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| 1 | Abnormal subchondral bone remodeling and its association with articular cartilage degradation in knees of type 2 diabetes patients显示文摘Type 2 diabetes(T2 D) is associated with systemic abnormal bone remodeling and bone loss. Meanwhile,abnormal subchondral bone remodeling induces cartilage degradation, resulting in osteoarthritis(OA).Accordingly, we investigated alterations in subchondral bone remodeling, microstructure and strength in knees from T2 D patients and their association with cartilage degradation. Tibial plateaus were collected from knee OA patients undergoing total knee arthroplasty and divided into non-diabetic(n = 70) and diabetes(n = 51) groups. Tibial plateaus were also collected from cadaver donors(n = 20) and used as controls.Subchondral bone microstructure was assessed using micro-computed tomography. Bone strength was evaluated by micro-finite-element analysis. Cartilage degradation was estimated using histology. The expression of tartrate-resistant acidic phosphatase(TRAP), osterix, and osteocalcin were calculated using immunohistochemistry. Osteoarthritis Research Society International(OARSI) scores of lateral tibial plateau did not differ between non-diabetic and diabetes groups, while higher OARSI scores on medial side were detected in diabetes group. Lower bone volume fraction and trabecular number and higher structure model index were found on both sides in diabetes group. These microstructural alterations translated into lower elastic modulus in diabetes group. Moreover, diabetes group had a larger number of TRAP^+ osteoclasts and lower number of Osterix^+ osteoprogenitors and Osteocalcin^+ osteoblasts. T2 D knees are characterized by abnormal subchondral bone remodeling and microstructural and mechanical impairments, which were associated with exacerbated cartilage degradation. In regions with intact cartilage the underlying bone still had abnormal remodeling in diabetes group, suggesting that abnormal bone remodeling may contribute to the early pathogenesis of T2 D-associated knee OA. | Yan Chen Yong-Can Huang Chun Hoi Yan Kwong Yuen Chiu Qingjun Wei Jingmin Zhao X Edward Guo Frankie Leung William W Lu | 2017 | Bone Research2017，5，4： | 10 |
| 2 | Destruction of phenol aqueous solution by photocatalysis or direct photolysis 显示文摘 | Chun H Wang Y Z Tang H X | 2000 | Chemosphere2000，41，： | 1 |
| 3 | Cloning and expression of interferon-α/γ from a domestic porcine breed and its effect on classical swine fever virus 显示文摘 | Chun X Wu D Wu W X | 2005 | Vet Immunol Immunopathol2005，104，： | 1 |
| 4 | Active phase of Ni2P/SiO2 in hydroprocessing reactions显示文摘 | OYAMA S T WAND X LEE Y-K CHUN W-J | 2004 | J Catal2004，221，2： | 1 |
| 5 | Highly sensitive and selective fluorescent sensor for distinguishing cadmium from zincions in aqueous media显示文摘 | Lin X Chun L HuaJ | 2009 | Org Lett2009，11，7： | 1 |
| 6 | A comparative study on unfilled and filled crack propagation for rock-like brittle material显示文摘 | Zhuang X Chun J Zhu H | 2014 | Theoretical and Applied Fracture Mechanics2014，72，： | 1 |
| 7 | Localization of Nogo-A and Nogo-66 receptor proteins at sites of axon-myelin and synaptic contact显示文摘 | Wang X Chun SJ Treloar H Vartanian T Greer CA Strittmatter SM | 2002 | J Neurosci2002，22，13： | 1 |
| 8 | Localization of Nogo-A and Nogo-66 receptor proteins at sites of axon-myelin and synaptic contact显示文摘 | Wang X X Chun S J freloar H | | 0，，13： | 1 |
| 9 | Peptide mediated active targeting and intelligent particle size reduction-mediated enhanced penetrating of fabricated nanoparticles for triple-negative breast cancer treatment显示文摘 | Hu G Chun X Wang Y | 2015 | Oncotarget2015，12，10： | 1 |
| 10 | Optimum multiple tuned mass dampers for structures under ground acceleration based on the uniform distribution of system parame- ters显示文摘 | Li Chun X Liu Y X | 2003 | Earthquake Engineering and Structural Dy- namics2003，32，5： | 1 |
| 11 | Body mass index as a predictor of postoperative complications in reduction mammaplasty 显示文摘 | Chun YS Schwartz MA Gu X | 2012 | Plast Reconstr Surg2012，129，2： | 1 |
| 12 | Localization of Nogo-A and Nogo-66 receptor proteins at sites of axon- myelin and synaptic contact 显示文摘 | Wang X Chun SJ Treloar H | 2002 | J Neurosci2002，22，13： | 1 |
| 13 | Determination of Routing Velocity with GPS Floating Car Data and WebGIS Based Instantaneous Traffic Information Dissemination显示文摘 | Liu Chun Meng X Fan Yemin | 2008 | Journal of Navigation2008，61，2： | 1 |
| 14 | Vialinin A, A Novel 2,2-Diphenyl-l-picrylhydrazyl (DPPH) radi- cal scavenger from an Edible Mushroom in China显示文摘 | Chun X Hiroyuki K Yasuaki E | 2005 | Biosci Biotechnol Biochem2005，69，12： | 1 |
| 15 | Inflammasome-indepen- dent NLRP3 augments TGF-显示文摘 | Wang W Wang X Chun J | 2013 | J Immunol2013，190，3： | 1 |
| 16 | Changes of NPP and their relationship to climate factors based on the transformation of different scales in Gansu, China显示文摘 | Liu Chun Dong X Liu Y | 2015 | CATENA2015，，： | 1 |
| 17 | Localization of Nogo-A and Nogo-66 receptor protein satsites of axon-myelin and synaptic contact显示文摘 | Wang X Chun S J Treloar H | 2002 | J Neurosci2002，22，13： | 1 |
| 18 | S-RNase triggers mitochondrial alteration and DNA degradation in the incompatible pollen tube of Pyrus pyrifolia in vitro显示文摘 | Chun L Guo H X Xeu T J et ol | 2009 | The Plant Journal2009，57，： | 1 |
| 19 | Localization of Nogo-A and Nogo-66 receptor proteins at sites of axon-myelin and synaptic contact显示文摘 | Wang X Chun SJ Treloar H | 2002 | J Neurosci2002，22，13： | 1 |
| 20 | Evidence that integrins contribute to multiple stages in the consolidation of long- term potentiation显示文摘 | Chun D Gall C M Bi X | 2001 | Neuroscience2001，105，： | 1 |
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