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| 1 | Targeting inflammation in pancreatic cancer: Clinical translation显示文摘Preclinical modelling studies are beginning to aid development of therapies targeted against key regulators of pancreatic cancer progression. Pancreatic cancer is an aggressive, stromally-rich tumor, from which few people survive. Within the tumor microenvironment cellular and extracellular components exist, shielding tumor cells from immune cell clearance, and chemotherapy, enhancing progression of the disease. The cellular component of this microenvironment consists mainly of stellate cells and inflammatory cells. New findings suggest that manipulation of the cellular component of the tumor microenvironment is possible to promote immune cell killing of tumor cells. Here we explore possible immunogenic therapeutic strategies. Additionally extracellular stromal elements play a key role in protecting tumor cells from chemotherapies targeted at the pancreas. We describe the experimental findings and the pitfalls associated with translation of stromally targeted therapies to clinical trial. Finally, we discuss the key inflammatory signal transducers activated subsequent to driver mutations in oncogenic Kras in pancreatic cancer. We present the preclinical findings that have led to successful early trials of STAT3 inhibitors in pancreatic adenocarcinoma. | Colin William Steele Nina Angharad Kaur Gill Nigel Balfour Jamieson Christopher Ross Carter | 2016 | World Journal of Gastrointestinal Oncology2016，8，4： | 2 |
| 2 | ‘Step‐port’ l aparoscopic c ystgastrostomy for the management of organized solid predominant post‐acute fluid collections after severe acute pancreatitis显示文摘 | Simon C. Gibson Bernard F. Robertson Euan J. Dickson Colin J. McKay C. Ross Carter | 2014 | HPB2014，，2： | 2 |
| 3 | Hemorheological abnormalities in lipoprotein lipase deficient mice with severe hypertriglyceridemia显示文摘 | Tieqiang Zhao Jun Guo Hui Li Wei Huang Xunde Xian Colin J.D. Ross Michael R. Hayden Zongyao Wen George Liu | 2006 | Biochemical and Biophysical Research Communications2006，，4： | 2 |
| 4 | 分离体验量表中文版信度和效度的初步研究显示文摘目的:探讨对住院精神障碍患者分离体验量表第二版(DES-II)中文版评定的信度和效度。方法:404例住院精神障碍患者进行分离体验量表的评定。6周后在初筛病例中随机抽取样本数20%进行量表重测。将DES-II量表初筛评定结果按得分高低随机排序并分组抽样:0~10分第一组抽取样本数的10%;10~20分第二组抽取30%;20~40分第三组抽取50%;40分以上第四组抽取100%。抽取99例样本进行DDIS量表评定,其中完成量表并符合分析要求量表80例,验证DES-II中文版和DDIS分量表的相关效度。结果:DES量表各项目与总分间的相关系数在0.566~0.728之间;DES-II中文版评定量表的Cronbach's的α系数为0.957;量表奇偶分半系数分别是0.843、0.883。6周后重测量表相关系数为0.617;DES得分分组的一致性Kappa值为0.549。DES量表因子分析结果表明,量表为单一因子的一维量表。对DDIS量表除外躯体性主诉和物质滥用之外所有的13个分量表和DES量表进行关联效度分析,DDIS分量表和DES得分相关系数在0.306~0.720之间,DDIS分量表得分相加的和DES因子分的相关系数为0.994。结论:分离体验量表DES-II中文版信度和效度较好,DES和DDIS各分量表的相关性较高。DES量表可以作为临床筛查的有效工具,具有临床和科研应用价值。 | 张璇 俞峻瀚 张叶文 Colin A Ross Benjamin Keyes 肖泽萍 | 2011 | 临床精神医学杂志2011，21，5： | 2 |
| 5 | Intramuscular Administration of AAV1-Lipoprotein LipaseS447X Lowers Triglycerides in Lipoprotein Lipase–Deficient Patients显示文摘 | Erik S. Stroes Melchior C. Nierman Janneke J. Meulenberg Remco Franssen Jaap Twisk C Pieter Henny Mario M. Maas Aeilko H. Zwinderman Colin Ross Eleonora Aronica Katherine A. High Marcel M. Levi Michael R. Hayden John J. Kastelein Jan Albert Kuivenhoven | 2008 | Arteriosclerosis Thrombosis and Vascular Biology2008，，12： | 1 |
| 6 | Optimization of a chirped-pulse amplification Nd:glass laser显示文摘 | Ross I N Mark Trentelman Colin N | 1997 | Appl Opt1997，36，36： | 1 |
| 7 | Bacteriocins:developing innate immunity for food显示文摘 | Paul D Cotter Colin Hill Paul Ross R | 2005 | Nature2005，，3： | 1 |
| 8 | Optimization of a chirped-pulse amplification Nd:glass laser显示文摘 | Ross I N Mark T Colin N | 1997 | Appl Opt1997，36，36： | 1 |
| 9 | Inside the high - tech black box: A critique of technology entrepreneurship policy 显示文摘 | Ross Brown Colin Mason | 2014 | Techno- vation2014，，： | 1 |
| 10 | Controlled Autolysis and Enzyme Release in a Recombinant Lactococcal Strain Expressing the Metalloendopeptidase Enterolysin A 显示文摘 | Rita M Hickey R Paul Ross Colin Hill | 2004 | Appl and Environmental Microbiology2004，70，： | 1 |
| 11 | Fast DNA and protein microarray tests for the diagnosis of hepatitis C virus infection on a single platform显示文摘 | Stuart W. J. Ember Holger Schulze Alan J. Ross Julie Luby Mizanur Khondoker Gerard Giraud Jonathan G. Terry Ilenia Ciani Chaker Tlili Jason Crain Anthony J. Walton Andrew R. Mount Peter Ghazal Till T. Bachmann Colin J. Campbell | 2011 | Analytical and Bioanalytical Chemistry2011，，8： | 1 |
| 12 | Isolation and Analysis of Bacteria with Antimicrobial Activities from the Marine Sponge Haliclona simulans Collected from Irish Waters显示文摘 | Jonathan Kennedy Paul Baker Clare Piper Paul D. Cotter Marcella Walsh Marlies J. Mooij Marie B. Bourke Mary C. Rea Paula M. O’Connor R. Paul Ross Colin Hill Fergal O’Gara Julian R. Marchesi Alan D. W. Dobson | 2009 | Marine Biotechnology2009，，3： | 1 |
| 13 | Exploiting gut bacteriophages for human health显示文摘 | Marion Dalmasso Colin Hill R. Paul Ross | 2014 | Trends in Microbiology2014，，： | 1 |
| 14 | Activation of the IL-6R/Jak/Stat Pathway is Associated with a Poor Outcome in Resected Pancreatic Ductal Adenocarcinoma显示文摘 | Simon M. Denley Nigel B. Jamieson Pamela McCall Karin A. Oien Jennifer P. Morton C. Ross Carter Joanne Edwards Colin J. McKay | 2013 | Journal of Gastrointestinal Surgery2013，，： | 1 |
| 15 | Enhanced atherothrombotic formation after oxidative injury by FeCl 3 to the common carotid artery in severe combined hyperlipidemic mice显示文摘 | Xunde Xian Yu Ding Ling Zhang Yanan Wang Michael A. McNutt Colin Ross Michael R. Hayden Xuming Deng George Liu | 2009 | Biochemical and Biophysical Research Communications2009，，4： | 1 |
| 16 | Inside the high-tech black box: A critique of technology entrepreneurship policy显示文摘 | Ross Brown Colin Mason | 2014 | Technovation2014，，34： | 1 |
| 17 | The Prognostic Influence of Resection Margin Clearance Following Pancreaticoduodenectomy for Pancreatic Ductal Adenocarcinoma显示文摘 | Nigel B. Jamieson Nigel I. J. Chan Alan K. Foulis Euan J. Dickson Colin J. McKay C. Ross Carter | 2013 | Journal of Gastrointestinal Surgery2013，，3： | 1 |
| 18 | A Food-Grade Approach for Functional Analysis and Modification of Native Plasmids in Lactococcus lactis 显示文摘 | Paul D Cotter Colin Hill R Paul Ross | 2003 | Appl and Environmental Microbiology2003，69，： | 1 |
| 19 | Prognostic Value of the Index of Microcirculatory Resistance Measured After Primary Percutaneous Coronary Intervention显示文摘 | William F. Fearon Adrian F. Low Andy S. Yong Ross McGeoch Colin Berry Maulik G. Shah Michael Y. Ho Hyun-Sook Kim Joshua P. Loh Keith G. Oldroyd | 2013 | Circulation2013，，24： | 1 |
| 20 | Identification andoverexpression of ItnI,a novel gene which confers immunity to the twocomponent lantibiotic lactincin 3147显示文摘 | Olivia McAuliffe Colin Hill R Paul Ross | 2000 | Microbiology2000，146，： | 1 |
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