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| 1 | Protective effects of intravenous anesthetics on kidney tissue in obstructive jaundice显示文摘AIM:To evaluate the protective effects on kidney tissue of frequently used intravenous anesthetics(ketamine,propofol,thiopental,and fentanyl)in rats with obstructive jaundice.METHODS:There is an increased incidence of postoperative acute renal failure in patients with obstructive jaundice.Thirty-two Wistar-albino rats were randomly divided into four equal groups.Laparatomy was performed on each animal in the four groups and common bile ducts were ligated and severed on day 0.After 7 d,laparotomy was again performed using ketamine,propofol,thiopental,or fentanyl anesthesia whose antioxidative properties are well known in oxidative stress in a rat liver model of obstructive jaundice.After 2 h,the rats were sacrificed.Renal tissue specimens were analyzed for catalase,superoxide dismutase and malondialdehyde enzymes activities.All values are expressed as the mean±SD.P values less than 0.05 were considered statistically significant.RESULTS:All animals survived without complications until the end of the study.Enlargement in the bile duct and obstructive jaundice were observed in all rats.Catalase was found to be significantly lower in the fentanyl group than in the ketamine(P=0.039),propofol(P=0.012),and thiopental(P=0.001)groups.Superoxide dismutase activities were similar in all groups(P>0.05).Malondialdehyde was found to be significantly lower in the ketamine group than in the propofol(P=0.028),thiopental(P=0.002)and fentanyl(P=0.005)groups.Malondialdehyde was also lower in the fentanyl group than in the thiopental group(P=0.001).The results showed that obstructive jaundice sensitizes renal tissue to damage under the different anesthetics.CONCLUSION:Among the agents tested,ketamine and propofol generated the least amount of oxidative stres on renal tissues in this rat model of obstructive jaundice created by common bile duct ligation.The importance of free radical injury in renal tissue in obstructive jaundice under different intravenous anesthetics during hepatobiliary and liver transplant surgery should be considered for prevention of postoperative acute renal failure. | Sinan Hatipoglu Huseyin Yildiz Ertan Bulbuloglu Ismail Coskuner Ergul Belge Kurutas Filiz Hatipoglu Harun Ciralik Mehmet Sait Berhuni | 2014 | World Journal of Gastroenterology2014，20，12： | 9 |
| 2 | Comparison of trans- forming growth factor β1 concentrations in the ovaries of rats stimulated by human menopausal gonadotropin or re- combinant follicle-stimulating hormone显示文摘 | Kiran G Ciralik H Ozbag D | 2012 | European Jour- nal of Obstetrics Gynecology and Reproductive Biology: An International Journal2012，163，1： | 1 |
| 3 | Protective agent,erdosteine,against cisplatin-induced hepatic oxidant injury in rats显示文摘 | Koc A Duru M Ciralik H | 2005 | Mol Cell Biochem2005，278，12： | 1 |
| 4 | Effects of intrave- nous anesthetics on renal ischemia/reperfusion injury显示文摘 | Yuzer H Yuzbasioglu M F Ciralik H | 2009 | Ren Fail2009，31，4： | 1 |
| 5 | Ischemia-reperfusion injury of adipofascial tissue: anexperimental studuy evaluationg early histology and biochemical alteration in rats 显示文摘 | Coban YK Kurutas EB Ciralik H | 2005 | Mediators Inflamm2005，5，： | 1 |
| 6 | Resveratrol, a natural antioxidant, attenuates intestinal ischemia/reperfusion injury in rats 显示文摘 | Ozkan O V Yuzbasioglu M F Ciralik H | 2009 | Tohoku J Exp Med2009，218，3： | 1 |
| 7 | Efficacy of micronised vaginal progesterone versus oral dydrogestrone in the treatment of irregular dysfunctional uterine bleeding:a pilot randomised controlled trial显示文摘 | Karakus S Kiran G Ciralik H | 2009 | Aust N Z J Obstet Gynaecol2009，49，6： | 1 |
| 8 | Resvera-trol,a natural antioxidant,attenuates intestinal ischemia/reperfu-sion injury in rats显示文摘 | OZKAN O V YUZBASIOGLU M F CIRALIK H | 2009 | Tohoku J Exp Med2009，218，3： | 1 |
| 9 | Resveratrol,a natural antioxidant,attenuates intestinal ischemia/reperfusion injury in rats显示文摘 | Ozkan OV Yuzbasioglu MF Ciralik H | | 0，，03： | 1 |
| 10 | Efficacy of micronised vaginal progesterone versus oral dydrogestrone in the treatment of irregular dysfunctional uterine bleeding:a pilot randomised controlled trial显示文摘 | Karakus S Kiran G Ciralik H | | 0，，06： | 1 |
| 11 | Resveratrol, a natural antioxidant, attenuates intestinal ischemia/reperfusion injury in rats 显示文摘 | Ozkan O V Yuzbasioglu M F Ciralik H | 2009 | Tohoku J Exp Med2009，218，3： | 1 |
| 12 | Resveratrol, a natural antioxidant, attenuates intestinal ischemia/reperfusion injury in rats 显示文摘 | Ozkan OV Yuzbasioglu MF Ciralik H | 2009 | Tohoku J Exp Med2009，218，3： | 1 |
| 13 | Resveratrul,a natural antioxidant,attenuates intestinal ischemia/reperfusion injury in rats显示文摘 | Ozkan OV Yuzbasioglu MF Ciralik H | | 0，，3： | 1 |
| 14 | Resveratrol, a natural antioxidant,attenuates intestinal ischemia/reperfusion injury in rats 显示文摘 | Ozkan OV Yuzbasioglu MF Ciralik H | 2009 | Tohoku J Exp Med2009，218，3： | 1 |
| 15 | Comparison of trans- forming growth factor 131 concentrations in the ovaries of rats stimulated by human menopausal gonadotropin or re- combinant follicle-stimulating hormone 显示文摘 | Kiran G Ciralik H Ozbag D | 2012 | Eur J Obstet Gynecol Reprod Biol2012，163，1： | 1 |
| 16 | Resveratrol,a natural antioxidant,attenuates intestinal ischemia/reperfusion injury in rats显示文摘 | Ozkan OV Yuzbasioglu MF Ciralik H | 2009 | Tohoku J Exp Med2009，218，3： | 1 |
| 17 | Critical ischemic time for the rat ovary:experimental study evaluating early histopathologic changes显示文摘 | Coskun A Coban Y K Ciralik H | | 0，，02： | 1 |
| 18 | Resveratrol,a natural antioxidant,attenuates intestinal ischemia/reperfusion injury in rats显示文摘 | Ozkan O V Yuzbasioglu M F Ciralik H | 2009 | Tohoku J Exp Med2009，218，3： | 1 |
| 19 | Ischemia-reper- fusion injury of adipofascial tissue: an experimental study evaluating early histologic and biochemical alterations in rats 显示文摘 | Coban YK Kurutas EB Ciralik H | 2005 | Mediators Inflamm2005，2005，5： | 1 |
| 20 | Resveratrol, a natural antioxidant, attenuates intestinal ischemia/reperfusion injury in rats 显示文摘 | OZKAN O V YUZBASIOGLU M F CIRALIK H | 2009 | Tohoku J Exp Med2009，218，3： | 1 |
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