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| 1 | Recent advances in nano scaffolds for bone repair显示文摘Biomedical applications of nanomaterials are exponentially increasing every year due to analogy to various cell receptors, ligands, structural proteins, and genetic materials(that is, DNA). In bone tissue, nanoscale materials can provide scaffold for excellent tissue repair via mechanical stimulation, releasing of various loaded drugs and mediators, 3D scaffold for cell growth and differentiation of bone marrow stem cells to osteocytes. This review will therefore highlight recent advancements on tissue and nanoscale materials interaction. | Huan Yi Fawad Ur Rehman Chunqiu Zhao Bin Liu Nongyue He | 2016 | Bone Research2016，4，4： | 17 |
| 2 | Abrasive-assisted Nickel Electroforming Process with Moving Cathode显示文摘In traditional electroforming process for revolving parts with complex profiles, the drawbacks on surface of deposits, such as pinholes and nodules, will lead to varying physical and mechanical properties on different parts of electroformed components. To solve the problem,compositely moving cathode is employed in abrasive-assisted electroforming of revolving parts with complicated profiles. The cathode translates and rotates simultaneously to achieve uniform friction effect on deposits without drawbacks. The influences of current density and translation speed on the microstructure and properties of the electroformed nickel layers are investigated. It is found that abrasive-assisted electroforming with compound cathode motion can effectively remove the pinholes and nodules,positively affect the crystal nucleation, and refine the grains of layer. The increase of current density will lead to coarse microstructure and lower micro hardness, from 325 HV down to 189 HV. While, faster translational linear speed produces better surface quality and higher micro hardness, from 236 HV up to 283 HV. The weld-ability of the electroformed layers are also studied through the metallurgical analysis of welded joints between nickel layer and 304 stainless steel. The electrodeposited nickel layer shows fine performance in welding. The novel compound motion of cathode promotes the mechanical properties and refines the microstructure of deposited layer. | Jianhua REN Zengwei ZHU Chunqiu XIA Ningsong QU Di ZHU | 2017 | Chinese Journal of Mechanical Engineering2017，30，2： | 4 |
| 3 | Iguratimod: a valuable remedy from the Asia Pacific region for ameliorating autoimmune diseases and protecting bone physiology显示文摘Autoimmune diseases are affected by complex pathophysiology involving several cell types,cytokines,antibodies,and mimicking factors.Different drugs are used to ameliorate these autoimmune reactions,including nonsteroidal anti-inflammatory drugs(NSAIDs),corticosteroids,antiantibodies,and small molecular drugs(DMARDs),and they are clinically in vogue for diseases such as rheumatoid arthritis(RA).Nevertheless,low cost-effectiveness,reduced efficacy,adverse effects,and patient nonresponse are unappealing factors driving the development of new drugs such as iguratimod.Iguratimod is primarily used to ameliorate RA in Japanese and Chinese clinics.However,its efficacy against other autoimmune ailments is also under intense investigation,and the number of investigations is becoming increasingly larger with each passing day.The articular structure comprises synovium,ligaments,and bone.The latter is more complex than the others since it regulates blood cells and autoimmunity in addition to providing skeletal support to the body.Therefore,its protection is also of prime importance in RA and other autoimmune diseases.Herein,we have highlighted the role of iguratimod in autoimmune diseases and bone protection.We suggest that iguratimod’s unique mode of action compared with that of other DMARDs and its good patient response makes it a suitable antirheumatic and bone-protecting drug. | Jie Li Jun Bao Jian Zeng Aizhu Yan Chunqiu Zhao Qiang Shu | 2019 | Bone Research2019，7，4： | 4 |
| 4 | Competitive adsorption and desorption of copper and lead in some soil of North China显示文摘 | Fengjic ZHANG Xiaoxia OU Shuo CHEN Chunqiu RAN Xie QUAN | 2012 | Frontiers of Environmental Science & Engineering2012，6，4： | 3 |
| 5 | Antinociceptive effects of novel melatonin receptor agonists in mouse models of abdominal pain显示文摘AIM: To characterize the antinociceptive action of the novel melatonin receptor(MT) agonists, Neu-P11 and Neu-P12 in animal models of visceral pain. METHODS: Visceral pain was induced by intracolonic(ic) application of mustard oil or capsaicin solution or by intraperitoneal(ip) administration of acetic acid. Neu-P11, Neu-P12, or melatonin were given ip or orally and their effects on pain-induced behavioral responses were evaluated. To identify the receptors involved, thenon-selective MT1/MT2 receptor antagonist luzindole, the MT2 receptor antagonist 4-P-PDOT, or the μ-opioid receptor antagonist naloxone were injected ip or intracerebroventricularly(icv) prior to the induction of pain. RESULTS: Orally and ip administered melatonin, Neu-P11, and Neu-P12 reduced pain responses in a dose-dependent manner. Neu-P12 was more effective and displayed longer duration of action compared to melatonin. The antinociceptive effects of Neu-P11 or Neu-P12 were antagonized by ip or icv. administered naloxone. Intracerebroventricularly, but not ip administration of luzindole or 4-P-PDOT blocked the antinociceptive actions of Neu-P11 or Neu-P12. CONCLUSION: Neu-P12 produced the most potent and long-lasting antinociceptive effect. Further development of Neu-P12 for future treatment of abdominal pain seems promising. | Chunqiu Chen Jakub Fichna Moshe Laudon Martin Storr | 2014 | World Journal of Gastroenterology2014，20，5： | 3 |
| 6 | In vivo rapid fluorescence imaging of Alzheimer's disease through accurate target bio-marking of zinc gluconate显示文摘Alzheimer's disease(AD) is a progressive and age-related irreversible neurodegenerative disease. When AD occurs, the relevant amount of zinc ions in brain considerably changes. In this contribution, we have explored the possibility of in vivo rapid fluorescence imaging of AD through accurate targeting biomarker of zinc gluconate. By using the 3- and 6-month-old Alzheimer's model mice(AD-1) as the experimental models, our observations demonstrate that zinc gluconate molecules could pass through the blood–brain barrier and then produce hippocampus region-specific accumulation of fluorescent zinc nanoclusters in vivo, thus allowing kinetically controlled selective imaging of AD by fluorescence bioimaging. | Lanmei Lai Chunqiu Zhao Meina Su Jing Ye Hui Jiang Xuemei Wang | 2015 | Science Bulletin2015，60，16： | 3 |
| 7 | Industrial TiO2 based nacreous pigments as functional building materials:Photocatalytic removal of NO显示文摘In this paper,the photocatalytic activity of industrial titanium dioxide(TiO2)based nacreous pigments was researched as functional building materials for photocatalytic NO remove.Three industrial TiO2 based nacreous pigments were selected to estimate the photocatalytic activity for NO remove.This study is a good proof that pearlescent pigments can eliminate NO,and its performance is positively correlated with its titanium dioxide content.And this research will widen the application of nacreous pigments in functional building materials,and provide a new way to eliminate in door nitric oxide pollution. | Jue Li Li Wang Chunqiu Han Fengyun Su Yumin Leng Liqun Ye | 2020 | Chinese Journal of Chemical Engineering2020，28，10： | 3 |
| 8 | Band structures of transverse waves in nanoscale multilayered phononic crystals with nonlocal interface imperfections by using the radial basis function method显示文摘A radial basis function collocation method based on the nonlocal elastic continuum theory is developed to compute the band structures of nanoscale multilayered phononic crystals. The effects of nonlocal imperfect interfaces on band structures of transverse waves propagating obliquely or vertically in the system are studied. The correctness of the present method is verified by comparing the numerical results with those obtained by applying the transfer matrix method in the case of nonlocal perfect interface. Furthermore, the influences of the nanoscale size, the impedance ratio and the incident angle on the cut-off frequency and band structures are investigated and discussed in detail. Numerical results show that the nonlocal interface imperfections have significant effects on the band structures in the macroscopic and microscopic scale. | Zhizhong Yan Chunqiu Wei Chuanzeng Zhang | 2017 | Acta Mechanica Sinica2017，33，2： | 2 |
| 9 | ELASTIC SH WAVE PROPAGATION IN PERIODIC LAYERED COMPOSITES WITH A PERIODIC ARRAY OF INTERFACE CRACKS显示文摘The interaction of anti-plane elastic SH waves with a periodic array of interface cracks in a multi-layered periodic medium is analyzed in this paper. A perfect periodic structure without interface cracks is first studied and the transmission displacement coefficient is obtained based on the transfer matrix method in conjunction with the Bloch-Floquet theorem. This is then generalized to a single and periodic distribution of cracks at the center interface and the result is compared with that of perfect periodic cases without interface cracks. The dependence of the transmission displacement coefficient on the frequency of the incident wave, the influences of material combination, crack configuration and incident angle are discussed in detail. Compared with the corresponding perfect periodic structure without interface cracks, a new phenomenon is found in the periodic layered system with a single and periodic array of interface cracks. | Zhizhong Yan Chunqiu Wei Chuanzeng Zhang | 2015 | Acta Mechanica Solida Sinica2015，28，5： | 2 |
| 10 | ANALYSIS OF DYNAMIC STABILITY OF SUBMERGED STRUCTURE显示文摘The submerged structure is basically a large three-dimensional structure of few statically redundant members. The structure is subjected to vertical dead and live loads in addition to the wave forces. An analysis of dynamic stability of the submerged structure without damping has been made by J. Thomas and Abbas (1980). In this paper the analyses of dynamic stability of the sumberged structure with damping are conducted. The case structure with damping is more complicated ’than the case without it. According to the principle of perturbation, a new model for dynamic stability calculation in consideration of damping effect is developed. In this paper, the formulas are deduced, the computational program is compiled, the practical examples are analysed, and this problem is solved very satisfactorily. The computational results show that the shape and value of the regions of dynamic instability can be changed significantly by damping. So only by considering damping can the property of dynamic stability of the submerged structure be reflected correctly. | Qu Naisi , Yang Chunqiu and Tao Zhengguo Associate Professor, Dalian University of Technology, Dalian, Engineer, Wuxi 706 Research Institute, Wuxi | 1990 | China Ocean Engineering1990，5，2： | 2 |
| 11 | RBF collocation method and stability analysis for phononic crystals显示文摘The mesh-free radial basis function(RBF) collocation method is explored to calculate band structures of periodic composite structures. The inverse multi-quadric(MQ), Gaussian, and MQ RBFs are used to test the stability of the RBF collocation method in periodic structures. Much useful information is obtained. Due to the merits of the RBF collocation method, the general form in this paper can easily be applied in the high dimensional problems analysis. The stability is fully discussed with different RBFs.The choice of the shape parameter and the effects of the knot number are presented. | Chunqiu WEI Zhizhong YAN Hui ZHENG Chuanzeng ZHANG | 2016 | Applied Mathematics and Mechanics(English Edition)2016，37，5： | 1 |
| 12 | Enzyme-instructed and mitochondria-targeting peptide self-assembly to efficiently induce immunogenic cell death显示文摘Immunogenic cell death(ICD) plays a major role in cancer immunotherapy by stimulating specific T cell responses and restoring the antitumor immune system.However,effective type Ⅱ ICD inducers without biotoxicity are still very limited.Herein,a tentative drug-or photo sensitizer-free strategy was developed by employing enzymatic self-assembly of the peptide F-pY-T to induce mitochondrial oxidative stress in cancer cells.Upon dephosphorylation catalyzed by alkaline phosphatase overexpressed on cancer cells,the peptide F-pY-T self-assembled to form nanoparticles,which were subsequently internalized.These affected the morphology of mitochondria and induced serious reactive oxygen species production,causing the ICD characterized by the release of danger-associated molecular patterns(DAMPs).DAMPs enhanced specific immune responses by promoting the maturation of DCs and the intratumoral infiltration of tumor-specific T cells to eradicate tumor cells.The dramatic immunotherapeutic capacity could be enhanced further by combination therapy of F-pY-T and anti-PD-L1 agents without visible biotoxicity in the main organs.Thus,our results revealed an alternative strategy to induce efficient ICD by physically promoting mitochondrial oxidative stress. | Debin Zheng Jingfei Liu Limin Xie Yuhan Wang Yinghao Ding Rong Peng Min Cui Ling Wang Yongjie Zhang Chunqiu Zhang Zhimou Yang | 2022 | Acta Pharmaceutica Sinica B2022，12，6： | 1 |
| 13 | Role of carbonyl cyanide m-chlorophenylhydrazone in enhancing photobiological hydrogen production by marine green alga Platyrnonas subcordiformis显示文摘 | RAN Chunqiu YU Xingju JIN Meifang | 2006 | Biotechnol Prog2006，22，2： | 1 |
| 14 | Modeling hydroionic transport in cement-based porous materials under drying wetting actions 显示文摘 | LI Kefei LI Chunqiu | 2013 | Journal of Applied Mechanics2013，80，2： | 1 |
| 15 | Research on emulator system of mine gas and coal dust explosion propagation显示文摘 | SI Rongjun WANG Chunqiu | 2006 | China Safety Science Journal2006，16，12： | 1 |
| 16 | Direct compression as an ap- propriately mechanical environment in bone tissue reconstruction in vitro显示文摘 | Chunqiu Z Xizheng Z Han W | 2006 | Med Hypotheses2006，67，6： | 1 |
| 17 | The protective effects of polyphenols from jujube peel (Ziziphus jujube Mill) 1 on isoproterenol-induced myocardial ischemia and aluminum-induced myocardial ischemia and aluminum-induced oxidative damage in rats 显示文摘 | CHENG Dai ZHU Chunqiu CAO Jiankang | 2012 | Food and Chemical Toxicology2012，50，： | 1 |
| 18 | Clinicopathological and Immunohistochemical Characterisation of Gastric Schwannomas in 29 Cases显示文摘 | Lijun Zheng Xiaojiang Wu Martin E. Kreis Zhen Yu Lijin Feng Chunqiu Chen Bin Xu Zhaode Bu Ziyu Li Jiafu Ji Paul Enck | 2014 | Gastroenterology Research and Practice2014，，： | 1 |
| 19 | Transportation of AIE-visualized nanoliposomes is dominated by the protein corona显示文摘Liposomes, especially cationic liposomes, are the most common and well-investigated nanocarriers for biomedical applications, such as drug and gene delivery. Like other types of nanomaterials, once liposomes are incubated in a biological milieu, their surface can be immediately cloaked by biological components to form a protein corona, which confers a new ‘biological identity’ and modulates downstream interactions with cells. However, it remains unclear how the protein corona affects the transportation mechanism after liposomes interact with cells. Here, we employed home-made aggregation-induced-emission-visualized nanoliposomes TR4@Lipo as a model to investigate transportation with or without the protein corona by optical imaging techniques. The results show that the protein corona can change the cellular transportation mechanism of TR4@Lipo from energy-independent membrane fusion to energy-dependent endocytosis.The protein corona also modulates the intracellular distribution of loaded cargoes. This knowledge furthers our understanding of bio-nano interactions and is important for the efficient use of cationic liposomes. | Yi-Feng Wang Chunqiu Zhang Keni Yang Yufei Wang Shaobo Shan Yan Yan Kenneth A.Dawson Chen Wang Xing-Jie Liang | 2021 | National Science Review2021，8，6： | 1 |
| 20 | Rapid and multimodal in vivo bioimaging of cancer cells through in situ biosynthesis of Zn&Fe nanoclusters显示文摘早诊断为有效癌症治疗仍然保持高度重要,并且因此,对有效成像策略的发展有重要兴趣。这个工作由介绍水的 Fe 2+ 和 Zn 2+ 离子进癌症房间为癌症房间的精确、快速的诊断报导一个新多模式的 bioimaging 方法(即, HeLa, U87,和 HepG2 癌症房间) 。我们发现 biocompatible 金属离子 Fe 2+ 和 Zn 2+ 强迫了癌症房间自发地综合荧光灯 ZnO nanoclusters 和磁性的 Fe 3 O 4 nanoclusters。这些簇然后能由把荧光成像与磁性的回声成像相结合被用于多模式的癌症成像并且计算断层摄影术成像。同时,为正常房间(即, L02 ) 并且纸巾,两荧光也不任何另外的明显的差别能在 preand 之间被检测注射以后。这多模式的 bioimaging 策略基于在里面 situ biosynthesized Zn&Fe 氧化物 nanoclusters 可能因此为早癌症诊断和治疗是有用的。 | Tianyu Du Chunqiu Zhao Fawad ur Rehman Lanmei Lai Xiaoqi Li Yi Sun Shouhua Luo Hui Jiang Matthias Selke Xuemei Wang | 2017 | Nano Research2017，10，8： | 1 |
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