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| 1 | In vitro differentiation of rat embryonic stem cells into functional cardiomyocytes显示文摘在老鼠的产生的最近的突破胚胎的干细胞(rESCs ) 打开门到基因指向为人的疾病的学习创造模型的申请。另外,在里面从进三细菌层的衍生物的 rESCs 的 vitro 区别系统将为哺乳动物的开发,房间函数,织物修理,和药发现的调查用作一个强大的工具和资源。然而,这些使用被困难限制了在 vitro 区别。这研究的目的是建立一在里面从 rESCs 并且到的 vitro 区别系统调查 rESCs 是否能够形成区分终端的 cardiomyocytes。用最新确定的 rESCs,我们发现那胚胎植物或动物身体(EB ) 基于在没能为没有浆液的栽培 rESCs 工作的老鼠转换字符(mESC ) 区别使用的方法。我们然后由三个化学禁止者和喂调节媒介的联合开发了一个协议。在这个条件下面, rESCs 变成了 EB,宣传并且区分三胚胎的细菌层。而且,形成 rESC 的 EB 能区分进自发地在 plating 以后打败 cardiomyocytes。分子、结构、功能的性质的分析表明导出 rESC 的 cardiomyocytes 类似于从胎儿的老鼠心和 mESCs 导出的那些。在结论,我们成功地发展了一在里面为功能的 myocytes 通过被产生并且显示老鼠的显型的 rESCs 的 vitro 区别系统胎儿的 cardiomyocytes。这个唯一的细胞的系统将提供一条新途径学习早开发和心脏的功能,并且在测试的药理学和房间治疗用作一个重要工具。 | Nan Cao Jing Liao Zumei Liu Wenmin Zhu Jia Wang Lijun Liu Lili Yu Ping Xu Chun Cui Lei Xiao Huang-Tian Yang | 2011 | Cell Research2011，21，9： | 13 |
| 2 | Effects of lysedEnterococcus faecalis FK-23 on experimental allergic rhinitis in a murine model显示文摘In the current study,we sought to investigate whether lysed Enterococcus faecalis FK-23(LFK),a heat-killed probiotic preparation,attenuated eosinophil influx into the upper airway and had immunomodulatory activity in a murine allergic rhinitis model.Eighteen BALB/c mice were divided into three groups;the ovalbumin(OVA)-sensitized/challenged group,which received saline orally for 6 weeks(OVA group),the OVA-sensitized/challenged group,which received LFK orally for 6 weeks(LFK-fed group),and the non-sensitized group,which received saline for 6 weeks(saline control group).Nasal rubbing and sneezing were monitored during the study.After the final challenge,interleukin(IL)-4,interferon(IFN)-γ,and OVA-specific IgE levels in the sera and splenocyte culture supernatants were determined,eosinophilic infiltrate into the upper airway was quantified,and splenic CD4+CD25+ regulatory T cells(Tregs) were examined by flow cytometry.We found that nasal rubbing was significantly reduced in LFK-fed mice compared to the OVA group on d 27 and 35,and sneezing was significantly inhibited by LFK administration for 35 d.LFK-fed mice had significantly less eosinophil influx into the nasal mucosa than the OVA group.There were no significant differences between the LFK-fed group and OVA group in the serum and splenocyte culture supernatant levels of IL-4,IFN-γ,and OVA-specific IgE.Interestingly,the LFK-fed mice had a significantly greater percentage of splenic CD4+CD25+ Tregs than OVA group.Our results indicate that oral administration of LFK may alleviate nasal symptoms,reduce nasal eosinophilia,and increase the percentage of CD4+CD25+ Tregs in experimental allergic rhinitis. | Luping Zhu Takashi Shimada Ruoxi Chen Meiping Lu Qingzhao Zhang Wenmin Lu Min Yin Tadao Enomoto Lei Cheng | 2012 | The Journal of Biomedical Research2012，26，3： | 11 |
| 3 | Applications and research trends of digital human models in the manufacturing industry显示文摘Virtual reality(VR)has been widely used in various manufacturing industries,and VR-based virtual manufacturing has received significant attention in the current intelligent manufacturing era.Digital human models(DHMs)are essential for virtual manufacturing applications.Additionally,researching new applications of DHMs has developed into an important academic research field.This paper aims to identify the applications and research trends of DHMs in the manufacturing industry and to provide a reference for the continued development of virtual manufacturing and DHMs.We selected a total of 49 related articles from a large number of articles published between 2014 and 2019.The applications of DHMs in the manufacturing industry are analyzed from different perspectives and various relevant technical limitations are discussed.The results indicate that the applications of DHMs differ significantly between different types of fields.The automotive industry is the main application field for DHMs,and assembly/maintenance simulations and evaluations are the main application types.Additionally,there are still some limitations in the establishment of virtual environments,motion control,and DHM evaluation that should be addressed.Finally,research trends in the application of DHMs are illustrated and discussed,including the planning and assessment of human-robot collaboration systems,the combination of DHMs and augmented reality,and improved motion planning for DHMs.In summary,the application of DHMs can improve the realism and effectiveness of virtual manufacturing,and DHMs will be more widely and deeply studied and applied in various manufacturing industries in the near future. | Wenmin ZHU Xiumin FAN Yanxin ZHANG | 2019 | Virtual Reality & Intelligent Hardware2019，1，6： | 5 |
| 4 | Temporal and spatial cellular and molecular pathological alterations with single-cell resolution in the adult spinal cord after injury显示文摘Spinal cord injury(SCI)involves diverse injury responses in different cell types in a temporally and spatially specific manner.Here,using single-cell transcriptomic analyses combined with classic anatomical,behavioral,electrophysiological analyses,we report,with single-cell resolution,temporal molecular and cellular changes in crush-injured adult mouse spinal cord.Data revealed pathological changes of 12 different major cell types,three of which infiltrated into the spinal cord at distinct times post-injury.We discovered novel microglia and astrocyte subtypes in the uninjured spinal cord,and their dynamic conversions into additional stage-specific subtypes/states.Most dynamic changes occur at 3-days post-injury and by day-14 the second wave of microglial activation emerged,accompanied with changes in various cell types including neurons,indicative of the second round of attacks.By day-38,major cell types are still substantially deviated from uninjured states,demonstrating prolonged alterations.This study provides a comprehensive mapping of cellular/molecular pathological changes along the temporal axis after SCI,which may facilitate the development of novel therapeutic strategies,including those targeting microglia. | Chen Li Zhourui Wu Liqiang Zhou Jingliang Shao Xiao Hu Wei Xu Yilong Ren Xingfei Zhu Weihong Ge Kunshan Zhang Jiping Liu Runzhi Huang Jing Yu Dandan Luo Xuejiao Yang Wenmin Zhu Rongrong Zhu Changhong Zheng Yi Eve Sun Liming Cheng | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 4 |
| 5 | Mahalanobis distance-based fading cubature Kalman filter with augmented mechanism for hypersonic vehicle INS/CNS autonomous integration显示文摘Inertial Navigation System/Celestial Navigation System(INS/CNS)integration,especially for the tightly-coupled mode,provides a promising autonomous tactics for Hypersonic Vehicle(HV)in military demands.However,INS/CNS integration is a challenging research task due to its special characteristics such as strong nonlinearity,non-additive noise and dynamic complexity.This paper presents a novel nonlinear filtering method for INS/CNS integration by adopting the emerging Cubature Kalman Filter(CKF)to handle the strong INS error model nonlinearity caused by HV's high dynamics.It combines the state-augmentation technique into the nonlinear CKF to decrease the negative effect of non-additive noise in inertial measurements.Subsequently,a technique for the detection of dynamic model uncertainty is developed,and the augmented CKF is modified with fading memory to tackle dynamic model uncertainty by rigorously deriving the fading factor via the theory of Mahalanobis distance without artificial empiricism.Simulation results and comparison analysis prove that the proposed method can effectively curb the adverse impacts of non-additive noise and dynamic model uncertainty for inertial measurements,leading to improved performance for HV navigation with tightly-coupled INS/CNS integration. | Bingbing GAO Wenmin LI Gaoge HU Yongmin ZHONG Xinhe ZHU | 2022 | Chinese Journal of Aeronautics2022，35，5： | 4 |
| 6 | Treatment for HIV prevention study in southwestern areas of China显示文摘Background:China has ambitious to achieve significant reductions in HIV transmission and HIV-related mortality by adopting the World Health Organization's“Treat All”approach.Such a prevention strategy is needed future study on regional scale.Methods:An observational cohort study of HIV epidemiology and treatment databases was used to study the effectiveness of antiretroviral therapy on the transmission of HIV in serodiscordant couples in Guangxi of China.Results:A total of 7713 couples were entered into the cohort study analysis which included 1885 couples in the treatment-naive cohort and 5828 couples in the treated cohort.During the follow-up of 18985.29 person-years from 2003 to 2014,the average incidence of HIV was 2.4 per 100 person-years(95%CI 2.1e2.6).HIV seroincidence rate was significantly higher among the treatment naive group(4.2 per 100 person-years,3.7e4.8)compared with the on treatment group(1.6 per 100 person-years,1.3e1.8).An overall 45%reduction in risk of HIV transmission among serodiscordant couple was associated with ART treatment(adjusted Hazard Ratio[HR]0.55,95%Confidence Interval[CI]0.44e0.69).Treatment prevention had significantly effectiveness for most baseline characteristics of index partners,such as for male,female,age above 25 years,education below high school,farmer,infected by heterosexual intercourse.Conclusion:Treatment-as-prevention can be implemented in the real-world on a national or regional scale,but ART adherence and comprehensive harm reduction while implementing this strategy require further study. | Huanhuan Chen Xiaoyi Yang Qiuying Zhu Xinghua Wu Li Chen Huaxiang Lu Liuhong Luo Guanghua Lan Xianming Ge Zhenzhu Tang Zhiyong Shen Stephen WPan Hui Xing Yuhua Ruan Yiming Shao Wenmin Yang | 2018 | Infectious Disease Modelling2018，3，1： | 1 |
| 7 | Effect of rare earths onn-hexane aromatization over HZSM-5 catalyst 显示文摘 | Liu Wenmin Li Fenyi Zhu Guangzong | 2002 | Journal of Rare Earths2002，20，： | 1 |
| 8 | Boosting the Rate Performance of Li–S Batteries via Highly Dispersed Cobalt Nanoparticles Embedded into Nitrogen-Doped Hierarchical Porous Carbon显示文摘Lithium–sulfur(Li–S)batteries are one of the most promising alternatives to lithium–ion batteries because of the advantageous high energy density and low cost.However,the practical applications of Li–S batteries are hampered by a severe shuttle effect and sluggish polysulfide redox conversion.Herein,highly dispersed cobalt nanoparticles(∼0.8 wt%)embedded into nitrogen-doped hierarchical porous carbon(Co@N-HPC)are designed as an effective electrocatalyst for Li–S batteries,which exhibit a synergistic effect of anchoring and dual-directional catalytic conversion of polysulfides. | Cheng Yuan Pan Zeng Chen Cheng Tianran Yan Genlin Liu Wenmin Wang Jun Hu Xin Li Junfa Zhu Liang Zhang | 2022 | CCS Chemistry2022，4，8： | 1 |
| 9 | Mechanical Behaviors of Anchorage Interfaces in Layered Rocks with Fractures under Axial Loads显示文摘Rock bolts are widely employed as an effective and efficient reinforcement method in geotechnical engineering.Sandwich composite structures formed by hard rock and weak rock are often encountered in practical projects.Furthermore,the spatial structure of the rock mass has a direct influence on the effect of the anchorage support.To investigate the impact of rock mass structure on the mechanical characteristics of anchorage interfaces,pull-out tests on reinforced specimens with different mudstone thicknesses and fracture dip angles are conducted.The experimental results indicate that the percentage of mudstone content and fracture dip angle have a significant influence on the pullout load of the samples.A weaker surrounding rock results in a lower peak load and a longer critical anchorage length,and vice versa.The results also show that 70%mudstone content can be considered a critical condition for impacting the peak load.Specifically,the percentage of mudstone content has a limited influence on the variation in the peak load when it exceeds 70%.Optical fiber deformation results show that compared to the rock mass with fracture dip angles of 0°and 60°,the rock mass with a fracture dip angle of 30°has a more uniformly distributed force at the anchorage interface.When the fracture dip angle exceeds 60°,the dip angle is no longer a key indicator of peak load.The accuracy of the experimentally obtained load-displacement curves is further verified although numerical simulation using the discrete element method. | Yan Wang Changdong Li Zhilan Cai Guoqiang Zhu Jiaqing Zhou Wenmin Yao | 2023 | Journal of Earth Science2023，34，2： | 0 |
| 10 | Frame interpolation with pixel-level motion vector field and mesh based hole filling显示文摘 | Chuanxin Tang Ronggang Wang Zhu Li Wenmin Wang Wen Gao | 2016 | CAAI Transactions on Intelligence Technology2016，1，1： | 0 |
| 11 | Correction to:Temporal and spatial cellular and molecular pathological alterations with single-cell resolution in the adult spinal cord after injury显示文摘 | Chen Li Zhourui Wu Liqiang Zhou Jingliang Shao Xiao Hu Wei Xu Yilong Ren Xingfei Zhu Weihong Ge Kunshan Zhang Jiping Liu Runzhi Huang Jing Yu Dandan Luo Xuejiao Yang Wenmin Zhu Rongrong Zhu Changhong Zheng Yi Eve Sun Liming Cheng | 2022 | Signal Transduction and Targeted Therapy2022，7，6： | 0 |
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