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| 1 | Training in endoscopic submucosal dissection显示文摘Endoscopic submucosal dissection (ESD) represents an important advancement in the therapy of early neoplastic gastrointestinal lesions by providing higher en-bloc curative resection rate with lower recurrence compared to endoscopic mucosal resection (EMR) and by sparing the involved organ and protecting patient' s quality of life. Despite these advantages ESD is associated with long procedure times and a higher rate of complications, making ESD a challenging procedure which requires advanced endoscopic skills. Thus, there has been a recognized need for structured training system for ESD to enhance trainee experience and, to reduce the risks of complications and inadequate treatment. ESD has a very flat learning curve. However, we do not have uniformly accepted benchmarks for competency. Nevertheless, it appears that, in Japan, more than 30 supervised gastric ESD procedures are required to achieve technical proficiency and minimize complications. A number of training algorithms have been pro-posed in Japan with the aim to standardize ESD training. These algorithms cannot be directly applied in the West due to substantial differences including the availability of highly qualified mentors, the type of pathology seen, choice of devices, and trainee's background. We propose a training algorithm for Western physicians which integrates both hands-on training courses, animal model work as well as visits to expert centers. No specific preceptor training programs have been yet developed but there is a consensus that these programs are important for permeation of ESD worldwide. | Roxana M Coman Takuji Gotoda Peter V Draganov | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，8： | 8 |
| 2 | Role of observation of live cases done by Japanese experts in the acquisition of ESD skills by a western endoscopist显示文摘AIM:To evaluate the role of observation of experts performing endoscopic submucosal dissection(ESD)in the acquisition of ESD skills.METHODS:This prospective study is documenting the learning curve of one Western endoscopist.The study consisted of three periods.In the first period(preobservation),the trainee performed ESDs in animal models in his home institution in the United States.The second period(observation)consisted of visit to Japan and observation of live ESD cases done by experts.The observation of cases occurred over a 5-wk period.During the third period(post-observation),the trainee performed ESD in animal models in a similar fashion as in the first period.Three animal models were used:live40-50 kg Yorkshire pig,explanted pig stomach model,and explanted pig rectum model.The outcomes from the ESDs done in the animal models before and after observation of live human cases(main study intervention)were compared.Statistical analysis of the data included:Fisher’s exact test to compare distributions of a categorical variable,Wilcoxon rank sum test to compare distributions of a continuous variable between the two groups(pre-observation and post-observation),and Kruskal-Wallis test to evaluate the impact of lesion location and type of model(ex-vivo vs live pig)on lesion removal time.RESULTS:The trainee performed 38 ESDs in animal model(29 pre-observation/9 post-observation).The removal times post-observation were significantly shorter than those pre-observation(32.7±15.0 min vs 63.5±9.8 min,P<0.001).To minimize the impact of improving physician skill,the 9 lesions post-observation were compared to the last 9 lesions pre-observation and the removal times remained significantly shorter(32.7±15.0 min vs 61.0±7.4 min,P=0.0011).Regression analysis showed that ESD observation significantly reduced removal time when controlling for the sequence of lesion removal(P=0.025).Furthermore,it was also noted a trend towards decrease in failure to remove lesions and decrease in complications after the period of observation.This study did not find a significant difference in the time needed to remove lesions in different animal models.This finding could have important implications in designing training programs due to the substantial difference in cost between live animal and explanted organ models.The main limitation of this study is that it reflects the experience of a single endoscopist.CONCLUSION:Observation of experts performing ESD over short period of time can significantly contribute to the acquisition of ESD skills. | Peter V Draganov Myron Chang Roxana M Coman Mihir S Wagh Qi An Takuji Gotoda | 2014 | World Journal of Gastroenterology2014，20，16： | 3 |
| 3 | Lenalidomide as salvage treatment for multiple myeloma relapsing after allogeneic hematopoietic stem cell transplantation:a report from the French Society of Bone Marrow and Cellular Therapy显示文摘 | Coman T Bachy E Michallet M | 2013 | Haematologica2013，98，5： | 1 |
| 4 | Benzylation of benzene with benzylalcoholonzeolitecatalysts显示文摘 | Candu N Florea M Coman S M | 2011 | AppliedCatalysisA: General2011，393，12： | 1 |
| 5 | Novel sol-gel synthesis for Bronsted and/or Lewis acidic MgF2-x ( OH ) x materials 显示文摘 | Wuttke S Coman S M Scholz G | 2008 | Chem Eur J2008，14，11： | 1 |
| 6 | A multipurpose CMOS sensor interface for low power applications显示文摘 | WOUTERS E DE COMAN M RUERS R | 1994 | IEEEJ Sol Sta Circ1994，29，8： | 1 |
| 7 | Novel sol-gel synthesis of acidic MgFx -x( OH )x Materials 显示文摘 | Wuttke S Coman S M Scholz G | 2008 | Chem Eur J2008，14，11： | 1 |
| 8 | Catalytic performance of nanoscopic, aluminium trifluoride based catalysts in the synthesis of( all- rac) - α- tocopherol 显示文摘 | Coman S M Wuttke S Vimont A | 2008 | Adv Synth Catal2008，350，： | 1 |
| 9 | Lenalidomide as salvage treatment for multiple myeloma relapsing after allogeneic hematopoietic stem cell transplantation: a report from the SFGM-TC显示文摘 | Coman T Bachy E Michallet M | 2013 | Haematologica2013，98，： | 1 |
| 10 | Benzylation of benzene withbenzyl alcohol on zeolite catalysts显示文摘 | Candu N Florea M Coman S M | 2011 | Applied Catalysis A:Gener- a12011，393，1： | 1 |
| 11 | The European strawberry database and building up a European core collection 显示文摘 | Geibbel M Masny A Coman M | 2004 | Acta Horticulturae2004，649，： | 1 |
| 12 | Tailor-made MgF2-based catalysts by sol-gel synthesis显示文摘 | Kenmitz E Wuttke S Coman S M | | 0，，31： | 1 |
| 13 | New heterogeneous catalysts for greener routes in the Synthesis of fine chemicals显示文摘 | Coman S M Pop G Stere C | 2007 | lournal of Catalysis2007，251，： | 1 |
| 14 | What is transforming growth factor-beta (TGF-β)?显示文摘 | David Chin Glen M Boyle Peter G Parsons William B Coman | 2004 | British Journal of Plastic Surgery2004，，3： | 1 |
| 15 | Efficacy of a meal replacement diet plan compared to a food-based diet plan after a period of weight loss and weight maintenance:a randomized controlled trial显示文摘 | Lisa M Davis Chirstoper Coman Jessica Kiel | 2010 | Nutrition Journal2010，9，3： | 1 |
| 16 | Cyclisation of citroneUal over heterogeneous inorganic fluorides--highly chemo- and diastereoselective catalysts for (+)-isopulegol 显示文摘 | COMAN S M PATIL P WUTTKE S | 2009 | Chemistry Communication2009，，4： | 1 |
| 17 | Serological levels of apoptotic bodies, sFAS and TNF in lupus erythematosus 显示文摘 | Alecu M Coman G Alecu S | 2000 | Rom J Intern Med2000，3839，： | 1 |
| 18 | Transesterification of vegetable oils over Ca O catalysts显示文摘 | Verziu M Coman S M Richards R | 2011 | Catalysis Today2011，167，1： | 1 |
| 19 | Cyclisation of citronellal over heterogeneous inorganic fluorides-highly chemo- and diastereoselective catalysts for (+)-isopulegol显示文摘 | Coman S M Patil P Wuttke S | 2009 | Chemistry Communication2009，，： | 1 |
| 20 | Implementation of polariza- tion agility in planar phased-array antennas by means of inter- leaved subarray显示文摘 | Simeoni M Lager I E Coman C I | 2009 | Radio Science2009，44，2： | 1 |
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