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| 1 | The HEPD particle detector of the CSES satellite mission for investigating seismo-associated perturbations of the Van Allen belts显示文摘CSES(China Seismo-Electromagnetic Satellite) is a mission developed by CNSA(Chinese National Space Administration) and ASI(Italian Space Agency), to investigate the near-Earth electromagnetic, plasma and particle environment, for studying the seismo-associated disturbances in the ionosphere-magnetosphere transition zone. The anthropogenic and electromagnetic noise,as well as the natural non-seismic electromagnetic emissions is mainly due to tropospheric activity. In particular, the mission aims to confirming the existence of possible temporal correlations between the occurrence of earthquakes for medium and strong magnitude and the observation in space of electromagnetic perturbations, plasma variations and precipitation of bursts with highenergy charged particles from the inner Van Allen belt. In this framework, the high energy particle detector(HEPD) of the CSES mission has been developed by the Italian LIMADOU Collaboration. HEPD is an advanced detector based on a tower of scintillators and a silicon tracker that provides good energy and angular resolution and a wide angular acceptance, for electrons of 3–100 Me V, protons of 30–200 Me V and light nuclei up to the oxygen. CSES satellite has been launched on February 2^(nd), 2018 from the Jiuquan Satellite Launch Center(China). | AMBROSI Giovanni BARTOCCI Simona BASARA Laurent BATTISTON Roberto BURGER William J. CARFORA Luca CASTELLINI Guido CIPOLLONE Piero CONTI Livio CONTIN Andrea DE DONATO Cinzia DE SANTIS Cristian FOLLEGA Francesco M. GUANDALINI Cristina IONICA Maria IUPPA Roberto LAURENTI Giuliano LAZZIZZERA Ignazio LOLLI Mauro MANEA Christian MARCELLI Laura MASCIANTONIO Giuseppe MERGE Matteo OSTERIA Giuseppe PACINI Lorenzo PALMA Francesco PALMONARI Federico PANICO Beatrice PATRIZII Laura PERFETTO Francesco PICOZZA Piergiorgio POZZATO Michele PUEL Matteo RASHEVSKAYA Irina RICCI Ester RICCI Marco RICCIARINI Sergio Bruno SCOTTI Valentina SOTGIU Alessando SPARVOLI Roberta SPATARO Bruno VITALE Vincenzo | 2018 | Science China(Technological Sciences)2018，61，5： | 6 |
| 2 | Impaired coagulation,liver dysfunction and COVID-19:Discovering an intriguing relationship显示文摘Coronavirus disease 2019(COVID-19)is,at present,one of the most relevant global health problems.In the literature hepatic alterations have been described in COVID-19 patients,and they are mainly represented by worsening of underlying chronic liver disease leading to hepatic decompensation and liver failure with higher mortality.Several potential mechanisms used by severe acute respiratory syndrome coronavirus 2(SARS-Co V-2)to cause liver damage have been hypothesized.COVID-19 primary liver injury is less common than secondary liver injury.Most of the available data demonstrate how liver damage in SARSCo V-2 infection is likely due to systemic inflammation,and it is less likely mediated by a cytopathic effect directed on liver cells.Moreover,liver alterations could be caused by hypoxic injury and drugs(antibiotics and non-steroidal antiinflammatory drugs,remdesivir,tocilizumab,tofacitinib and dexamethasone).SARS-Co V-2 infection can induce multiple vascular district atherothrombosis by affecting simultaneously cerebral,coronary and peripheral vascular beds.Data in the literature highlight how the virus triggers an exaggerated immune response,which added to the cytopathic effect of the virus can induce endothelial damage and a prothrombotic dysregulation of hemostasis.This leads to a higher incidence of symptomatic and confirmed venous thrombosis and of pulmonary embolisms,especially in central,lobar or segmental pulmonary arteries,in COVID-19.There are currently fewer data for arterial thrombosis,while myocardial injury was identified in 7%-17%of patients hospitalized with SARS-Co V-2 infection and 22%-31%in the intensive care unit setting.Available data also revealed a higher occurrence of stroke and more serious forms of peripheral arterial disease in COVID-19 patients.Hemostasis dysregulation is observed during the COVID-19 course.Lower platelet count,mildly increased prothrombin time and increased Ddimer are typical laboratory features of patients with severe SARS-Co V-2 infection,described as“COVID-19 associated coagulopathy.”These alterations are correlated to poor outcomes.Moreover,patients with severe SARS-Co V-2 infection are characterized by high levels of von Willebrand factor with subsequent ADAMTS13 deficiency and impaired fibrinolysis.Platelet hyperreactivity,hypercoagulability and hypofibrinolysis during SARS-Co V-2 infection induce a pathological state named as“immuno-thromboinflammation.”Finally,liver dysfunction and coagulopathy are often observed at the same time in patients with COVID-19.The hypothesis that liver dysfunction could be mediated by microvascular thrombosis has been supported by postmortem findings and extensive vascular portal and sinusoidal thrombosis observation.Other evidence has shown a correlation between coagulation and liver damage in COVID-19,underlined by the transaminase association with coagulopathy,identified through laboratory markers such as prothrombin time,international normalized ratio,fibrinogen,D-dimer,fibrin/fibrinogen degradation products and platelet count.Other possible mechanisms like immunogenesis of COVID-19 damage or massive pericyte activation with consequent vessel wall fibrosis have been suggested. | Damiano D'Ardes Andrea Boccatonda Giulio Cocco Stefano Fabiani Ilaria Rossi Marco Bucci Maria Teresa Guagnano Cosima Schiavone Francesco Cipollone | 2022 | World Journal of Gastroenterology2022，28，11： | 5 |
| 3 | Emphysematous pancreatitis associated with penetrating duodenal ulcer显示文摘In the 'proton pump inhibitors era',a penetrating peptic ulcer(PPU) represents an exceptional cause of abdominal pain,and was more frequently observed in the past where there was not an effective antacid treatment. Ulcer-induced pancreatitis is very rare,too,and manifests with persistent,intense pain radiating to the back. A mild to severe pancreatitis with peripancreatic fluid collection can be observed at imaging. However,only a few cases of association between PPU and emphysematous pancreatitis(EP) have been published in the literature. EP is a rare but potentially fatal form of acute necrotizing pancreatitis in which gas grows in and outside the pancreas,and typically involves the whole parenchyma in diabetic individuals.Here we report an extremely rare case of a duodenal ulcer penetrating the pancreas and complicated with EP.Unlike the classic form of EP,which involves the whole parenchyma and has a poor prognosis,we found that the emphysematous involvement of the pancreas by PPU has a benign course if a conservative therapy is promptly established. Gas is confined to the site of penetration,usual y the pancreatic head,and ulcers most often involve the duodenum. | Claudio Tana Mauro Silingardi Maria Adele Giamberardino Francesco Cipollone Tiziana Meschi Cosima Schiavone | 2017 | World Journal of Gastroenterology2017，23，48： | 2 |
| 4 | Ultrasound imaging of abdominal sarcoidosis: State of the art显示文摘Since it has been recognized that sarcoidosis(SA) is not an exclusive disorder of the lungs but can also affect other organs such as the liver and spleen, efforts have been made to define specific imaging criteria for the diagnosis of the single organ involvement, and the concept has been reinforced that the exclusion of alternative causes is important to achieve the correct diagnosis. Ultrasound(US)is a useful tool to evaluate patients with suspected abdominal SA, such as of the liver, spleen, kidney, pancreas and other organs, showing findings such as organomegaly, focal lesions and lymphadenopathy. While the diagnosis of abdominal SA is more predictable in the case of involvement of other organs(e.g.,lungs), the problem is more complex in the case of isolated abdominal SA. The recent use of contrast-enhanced ultrasound and endoscopic ultrasound elastography has provided additional information about the enhancement patterns and tissue rigidity in abdominal SA. Here we critically review the role of US in abdominal SA, reporting typical findings and limitations of current evidence and by discussing future perspectives of study. | Claudio Tana Cosima Schiavone Andrea Ticinesi Fabrizio Ricci Maria Adele Giamberardino Francesco Cipollone Mauro Silingardi Tiziana Meschi Christoph F Dietrich | 2019 | World Journal of Clinical Cases2019，7，7： | 2 |
| 5 | Real-time space object tracklet extraction from telescope survey images with machine learning显示文摘In this study,a novel approach based on the U-Net deep neural network for image segmentation is leveraged for real-time extraction of tracklets from optical acquisitions.As in all machine learning(ML)applications,a series of steps is required for a working pipeline:dataset creation,preprocessing,training,testing,and post-processing to refine the trained network output.Online websites usually lack ready-to-use datasets;thus,an in-house application artificially generates 360 labeled images.Particularly,this software tool produces synthetic night-sky shots of transiting objects over a specified location and the corresponding labels:dual-tone pictures with black backgrounds and white tracklets.Second,both images and labels are downscaled in resolution and normalized to accelerate the training phase.To assess the network performance,a set of both synthetic and real images was inputted.After the preprocessing phase,real images were fine-tuned for vignette reduction and background brightness uniformity.Additionally,they are down-converted to eight bits.Once the network outputs labels,post-processing identifies the centroid right ascension and declination of the object.The average processing time per real image is less than 1.2 s;bright tracklets are easily detected with a mean centroid angular error of 0.25 deg in 75%of test cases with a 2 deg field-of-view telescope.These results prove that an ML-based method can be considered a valid choice when dealing with trail reconstruction,leading to acceptable accuracy for a fast image processing pipeline. | Andrea De Vittori Riccardo Cipollone Pierluigi Di Lizia Mauro Massari | 2022 | Astrodynamics2022，6，2： | 2 |
| 6 | Overexpression of microRNA-145 in atherosclerotic plaques from hypertensive patients显示文摘 | Donato Santovito Claudia Mandolini Pamela Marcantonio Velia De Nardis Marco Bucci Camilla Paganelli Francesco Magnacca Sante Ucchino Daniela Mastroiacovo Giovambattista Desideri Andrea Mezzetti Francesco Cipollone | 2012 | Expert Opinion on Therapeutic Targets2012，，3： | 2 |
| 7 | Preprocedural level of soluble CD40L is predictive of enhanced inflammatory response and restenosis after coronary angioplasty显示文摘 | Cipollone F Ferri C Desideri G | 2003 | Circulation2003，108，22： | 1 |
| 8 | Association between enhanced soluble CD40L and protlirombotic state in hyperc- holesterolemia: effects of statin therapy显示文摘 | Cipollone F Mezzetti A Porreca E | 2002 | Circulation2002，106，4： | 1 |
| 9 | Association between enhanced soluble CD40L and prothrombotic state in hypercholesterolemia:effects of statin therapy显示文摘 | Cipollone F Mezzetti A Porreca E | 2002 | Circulation2002，106，： | 1 |
| 10 | Association between 5-lipoxygenase expression and plaque instability in humans 显示文摘 | CIPOLLONE F MEZZETTI A FAZIA M L | 2005 | Arterioscler Thromb Vasc Biol2005，25，： | 1 |
| 11 | Overexpression of functionally coupled cyclooxygenase-2 and prostaglandin E synthase in symptomatic atherosclerotic plaques as a basis of prostaglandin E(2)-dependent plaque instability 显示文摘 | Cipollone F Prontera C Pini B | 2001 | Circulation2001，104，8： | 1 |
| 12 | Increased expression of transforming growth factor - betal as a stabilizing factor in human atherosclerotic plaques 显示文摘 | Cipollone F Fazia M Mincione G | 2004 | Stroke2004，35，10： | 1 |
| 13 | The role of nitric oxide in the development of diabetic angiopathy 显示文摘 | Santilli F Cipollone F Mezzetti A | 2004 | Horm Metab Res2004，36，5： | 1 |
| 14 | Oxidant stress and aspirin-insensitive thromboxane biosynthesis in severe unstable angina显示文摘 | Cipollone F Ciabattoni G Patrignani P | 2000 | Circulation2000，102，： | 1 |
| 15 | The role of nitric oxide in the development of diabetic angiopathy显示文摘 | Santilli F Cipollone F Mezzetti A | 2004 | Horm Metab Res2004，36，5： | 1 |
| 16 | Overexpression of functionally coupled cyclooxygenase - 2 and prostaglandin E synthase in symptomatic atheroscle- rotic plaques as a basis of prostaglandin E2 - dependent plaque instability 显示文摘 | Cipollone F Prontera C Pini B | 2001 | Circulation2001，104，8： | 1 |
| 17 | Overexpression of functionally coupled cyclooxygenase- 2 and prostaglandin E synthesis in symptomatic atherosclerotic plaque as a basis of prostaglandin E (2) - dependent plaque instability显示文摘 | Prontera C Pini B | 2001 | Circulation2001，104，： | 1 |
| 18 | Cyclooxygenase-2 expression and inhibition in atherothrombosis显示文摘 | Cipollone F Rocca B Patrono C | 2004 | Arterioscler Thromb Vasc Biol2004，24，2： | 1 |
| 19 | Elevated circulating of monocyte chemottractant protein-1 in patients with restenosis after coronary angioplasty 显示文摘 | CIPOLLONE F MARINI M FAZIA M | 2001 | Artcrioscl Thromb Vasc Biol2001，21，3： | 1 |
| 20 | A/F and Liquid-Phase Control in LPG Injected Spark Ignition ICE显示文摘 | Carlo Villante | 2000 | SAE paper2000，，： | 1 |
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