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| 1 | Class I phosphatidylinositol 3-kinase inhibitor LY294002 activates autophagy and induces apoptosis through p53 pathway in gastric cancer cell line SGC7901显示文摘我们试图学习 LY294002 的效果,一级 phosphatidylinositol 3-kinase (PI3K ) 的一个禁止者在增长上,在胃的癌症房间的 apoptosis,和 autophagy 衬里 SGC7901。在这研究,我们证明 LY294002 禁止了胃的癌症 SGC7901 房间的生存能力。我们也证明 LY294002 增加了 1 点亮的联系微导管的蛋白质的表示链 3 (LC3 ) ,并且增加的 monodansylcadaverine (MDC ) 把泡标记。LY294002 由激活 p53 和 caspase-3 激活 autophagy,并且由 up-regulatingp53 和 apoptosis (美洲狮) 的 p53-up-regulated 调节的人导致了 apoptosis。因此, LY294002 可能通过 p53 和下游的点美洲狮的激活在 SGC7901 房间导致 cytotoxicity。这些调查结果建议表明小径的一级 PI3K 的抑制是为管理胃的癌症的潜在的策略。 | Chungen Xing Baosong Zhu Huihui Liu Huihua Yao Lifeng Zhang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，3： | 17 |
| 2 | PD-L1 is a direct target of cancer-FOXP3 in pancreatic ductal adenocarcinoma(PDAC),and combined immunotherapy with antibodies against PD-L1 and CCL5 is effective in the treatment of PDAC显示文摘High expression of PD-L1 marks the poor prognosis of pancreatic ductal adenocarcinomas(PDAC).However,the regulatory mechanism of PD-L1 remains elusive.We recently reported that cancer Forkhead box protein 3(Cancer-FOXP3 or C-FOXP3)promoted immune evasion of PDAC by recruiting Treg cells into PDAC via upregulation of CCL5.In this study,we confirmed that PD-L1 was overexpressed in PDAC samples from two independent cohorts of patients with radical resection.Moreover,C-FOXP3 was colocalized and correlated with the expression of PD-L1 in tumor cells at the mRNA and protein levels,and this finding was confirmed by the The Cancer Genome Atlas(TCGA)database.Chromatin immunoprecipitation(ChIP)revealed that C-FOXP3 directly bound to the promoter region of PD-L1 in pancreatic cancer cells.Furthermore,overexpression of C-FOXP3 activated the luciferase reporter gene under the control of the PD-L1 promoter.However,mutation of the binding motif-a completely reversed the luciferase activity.In addition,C-FOXP3-induced upregulation of PD-L1 effectively inhibited the activity of CD8+T cells.Based on our recent finding that the CCL-5 antibody achieved a better response to PDAC models with high C-FOXP3 levels,we further demonstrated that the PD-L1 antibody strengthened the antitumor effect of CCL-5 blockade in xenograft and orthotopic mouse models with high C-FOXP3 levels.In conclusion,C-FOXP3 directly activates PD-L1 and represents a core transcription factor that mediates the immune escape of PDAC.Combined blockade of PD-L1 and CCL-5 may provide an effective therapy for patients with PDAC that have high C-FOXP3 levels. | Xiuchao Wang Xin Li Xunbin Wei Haiping Jiang Chungen Lan Shengyu Yang Han Wang Yanhui Yang Caijuan Tian Zanmei Xu Jiangyan Zhang Jihui Hao He Ren | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 11 |
| 3 | Percutaneous osteoplasty for extraspinal metastases显示文摘As an extension of percutaneous vertebroplasty(PVP), percutaneous osteoplasty(POP) refers broadly to percutaneous bone cement injected into various parts of the body and narrowly to cement injected into extraspinal bone lesions. POP mainly includes such surgeries as percutaneous sacroplasty, percutaneous acetabuloplasty, percutaneous femoral osteoplasty, and percutaneous iliac osteoplasty(Figure 1). Currently, POP is a positive and an effective treatment for extraspinal bone lesions in that it can rapidly relieve pain, effectively prevent pathological fractures, and partially inactivate tumors, with few complications. The aim of this review is to detail the POP techniques and report their safety and efficacy in the treatment of extraspinal metastases. | Qinghua Tian Yongde Cheng Chungen Wu | 2018 | Journal of Interventional Medicine2018，1，3： | 9 |
| 4 | Hot corrosion behavior of nanostructured Gd2O3 doped YSZ thermal barrier coating in presence of Na2SO4+V2O5 molten salts显示文摘Nickel-based superalloy DZ125 was first sprayed with a NiCrAlY bond coat and followed with a nanostructured 2 mol% Gd_2O_3-4.5 mol% Y_2 O_3-ZrO_2(2 GdYSZ) topcoat using air plasma spraying(APS). Hot corrosion behavior of the as-sprayed thermal barrier coatings(TBCs) were investigated in the presence of 50 wt%Na_2SO_4 + 50 wt% V_2O_5 as the corrosive molten salt at 900 ℃ for 100 h. The analysis results indicate that Gd doped YVO_4 and m-ZrO_2 crystals were formed as corrosion products due to the reaction of the corrosive salts with stabilizers(Y_2O_3, Gd_2O_3) of zirconia. Cross-section morphology shows that a thin layer called TGO was formed at the bond coat/topcoat interface. After hot corrosion test, the proportion of m-ZrO_2 phase in nanostructured 2GdYSZ coating is lower than that of nano-YSZ coating. The result reveals that nanostructured 2GdYSZ coating exhibits a better hot corrosion resistance than nano-YSZ coating. | Yixiong Wang Chungen Zhou | 2017 | Progress in Natural Science:Materials International2017，27，4： | 7 |
| 5 | A new combined criterion to better predict malignant lesions in patients with pancreatic cystic neoplasms显示文摘Objective:Cystic lesions of the pancreas have been increasingly recognized.Some lesions exhibit benign behavior,while others have unequivocal malignant potential.Thus,accurate identification of malignancy in patients diagnosed with pancreatic cystic neoplasms(PCNs)remains a major challenge.The aim of this study was to define a combined criterion to better predict malignant lesions in patients with PCNs.Methods:We retrospectively analyzed 165 patients who underwent resection of PCNs from October 2011 to May 2017.The relationship among malignancy and serum carbohydrate antigen 19-9(CA19-9),preoperative neutrophil-to-lymphocyte ratio(NLR),and the presence of enhanced solid component on imaging was analyzed.Results:NLR before surgery in patients with malignant PCNs(2.81±2.14)was significantly higher than that in patients diagnosed with pancreatic neuroendocrine tumor(1.90±0.69,P=0.013)or healthy volunteers(1.40±0.48;P<0.001).Serum CA19-9≥39U/m L,NLR>1.976 and presence of enhanced solid component were independent predictors of PCN malignancy.A combined criterion meeting any two or more of the three elements including CA19-9≥39 U/m L,NLR>1.976,and presence of enhanced solid component on computed tomography imaging is an indicator with a high positive predictive value of 80.5%and a high negative predictive value of 87.9%,and thus,represents a highly accurate test(86.1%).Conclusions:The new combined criterion is an effective predictor of tumor malignancy in patients with PCNs. | Chungen Lan Xin Li Xiuchao Wang Jihui Hao He Ren | 2018 | Cancer Biology & Medicine2018，15，1： | 6 |
| 6 | Effect of Gd_2O_3 on the microstructure and thermal properties of nanostructured thermal barrier coatings fabricated by air plasma spraying显示文摘The nanostructured 4–8 mol% Gd_2O_3-4.5 mol% Y_2O_3-ZrO_2(4–8 mol% Gd YSZ) coatings were developed by the atmospheric plasma spraying technique. The microstructure and thermal properties of plasmasprayed 4–8 mol% Gd YSZ coatings were investigated. The experimental results indicate that typical microstructure of the as-sprayed coatings were consisted of melted zones, nano-zones, splats, nano-pores,high-volume spheroidal pores and micro-cracks. The porosity of the 4, 6 and 8 mol% Gd YSZ coatings was about 9.3%, 11.7% and 13.3%, respectively. It was observed that the addition of gadolinia to the nano-YSZ could significantly reduce the thermal conductivity of nano-YSZ. The thermal conductivity of Gd YSZ decreased with increasing Gd_2O_3 addition. And the reduction in thermal conductivity is mainly attributed to the addition of Gd_2O_3, which results in the increase in oxygen vacancies, lattice distortion and porosity. | Yixiong Wang Chungen Zhou | 2016 | Progress in Natural Science:Materials International2016，26，4： | 6 |
| 7 | Evaluation of Thermal Barrier Coatings Exposed to Hot Corrosion Environment by Impedance Spectroscopy显示文摘在这调查,阻抗光谱学() 被使用作为一个非破坏性的工具,暴露了检验热障碍涂层(TBC ) 的热腐蚀行为到 25wt% NaCl 和 75wt% Na2SO4 的混合物。热地成年的氧化物(TGO ) 沿着最高的上衣 / 契约上衣接口形成了的结果表演是混合氧化物层,即 Cr2O3,(Ni,公司)(Cr,艾尔) 2O4 尖晶石和 NiO。TGO 层的生长看起来跟随寓言的法律。当周期的数字是不到 110 时, TGO 的电阻由于厚度的增加增加。当时因为超过 110 骑车, TGO 的抵抗随 TGO 层的孔的增加减少,尽管 TGO 层的厚度增加。在最高的上衣以内的裂缝的成核和繁殖增加最高的上衣的电的抵抗。在相等的电路的参数能被用来描绘 TBC 的降级。 | LIU Chao HUANG Hui NI Liyong ZHOU Chungen | 2011 | Chinese Journal of Aeronautics2011，24，4： | 5 |
| 8 | Nontrivial Solutions of Superquadratic Hamiltonian Systems with Lagrangian Boundary Conditionsand the L-index Theory显示文摘In this paper, the authors study the existence of nontrivial solutions for the Hamiltonian systems z(t) = JH(t,z(t)) with Lagrangian boundary conditions, where H(t,z)=1/2((B)(t)z,z)+(H)(t,z),(B)(t) is a semipositive symmetric continuous matrix and (H) satisfies a superquadratic condition at infinity. We also obtain a result about the L-index. | Chong LI Chungen LIU | 2008 | Chinese Annals of Mathematics,Series B2008，29，6： | 5 |
| 9 | Minimal periodic solutions of first-order convex Hamiltonian systems with anisotropic growth显示文摘 | Chungen LIU Li ZUO Xiaofei ZHANG | 2018 | Frontiers of Mathematics in China2018，13，5： | 4 |
| 10 | Comparison of the postoperative pain change and spinal stenosis rate between percutaneous vertebroplasty combined with radiofrequency ablation and with ^(125)I particle implantation in the treatment of metastatic spinal cord compression:A retrospective st显示文摘Background context:Metastatic spinal cord compression(MSCC)seriously affects the survival rate.Objective:The therapeutic effects of two treatment strategies for MSCC:percutaneous vertebroplasty(PVP)combined with radiofrequency ablation(RFA)and PVP combined with^(125)I particle implantation,were compared.Study design:Retrospective study.Patient sample:40 patients with MSCC were divided into two groups:19 cases in the RFA group and 21 cases in the^(125)I group.Method:All patients were accessed to determine the differences in pain,which was evaluated using the visual analog scale(VAS)at 1 week,1 month,and 3 months after the operation,and spinal stenosis rates(SSRs),which were measured at 1 and 3 months after the operation,between the two groups.Results:The VAS scores and SSRs at baseline were comparable between the RFA group and the^(125)I group(7.19±2.07 vs 7.42±1.95,37.7%±11.2%vs 41.1%±11.4%).The VAS scores and SSRs at 1 month and 3 months after the operation were significantly reduced in both groups,compared with those at baseline.The VAS scores and SSRs in the^(125)I group were lower than those in the RFA group at 3 months after the operation(1.09±0.97 vs 1.75±1.06 p=0.048 and 12.3%±6.4%vs 18.1%±10.1%p=0.034),while the VAS scores at1 week after the operation in the RFA group were lower than those in the^(125)I group(4.39±1.34 vs 5.05±1.82 p=0.049).Conclusion:PVP combined with RFA has a slight advantage in relieving pain in the short term,while PVP combined with^(125)I particle implantation may have a better effect in the relieving pain and decreasing the SSRs at 3 months after the operation. | Yu He Shilong Han Chungen Wu Fei Ge Jianbo Wang | 2021 | Journal of Interventional Medicine2021，4，4： | 4 |
| 11 | Maslov P-Index Theory for a Symplectic Path with Applications显示文摘为一条 symplectic 路径的 Maslov P 索引理论被定义。象 homotopy 那样的这个索引理论的 Variousproperties 不变,有另外的莫尔斯索引的 symplectic 添加和关系被学习。作为一个应用程序,为 someasymptotically 线性的 Hamiltonian 系统的非周期性的问题被考虑。 | Chungen LIU | 2006 | Chinese Annals of Mathematics,Series B2006，27，4： | 4 |
| 12 | Vapor phase codeposition of Cr and Si on Nb-base in situ composites by pack cementation process显示文摘In order to identify suitable halide activators and pack compositions for codepositing Cr and Si to form diffusion coatings on Nb-base in situ composites by the pack cementation process, thermochemical calculation was taken to analyze the vapor pressure of halide species generated at high temperatures. NH4Cl, NaF and CrCl3·6H2O were selected as the halide salts. The results of thermochemical calculations suggested that the pack powder mixtures, which contained Cr, Si, halide salts and Al2O3, may be activated by NH4Cl and NaF. According to the thermochemical calculations, the pack powder mixture of 12Cr-6Si-5NH4Cl-77Al2O3 (wt%) activated by NH4Cl was formulated and coating deposition experiments were carried out at 1200 and 1300℃. With adequate control of pack compositions and deposition conditions, it was found that codeposition of Cr and Si could indeed be achieved at these temperatures. The coating has a three-layer structure, of which was mainly composed of Cr2(Nb,X) (X represents Ti and Hf elements), Nb5Si3 and (Nb,Cr)3Si. Then the kinetics of coating growth process affected by temperature was studied. The experimental results of the oxidation showed that the coating can efficiently prevent substrate from oxidizing. | Bifei Yuan Yang Li Min Qiao Chungen Zhou | 2013 | Progress in Natural Science:Materials International2013，23，2： | 3 |
| 13 | Corrosion resistance of carbon ion-implanted M50NiL aerospace bearing steel显示文摘The effect of carbon implantation on the corrosion behavior of M50NiL aerospace bearing steel through surface modification was investigated. X-ray photoelectron spectroscopy, Auger electron spectroscopy and X-ray diffraction were used to analyze the composition and structure of the carbon-implanted layer. The corrosion properties of the untreated and carbon ion-implanted samples were evaluated by potentiodynamic curves and electrochemical impedance spectroscopy, which were carried out in 3.5% NaCl solution. Ion implantation of carbon in the M50NiL bearing steel yielded a distinct decrease of the corrosion current densities and an obvious increase of the polarization resistance. The experimental results indicated that the content of chromium oxide in the passive film increased with carbon implantation and that the intergranular corrosion was suppressed in the carbon-implanted sample. Better corrosion protection was observed in the carbon ion implantation sample. | Fangfang Wang Chungen Zhou Lijing Zheng Hu Zhang | 2017 | Progress in Natural Science:Materials International2017，27，5： | 3 |
| 14 | Brake subharmonic solutions of first order Hamiltonian systems显示文摘In this paper,we mainly use the Galerkin approximation method and the iteration inequalities of the L-Maslov type index theory to study the properties of brake subharmonic solutions for the first order non-autonomous Hamiltonian systems.We prove that when the positive integers j and k satisfy the certain conditions,there exists a jT-periodic nonconstant brake solution zj such that zj and zkj are distinct. | LI Chong & LIU ChunGen School of Mathematical Sciences and LPMC,Nankai University,Tianjin 300071,China | 2010 | Science China Mathematics2010，53，10： | 3 |
| 15 | Improved photocatalytic activity of nano CuO-incorporated TiO_2 granules prepared by spray drying显示文摘4 wt% CuO–96 wt% TiO2 granules were prepared by a spray drying process. The microstructure and optical property of CuO–TiO2 granules were studied. The results indicate that copper existed in the form of CuO. The spray dried granules possess spherical geometry and smooth surface with grain size in the range of 40–80 μm. CuO–TiO2 has a relatively smaller E g value(2.85 eV) than Ti O2(3.17 eV). The photocatalytic property of CuO–TiO2 granules was investigated by degradation of a model pollutant(the azo dye methyl orange) under the irradiation of the xenon lamp equipped with a band pass fi lter of 365 nm. The CuO–TiO2spray-dried granules degrade about 10% more MO than TiO2spray-dried granules under UV irradiation within the same time. The XPS spectra suggested that Cu2 tand reduced copper species were coexistent in reacted CuO–TiO2 photocatalyst. The improvement of photocatalytic activity for CuO–TiO2 was mainly attributed to effective separation of photogenerated electron–hole pairs in the presence of CuO. | Zongjie Liu Chungen Zhou | 2015 | Progress in Natural Science:Materials International2015，25，4： | 2 |
| 16 | Integrated bioinformatics identifies the dysregulation induced by aberrant gene methylation in colorectal carcinoma显示文摘Colorectal carcinoma(CRC)is one of the most common cancers,and is associated with a poor dlinical outcome.The key genes and potential prognostic markers in colorectal carcinoma remain to be identfed and explored for clinical application.DNA expression/methyl-ation profles were downloaded from the Gene Expression Omnibus(GEO)database to identify differentially expressed/methylated genes(DEGs and DEMs).A total of 255 genes and 372 genes were identified as being up-regulated and down-regulated,respectively,in GSE113513,GSE81558,and GSE89076.There were a total of 3350 hypermethylated genes and 443 hypomethylated genes identifed in GSE 48684.Twenty genes were found to be hypermethylated as well as down-regulated,and a functional enrichment analysis revealed that these genes were mainly involved in cancer-related pathways.Among these 20 genes,GPM6A,HAND2 and C2orf40 were related to poor outcomes in cancer patients based on a survival analysis.Concurrent decreases of GPM6A,HAND2 and C2orf40 protein expression were observed in highly-dif ferentiated colorectal carcinoma tissues,and higher expression levels were found in undifferentiated or minimally-differentiated colorectal carcinoma tissues.In conclusion,20 genes were found to be downregulated and hypermethylated in CRC,among which GPM6A,HAND2 and C2orf40 were explored for their potential prognostic value. | Zhenyu Ye Yecheng Li Jiaming Xie Zhenyu Feng Xiaodong Yang Yong Wu Yuwei Pu Jiawei Gao Xiangrong Xu Zhaobi Zhu Wei Li Wei Chen Chungen Xing | 2021 | Genes & Diseases2021，8，4： | 2 |
| 17 | Cyclic-Oxidation Behavior of Multilayered Pt/Ru-Modified Aluminide Coating显示文摘Multilayered Pt/Ru modified aluminide coating for thermal barrier coating(TBC) systems has been investigated.2 μm Pt+2 μm Ru+2 μm Pt was first deposited on nickel-base superalloy DZ125 by electrodeposition,and then the coating was treated by annealing and a conventional pack-cementation aluminizing process.The cyclic oxidation tests were carried out at 1423 K in air.It was found that the thermal cyclic oxidation resistance of Pt/Ru-modified aluminide coating was comparable to that of Pt-modified aluminide coating,which was much better than simply aluminized DZ125.The addition of Ru to Pt-modified aluminide coating increased the resistance to rumpling.The microstructures and phase constitutions of the coating before and after oxidation were investigated. | Yingxue Song Hideyuki Murakami Chungen Zhou | 2011 | Journal of Materials Science & Technology2011，27，3： | 2 |
| 18 | Minimal P-symmetric period problem of first-order autonomous Hamiltonian systems显示文摘让 P Sp (2n ) 令人满意的 P k = 我 2n 。我们考虑自治非线性的 Hamiltonian 系统 \ 的最小的 P 对称的时期问题(\dot x\left (t \right )= JH\left ({ x\left (t \right )}\right )\) 。为一些 symplectic 矩阵 P ,我们显示出那为任何> 0 ,上述 Hamiltonian 系统拥有 k 有是的 k 的周期的答案 x 它的时期提供了足够 Fies Rabinowitzs 在最小的最小的P对称的时期上调节的 H 推测,和那 H 是凸的并且 H ( Px )= H (x)。 | Chungen LIU Benxing ZHOU | 2017 | Frontiers of Mathematics in China2017，12，3： | 2 |
| 19 | Experimental study and modeling of high temperature oxidation of Nb-base in situ composites显示文摘 | Dengzun Yao Rui Cai Chungen Zhou Jiangbo Sha Huiren Jiang | 2008 | Corrosion Science2008，，2： | 2 |
| 20 | THE STABILITY OF THE PERIODIC SOLUTIONS OF SECOND ORDER HAMILTONIAN SYSTEMS显示文摘This paper studies the stability of the periodic solutions of the second order Hamiltonian systems with even superquadratic or subquadratic potentials. The author proves that in the subquadratic case, there exist infinite geometrically distinct elliptic periodic solutions, and in the superquadratic case, there exist infinite geometrically distinct periodic solutions with at most one instability direction if they are half period non-degenerate, otherwise they are elliptic. | LIU CHUNGEN(Department of Mathematics, Nankai University, Tianjin 300071, China.) | 2000 | Chinese Annals of Mathematics,Series B2000，21，2： | 2 |
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