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| 1 | Autophagy: a double-edged sword for neuronal survival after cerebral ischemia显示文摘Evidence suggests that autophagy may be a new therapeutic target for stroke, but whether activation of autophagy increases or decreases the rate of neuronal death is still under debate. This review summarizes the potential role and possible signaling pathway of autophagy in neuronal survival after cerebral ischemia and proposes that autophagy has dual effects. | Wenqi Chen Yinyi Sun Kangyong Liu Xiaojiang Sun | 2014 | Neural Regeneration Research2014，9，12： | 57 |
| 2 | Level of circulating PD-L1 expression in patients with advanced gastric cancer and its clinical implications显示文摘Objective:The programmed cell death-1 receptor/programmed cell death-1 ligand(PD-1/PD-L1) pathway plays a crucial role in tumor evasion from host immunity.This study was designed to evaluate the association between circulating PD-L1 expression and prognosis in patients with advanced gastric cancer.Methods:Totally 80 advanced gastric cancer patients and 40 health controls from Beijing Cancer Hospital were enrolled in the present study.Circulating PD-L1 expression was tested by enzymelinked immunosorbent assay(ELISA).The associations between the expression level of PD-L1 and clinicopathological features and prognosis were analyzed statistically.Results:Expression of PD-L1 in advanced gastric cancer patients was significantly up-regulated compared with health people(P=0.006).The expression of PD-L1 was significantly correlated with differentiation and lymph node metastasis(P=0.026 and P=0.041,respectively).Although we didn't find significant difference in all advanced gastric cancer patients with different PD-L1 expression,the adenocarcinoma patients with higher up-regulated PD-L1 expression had much better prognosis than low expression patients(65.6% vs.44.7%,P=0.028).Conclusions:PD-L1 was elevated in advance gastric cancer patients and may play an important role in tumor immune evasion and patients prognosis. | Zhixue Zheng Zhaode Bu Xijuan Liu Lianhai Zhang Ziyu Li Aiwen Wu Xiaojiang Wu Xiaojing Cheng Xiaofang Xing Hong Du Xiaohong Wang Ying Hu Jiafu Ji | 2014 | Chinese Journal of Cancer Research2014，26，1： | 37 |
| 3 | A diterpenoid derivative 15-oxospiramilactone inhibits Wnt/ β-catenin signaling and colon cancer cell tumorigenesis显示文摘表明小径的 Wnt/-catenin 是在有机体进化的一条高度保存的小径并且调整许多生物过程。表明小径的 Wnt/-catenin 的异常激活是仔细与 tumorigenesis 有关。以便识别有势力小分子到对待过去激活的 Wnt 调停信号的癌症我们例如结肠癌,建立了一个哺乳动物的房间基于线的记者基因屏蔽系统。屏幕在 HEK293T 房间和结肠癌房间, SW480 和 Caco-2 的生长揭示了 diterpenoid 衍生物,禁止 Wnt3a 的 15-oxospiramilactone (NC043 ) 或刺激 LiCl 的最高闪光的记者活动。有导致的 NC043 的 SW480 房间的治疗在 mRNA 或 Wnt 目标基因 Axin2, Cyclin D1 和 Survivin 的蛋白质表示减少,以及在 Cdc25c 和 Cdc2 的蛋白质层次减少。NC043 没影响 cytosol 原子的分发和可溶的 -catenin, 的蛋白质水平,但是减少在 SW480 房间的 -catenin/TCF4 协会。而且, NC043 禁止了 SW480 细胞的抛锚无关的生长和异种皮移植 tumorigenesis。一起,这些结果证明 NC043 是禁止 -catenin 稳定性下游地发信号的正规 Wnt 的一个新奇小分子并且可以是为治疗 colorectal 癌症的潜在的混合物。 | Wei Wang Haiyang Liu Sheng Wang Xiaojiang Hao Lin Li | 2011 | Cell Research2011，21，5： | 19 |
| 4 | Prognostic nutritional index is an independent prognostic factor for gastric cancer patients with peritoneal dissemination显示文摘Objective: The predictive and prognostic role of prognostic nutritional index(PNI) in gastric cancer patients with peritoneal dissemination remains unclear. This study aims to explore the role of the PNI in predicting outcomes of gastric cancer patients with peritoneal dissemination.Methods: A total of 660 patients diagnosed with gastric adenocarcinoma with peritoneal metastasis between January 2000 and April 2014 at Sun Yat-sen University Cancer Center and the Sixth Affiliated Hospital of Sun Yatsen University were retrospectively analyzed. The clinicopathologic characteristics and clinical outcomes of patients with peritoneal dissemination were analyzed.Results: Compared with PNI-high group, PNI-low group was correlated with advanced age(P=0.036), worse performance status(P<0.001), higher frequency of ascites(P<0.001) and higher frequency of multisite distant metastasis(P<0.001). Kaplan-Meier survival curves showed that PNI-high group had a significantly longer median overall survival than PNI-low group(13.13 vs. 9.03 months, P<0.001). Multivariate survival analysis revealed that Borrmann type IV(P=0.014), presence of ascites(P=0.017) and lower PNI(P=0.041) were independent poor prognostic factors, and palliative surgery(P<0.001) and first-line chemotherapy(P<0.001) were good prognostic factors. For patients receiving palliative surgery, the postoperative morbidity rates in the PNI-low group and PNIhigh group were 9.1% and 9.9%, respectively(P=0.797). The postoperative mortality rate was not significantly different between PNI-low and PNI-high groups(2.3% vs. 0.9%, P=0.362).Conclusions: PNI is a useful and practical tool for evaluating the nutritional status of gastric cancer patients with peritoneal dissemination, and is an independent prognostic factor for these patients. | Runcong Nie Shuqiang Yuan Shi Chen Xiaojiang Chen Yongming Chen Baoyan Zhu Haibo Qiu Zhiwei Zhou Junsheng Peng Yingbo Chen | 2016 | Chinese Journal of Cancer Research2016，28，6： | 19 |
| 5 | A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30显示文摘Mitochondrial 熔化是为正常 mitochondrial 功能和 mitochondrial DNA 继承混合并且统一 mitochondrial 分隔空间的一个高度协调的过程。Dysregulated mitochondrial 熔化原因 mitochondrial 破碎,反常 mitochondrial 生理学和继承,并且有原因地与很多 neuronal 疾病被连接了。这里,我们识别了 potently 导致了 mitochondrial 熔化在在 Mfn1 或 Mfn2 是缺乏的房间恢复 mitochondrial 网络和氧化呼吸的 diterpenoid 衍生物 15-oxospiramilactone (S3 ) 。线粒体局部性的 deubiquitinase USP30 是 S3 的一个目标。由 S3 的 USP30 的抑制导致 Mfn1/2 的 non-degradative ubiquitination 的增加,它提高 Mfn1 和 Mfn2 活动并且支持 mitochondrial 熔化。通过 USP30 的一个禁止者的使用,因此,我们的学习揭开在支持 mitochondrial 的 Mfns 的 non-degradative ubiquitination 的异乎寻常的功能熔化。 | Wen Yue Ziheng Chen HaiYang Li Chen Yan Ming Chen Du Feng Chaojun Yan Hao Wu Lei Du Yueying Wang Jinhua Liu Xiaohu Huang Laixin Xia Lei Liu Xiaohui Wang Haijing Jin Jun Wang Zhiyin Song Xiaojiang Hao Quan Chen | 2014 | Cell Research2014，24，4： | 18 |
| 6 | LGR5 is a promising biomarker for patients with stage Ⅰ and Ⅱ gastric cancer显示文摘Objective: To investigate Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) expressions in gastric cancer and to evaluate its clinical significance. Methods: LGR5 expression was assessed by immunohistochemistry in 257 gastric cancer patients after surgery. The relationships between LGR5 expression and clinicopathological features and patients prognosis were statistically analyzed. Results: The expression of LGR5 was significantly higher in gastric cancers as a cancer stem cell marker than in adjacent normal tissues (P<0.001), and more frequently in patients with intestinal type, well-moderate differentiation and stage Ⅰ and Ⅱ (P<0.05). Although we found gastric cancer patients with LGR5 positive expression had a poorer prognosis, it didn't meet statistical significance (P>0.05). LGR5 negative expression was significantly related to the favorable overall survival in stage Ⅰ and Ⅱ gastric cancer patients (P<0.05). Furthermore, patients with high LGR5 expression tended to be more likely to get progression and have poorer progress-free survival (P<0.05). Multivariate Cox regression analysis revealed that LGR5 expression was an independent factor of overall survival for the patients with stage Ⅰ and Ⅱ gastric cancer (P<0.05). Conclusions: Our results show that LGR5 may play an important role in tumorigenesis and progression and would be a powerful marker to predict the prognosis of patients with stage Ⅰ and Ⅱ gastric cancer. | Zhaode Bu Zhixue Zheng Lianhai Zhang Ziyu Li Yu Sun Bin Dong Aiwen Wu Xiaojiang Wu Xiaohong Wang Xiaojing Cheng Xiaofang Xing Yingai Li Hong Du Jiafu Ji | 2013 | Chinese Journal of Cancer Research2013，25，1： | 17 |
| 7 | Genome sequences of horticultural plants:past,present,and future显示文摘Horticultural plants play various and critical roles for humans by providing fruits,vegetables,materials for beverages,and herbal medicines and by acting as ornamentals.They have also shaped human art,culture,and environments and thereby have influenced the lifestyles of humans.With the advent of sequencing technologies,there has been a dramatic increase in the number of sequenced genomes of horticultural plant species in the past decade.The genomes of horticultural plants are highly diverse and complex,often with a high degree of heterozygosity and a high ploidy due to their long and complex history of evolution and domestication.Here we summarize the advances in the genome sequencing of horticultural plants,the reconstruction of pan-genomes,and the development of horticultural genome databases.We also discuss past,present,and future studies related to genome sequencing,data storage,data quality,data sharing,and data visualization to provide practical guidance for genomic studies of horticultural plants.Finally,we propose a horticultural plant genome project as well as the roadmap and technical details toward three goals of the project. | Fei Chen Yunfeng Song Xiaojiang Li Junhao Chen Lan Mo Xingtan Zhang Zhenguo Lin Liangsheng Zhang | 2019 | Horticulture Research2019，6，1： | 16 |
| 8 | Depth of tumor invasion and tumor-occupied portions of stomach are predictive factors of intra-abdominal metastasis显示文摘Objective:Diagnostic laparoscopy is recommended for the pretherapeutic staging of gastric cancer to detect any unexpected or unconfirmed intra-abdominal metastasis.The aim of this study was to evaluate the role and indications of diagnostic laparoscopy in the detection of intra-abdominal metastasis.Methods:Standard diagnostic laparoscopy with peritoneal cytology examination was performed prospectively on patients who were clinically diagnosed with primary local advanced gastric cancer(c T≥2M0).We calculated the rate of intra-abdominal metastases identified by diagnostic laparoscopy,and examined the relationship between peritoneal dissemination(P)and cytology results(CY).Split-sample method was applied to find clinical risk factors for intra-abdominal metastasis.Multivariate logistic regression analysis and receiver-operator characteristic(ROC)analysis were performed in training set to find out risk factors of intra-abdominal metastasis,and then validate it in testing set.Results:Out of 249 c M0 patients,51(20.5%)patients with intra-abdominal metastasis were identified by diagnostic laparoscopy,including 20(8.0%)P1CY1,17(6.8%)P0CY1 and 14(5.6%)P1CY0 patients.In the training set,multivariate logistic regression analysis and ROC analysis showed that the depth of tumor invasion on computer tomography(CT)scan≥21 mm and tumor-occupied≥2 portions of stomach are predictive factors of metastasis.In the testing set,when diagnostic laparoscopy was performed on patients who had one or two of these risk factors,the sensitivity and positive predictive value for detecting intra-abdominal metastasis were 90.0%and32.1%,respectively.Conclusions:According to our results,depth of tumor invasion and tumor-occupied portions of stomach are predictive factors of intra-abdominal metastasis. | Ziyu Li Zhemin Li Shuqin Jia Zhaode Bu Lianhai Zhang Xiaojiang Wu Shuangxi Li Fei Shan Xin Ji Jiafu Ji | 2017 | Chinese Journal of Cancer Research2017，29，2： | 14 |
| 9 | Construction and external validation of a nomogram that predicts lymph node metastasis in early gastric cancer patients using preoperative parameters显示文摘Objective: To create a nomogram to predict the incidence of lymph node metastasis(LNM) in early gastric cancer(EGC) patients and to externally validate the nomogram.Methods: To construct the nomogram,we retrospectively analyzed a primary cohort of 272 EGC patients.Univariate analysis and a binary logistic regression were performed.A nomogram predicting the incidence of LNM in EGC patients was created.The discrimination ability of the nomogram was measured using the concordance index(c-index),and the nomogram was also calibrated.Then,another prospective cohort of 81 patients was analyzed to validate the nomogram.Results: In the primary cohort,LNM was pathologically confirmed in 37(13.6%) patients.In multivariate analysis,the presence of an ulcer,the maximum lesion diameter observed via gastroscopy,the thickness of the lesion observed via endoscopic ultrasonography,and the presence of enlarged lymph nodes on computed tomography(CT) were independent risk factors for LNM.A nomogram was then created based on the regression model with the c-index of 0.905,and the calibration curve of the nomogram fell approximately on the ideal 45-degree line.The cut-off score of the nomogram was 110,and the sensitivity,specificity,positive predictive and negative predictive values of the nomogram in the primary cohort were 81.1%,86.0%,47.6% and 96.7%,respectively,and in the prospective validation cohort were 75.0%,91.0%,60.0% and 95.5%,respectively.The calibration curve of the external validation cohort was almost on the 45-degree line.Conclusions: We developed an effective nomogram predicting the incidence of LNM for EGC patients. | Yinan Zhang Yiqiang Liu Ji Zhang Xiaojiang Wu Xin Ji Tao Fu Ziyu Li Qi Wu Zhaode Bu Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，6： | 12 |
| 10 | Land Use Effects on the Distribution and Speciation of Heavy Metals and Arsenic in Coastal Soils on Chongming Island in the Yangtze River Estuary, China显示文摘The reclamation of tidal flats has been one of the important approaches to replenish the arable lands in the coastal areas; pollution status of reclaimed soils has received wide attention recently, especially for the study of heavy metals due to the relative high pollutant concentrations in wetlands. To understand the impact of land use change on heavy metal and arsenic(As) geochemistry by the reclamation of wetlands for agriculture, surface soils and soil profiles were collected from the agricultural land reclaimed in the 1990 s and the intertidal flat wetland at Dongtan on Chongming Island in the Yangtze River Estuary, China. The soil samples were analyzed for total concentrations and chemical speciation of chromium(Cr), zinc(Zn), copper(Cu), lead(Pb), nickel(Ni), cadmium(Cd) and As using inductively coupled plasma mass spectrometry(ICP-MS). Results showed that soil properties(salinity, total organic carbon and grain-size distribution) and the concentrations of heavy metals and As in the soils differed under the different land use types. The conversion of wetland to forest had caused obvious losses of all the measured heavy metals. In paddy field and dryland with frequent cultivation, the concentrations of Cr, Zn, Cu, Ni and As were higher when compared to forest land which was disturbed rarely by human activities. Speciation analysis showed that Cr, Zn, Cu, Ni and As were predominated by the immobile residual fraction, while Pb and Cd showed relatively higher mobility. In general, metal(except Ni) and As mobility decreased in the following order: wetland> dryland ≥ paddy field > forest land, which suggested that the reclaimed soils had lower metal and As mobility than the intertidal flat wetland. The results of this study contribute to a better understanding of the effects of land use on heavy metals and As in the reclaimed soils of the study area and other similar coastal areas. | ZHENG Rong ZHAO Jiale ZHOU Xiu MA Chao WANG Li GAO Xiaojiang | 2016 | Pedosphere2016，26，1： | 12 |
| 11 | Study on stabilities and electrochemical behavior of V(V) electrolyte with acid additives for vanadium redox flow battery显示文摘Several acid compounds have been employed as additives of the V(V) electrolyte for vanadium redox flow battery(VRB) to improve its stability and electrochemical activity. Stability of the V(V) electrolyte with and without additives was investigated with ex-situ heating/cooling treatment at a wide temperature range of-5 ?C to 60 ?C. It was observed that methanesulfonic acid, boric acid, hydrochloric acid, trifluoroacetic acid,polyacrylic acid, oxalic acid, methacrylic acid and phosphotungstic acid could improve the stability of the V(V) electrolyte at a certain range of temperature. Their electrochemical behaviors in the V(V) electrolyte were further studied by cyclic voltammetry(CV), steady state polarization and electrochemical impedance spectroscopy(EIS). The results showed that the electrochemical activity, including the reversibility of electrode reaction, the diffusivity of V(V) species, the polarization resistance and the flexibility of charge transfer for the V(V) electrolyte with these additives were all improved compared with the pristine solution. | Gang Wang Jinwei Chen Xueqin Wang Jing Tian Hong Kang Xuejing Zhu Yu Zhang Xiaojiang Liu Ruilin Wang | 2014 | Journal of Energy Chemistry2014，23，1： | 10 |
| 12 | Therapeutic potential of berberine against neurodegenerative diseases显示文摘Berberine(BBR) is an organic small molecule isolated from various plants that have been used in traditional Chinese medicine. Isolation of this compound was its induction into modern medicine, and its usefulness became quickly apparent as seen in its ability to combat bacterial diarrhea, type 2 diabetes, hypercholesterolemia, inflammation, heart diseases, and more. However, BBR's effects on neurodegenerative diseases remained relatively unexplored until its ability to stunt Alzheimer's disease(AD) progression was characterized. In this review, we will delve into the multi-faceted defensive capabilities and bio-molecular pathways of BBR against AD, Parkinson's disease(PD), and trauma-induced neurodegeneration. The multiple effects of BBR, some of which enhance neuro-protective factors/pathways and others counteract targets that induce neurodegeneration, suggest that there are many more branches to the diverse capabilities of BBR that have yet to be uncovered. The promising results seen provide a convincing and substantial basis to support further scientific exploration and development of the therapeutic potential of BBR against neurodegenerative diseases. | JIANG WenXiao LI ShiHua LI XiaoJiang | 2015 | Science China(Life Sciences)2015，58，6： | 9 |
| 13 | Purification and Characterization of a New Ribosome Inactivating Protein from Cinchonaglycoside C-treated Tobacco Leaves显示文摘A new ribosome-inactivating protein(RIP)with a molecular weight of 31 kDa induced by Cinchonaglycoside C(1)designatedCLP31,was isolated from tobacco leaves.Analysis of this protein sequence indicated that it belongs to the RIP family and itwas distinct from the other plant RIPs reported previously at its N-terminal amino acid sequence.CIP31 can directly impairsynthesis of coat protein(CP)of tobacco mosaic virus(TMV),which resulted in inhibition of TMV long distance movementand multiplication in tobacco plants at concentrations of ng/mL.Furthermore,no toxicity was shown to the growth andfertility of the plants.CIP31 was synthesized only in the presence of Cinchonaglycoside C(1)and was independent of thesalicylic acid(SA)signal pathway.We provided evidence for the SA-independent biological induction of resistance. | Yanmei Li Yantao Jia Zhongkai Zhang Xiaoying Chen Hongping He Rongxiang Fang Xiaojiang Hao | 2007 | Journal of Integrative Plant Biology2007，49，9： | 8 |
| 14 | COVID-19 in cancer patients:risk,clinical features,and management显示文摘A novel coronavirus known as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has spread across the world,prompting the World Health Organization to declare the coronavirus disease of 2019(COVID-19)a public health emergency of international concern.Cancer patients are regarded as a highly vulnerable population to SARS-CoV-2 infection and development of more severe COVID-19 symptoms,which is possibly due to the systemic immunosuppressive state caused directly by tumor growth and indirectly by effects of anticancer treatment.Currently,much effort has been directed toward studying the pathogenesis and treatment of COVID-19,but the risk profiles,prognoses,and treatment outcomes in cancer patients remain unclear.Based on the current literature,we summarize the risk profiles,clinical and biochemical characteristics,and therapy outcomes of COVID-19 infections in cancer patients.The challenges in the clinical care of cancer patients with COVID-19 are discussed.The goal of this review is to stimulate research to better understand the biological impact and prognoses of COVID-19 infections in cancer patients,thus facilitating improvement of the clinical management of these patients. | Cuiwei Liu Yanxia Zhao Derick Okwan-Duodu Reva Basho Xiaojiang Cui | 2020 | Cancer Biology & Medicine2020，17，3： | 8 |
| 15 | Removal of organic matter and disinfection by-products precursors in a hybrid process combining ozonation with ceramic membrane ultrafiltration显示文摘包括凝结, ozonation,陶器的 ultrafiltration (UF ) 和生物学的激活的碳(用绳子拖的平底渡船) 的综合进程的性能过滤从微弄脏表面水为有机物和消毒副产品(DBP ) 先锋的移动被调查。有 120 m 的能力的飞行员规模植物 < 啜 class= “ a-plus-plus ” > 3 为喝水的处理每天被建立并且操作。陶器的膜与 50 m 的过滤区域被使用 < 啜 class= “ a-plus-plus ” > 2 和 60 nm 的一种毛孔尺寸。溶解有机物包括恐水病的酸(HoA ) 被划分成五部分,底(壁炉内部的一锅架) 并且中立(爱人) ,弱恐水病的酸(停) 并且吸水的物质(他) 由 DAX-8 和 XAD-4 树脂。实验结果证明有机物的移动显著地预先与 ozonation 被改进。简言之,综合过程移开73%溶解的器官的碳(文档),中的87%个紫外<潜水艇class=“ a-plus-plus ”> 254 ,77% trihalomethane ( THM )先锋,76% haloacetic 酸( HAA )先锋, 83%of trichloracetic 醛( CH )先锋,77% dichloroacetonitrile ( DCAN )先锋,51% trichloroacetonitrile ( TCAN )先锋,96% 1,1,1-trichloroacetone ( TCP )先锋并且63% trichloronitromethane ( TCNM )先锋。恐水病的有机物在 ozonation/UF 期间被变换成吸水的有机物,当有 10003000 Da 的分子的重量的有机物显著地被减少并且变换成更低的分子的重量时有机物从 200500 Da 。文档与 DBP 的形成潜力有一种近线性的关系。 | Xiaojiang FAN Yi TAO Dequan WEI Xihui ZHANG Ying LEI Hiroshi NOGUCHI | 2015 | Frontiers of Environmental Science & Engineering2015，9，1： | 7 |
| 16 | Services and Key Technologies of the Internet of Things显示文摘This article introduces the services and development of the Internet of Things,and analyzes the driving forces and obstacles behind such development. Looking at application types and the different development stages of the Internet of Things,this article categorizes its services into four types:identity related services,information aggregation services,collaborative-aware services,and ubiquitous services. For the first two types of services,applications and system framework are discussed; for the last two types,development trends are discussed. Services provided by the Internet of Things will gradually be integrated into human life and society; with the development of the Internet of Things,applications will evolve from relatively simple identity-related and information aggregation-related applications,to collaboratively-aware,and finally ubiquitous applications. It will then be possible for the Internet of Things to be fully integrated with Internet and telecommunications networks. | Xing Xiaojiang Wang Jianli Li Mingdong | 2010 | ZTE Communications2010，8，2： | 6 |
| 17 | High salt diet accelerates the progression of murine lupus through dendritic cells via the p38 MAPK and STAT1 signaling pathways显示文摘The increased incidence of systemic lupus erythematosus(SLE)in recent decades might be related to changes in modern dietary habits.Since sodium chloride(NaCl)promotes pathogenic T cell responses,we hypothesize that excessive salt intake contributes to the increased incidence of autoimmune diseases,including SLE.Given the importance of dendritic cells(DCs)in the pathogenesis of SLE,we explored the influence of an excessive sodium chloride diet on DCs in a murine SLE model.We used an induced lupus model in which bone marrow-derived dendritic cells(BMDCs)were incubated with activated lymphocyte-derived DNA(ALD-DNA)and transferred into C57BL/6 recipient mice.We observed that a high-salt diet(HSD)markedly exacerbated lupus progression,which was accompanied by increased DC activation.NaCl treatment also stimulated the maturation,activation and antigenpresenting ability of DCs in vitro.Pretreatment of BMDCs with NaCl also exacerbated BMDC-ALD-DNA-induced lupus.These mice had increased production of autoantibodies and proinflammatory cytokines,more pronounced splenomegaly and lymphadenopathy,and enhanced pathological renal lesions.The p38 MAPK–STAT1 pathway played an important role in NaClinduced DC immune activities.Taken together,our results demonstrate that HSD intake promotes immune activation of DCs through the p38 MAPK–STAT1 signaling pathway and exacerbates the features of SLE.Thus,changes in diet may provide a novel strategy for the prevention or amelioration of lupus or other autoimmune diseases. | Ze Xiu Xiao Xiaojiang Hu Ximei Zhang Zhigang Chen Julie Wang Ke Jin Feng Lin Cao Baoqing Sun Joseph A.Bellanti Nancy Olsen Song Guo Zheng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 6 |
| 18 | A novel mechanism controls anther opening and closing in Paris polyphylla var. Yunnanensis显示文摘The phenomena of anther opening and closing in Paris polyphylla var. yunnanensis (Franch) Hand.-Mazz were described in detail, and the effects of ecological factors on those phenomena related to anther opening, closing and the fly-pollination mechanism were discussed. Anthers of P. polyphylla var. yunnanensis open in the morning and close in the evening every day during an over 20 days’ period of anthesis. Light was detected as the main factor controlling this daily anther opening and closing. Anther opening can be reversed in response to rain and re-opens when rain stops. Relative humidity (RH) has a slight effect on anther opening and closing. Flower spans can be prolonged under laboratory conditions. This novel behavior of anther is likely to be a mechanism to enhance the male fitness in this species, of which has no inherited structure to protect pollen from the perianth. | WANG DingKang SUN GuiFang WANG LiFang ZHAI ShuHua CEN XiaoJiang | 2009 | Chinese Science Bulletin2009，54，2： | 5 |
| 19 | A new constitutive law for the nonlinear normal deformation of rock joints under normal load显示文摘In view of the deviation of the fitting results of the classical exponential model and the hyperbolic model(the BB model) from several experiment data during intermediate stress period,a new constitutive model for the nonlinear normal deformation of rock joints under normal monotonous load is established with flexibility-deformation method.First of all,basic laws of the deformation of joints under normal monotonous load are discussed,based on which three basic conditions which the complete constitutive equation for rock joints under normal load should meet are put forward.The analysis of the modified normal constitutive model on stress-deformation curve shows that the general exponential model and the improved hyperbolic model are not complete in math theory.Flexibility-deformation monotone decreasing curve lying between flexibility-deformation curve of the classical exponential model and the BB model is chosen,which meets basic conditions of normal deformation mentioned before,then a new normal deformation constitutive model of rock joints containing three parameters is established.Two main forms of flexibility-deformation curve are analyzed and specific math formulas of the two forms are deduced.Then the range of the parameters in the g-ζmodel and the g-ζ model and the correlative influence factor in geology are preliminarily discussed.Referring to different experiment data,the validating analysis of the g-ζ model and the g-ζ model shows that the g-ζ model can be applied to both the mated joints and unmated joints.Besides,experiment data can be better fit with the g-ζ model with respect to the BB model,the classical exponential model and the logarithm model. | RONG Guan HUANG Kai ZHOU ChuangBing WANG XiaoJiang PENG Jun | 2012 | Science China(Technological Sciences)2012，55，2： | 5 |
| 20 | Face Detection Detection, Alignment Alignment, Quality Assessment and Attribute Analysis with Multi-Task Hybrid Convolutional Neural Networks显示文摘This paper proposes a universal framework,termed as Multi-Task Hybrid Convolutional Neural Network(MHCNN),for joint face detection,facial landmark detection,facial quality,and facial attribute analysis.MHCNN consists of a high-accuracy single stage detector(SSD)and an efficient tiny convolutional neural network(T-CNN)for joint face detection refinement,alignment and attribute analysis.Though the SSD face detectors achieve promising results,we find that applying a tiny CNN on detections further boosts the detected face scores and bounding boxes.By multi-task training,our T-CNN aims to provide five facial landmarks,facial quality scores,and facial attributes like wearing sunglasses and wearing masks.Since there is no public facial quality data and facial attribute data as we need,we contribute two datasets,namely FaceQ and FaceA,which are collected from the Internet.Experiments show that our MHCNN achieves face detection performance comparable to the state of the art in face detection data set and benchmark(FDDB),and gets reasonable results on AFLW,FaceQ and FaceA. | GUO Da ZHENG Qingfang PENG Xiaojiang LIU Ming | 2019 | ZTE Communications2019，17，3： | 5 |
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