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| 1 | Elevated serum alpha fetoprotein levels promote pathological progression of hepatocellular carcinoma显示文摘AIM:To investigate the biological role of alpha fetoprotein (AFP) and its clinical signif icance in carcinogenesis of hepatocellular carcinoma (HCC).METHODS:Clinical analysis of HCC patients and im-munohistochemical examination were conducted to evaluate the relationship between serum AFP level and patient mortality. Confocal microscopy,Western blotting, dimethylthiahzolyl-2,5-diphenyl-tetrazolium bromide,Cell Counting Kit-8 assays and flow cytometry were performed to explore the possible mechanism.RESULTS: Among the 160 HCC patients enrolled in this study,130 patients survived 2 years (81.25%),with a survival rate of 86.8% in AFP < 2 0 μg/L group,88.9% in AFP 20-250 μg/L group,and 69.6% in AFP > 250 μg/L group, demonstrating a higher mortality rate in HCC patients with higher AFP levels. Surgical treatment was benef icial only in patients with low AFP levels.The mortality rate of HCC patients with high AFP levels who were treated surgically was apparently higher than those treated with conservative management.The results of immunohistochemistry showed that AFP and AFP receptor were merely expressed in tissues of HCC patients with positive serum AFP.Consistently,in vitro analysis showed that AFP and AFPS were expressed in HepG2 but not in HLE cells. AFP showed a capability to promote cell growth,and this was more apparent in HepG2 cells,in which the proliferation was increased by 3.5 folds. Cell cycle analysis showed that the percent-age of HepG2 cells in S phase after exposure to AFP was modestly increased.CONCLUSION:HCC patients with higher AFP levels show a higher mortality rate,which appears to be attributable to the growth promoting properties of AFP. | Peng Li Shan-Shan Wang Hui Liu Ning Li Michael A McNutt Gang Li Hui-Guo Ding | 2011 | World Journal of Gastroenterology2011，17，41： | 23 |
| 2 | Autophagy process is associated with anti-neoplastic function显示文摘Autophagy 是细胞的降级的一个高度保存的过程,它在酵母,植物,和哺乳动物是在场的。在正常生理的条件下面, autophagy 行动维持细胞的动态平衡并且调整细胞器的周转。响应细胞的压力, autophagy 阻止损害蛋白质和细胞器的累积,它服务禁止 carcinogenesis。在这个基础上,这广泛地被接受大多数肿瘤 suppressors,例如 beclin, 1 联系蛋白质, forkhead 框类 O (FoxO ) 家庭蛋白质, Rapamycin (mTOR ) inactivators 的多重哺乳动物的目标,和原子 p53 在导致 autophagy 起一个作用。这里,我们集中 autophagy 的过程怎么与反肿瘤的功能被联系。 | Chong Wang Yachen Wang Michael A. McNutt Wei-Guo Zhu | 2011 | Acta Biochimica et Biophysica Sinica2011，43，6： | 18 |
| 3 | Corporate governance and earnings management at large U.S. bank holding companies显示文摘 | Marcia Millon Cornett Jamie John McNutt Hassan Tehranian | 2009 | Journal of Corporate Finance2009，，4： | 3 |
| 4 | HER-2/neu expression as a predictor of response to neoadjuvant docetaxel in patients with operable breast carcinoma显示文摘 | Learn P A Yeh I T McNutt M | 2005 | Cancer2005，103，11： | 1 |
| 5 | Think tanks and the web: Measuring visibility and influence显示文摘 | MCNUTT K MARCHILDON G | 2009 | Canadian Public Policy2009，35，2： | 1 |
| 6 | The Effect of Blinding on the Quality of Peer Review显示文摘 | McNutt R A Evans A T Fletcher R H | 1990 | JAMA1990，263，： | 1 |
| 7 | Insulation thermal life considerations for transformer loading guides显示文摘 | McNutt W J | 1992 | IEEE Transactions on Power Delivery1992，7，1： | 1 |
| 8 | Lichen planus-like keratosis: A clinical and histological reexamination显示文摘 | Prieto VG Casal M McNutt NS | 1993 | Am J Surg Pathol1993，17，3： | 1 |
| 9 | SmartArc-Based Volumetric Modulated Arc Therapy for Oropharyngeal Cancer: A Dosimetric Comparison With Both Intensity-Modulated Radiation Therapy and Helical Tomotherapy显示文摘 | Stefania Clemente BinBin Wu Giuseppe Sanguineti Vincenzo Fusco Francesco Ricchetti John Wong Todd McNutt | 2011 | International Journal of Radiation Oncology, Biology, Physics2011，，： | 1 |
| 10 | Cancer immunotherapy 显示文摘 | McNutt M | 2013 | Science2013，342，： | 1 |
| 11 | Distal pachydermodactyly 显示文摘 | Tompkins SD McNutt NS Shea CR | 1998 | J Am Acad Dermatol1998，38，2： | 1 |
| 12 | The effect of blinding on the quality of peer review显示文摘 | McNutt R A Evans A T Fletcher R H | 1990 | JAMA1990，263，： | 1 |
| 13 | Expression of myogenic regulatory proteins (myogenin and MyoD1) in small blue round cell tumors of childhood 显示文摘 | WANG N P MARX J MCNUTT M | 1995 | Am J Pathol1995，147，： | 1 |
| 14 | Nested case-control study of the effects of non-steroidal anti-inflammatory drugs on breast cancer risk and stage显示文摘 | Collet JP McNutt M | 2000 | Br J Cancer2000，83，1： | 1 |
| 15 | HER-2/neu expression as a predictor of response to neoadjuvant docetaxel in patients with operable breast carcinoma显示文摘 | Learn PA Yeh IT McNutt M | 2005 | Cancer2005，103，11： | 1 |
| 16 | Cancer immtmotherapy显示文摘 | Mcnutt M | 2013 | Science2013，342，6165： | 1 |
| 17 | Vulvovaginit is in swine 显示文摘 | Mcnutt S H Purwin P Murray C | 1928 | Journal of Americal Vet Medicine Associ- ation1928，，73： | 1 |
| 18 | Direct measurement of transformer winding hot spot temperature显示文摘 | McNutt W J McIver J C Leibinger G E | 1984 | IEEE Transaction on Power Apparatus and Systems1984，103，6： | 1 |
| 19 | The potential of urban runoff to surface sediments of the Passaic River: sources and chemical characteristics显示文摘 | Walker W J McNutt R P Maslanka C A | 1999 | Chemosphere1999，35，： | 1 |
| 20 | Antihypertensive Medication Use During Pregnancy and the Risk of Cardiovascular Malformations显示文摘 | Alissa R. Caton Erin M. Bell Charlotte M. Druschel Martha M. Werler Angela E. Lin Marilyn L. Browne Louise-Anne McNutt Paul A. Romitti Allen A. Mitchell Richard S. Olney Adolfo Correa | 2009 | Hypertension2009，，1： | 1 |
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