehensive performance evaluation of Phytium 2000+,an ARMv8-based 64-core architecture.We focus on the cache and memory subsystems,analyzing the characteristics that impact the high-performance computing applications.We provide insights into the memory-relevant performance behaviours of the Phytium 2000+system through micro-benchmarking.With the help of the well-known roofline model,we analyze the Phytium 2000+system,taking both memory accesses and computations into account.Based on the knowledge gained from these micro-benchmarks,we evaluate two applications and use them to assess the capabilities of the Phytium 2000+system.The results show that the ARMv8-based many-core system is capable of delivering high performance for a wide range of scientific kernels. | Jian-Bin Fang Xiang-Ke Liao Chun Huang De-Zun Dong | 2021 | Journal of Computer Science & Technology2021，36，1： | 2 |
| 19 | Study of a three-stage reconnection electromagnetic launcher using triggered vacuum switches显示文摘 | ZHAO Chun ZOU Ji-yan LIAO Xiao-peng | 2007 | IEEE Transactions on magnetics2007，43，1： | 1 |
| 20 | A study on the dual-phase treatment of weathering steel 09CuPCrNi 显示文摘 | Chun Lingzhang Da Yongcai Bo Liao | 2004 | Materials Letters2004，58，： | 1 |
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