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240篇 您的检索式：作者名="Clemen T"

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	题名	作者	年代	出处	被引量
1	The hypoxia-inducible factor-1α activates ectopic production of fibroblast growth factor 23 in tumor-induced osteomalacia显示文摘Tumor-induced osteomalacia(TIO) is a rare paraneoplastic syndrome in which ectopic production of fibroblast growth factor 23(FGF23) by non-malignant mesenchymal tumors causes phosphate wasting and bone fractures. Recent studies have implicated the hypoxia-inducible factor-1α(HIF-1α) in other phosphate wasting disorders caused by elevated FGF23, including X-linked hypophosphatemic rickets and autosomal dominant hypophosphatemia. Here we provide evidence that HIF-1α mediates aberrant FGF23 in TIO by transcriptionally activating its promoter. Immunohistochemical studies in phosphaturic mesenchymal tumors resected from patients with documented TIO showed that HIF-1α and FGF23 were co-localized in spindleshaped cells adjacent to blood vessels. Cultured tumor tissue produced high levels of intact FGF23 and demonstrated increased expression of HIF-1α protein. Transfection of MC3T3-E1 and Saos-2 cells with a HIF-1α expression construct induced the activity of a FGF23 reporter construct. Prior treatment of tumor organ cultures with HIF-1α inhibitors decreased HIF-1α and FGF23 protein accumulation and inhibited HIF-1α-induced luciferase reporter activity in transfected cells. Chromatin immunoprecipitation assays confirmed binding to a HIF-1α consensus sequence within the proximal FGF23 promoter, which was eliminated by treatment with a HIF-1α inhibitor. These results show for the first time that HIF-1α is a direct transcriptional activator of FGF23 and suggest that upregulation of HIF-1α activity in TIO contributes to the aberrant FGF23 production in these patients.	Qian Zhang Michele Doucet Ryan E Tomlinson Xiaobin Han L Darryl Quarles Michael T Collins Thomas L Clemens	2016	Bone Research2016，4，2：	6
2	Single-Dose Gamma-Irradiation Induces Up-Regulation of Chemokine Gene Expression and Recruitment of Granulocytes into the Portal Area but Not into Other Regions of Rat Hepatic Tissue显示文摘	Ihtzaz Ahmed Malik Federico Moriconi Nadeem Sheikh Naila Naz Sajjad Khan Jozsef Dudas Tümen Mansuroglu Clemens Friedrich Hess Margret Rave-Fr?nk Hans Christiansen Giuliano Ramadori	2010	The American Journal of Pathology2010，，4：	2
3	Large-scale structure and entrainment in the supersonic mixing layers 显示文摘	Clemens N T Mungal M G	1995	J Fluid Mech1995，284，：	1
4	Contrast-enhanced ultra- sound (CEUS)for differentiating between hepatocellular and cholangiocellu\|arcarcinoma显示文摘	Bohle W Clemens PU Heubach T	2012	U\|trascha\|l Med2012，33，7：	1
5	The effect of calcium on the rate and products of steam gasification of char from low rank coal显示文摘	Clemens A H Damiano L F Matheson T W	1998	Fuel1998，77，910：	1
6	A protocal for the inhos- pital emergency drug management of convulsive status epilepti- cuss in adults显示文摘	Shelley J Clemens P Eugen T	2014	Pract Neurol2014，14，：	1
7	Understanding strategic re- sponses to institutional pressures 显示文摘	Clemens B W Douglas T J	2005	Journal of Busi- ness Research2005，58，9：	1
8	Solid desiccant tech- nology review 显示文摘	Wurm J Kosar D Clemens T	2002	Bulletin of the International Insti- tute of Refrigeration2002，82，3：	1
9	Collinearity and the Use of Latent Root Regression for Combining GNP Forecasts 显示文摘	Guerard J B Clemen R T	1989	Journal of Forecasting1989，8，3：	1
10	Forum on bone and skel- etal muscle interactions: summary of the proceedings of an ASBMR workshop显示文摘	Bonewald L F Kiel D P Clemens T L	2013	J Bone Miner Res2013，28，9：	1
11	Assessing Dependence : Some Experimental Results 显示文摘	Robert T Clemen Gregory W Fischer Robert L Winkler	2000	Management Science2000，46，8：	1
12	Linear constrains and the efficiency of combined foreeasts显示文摘	Clemen R T	1986	Journal of Forecasting1986，5，1：	1
13	Aggregating point estimates:A flexible modeling approach显示文摘	Clemen R T Winkler R L	1993	Management Science1993，39，：	1
14	显示文摘	Clemens S Sehneller T van der Hart A	2005	Adv Mater2005，17，11：	1
15	Drug-induced neuroprotection from global ischemia is associated with prevention of persistent but not transient activation of nuclear factor-kappaB in rats显示文摘	CLEMENS J A STEPHENSON D T YIN T	1998	Stroke1998，29，3：	1
16	Copula models for aggregating expert opinions显示文摘	Jouini M N Clemen R T	1996	Operations Research1996，44，：	1
17	VEGF- initiated blood-retinal barrier breakdown in earlydiabetes 显示文摘	Qaum T Xu Q’Joussen AM Clemens MW Qin W Miyamoto K	2001	Invest Ophthalmol Vis Sci2001，42，10：	1
18	Simultaneous LII and PIV measurements in the soot formation region of turbulent non-premixed jet flames显示文摘	Narayanaswamy V Clemens N T	2013	Proceedings of the Combustion Institute2013，34，1：	1
19	Large-scale structure andentrainment in the supersonic mixing layer 显示文摘	Clemens N T Mungal M G	1995	Journal ofFluid Mechanics1995，284，：	1
20	Deformation mechanisms in TiAI intermetallics-experiments and modeling 显示文摘	Marketz W T Fischer F D Clemens H	2003	International Journal of Plasticity2003，19，3：	1

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