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36篇 您的检索式：作者名="Closa M"

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	题名	作者	年代	出处	被引量
1	Pancreatic and pulmonary mast cells activation during experimental acute pancreatitis显示文摘AIM:To study the activation of pancreatic and pulmonary mast cells and the effect of mast cell inhibition on the activation of peritoneal and alveolar macrophages during acute pancreatitis.METHODS:Pancreatitis was induced by intraductal infusion of 5% sodium taurodeoxycholate in rats.The mast cell inhibitor cromolyn was administered intraperitoneally(i.p.) 30 min before pancreatitis induction.The pancreatic and pulmonary tissue damage was evaluated histologically and mast cells and their state of activation were evaluated.Peritoneal and alveolar macrophages were obtained and the expression of tumor necrosis factor α was determined.Myeloperoxidase activity was measured to evaluate the effect of mast cell inhibition on the progression of the inflammatory process.Finally,the effect of plasma on cultured mast cells or macrophages was evaluated in vitro.RESULTS:The mast cell stabilizer signif icantly reduced inflammation in the pancreas and lung and the activation of alveolar macrophages but had no effect on peritoneal macrophages.Mast cell degranulation was observed in the pancreas during pancreatitis but no changes were observed in the lung.Plasma from rats with pancreatitis could activate alveolar macrophages but did not induce degranulation of mast cells in vitro.CONCLUSION:Pancreatic mast cells play an important role in triggering the local and systemic inflammatory response in the early stages of acute pancreatitis.In contrast,lung mast cells are not directly involved in the inflammatory response related to pancreatic damage.	Inmaculada Lopez-Font Sabrina Gea-Sorlí Enrique de-Madaria Luis M Gutiérrez Miguel Pérez-Mateo Daniel Closa	2010	World Journal of Gastroenterology2010，16，27：	10
2	Intestinal preconditioning is mediated by a transient increase in nitric oxide显示文摘	Hotter G Closa D Prados M	1996	Biochem Biophys Res Commun1996，222，1：	1
3	Prostanoids and free radicals in CC14-induced hepatotoxicity in rats: effect of Astilbin 显示文摘	Closa D Torres M Hotter G	1997	Prosta- glandins Leukot Essent Fatty Acids1997，56，4：	1
4	Hepatic involvement in pancreatitis-induced lung injury显示文摘	Closa D Bardaji M Hotter G	1996	Am J Physiol1996，270，11：	1
5	Glutathione S-transferase Mu and Theta polymorphisms and breast cancer susceptibility显示文摘	Garcia Closas M Kelsey KT Hankinson SE	1999	J Nat Cancer Inst1999，91，22：	1
6	Genetic variation in the nucleotide excision repair pathway and bladder cancer risk 显示文摘	Garcia- Closas M Malats N Real FX	2006	Cancer Epidemiol Biomarkers Prey2006，15，3：	1
7	Arabidopsis thaliana contains a single gene encoding squalene synthase 显示文摘	Busquets A Keim V Closa M	2008	Plant Mol Biol2008，67，：	1
8	Intestinal preconditioning is mediated by a transient increase in nitric oxide显示文摘	Closa D Prados M	1996	Biochem Biophys Res Commun1996，222，：	1
9	Prostanoids and free CC14 induced hepatotoxicity in rats:effect of astilbin 显示文摘	Closa D Torres M Hotter G	1997	dins Leukot Essent Fatty Acids1997，56，4：	1
10	Hepaticinvo lvement in pancrcat it is2induced lungdamage 显示文摘	Closa D Bardaji M Hotter G	1996	AmJ Physio l1996，270，11：	1
11	Arabidopsis thaliana contains a single gene encoding squalene synthase显示文摘	Busquets A Keim V Closa M del Arco A Boronat A Arró M and Ferrer A		0，，：	1
12	Common genetic variation in Tp53 and its flanking genes, WDR79 and ATP1B2, and susceptibility to breast cancer 显示文摘	Garcia- Closas M Kristensen V Langerod A	2007	Cancer2007，121，11：	1
13	Arabidopsis thaliana con- tains a single gene encoding squalene synthase 显示文摘	Busquets A Keim V Closa M	2008	Plant Mol Biol2008，67，12：	1
14	Power and sample size calculations in case - control studies of gene - environment interactions: comments on different approaches显示文摘	Lubin J	1999	Am J Epidemiol1999，149，：	1
15	The Arabidopsis thaliana FPP synthase isozymes have overlapping and specific functions in isoprenoid biosynthesis,and complete loss of FPP synthase activity causes early developmental arrest显示文摘	Closa M Vranová E Bortolotti C Bigler L Arró M Ferrer A and Gruissem W		0，，：	1
16	Intestinal precondtiioning is mediated by a transient increase in nitric oxide显示文摘	Hotter G Closa D Prados M		Biochemical and Biophysical Research Communications0，，：	1
17	Prostanoids and free radicals in C14C-induced hepatotoxicity in rats: effect of astilbin显示文摘	CLOSA D TORRES M HOTTER G	1997	Prostaglandins Leukotrienes and Essential Fatty Acids1997，56，4：	1
18	Bladder cancer, disinfection byproducts, and markers of geneticious captibility in a case control study from Spain 显示文摘	Cantor KP Villanueva C Garcia Closas M etal	2006	Epidemiology2006，，17：	1
19	Hepatic involvement in pancreatitis-induced lung damage显示文摘	Closa D Bardaji M Hotter G	1996	Am J Physiol1996，270，11：	1
20	Intestinal preconditioning is mediated by a transient increase in nitric oxide显示文摘	Hotter G Closa D Prados M	1996	Biochem Biophys Res Commun1996，221，1：	1

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