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| 1 | Expression and regulation of IL-22 in the IL-17.producing CD4+T lymphocytes显示文摘IL-22 是在工作对感染支持纸巾的天生的免疫的 IL-10 家庭的新奇 cytokine。尽管 CD4+ 助手 T 淋巴细胞(TH ) 作为 IL-22 的来源被发现,这 cytokine 的规定糟糕被理解。这里,我们证明 IL-22 被也做 IL-17 的 TH 房间的一个新奇子集在 mRNA 和蛋白质层次表示。IL-22 和 IL-17 被发现被即时 PCR 以及 ELISA 分析被 TGFbeta 和 IL-6 并列地在 TH 区别期间调整。然而, IL-22 不调整 TH 区别;外长的 IL-22 或一个 IL-22 对手没在 TH 区别上有效果。这些数据表明 IL-17-producing T 房间表示的新奇 cytokine,并且建议在组织发炎和自体免疫的疾病表明小径的 IL-22 和 IL-17 的相互作用和协同作用。 | Yeonseok Chung Xuexian Yang Seon Hee Chang Li Ma Qiang Tian Chen Dong | 2006 | Cell Research2006，16，11： | 20 |
| 2 | Regulation of cytokine production during phagocytosis of apoptotic cells显示文摘自我忍耐的损失和汽车反应的淋巴细胞的扩大是汽车免疫的基础。当保证的协调过程与非病理学的结果调整了细胞质和压力反应, Apoptosis 和由吞噬细胞的 apoptotic 房间的快速的清理通常发生。在 apoptotic 房间的清理的缺点将贡献自我反应的淋巴细胞的产生,它驾驶象风湿性关节炎(RA ) 和全身的豺狼座 erythematosus (SLE ) 那样的自体免疫的混乱。cytokines (IL-12, IL-23,和 IL-27 ) 和 IL-10 的 IL-12 家庭被吞噬细胞的巨噬细胞生产并且在对病原体的有免疫力的回答期间在介绍抗原的房间(APC ) 和受动器淋巴细胞的规定起关键作用。这些 cytokines 和他们的 dysregulated 活动的不恰当的表示强烈在几自体免疫的疾病的致病被含有。由吞噬细胞的 APC 的支持 inflammatory 和反煽动性的 cytokines 的生产精巧地作为内在的机制的部分在 apoptotic 房间的摄取期间被调整阻止煽动性的自体免疫的反应。怎么导出房间的信号调整的 apoptotic cytokine 生产糟糕被理解。由我们的组的最近的研究证明由激活的巨噬细胞的 apoptotic 房间的那个吞噬作用由激活一个新奇抄写抑压者导致 IL-12 p35 基因表示的强壮的抑制,我们把它称为 GC 有约束力的蛋白质(GC-BP ) ,通过酷氨酸 dephosphorylation。我们开始也正在理解位于 apoptotic 下面的分子的机制由吞噬细胞的 IL-10 的被触发房间的生产。阐明的这些研究愿望帮助一些新奇有免疫力的规章的机制并且与潜力探索对汽车抗原的有免疫力的回答的规定为自体免疫的混乱的处理发现新治疗学的目标。 | Elaine Y Chung Sun Jung Kim Xiao Jing Ma | 2006 | Cell Research2006，16，2： | 9 |
| 3 | A sperm GPI-anchored protein elicits sperm-cumulus cross-talk leading to the acrosome reaction显示文摘 | Yin, L. Chung, C. M. Huo, R. Liu, H. Zhou, C. Xu, W. Zhu, H. Zhang, J. Shi, Q. Wong, H. Y.C. Chen, J. Lu, Y. Bi, Y. Zhao, C. Du, Y. Ma, M. Cai, Y. Chen, W. Y. Fok, K. L. Tsang, L. L. Li, K. Ni, Y. Chung, Y. W. Zhou, Z. Sha, J. Chan, H. C. | 2009 | 南京医科大学学报(自然科学版)2009，29，4： | 5 |
| 4 | T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ显示文摘 | Xuexian O. Yang Bhanu P. Pappu Roza Nurieva Askar Akimzhanov Hong Soon Kang Yeonseok Chung Li Ma Bhavin Shah Athanasia D. Panopoulos Kimberly S. Schluns Stephanie S. Watowich Qiang Tian Anton M. Jetten Chen Dong | 2008 | Immunity2008，，1： | 3 |
| 5 | Impact of small-for-size liver grafts on medium-term and long-term graft survival in living donor liver transplantation: A meta-analysis显示文摘BACKGROUND Small-for-size grafts (SFSGs) in living donor liver transplantation (LDLT) could optimize donor postoperative outcomes and also expand the potential donor pool. Evidence on whether SFSGs would affect medium-term and long-term recipient graft survival is lacking. AIM To evaluate the impact of small-for-size liver grafts on medium-term and longterm graft survival in adult to adult LDLT. METHODS A systematic review and meta-analysis were performed by searching eligible studies published before January 24, 2019 on PubMed, EMBASE, and Web of Science databases. The primary outcomes were 3-year and 5-year graft survival. Incidence of small-for-size syndrome and short term mortality were also extracted. RESULTS This meta-analysis is reported according to the guidelines of the PRISMA 2009 Statement. Seven retrospective observational studies with a total of 1821 LDLT recipients were included in the meta-analysis. SFSG is associated with significantly poorer medium-term graft survival. The pooled odds ratio for 3-year graft survival was 1.58 [95% confidence interval 1.10-2.29, P = 0.014]. On the other hand, pooled results of the studies showed that SFSG had no significant discriminatory effect on 5-year graft survival with an odds ratio of 1.31 (95% confidence interval 0.87-1.97, P = 0.199). Furthermore, incidence of small-for-size syndrome detected in recipients of SFSG ranged from 0-11.4% in the included studies. CONCLUSION SFSG is associated with inferior medium-term but not long-term graft survival. Comparable long-term graft survival based on liver graft size shows that smaller grafts could be accepted for LDLT with appropriate flow modulatory measures. Close follow-up for graft function is warranted within 3 years after liver transplantation. | Ka Wing Ma Kelly Hiu Ching Wong Albert Chi Yan Chan Tan To Cheung Wing Chiu Dai James Yan Yue Fung Wong Hoi She Chung Mau Lo Kenneth Siu Ho Chok | 2019 | World Journal of Gastroenterology2019，25，36： | 3 |
| 6 | Determination of Young's modulus by nanoindentation显示文摘A methodology for determining Youngs modulus of materials by non-ideally sharp indentation has been developed. According to the principle of the same area-to-depth ratio, a non-ideally pyramidal indenter like a Berkovich one can be approximated by a non-ideally conical indenter with a spherical cap at the tip. By applying dimensional and finite element analysis to the non-ideally conical indentation, a set of approximate one-to-one relationships between the ratio of nominal hardness/reduced Youngs modulus and the ratio of elastic work/total work, which correspond to different tip bluntness, have been revealed. The nominal hardness is defined as the maximum indentation load divided by the cross-section area of the conical indenter specified at the maximum indentation depth. As a consequence, Youngs modulus can be determined from a nanoindentation test only using the maximum indentation load and depth, and the work done during loading and unloading processes. The new method for determining Youngs modulus is referred to as pure energy method. The validity of the method was examined by performing indentation tests on five materials. The experimental results and the standard reference values are in good agreement, indicating that the proposed pure energy method is a promising substitution for the most widely used analysis models at present. | MA Dejun1, Chung Wo Ong2, LIU Jianmin1 & HE Jiawen3 1. Surface Engineering Research Institute, CMES, Beijing 100072, China 2. Department of Applied Physics and Materials Research Center, The Hong Kong Polytechnic University, Hong Kong, China 3. State Key Laboratory for Mechanical Behavior of Materials, Xian Jiaotong University, Xian 710049, China | 2004 | Science China(Technological Sciences)2004，47，4： | 3 |
| 7 | Pandemic of the aging society—sporadic cerebral small vessel disease显示文摘Age-related sporadic cerebral small vessel disease(CSVD)has gained increasing attention over the past decades because of its increasing prevalence associated with an aging population.The widespread application of and advances in brain magnetic resonance imaging in recent decades have significantly increased researchers’understanding in the in vivo evolution of CSVD,its impact upon the brain,its risk factors,and the mechanisms that explain the various clinical manifestation associated with sporadic CSVD.In this review,we aimed to provide an update on the pathophysiology,risk factors,biomarkers,and the determinants and spectrum of the clinical manifestation of sporadic CSVD. | Alexander Yuk Lun Lau Bonaventure Yiu Ming Ip Ho Ko Bonnie Yin Ka Lam Lin Shi Karen Ka Yan Ma Lisa Wing Chi Au Yannie Oi Yan Soo Thomas Wai Hong Leung Adrian Wong Vincent Chung Tong Mok | 2021 | Chinese Medical Journal2021，，2： | 3 |
| 8 | An Iterative Compensation Algorithm for Springback Control in Plane Deformation and Its Application显示文摘In order to solve the springback problem in sheet metal forming, the trial and error method is a widely used method in the factory, which is time-consuming and costly for its non-direction and non-quantitative. Finite element simulation is an e ective method to predict the springback of complex shape parts, but its precision is sensitive to the simulation model, particularly material model and boundary conditions. In this paper, the simple iterative method is introduced to establish the iterative compensation algorithm, and the convergence criterion of iterative parameters is put forward. In addition, the new algorithm is applied to the V-free bending and stretch-bending processes, and the convergence of curvature and bending angle is proved theoretically and verified experimentally. At the same time,the iterative compensation experiments for plane bending show that, the new method can predict the next compensaantido tnh ev atlaureg ebta cseurdv oatnu trhe ew sitphri tnhgeb earcrko ro fo fe laecshs ttehsat,n s0 o. 5 th%a ta rteh eo btatraigneet db aefntedri n2 g-3 a nitgelrea tiwoitnhs.t Thhei se rrreosre aorf clhe sps rtohpaons e±s 0 a.1%new iterative compensation algorithm to predict springback in sheet metal forming process, where each compensation value depends only on the iteration parameter di erence before and after springback for the same forming process of same material. | Rui Ma Chunge Wang Ruixue Zhai Jun Zhao | 2019 | Chinese Journal of Mechanical Engineering2019，32，2： | 2 |
| 9 | Whole Exome Sequencing to Identify a Novel Gene (Caveolin-1) Associated With Human Pulmonary Arterial Hypertension显示文摘 | Eric D. Austin Lijiang Ma Charles LeDuc Erika Berman Rosenzweig Alain Borczuk John A. Phillips Teresa Palomero Pavel Sumazin Hyunjae R. Kim Megha H. Talati James West James E. Loyd Wendy K. Chung | 2012 | Circulation: Cardiovascular Genetics2012，，3： | 2 |
| 10 | Role of C11-FDG dual-tracer PET-CT scan in metastatic screening of hepatocellular carcinoma-a cost-effectiveness analysis显示文摘Background:We aimed to identify predictive factors for positron emission tomography(PET)-detected hepatocellular carcinoma(HCC)metastasis and a cost-effective approach to preoperative PET-computed tomography(CT)for detecting metastasis.Methods:Clinicopathological and survival data of HCC patients having PET-CT with 18F-fludeoxyglucose(FDG)and 11C-acetate(ACT)following contrast-enhanced CT/magnetic resonance imaging(MRI)for preoperative tumor staging were reviewed.Binary logistic regression was performed to identify predictive factors for PET-detected metastasis.A cost-benefit analysis model was built for the incurred costs and the impact of PET-CT findings on treatment strategy was studied.Results:Totally 152 patients were analyzed.Dual-tracer PET-CT detected metastasis in 17 patients(11%).By multivariate analysis,alpha-fetoprotein(AFP)≥400 ng/mL[relative risk(RR):4.30,95%confidence interval(CI):1.41-13.15,P=0.011]and bilobar disease(RR:3.94,95%CI:1.24-12.52,P=0.014)were independent predictive factors for PET-detected metastasis.PET-CT findings altered the treatment strategy for 12 patients(7.9%);three partial hepatectomies,eight episodes of transarterial chemoembolization(TACE)and one episode of ablation were avoided,with an estimated cost-saving of US$91,000,$150,000 and$10,600 respectively.Had the PET-CT been performed only for patients with AFP≥400 ng/mL or bilobar disease(n=74),metastasis would have been confirmed in 14 patients(18.9%),and the cost-saving per patient was estimated at US$1,070.Conclusions:Dual-tracer PET-CT is cost-effective and useful for preoperative HCC staging in patients with AFP≥400 ng/mL or bilobar disease.Its routine use in preoperative workup for all HCC patients is not recommended.Unilobar disease with AFP<400 ng/mL can achieve good negative predictive value for PET-detected metastasis.Screening patients with either factor can avoid unnecessary procedures and is thus cost-effective for preoperative HCC workup. | Kevin K.W.Chu Albert C.Y.Chan Ka Wing Ma Wong Hoi She Wing Chiu Dai Kenneth S.H.Chok Tan To Cheung Chung Mau Lo | 2021 | Hepatobiliary Surgery and Nutrition2021，10，3： | 2 |
| 11 | Liver transplantation:would it be the best and last chance of cure for hepatocellular carcinoma with major venous invasion?显示文摘Background:Hepatocellular carcinoma(HCC)with portal vein tumour thrombus(PVTT)signifies advanced disease,whether LT confers any survival superiority over resection remains uncertain.Methods:A propensity score matched(PSM)analysis of liver transplantation(LT)and liver resection(LR)for HCC with PVTT was performed.Results:A consecutive series of 88 patients who received either LT(10 DDLTs and 3 LDLTs)or LR(n=75)respectively were recruited.Before PSM,the LT group has a higher MELD score(17.3 vs.7.8,P<0.001),lower serum AFP levels(96 vs.2,164 ng/mL,P=0.017)and smaller tumour size(4 vs.10 cm,P<0.001).The 5-year overall survival for LT and LR were 55.4%and 15.9%respectively(P=0.007).After matching for serum AFP levels and tumour size,1-,3-and 5-year overall survival for LT were 81 ng/mL,3.9 cm,80%,70%and 70%and the corresponding rates for LR were 1,417 ng/mL,5.3 cm,51.8%,19,6%and 9.8%(P value=0.12,0.27 and 0.009 respectively).Conclusions:LT is associated with significantly better oncological outcomes in HCC patients with PVTT involving the lobar or segmental level.A modest expansion of selection criteria to include small HCC with segmental PVTT should be considered. | Ka Wing Ma Albert Chi Yan Chan Kenneth Siu Ho Chok Wong Hoi She Tan To Cheung Wing Chiu Dai James Yan Yue Fung Chung Mau Lo | 2021 | Hepatobiliary Surgery and Nutrition2021，10，3： | 2 |
| 12 | New synthesis of amphiphilic copolymers PE-g-PEO via esterfication显示文摘A new series of high molecular weight amphi-philic graft copolymers PE-g-PEO has been prepared. The esterifications between PE-p-MS-g-MA and PEO with OH group at the chain end are carried out under different condi-tions. The compositions of these graft copolymers are studied by NMR and FTIR. It is found to be a convenient and effi-cient way to prepare high molecular weight PE-g-PEO graft copolymers. | L?Yingying1, MA Zhi1,2, HU Youliang1, XU G. X.3 & CHUNG T. C.3 1. State Key Laboratory of Engineering Plastics, Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Bei-jing Beijing Lab of Catalysis, Key Lab of Catalysis of China Na-tional Petroleum Corporation, Beijing 100080, China 2. Graduate School of Chinese Academy of Sciences, Beijing 100039, China 3. Department of Material Science and Engineering, Pennsylvania State University, University Park, PA 16802, USA | 2003 | Chinese Science Bulletin2003，48，6： | 2 |
| 13 | Ionic Liquid Mediated Synthesis of Lath Shaped CuO Micro-Assembles as Extremely Stable Anode Material for Lithium-Ion Batteries显示文摘 | Man Wang Ruguang Ma Ying Liu C.Y. Chung Yonghong Deng Zhouguang Lu | 2017 | Chinese Journal of Chemistry2017，35，8： | 2 |
| 14 | miR-130b Promotes CD133 + Liver Tumor-Initiating Cell Growth and Self-Renewal via Tumor Protein 53-Induced Nuclear Protein 1显示文摘 | Stephanie Ma Kwan Ho Tang Yuen Piu Chan Terence K. Lee Pak Shing Kwan Antonia Castilho Irene Ng Kwan Man Nathalie Wong Ka-Fai To Bo-Jian Zheng Paul B.S. Lai Chung Mau Lo Kwok Wah Chan Xin-Yuan Guan | 2010 | Cell Stem Cell2010，，： | 2 |
| 15 | CFTR mediates bicarbonate-dependent activation of miR-125b in preimplantation embryo development显示文摘尽管 HCO 3− 被知道为早胚胎开发被要求,它的准确角色留下逃犯。这里,我们报导 HCO 3− 在在 preimplantation 胚胎开发期间通过调停 CFTR 的流入调整 miR-125b 表示充当环境暗示。结果证明在 preimplantation 胚胎开发的 HCO 3− 的效果能被介入压制一条 HCO 3−-conducting 隧道的函数, CFTR,由一个特定的禁止者或基因大美人。细胞外的 HCO 3− 的移动或 CFTR 的抑制在 2 个房间阶段老鼠胚胎减少 miR-125b 表示。miR-125b 击倒模仿 HCO 3− 移动和 CFTR 抑制的效果,当 miR-125b 先锋的注射颠倒它时。在人和老鼠胚胎的 miR-125b upregulates p53 串联的 Downregulation。miR-125b 的激活被显示被 sAC/PKA-dependent 调停 NF-κ 的原子 shuttling; B。这些结果在在 preimplantation 胚胎开发期间连接环境 HCO 3− 到 miR-125b 的激活的信号 transduction 揭示了 CFTR 的一个关键角色并且在 miRNAs 的规定显示了离子隧道的重要性。 | Yong Chao Lu Hui Chen Kin Lam Fok Lai Ling Tsang Mei Kuen Yu Xiao Hu Zhang Jing Chen Xiaohua Jiang Yiu Wa Chung Alvin Chun Hang Ma Anskar Yu Hung Leung He Feng Huang Hsiao Chang Chan | 2012 | Cell Research2012，22，10： | 2 |
| 16 | In vivo genome editing thrives with diversified CRISPR technologies显示文摘Prokaryotic type Ⅱ adaptive immune systems have been developed into the versatile CRISPR technology, which has been widely applied in sitespecific genome editing and has revolutionized biomedical research due to its superior efficiency and flexibility. Recent studies have greatly diversified CRISPR technologies by coupling it with various DNA repair mechanisms and targeting strategies.These new advances have significantly expanded the generation of genetically modified animal models, either by including species in which targeted genetic modification could not be achieved previously, or through introducing complex genetic modifications that take multiple steps and cost years to achieve using traditional methods. Herein, we review the recent developments and applications of CRISPR-based technology in generating various animal models, and discuss the everlasting impact of this new progress on biomedical research. | Xun Ma Avery Sum-Yu Wong Hei-Yin Tam Samuel Yung-Kin Tsui Dittman Lai-Shun Chung Bo Feng | 2018 | Zoological Research2018，39，2： | 2 |
| 17 | Validated model for prediction of recurrent hepatocellular carcinoma after liver transplantation in Asian population显示文摘BACKGROUND Liver transplantation(LT) is regarded as the best treatment for both primary and recurrent hepatocellular carcinoma(HCC). Post-transplant HCC recurrence rate is relatively low but significant, ranging from 10%-30% according to different series. When recurrence happens, it is usually extrahepatic and associated with poor prognosis. A predictive model that allows patient stratification according to recurrence risk can help to individualize post-transplant surveillance protocol and guidance of the use of anti-tumor immunosuppressive agents.AIM To develop a scoring system to predict HCC recurrence after LT in an Asian population.METHODS Consecutive patients having LT for HCC from 1995 to 2016 at our hospital were recruited. They were randomized into the training set and the validation set in a60:40 ratio. Multivariable Cox regression model was used to identity factors associated with HCC recurrence. A risk score was assigned to each factor according to the odds ratio. Accuracy of the score was assessed by the area under the receiver operating characteristic curve.RESULTS In total, 330 patients were eligible for analysis(183 in training and 147 invalidation). Recurrent HCC developed in 14.2% of them. The median follow-up duration was 65.6 mo. The 5-year disease-free and overall survival rates were78% and 80%, respectively. On multivariate analysis, alpha-fetoprotein > 400 ng/mL [P = 0.012, hazard ratio(HR) 2.92], sum of maximum tumor size and number(P = 0.013, HR 1.15), and salvage LT(P = 0.033, HR 2.08) were found to be independent factors for disease-free survival. A risk score was calculated for each patient with good discriminatory power(c-stat 0.748 and 0.85, respectively,in the training and validation sets). With the derived scores, patients were classified into low-(0–9), moderate-(> 9–14), and high-risk groups(> 14), and the risk of HCC recurrence in the training and validation sets was 10%, 20%, 54%(cstat 0.67) and 4%, 22%, 62%(c-stat 0.811), accordingly. The risk stratification model was validated with chi-squared goodness-of-fit test(P = 0.425).CONCLUSION A validated predictive model featuring alpha-fetoprotein, salvage LT, and the sum of largest tumor diameter and total number of tumor nodule provides simple and reliable guidance for individualizing postoperative surveillance strategy. | Ka Wing Ma Wong Hoi She Albert Chi Yan Chan Tan To Cheung James Yan Yue Fung Wing Chiu Dai Chung Mau Lo Kenneth Siu Ho Chok | 2019 | World Journal of Gastrointestinal Oncology2019，11，4： | 2 |
| 18 | Molecular genetiC diversity and population structure in Lycium accessions using SSR markers显示文摘 | Zhao W G Chung J W Cho Y I Rha W H Lee G A Ma K H Han S H Bang K H Park C B Kim S M Park Y J | 2010 | C R Bioi2010，333，： | 1 |
| 19 | Is Axillary Lymph node dissection nec- essary after sentinel lymph node biopsy in patients with mastectomy and pathological N1 breast cancer 显示文摘 | Fu Y Chung D Cao MA | 2014 | Ann Surg Oncol2014，21，13： | 1 |
| 20 | A modified damage model for advanced high strength steel sheets显示文摘 | Chung K Ma N Park T | 2011 | Inter J Plasticity2011，27，10： | 1 |
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