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| 1 | Endoscopic transpapillary brush cytology and forceps biopsy in patients with hilar cholangiocarcinoma显示文摘AIM: To evaluate the sensitivity of brush cytology and forceps biopsy in a homogeneous patient group with hilar cholangiocarcinoma.METHODS: Brush cytology and forceps biopsy were routinely performed in patients with suspected malignant biliary strictures. Fifty-eight consecutive patients undergoing endoscopic retrograde cholangio-pancreatography (ERCP) including forceps biopsy and brush cytology in patients with hilar cholangiocarcinoma between 1995-2005.RESULTS: Positive results for malignancy were obtained in 24/58 patients (41.4%) by brush cytology and in 31/58 patients (53.4%) by forceps biopsy. The combination of both techniques brush cytology and forceps biopsy resulted only in a minor increase in diagnostic sensitivity to 60.3% (35/58 patients). In 20/58 patients (34.5%), diagnosis were obtained by both positive cytology and positive histology, in 11/58 (19%) by positive histology (negative cytology) and only 4/58 patients (6.9%) were confirmed by positive cytology (negative histology).CONCLUSION: Brush cytology and forceps biopsy have only limited sensitivity for the diagnosis of malignant hilar tumors. In our eyes, additional diagnostic techniques should be evaluated and should become routine in patients with negative cytological and histological findings. | Andreas Weber Claus von Weyhern Falko Fend Jochen Schneider Bruno Neu Alexander Meining Hans Weidenbach Roland M Schmid Christian Prinz | 2008 | World Journal of Gastroenterology2008，14，7： | 17 |
| 2 | Analysis of monocyte chemotactic protein-1 gene polymorphism in patients with spontaneous bacterial peritonitis显示文摘AIM:To investigate a genetic polymorphism of the monocyte chemotactic protein-1 (MCP-1 ) gene in patients with spontaneous bacterial peritonitis (SBP).METHODS:MCP-1 genotyping was performed in 23 patients with SBP and 83 cirrhotic control patients with non-infected ascites.RESULTS:The frequency of carriers of the G-allele was lower in SBP patients but this difference did not reach statistical significance. However,in the subgroup of patients with alcoholic cirrhosis (n=80),carriers of the G-allele were significantly less frequent in SBP-patients (38.1%) than in cirrhotic controls (67.8%,P=0.021). CONCLUSION:In patients with alcoholic liver cirrhosis,the-2518 MCP-1 genotype AA is a risk factor for the development of SBP. | Erwin Gbele Marcus Mhlbauer Hartwig Paulo Monika Johann Christin Meltzer Franz Leidl Norbert Wodarz Reiner Wiest Jrgen Schlmerich Claus Hellerbrand | 2009 | World Journal of Gastroenterology2009，15，44： | 7 |
| 3 | Outcome of Operative Therapy of Hepatic Metastatic Stomach Carcinoma: A Retrospective Analysis显示文摘 | Claus Schildberg R. Croner S. Merkel V. Schellerer V. Müller S. Yedibela W. Hohenberger G. Peros A. Perrakis | 2012 | World Journal of Surgery2012，，4： | 2 |
| 4 | Chronic hepatitis C:Treat or wait? Medical decision making in clinical practice显示文摘AIM:To analyzes the decision whether patients with chronic hepatitis C virus (HCV) infection are treated or not.METHODS:This prospective cohort study included 7658 untreated patients and 6341 patients receiving pegylated interferon α2 a/ribavirin,involving 434 physicians/institutions throughout Germany (377 in private practice and 57 in hospital settings).A structured questionnaire had to be answered prior to the treatment decision,which included demographic data,information about the personal life situation of the patients,anamnesis and symptomatology of hepatitis C,virological data,laboratory data and data on concomitant diseases.A second part of the study analyzes patients treated with pegylated interferon α2a.All questionnaires included reasons against treatment mentioned by the physician.RESULTS:Overall treatment uptake was 45%.By multivariate analysis,genotype 1/4/5/6,HCV-RNA ≤ 520 000 IU/mL,normal alanine aminotransferase (ALT),platelets ≤ 142 500/μL,age > 56 years,female gender,infection length > 12.5 years,concomitant diseases,human immunodeficiency virus co-infection,liver biopsy not performed,care in private practice,asymptomatic disease,and unemployment were factors associated with reduced treatment rate.Treatment and sustained viral response rates in migrants (1/3 of cohort) were higher than in German natives although 1/3 of migrants had language problems.Treatment rate and liver biopsy were higher in clinical settings when compared to private practice and were low when ALT and HCV-RNA were low.CONCLUSION:Some reasons against treatment were medically based whereas others were related to fears,socio-economical problems,and information deficits both on the side of physicians and patients. | Claus Niederau Dietrich Hüppe Elmar Zehnter Bernd Mller Renate Heyne Stefan Christensen Rainer Pfaff Arno Theilmeier Ulrich Alshuth Stefan Mauss | 2012 | World Journal of Gastroenterology2012，18，12： | 2 |
| 5 | Selenium redox biochemistry of zinc - sulfur co- ordination sites in proteins and enzymes显示文摘 | Claus J wolfgang M Bert V | 1999 | Proc Natl Acad Sci USA1999，96，： | 1 |
| 6 | Anti-Interleukin-17 Monoclonal Antibody Ixekizumab in Chronic Plaque Psoriasis显示文摘 | Craig L Robert M Claus Z | 2012 | N Engl J Med2012，366，： | 1 |
| 7 | Interpleural analgesia doesnot influence postthoracotomy pain 显示文摘 | Silomon M Claus T Huwer H | 2000 | Anesth Analg2000，91，1： | 1 |
| 8 | Blood pressure control with valsartan and hydrochlorothiazide in clinical practice:The MACHT Observational Study显示文摘 | Abts M claus V Lataster M | 2006 | Blood Press2006，15，1： | 1 |
| 9 | Effects of substituting added water for fat on the textural, sensory, and processing characteristics of bologna显示文摘 | CLAUS J R HUNT M C KASTNER C L | 1990 | Journal of Muscle Foods1990，1，1： | 1 |
| 10 | Effects of marine microbial biofilms on the biocide release rate from antifouling paints- A model-based analysis显示文摘 | Diego M Y Soren K Claus E | 2006 | Prog Org Coat2006，57，： | 1 |
| 11 | Rapid and accurate high-performance liquid chromatographic method for the determina- tion of 3-methylindole (skatole) in faeces of various species 显示文摘 | Dehnhard M Bernal-Barragan H Claus R | 1991 | J Chromatogr1991，566，1： | 1 |
| 12 | Capsule null locus meningococci:Typing of antigens used in an investigational multicomponent meningococcus serogroup B vaccine显示文摘 | CLAUS H JORDENS M S KRIZ P | 2012 | Vaccine2012，30，2： | 1 |
| 13 | Media for the culture of oceanic ultra phytoplankton显示文摘 | Keller M D Selvin R C Claus W | 1987 | Pycology1987，，23： | 1 |
| 14 | A multicenter phase II trial of decitabine as first-line treatment for older patients with acute myeloid leukemia judged unfit for induction chemotherapy 显示文摘 | LiJbbert M Rfiter BH Claus R | 2012 | Haematologica2012，97，3： | 1 |
| 15 | Parallel measurements of indole and skatole (3-methylindole) in feces and blood plasma of pigs by HPLC 显示文摘 | Claus R Dehnhard M Herzog A | 1993 | Livestock Production Science1993，34，1： | 1 |
| 16 | Interpleural analgesia does not influence postthoracotomy pain显示文摘 | SILOMON M CLAUS T HUWER H | | 0，，01： | 1 |
| 17 | Epidemiology and etiology of meningioma显示文摘 | Wiemels J Wrensch M Claus EB | 2010 | J Neurooncol2010，，3： | 1 |
| 18 | The balance between von-Willebrand factor and its cleaving protease ADAMTS13: biomarker in systemic inflammation and develop- ment of organ failure? 显示文摘 | Claus RA Bockmeyer CL Sossdorf M | 2010 | Curr Mol Med2010，10，2： | 1 |
| 19 | Risks of Future Drugs: A Danish Expert Delphi显示文摘 | Claus M Janine MM | 2001 | Technological Forecasting and Social Change2001，67，23： | 1 |
| 20 | Elliptical-core two mode optical-fiber sensor implementation methods显示文摘 | K A Murphy M S Miller A M Vengsarkar R O Claus | | 0，，： | 1 |
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