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| 1 | Indoor Allergen Levels and Household Distributions in Nine Cities Across China显示文摘Objective Chinese allergic subjects have high levels of sensitization to house dust mite(HDM) and other indoor allergens. This study quantifies common indoor allergen levels in Chinese households. Methods Dust samples were collected from nine cities. Major allergens Der p 1 and Der f 1 from Dermatophagoides pteronyssinus and D. farinae, and specific antigens of Blomia tropicalis, Tyrophagus putrescentiae, Acarus siro, and cockroach species Blattella germanica and Periplaneta americana were measured by ELISA. Results HDM allergens were found in dust samples from bedding in 95% of the Chinese households. The median levels varied from <0.006 to 9.2 μg/g of dust, depending on the city. The percentages of households having HDM allergen levels associated with the risk of developing allergy sensitization and asthma were 65% and 25%, respectively. Specific antigens of the storage mite and cockroach were only found in samples from the southern and tropical regions of China. Levels of mite allergens were generally higher in samples from bedding compared to samples from the living room, even for storage mites, whereas levels of cockroach antigens were higher in the living room samples. Conclusion HDM allergens are present in bedding dust samples from most Chinese households. Cities in southern and central China have relatively high levels of HDM major allergens compared to cities in northern and western China. Antigens of storage mites and cockroaches are not as common as HDM allergens. | ZHENG Yi Wu LAI Xu Xin ZHAO De Yu ZHANG Chun Qing CHEN Jian Jun ZHANG Luo WEI Qing Yu CHEN Shi LIU En Mei NORBACK Dan GJESING Birgitte ZHONG Nan Shan SPANGFORT D.Michael | 2015 | Biomedical and Environmental Sciences2015，28，10： | 24 |
| 2 | Multilinear Hausdorff Operators and Their Best Constants显示文摘In this paper, we study two different extensions of the Hausdorff operator to the multilinear case. Boundedness on Lebesgue spaces and Herz spaces is obtained. The bound on the Lebesgue space is optimal. Our results are substantial extensions of some known results on Multilinear high dimensional Hardy operator. | Jie Cheng CHEN Da Shan FAN Chun Jie ZHANG | 2012 | Acta Mathematica Sinica,English Series2012，28，8： | 12 |
| 3 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 4 | Methylation of 2-methylnaphthalene with methanol to 2,6-dimethylnaphthalene over HZSM-5 modified by NH_4F and SrO显示文摘进 2,6-dimethylnaphthalene (2,6-DMN ) 的 2-methylnaphthalene (2-MN ) 的 methylation 在稳固的酸催化剂上被调查。结果证明 NH4F 修改的 HZSM-5 在酸味由于减少比父母 HZSM-5 有更好催化的性能。当 NH4F/HZSM-5 被 SrO 进一步修改时,它的催化活动在全部的酸数量和酸的力量由于减少减少。作为结果,当 2-MN 变换是 10% 时, NH4F 和 SrO 的全面修正在 2,6-DMN 选择(到 DMN 的 2,6-DMN ) 导致增加,直到 64.8% 。我们由功能的理论和结果显示出的密度计算了 ESP 费用在 2-MN 的 6 位置让更高的 ESP 比 7 位置控告价值。2,6-DMN 的形成为 2,7-DMN 作为与那相比精力充沛地被赞成。这在 ZSM-5 隧道内在 2-MN 的完化期间建议, 2,6-DMN 的形成比 2,7-DMN 的电子地被赞成。因此,降低催化剂的酸味是一个关键因素获得 2,6-DMN 的高选择。 | Chen Zhang Xin Wen Guo Ya Nan Wang Xiang Sheng Wang Chun Shan Song | 2007 | Chinese Chemical Letters2007，18，10： | 7 |
| 5 | Anti-inflammatory and hepatoprotective effects of total flavonoid C-glycosides from Abrus mollis extracts显示文摘The aim of this study was to evaluate the anti-inflammatory and hepatoprotective effects of the total flavonoid C-glycosides isolated from Abrus mollis extracts(AME). In the anti-inflammatory tests, xylene-induced ear edema model in mice and carrageenan-induced paw edema model in rats were applied. The hepatoprotective effects of AME were evaluated with various in vivo models of acute and chronic liver injury, including carbon tetrachloride(CCl4)-induced hepatitis in mice, D-galactosamine(D-GalN)-induced hepatitis in rats, as well as CCl4-induced hepatic fibrosis in rats. In the acute inflammation experiment, AME significantly suppressed xylene-induced ear edema and carrageenan-induced paw edema, respectively. In the acute hepatitis tests, AME significantly attenuated the excessive release of ALT and AST induced by CCl4 and D-GalN. In CCl4-induced hepatic fibrosis model, AME alleviated liver injury induced by CCl4 shown by histopathological sections of livers and improved liver function as indicated by decreased liver index, serum ALT, AST, TBIL, and ALP levels and hydroxyproline contents in liver tissues, and increased serum ALB and GLU levels. These results indicated that AME possesses potent anti-inflammatory activity in acute inflammation models and hepatoprotective activity in both acute and chronic liver injury models. In conclusion, AME is a potential anti-inflammatory and hepatoprotective agent and a viable candidate for treating inflammation, hepatitis, and hepatic fibrosis. | CHEN Mi WANG Tao JIANG Zhen-Zhou SHAN Chun WANG Hao WU Mei-Juan ZHANG Shuang ZHANG Yun ZHANG Lu-Yong | 2014 | Chinese Journal of Natural Medicines2014，12，8： | 7 |
| 6 | In Vitro and In Vivo Evaluation of Antitumor Activity ofLigustrum robustum, A Chinese Herbal Tea显示文摘Objective: To examine the effect of the aqueous extract of Ligustrum robustum on tumor growth in vitro and in vivo and explore the possible molecular mechanisms. Methods: In in vitro study, cell viabilities of human cervical carcinoma cells(HeLa), human breast cancer cells(MCF-7), human prostate cancer cells(PC-3),human hepatoma cells(7721) and human colon carcinoma cells(SW480) were evaluated with cell counting kit-8.For L. robustum-treated Hela cells, early or late apoptosis were evaluated by annexin V/PI staining. Mitochondrial membrane potential was measured by staining cells with JC-1. Apoptosis was monitored by nuclear morphology based on chromatin condensation and fragmentation by 4’,6-diamidino-2-phenylinole(DAPI) staining. Caspase-3 and-8 activity levels were measured by a colorimetric assay. In vivo, to evaluate the possible mechanism of L. robustum-mediated antitumor effect, nude mouse xenograft study was also conducted. Results: In in vitro study, L. robustum was found to be toxic to HeLa, MCF-7, PC-3, 7721, SW480, with an half maximal inhibitory concentration value of 2–5 mg/mL(P<0.05). Moreover, externalization of phosphatidylserine, loss of mitochondrial membrane potential, DNA fragmentation and activation of caspase-3 and-8 were detected in L. robustumtreated Hela cells. Using a nude mouse model bearing Hela xenografts, we found that L. robustum reduced tumor volume and tumor weight(P<0.05), but had no effect on body weight and histological damage of important organs. Intraperitoneal injection of L. robustum caused a signi?cant reduction in serum aspartate transaminase and alanine transaminase levels(P<0.05). Furthermore, cleaved caspase-3-positive and terminal nucleotidyl transferase-mediated nick end labeling(TUNEL)-positive cells were observed in L. robustum-treated tumor tissues.Conclusions: L. robustum inhibits tumor cell growth both in vitro and in vivo by inducing apoptosis in a caspasedependent way without apparent hepatic toxicity and histological damage, which may offer partial scienti?c support for the ethnopharmacological claims of L. robustum as a herbal tea for its antitumor activity. | ZUO Hao-jiang LIU Shan YAN Chun LI Li-man PEI Xiao-fang | 2019 | Chinese Journal of Integrative Medicine2019，25，6： | 7 |
| 7 | Comparing the Diagnostic Criteria of MAFLD and NAFLD in the Chinese Population:A Population-based Prospective Cohort Study显示文摘Background and Aims:Metabolic dysfunction-associ-ated fatty liver disease(MAFLD)is a new concept,pro-posed in 2020;however,its applicability in Asia populations has yet to be evaluated.Therefore,we aimed to compare the difference in epidemiological and clinical characteris-tics between MAFLD and non-alcoholic fatty liver disease(NAFLD)among Asian populations.Methods:Based on the Jinchang cohort,30,633 participants were collected.The prevalence and incidence of MAFLD and NAFLD were used to analyze the epidemic characteristics and its overlapping effects.In addition,the corresponding clinical character-istics of the two diagnostic criteria populations were com-pared.Results:The prevalence rates of MAFLD and NAFLD were 21.03%and 18.83%,respectively.After an average 2.28-year follow-up,the incidence densities of MAFLD and NAFLD were 41.58 per 1,000 person-years and 37.69 per 1,000 person-years,respectively.With the increase of baseline age,body mass index(BMI),and waist circumfer-ence(WC)levels,the prevalence and incidence of MAFLD and NAFLD were on the rise(all ptrend<0.05).Among the total patients diagnosed at baseline or follow-up,most pa-tients had both MAFLD and NAFLD,accounting for 78.84%and 82.88%,respectively.Compared with NAFLD,MAFLD patients had greater proportions of males and metabolic diseases(diabetes,dyslipidemia),and had higher BMI,WC,liver enzymes,blood glucose,and lipid levels in the base-line diagnosis patients(p<0.05).Additionally,lean MAFLD patients had higher metabolic disorders than lean NAFLD patients(p<0.05).Conclusions:Compared with NAFLD,the newly proposed definition of MAFLD is more practical and accurate,and it can help identify more fatty liver pa-tients with high-risk diseases. | Cheng Yu Minzhen Wang Shan Zheng Miao Xia Hongyan Yang Desheng Zhang Chun Yin Ning Cheng Yana Bai | 2022 | Journal of Clinical and Translational Hepatology2022，10，1： | 7 |
| 8 | Protein expression and fucosylated glycans of the serum haptoglobin-β subunit in hepatitis B virus-based liver diseases显示文摘Glycosylation,调整 glycoproteins 的配置和功能,是最重要的 translational 以后修正。学习是在 glycan 和浆液 haptoglobin- 子单元(Hp-) 的蛋白质部分观察微分模式的这的目的与肝炎 B 从病人净化了病毒(HBV ) 感染,肝肝硬化(LC ) ,或 hepatocellular 癌(HCC ) 。2-D 胶化电气泳动和多路的 proteomics 染色技术被采用调查 Hp- glycan 水平是否与蛋白质水平成正比。Multi-lectin 污点,高效的液体层析(HPLC ) ,和西方的污点分析被执行识别 Hp- 份量上的 glycoform。我们的实验证明到 Hp- 的 glycosylated 形式的全部的浆液 Hp- 的比率与不同的肝疾病在病人之中变化了。全部的 Hp- 蛋白质表示水平比 LC 在 HCC 是高得多的,当 fucosylated Hp- 的一个增长比例也在 HBV 和健康控制与那相比在 LC 和 HCC 病人被观察时。微分 fucosylation 被 HPLC 和反人的 SialylLewis X 抗体进一步作为路易斯十世结构识别。在结论, Hp- glycan 和全部的蛋白质表示的异常引申可以是为早 hepatocarcinogenesis 的有希望的 biomarker。 | Hong Shu Shu Zhang Xiaonan Kang Shan Li Xue Qin Chun Sun Haojie Lu Yinkun Liu | 2011 | Acta Biochimica et Biophysica Sinica2011，43，7： | 6 |
| 9 | Predictors of post coronary artery bypass grafting atrial fibrillation显示文摘Objective: To investigate the incidence and relative risk factors of post coronary artery bypass grafting(post-CABG) atrial fibrillation(AF). Methods: 312 patients with CABG were reviewed and divided into an AF group and a non-AF group. Statistical analysis was used to compare the data between the two groups and screen for risk factors of post-CABG AF. Results: 103/312 (33.01%) patients developed post-CABG AF. Univariate analysis showed that patients in AF group compared with those in non-AF group were more likely to have advanced age (≥70 years), early postoperative withdrawal of β-blockers, hypertension, left atrial enlargement (≥40 mm), a history of AF, prolonged p-wave duration (≥120 ms) and increased number of grafts (≥3). Multivariate logistic regression analysis showed that advanced age (≥70 years), early postoperative withdrawal of β-blockers, hypertension, left atrial enlargement (≥40 mm) and a history of AF were highly related to post-CABG AF. Conclusion: The incidence of AF in patients following CABG was 33.01% in this study. Advanced age, early postoperative withdrawal of β-blockers, hypertension, left atrial enlargement and a history of AF were independent risk factors of post-CABG AF. | Tongtong Shen Qijun Shan Biao Yuan Bing Yang Chun Chen Dongjie Xu Minglong Chen Jiangang Zou Kejiang Cao | 2007 | Journal of Nanjing Medical University2007，21，3： | 5 |
| 10 | Preparation,structural characterization of a novel egg-shell palladium sulfide catalyst and its application in selective reductive alkylation reaction显示文摘有核心和钯硫化物的膜被 sulphidizing Pd/C 与 H2S 作为表面准备了的钯金属的新奇卵壳 PdS 催化剂。这催化剂是有效的让 p 氨基的二苯胺(PADPA ) 和 methylisobutyl 酉同类(MIBK ) 的减少的完化负担得起 N-(1,3-dimethylbutyl ) 有直到 99.42% 的变换和到 97.46% 的选择的 -N-phenyl-p-phenylenedianine (DBPPD ) 。与另外的普通的钯硫化物催化剂作比较,表面上的硫化物和钯金属的核心在更低的硫协作在新催化剂的表面上引起 Pd 的钯的膜,它改进它的活动。我们的结果显示这新卵壳 PdS/C 是有效加氢催化剂。 | Qun Feng Zhang Jia Chun Wu Chang Su Feng Feng Qiao Ling Ding Zhao Lian Yuan Hong Wang Lei Ma Chun Shan Lu Xiao Nian Li | 2012 | Chinese Chemical Letters2012，23，10： | 5 |
| 11 | Synthesis and fungicidal activity of novel strobilurin analogues containing substituted N-phenylpyrimidin-2-amines显示文摘包含代替的 N-phenylpyrimidin-2-amines 的很多新奇 strobilurin 类似物被综合。这些新混合物的结构被 1 H NMR,红外和元素的分析。在温室的生物评估证明几混合物在 25 mg/L 举办好杀菌剂活动。 | Hui Chao Li Bao Shan Chai Zhi Nian Li Ji Chun Yang Chang Ling Liu | 2009 | Chinese Chemical Letters2009，20，11： | 4 |
| 12 | Comparison of long-lasting therapeutic effects between succimer and penicillamine on hepatolenticular degeneration显示文摘INTRODUCTIONHepatolenticulardegeneration(HLD)isanautosomalrecesivedisorderthatcauseschangesinthebasalgangliaandliverthatrespe... | REN Ming Shan, ZHANG Zhi, WU Jun Xia, LI Fei, XUE Ben Chun and YANG Ren Min | 1998 | World Journal of Gastroenterology1998，4，6： | 3 |
| 13 | Molecular Evidence for the Hybrid Origin of Bauhinia blakeana(Caesalpinioideae)显示文摘Bauhinia blakeana Dunn is the Hong Kong Special Administrative Region emblem and a popular horticultural species in many Asian countries. It was first described as a new species from Hong Kong almost a century ago. This plant is sterile and has long been considered a hybrid,possibly from two related species,B. purpurea and B. variegata. However,not much evidence based on molecular methods was available to support this hypothesis. In this study,sequences of internal transcribed spacer 1(ITS1) ,rbcL and atpB-rbcL intergenic spacer for five Bauhinia species and two varieties of one of the species were determined and compared. There were two types of ITS1 sequences in B. blakeana,one indistinguishable from that of B. purpurea and the other one identical to that of B. variegata. This confirmed that B. blakeana was a hybrid of these two species. Chloroplast atpB-rbcL intergenic spacer sequence of B. blakeana was identical to that of B. purpurea,indicating that B. purpurea was the female parent. The hybridization event seemed to occur only recently and was a rare incident. Its occurrence was likely facilitated by interspecific pollen competition. It appeared that human efforts played a crucial role in the preservation and ubiquity of B. blakeana. | Chun Yin Mak Ka Shing Cheung Pui Ying Yip Hoi Shan Kwan | 2008 | Journal of Integrative Plant Biology2008，50，1： | 3 |
| 14 | Synthesis and characterization of a new chromophor with acid/base-sensitive fluorescence emission显示文摘新二光子的吸收混合物, 2-{4-[(dicyanomethylidene-5,5-dimethylcyclohexl ) 乙烯基] 苯基 } imidazo [4,5-f ][1,10 ] phenanthroline (DDVPIP ) ,被综合并且描绘。一个光子使荧光(OPEF ) 和 DDVPIP 的二光子的激动的荧光(TPEF ) 激动对答案的酸 / 底敏感,它在基本答案被提高,但是在酸的答案变弱。DDVPIP 的费用转移(CT ) 状态通过理论方法被计算解释它的 acid/base-sensitive 荧光灯性质。 | Hai Guang Zhang Xu Tang Tao Kao Shan Chen Chun Xue Yuan Shi Na Yan Min Hua Jiang | 2011 | Chinese Chemical Letters2011，22，9： | 3 |
| 15 | Total Synthesis of (±)-Calanolide A and Its Anti-HIV Activity显示文摘Anti-HIV agent (±)-calanolide A has been synthesized by a four-step approach startingfrom phloroglucinol, including the Pechmann reaction, Friedel-Crafts acylation, cyclization,chromenylation and Luche reduction. | Chun Mei ZHOU Lin WANG Ming Long ZHANG Zhi Zhong ZHAO (Institute of Materia Medica, Peking Union Medical College &Chinese Academy of Medical Sciences, Beijing 100050)Xing Quan ZHANG Xiang Hong CHEN Hong Shan CHEN (Institute of Medicinal Biotechno | 1998 | Chinese Chemical Letters1998，9，5： | 3 |
| 16 | Decomposition and Reformulation of Banxia Baizhu Tianma Decoction:A Vasodilatory Approach显示文摘Objective To decompose and reformulate Banxia Baizhu Tianma Decoction(BBT) in order to optimize its ratio for vasodilatory effect.The fingerprints of these six component herbs were also studied via Tri-step FTIR analysis.Methods The herbal components of BBT were extracted separately with different solvents,such as 95%ethanol,50%ethanol,and distilled water.The vasodilatory effect of the extracts was studied using the in vitro pre-contracted aortic ring model.Among these extracts,the water extracts of Pinellia ternata[PT(W)]and Citri reticulatae[CR(W)],50%ethanol extracts of Castrodia elata[GE(50)]and Clycyrrhiza uralensis[GU(50)],and 95%ethanol extracts of Atractylodes macrocephala[AM(E)],and Poria cocos[PC(E)]were selected for the orthogonal stimulus-response compatibility group study due to their high effectiveness in vasodilation.Results The best combination ratio(G2) was GE(50),GU(50),AM(E),PC(E),CR(W),and PT(W) at EC_0,EC_5,EC_5,EC_5,EC_5,and EC_5,with EC_(50) of(0.06 ± 0.01) mg/mL.Comparison between the vasodilatory effects of extracts derived from G2 and BBT were also studied.From the results,the 50%ethanol extract following G2 ratio was found to be most potent extract with the highest vasodilatory effect compared with other extracts derived from G2 or BBT,with EC_(50) of(0.05 ±0.005) mg/mL.Conclusion The optimum ratio and appropriate extraction method for the new BBT formulae are obtained.G2 is determined as the best formulae with the highest potency in producing the vasodilatory effect on isolated rat aortic rings.The results obtained suggest that 50%ethanol is found to be the best solvent to extract the vasoactive compounds of G2 in order to exhibit the highest efficacy of vasodilatory effect. | Chu Shan Tan Yean Chun Loh Yung Sing Ch'ng Mariam Ahmad Mohd.Zaini Asmawi Mun Fei Yam | 2017 | Chinese Herbal Medicines2017，9，2： | 3 |
| 17 | Hypoxia reoxygenation induces premature senescence in neonatal SD rat cardiomyocytes显示文摘目的:调查组织缺氧氧化是否导致早熟的 senescencein 新生的 Sprague-Dawley ( SD )老鼠 cardiomyocytes.Methods : Cardiomyocytes 是孤立的 fromneonatal SD 老鼠心并且由 immunohisto-chemistry.The 控制鉴别文化被孵化在5% CO_2 和95% air.The hypoxic 的 humidified 气氛的 at37 deg C 文化在孵卵器房间充满了的 amodular 被孵化为 6 h.The reoxygen-atedcultures 的 1 %O_2,5% CO_2 ,和平衡 N_2 受到1% O_2 和5% CO_2 | Feng-xiang ZHANG Ming-long CHEN Qi-jun SHAN Jian-gang ZOU Chun CHEN Bing YANG Dong-jie XU Yu JIN Ke-jiang CAO | 2007 | Acta Pharmacologica Sinica2007，28，1： | 3 |
| 18 | RRAS:A key regulator and an important prognostic biomarker in biliary atresia显示文摘AIM:To characterize the differentially expressed gene profiles in livers from biliary atresia (BA) patients including,ascertain genes,functional categories and pathways that play a central role in the pathogenesis of BA,and identify the novel prognostic markers for BA.METHODS:Liver tissue samples from control patients,neonatal cholestasis patients,and BA patients at the age of < 60 d,60-90 d,and > 90 d were pooled for DNA microarray analysis.Bioinformatics analysis was performed using,series test cluster of gene ontology,and Pathway-Finder software.Reverse-transcription polymerase chain reaction was performed to confirm changes in selected genes.Relation between RRAS gene expression and prognosis of 40 BA patients was analyzed in a 2-year follow-up study.RESULTS:The 4 identified significant gene expression profiles could confidently separate BA liver tissue from normal and other diseased liver tissues.The included genes were mainly involved in inflammation response and reconstruction of cellular matrix.The significant pathways associated with BA were primarily involved in autoimmune response,activation of T lymphocytes and its related cytokines.The RRAS,POMC,SLC26A6 and STX3 genes were important regulatory modules in pathogenesis of BA.The expression of RRAS was negatively correlated with the elimination rate of jaundice and positively correlated with the occurrence rate of cholangitis.CONCLUSION:Autoimmune response mediated by T lymphocytes may play a vital role in the pathogenesis of BA.The RRAS gene is an important regulatory module in the pathogenesis of BA,which may serve as a novel prognostic marker for BA. | Rui Zhao Hao Li Chun Shen Shan Zheng | 2011 | World Journal of Gastroenterology2011，17，6： | 3 |
| 19 | Off-on-off luminescent switching of a dye containing imidazo[4,5-f][1,10]phenanthroline显示文摘A new acid-base fluorescent switch containing both imidazo[4,5-f][1,10]-phenanthroline and triphenylamine groups has been synthesized.Its fluorescence emissions and absorptions can be reversibiy changed through protonation/deprotonation of imidazole and amine moiety by controlling the intramolecular charge transfer(ICT) process,leading to off-on-off fluorescent molecular switching. | Hai Guang Zhang Xu Tang Tao Kao Shan Chen Chun Xue Yuan Shi Na Yan Min Hua Jiang | 2011 | Chinese Chemical Letters2011，22，6： | 3 |
| 20 | The Besov Space B_1^(0.1) on Domains | Yi Qing GUI Shan Zhen LU Da Chun YANG Department of Mathematics. Beijing Normal University. Beijing 100875. P. R. China | 2001 | Acta Mathematica Sinica,English Series2001，17，2： | 2 |
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