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| 1 | Hydrological and water cycle processes of inland river basins in the arid region of Northwest China显示文摘The increasing shortage in water resources is a key factor affecting sustainable socio-economic development in the arid region of Northwest China(ARNC). Water shortages also affect the stability of the region's oasis ecosystem. This paper summarizes the hydrological processes and water cycle of inland river basins in the ARNC, focusing on the following aspects: the spatial-temporal features of water resources(including air water vapor resources, runoff, and glacial meltwater) and their driving forces; the characteristics of streamflow composition in the inland river basins; the characteristics and main controlling factors of baseflow in the inland rivers; and anticipated future changes in hydrological processes and water resources. The results indicate that:(1) although the runoff in most inland rivers in the ARNC showed a significant increasing trend, both the glaciated area and glacial ice reserves have been reduced in the mountains;(2) snow melt and glacier melt are extremely important hydrological processes in the ARNC, especially in the Kunlun and Tianshan mountains;(3) baseflow in the inland rivers of the ARNC is the result of climate change and human activities, with the main driving factors being the reduction in forest area and the over-exploitation and utilization of groundwater in the river basins; and(4) the contradictions among water resources, ecology and economy will further increase in the future. The findings of this study might also help strengthen the ecological, economic and social sustainable development in the study region. | CHEN Yaning LI Baofu FAN Yuting SUN Congjian FANG Gonghuan | 2019 | Journal of Arid Land2019，11，2： | 12 |
| 2 | Distribution of IgG galactosylation as a promising biomarker for cancer screening in multiple cancer types显示文摘 | Shifang Ren Zejian Zhang Congjian Xu Lin Guo Renquan Lu Yihong Sun Jianming Guo Ruihuan Qin Wenjun Qin Jianxin Gu | 2016 | Cell Research2016，26，8： | 8 |
| 3 | RNA-binding protein LIN28B inhibits apoptosis through regulation of the AKT2/FOXO3A/BIM axis in ovarian cancer cells显示文摘LIN28B is an evolutionarily conserved RNA-binding protein that regulates mRNA translation and miRNA let-7 maturation in embryonic stem cells and developing tissues.Increasing evidence demonstrates that LIN28B is activated in cancer and serves as a critical oncogene.However,the underlying molecular mechanisms of LIN28B function in tumorigenesis are still largely unknown.Here we report that LIN28B was expressed in over half of the patients with epithelial ovarian cancer who were examined(n=584).Functional experiments demonstrated that LIN28B inhibited ovarian cancer cell apoptosis.Furthermore,we showed that the proapoptotic factor BIM played an essential role in the antiapoptotic function of LIN28B.RNA-IP microarray analysis suggested that LIN28B binds to mRNAs that are associated with the DNA damage pathway,such as AKT2,in ovarian cancer cells.By binding to AKT2 mRNA and enhancing its protein expression,LIN28B regulated FOXO3A protein phosphorylation and decreased the transcriptional level of BIM,which antagonized the antiapoptosis activity of LIN28B.Taken together,these results mechanistically linked LIN28B and the AKT2/FOXO3A/BIM axis to the apoptosis pathway.The findings may have important implications in the diagnosis and therapeutics of ovarian cancer. | Xiaojuan Lin Jianfeng Shen Dan Peng Xinhong He Congjian Xu Xiaojun Chen Janos LTanyi Kathleen Montone Yi Fan Qihong Huang Lin Zhang Xiaomin Zhong | 2018 | Signal Transduction and Targeted Therapy2018，3，1： | 8 |
| 4 | Magnetite-Fluorite Rock:A New Rock Type of Hot Water Sedimentation显示文摘新类型热水沉积岩石磁铁矿荧石岩石在 Changshan 县的 Bamianshan 在在岩石身体和阶层之间的接触地区的扁平的部分作为伪层发生,浙江省,中国。主要矿物质集合是 fluorite+magnetite+cassiterite。岩石显示出典型把压成薄片的结构和明显的马赛克质地。它的形成温度在 123 潲数瑲敩之间吗? | XU Shaokang XIA Xuehui YUAN Congjian WANG Bingquan YAN Fei YAN Shengxian ZHENG Xingquan | 2008 | Acta Geologica Sinica(English Edition)2008，82，4： | 6 |
| 5 | Two less common human microRNAs miR-875 and miR-3144 target a conserved site of E6 oncogene in most high-risk human papillomavirus subtypes显示文摘人的乳头状瘤病毒(HPV ) 包括高风险(HR ) 并且低风险(LR ) 子类型在遗传型和显型上有可区分的变化。多重 HR-HPVs 的合作感染,由 HPV16 出发了,在在女性的颈的癌症是普通的。最近积累的报告集中了于在病毒和主人之间的相互作用,特别地在由指向病毒的染色体的抗病毒的防卫的人的 microRNAs (miRNAs ) 的角色。这里,我们在大多数 HR-HPVs,不是 LR-HPVs 的染色体发现了 miRNAs 的一个保存得好的目标地点,由扫描风险的不含糊的子类型的 24 HPV 上的人的 miRNAs 的所有潜在的目标地点。这个地点被二不太普通的人的 miRNAs, miR-875 和 miR-3144 指向,并且位于 E6 oncogene 开的读框架(ORF ) 和有第一种选择的重叠拼接病毒的早抄本的 exon。在确认测试, miR-875 和 miR-3144 被识别显著地压制目标记者活动并且禁止两综合地外长的 E6 和内长的 E6 oncogene 的表示。二 miRNAs 的高水平能禁止房间生长并且在 HPV16 积极的颈的癌症房间支持 apoptosis。这研究为大多数 HR-HPVs 提供 miRNAs 的一个有希望的普通目标并且在瘤抑制上加亮二低表示人的 miRNAs 的效果。 | Lin Lin Qingqing Cai Xiaoyan Zhang Hongwei Zhang Yang Zhong Congjian Xu Yanyun Li | 2015 | Protein & Cell2015，6，8： | 3 |
| 6 | Mineralization of a Proterozoic Sulfide Black Smoker Chimney and Thermophilous Microorganisms in Eastern Hebei,China显示文摘一个硫化物黑人吸烟者烟囱在 Gaobanhe 海床呼气存在在 Xinglong-Kuancheng 第二等的差错盆的巨大的硫化物沉积物原生地在 Hebei 省的 Yanliao 裂缝马槽,拿墩的形状,个别地大约 23 厘米高。在完美的保藏的 thermophilous 细菌和水藻的丰富的石块在包围黑吸烟者烟囱的矿石被发现。扫描电子显微镜学(SEM ) 和分子的 biomarker 在在硫化物矿石的微生物事实上是 probiotic 细菌和水藻的一个沉积产品的 microorganismal 矿石织物表演学习。在古老的海床基于黑吸烟者烟囱在特殊食物锁住 -- thermophilous 细菌, thermophilous 细菌和水藻在大数量复制。间歇地为硫化物沉积物的形成从烟囱 creats 条件液体爆发。在热液体的呼气行动的过程, thermophilous 细菌和水藻成长并且在硫化物黑人吸烟者烟囱附近复制,吸收液体带的使矿物化的物质。巨大的硫化物存款在海床黑人吸烟者烟囱的吸收的这个过程被形成使矿物化呼气的液体 pulsation-thermophilous 微生物。 | XIA Xuehui LIAN Wei YUAN Congjian YAN Fei YUAN Jiazhong | 2008 | Acta Geologica Sinica(English Edition)2008，82，4： | 3 |
| 7 | Minimal deviation adenocarcinoma of the uterine cervix显示文摘 | Guiling Li Wei Jiang Suiqi Gui Congjian Xu | 2010 | International Journal of Gynecology and Obstetrics2010，，： | 1 |
| 8 | mir-30d regulates multiple genes in the autophagy pathway and impairs autophagy process in human cancer cells显示文摘 | Xiaojun Yang Xiaomin Zhong Janos L. Tanyi Jianfeng Shen Congjian Xu Peng Gao Tim M. Zheng Angela M. DeMichele Lin Zhang | 2012 | Biochemical and Biophysical Research Communications2012，，： | 1 |
| 9 | Ordered arrays of shape tunable CuInS2 nanostructures,from nanotubes to nano test tubes and nanowires显示文摘 | Shi Liang Pei Congjian Li Quan | | 0，，： | 1 |
| 10 | A kind of new type hydrothermal sedimentary rock: magnetite-fluorite rock 显示文摘 | Xu Shaokang Xia Xuehui Yuan Congjian | 2008 | Acta Geo- logica Sinica2008，82，4： | 1 |
| 11 | Antitumor Activity and Underlying Mechanisms of Ganopoly, The Refined Polysaccharides Extracted from Ganoderma Lucidum , in Mice显示文摘 | Yihuai Gao He Gao Eli Chan Wenbo Tang Anlong Xu Hongyuan Yang Min Huang Jin Lan Xiaotian Li Wei Duan Congjian Xu Shufeng Zhou | 2005 | Immunological Investigations2005，，2： | 1 |
| 12 | Clinical Diagnosis and Treatment of Minimal Deviation Adenocarcinoma of the Cervix: a Report of Thirtheen Cases显示文摘 | Yingying Lu Guiling Li Congjian Xu | 2013 | 中国药理通讯2013，30，4： | 0 |
| 13 | Non-viral targeted delivery system mediates transfection of thymidine kinase gene of herpes simplex virus into ovarian cancer cells:a comparison between one time and continuous mediation显示文摘Objective: To compare the transferring efficiency and killing effects of one time and continuous mediation with GE7,a non-viral targeted delivery system,in transfection of thymidine kinase gene of herpes simplex virus (HSV-tk) into ovarian cancer cells. Methods: GE7 was used to prepare recombinants with β-galactosidase (β-gal) and HSV1-tk; the re-combinants were then used to transfect human ovarian cancer line CaOV3 once and continuously. β-gal staining was used to compare the efficiencies of one time and continuous mediation with GE7 system. Ganciclovior (GCV) was introduced into HSV1-tk transfected ovarian cells. Through drawing the cell growth curve and flow cytometry,the killing effects of GCV on once and continuously GE7/HSV1-tk transfected cells were observed. Results: We found that the one time and continuous exogenous gene transfer efficiencies were about 80% and 85%,respectively. When 1μg/mL GCV was used to treat ovarian cell transfected with HSV1-tk gene,growth inhibiting rates of ovarian cells of one time and continuous transferring were 82% and 90%,respectively; their apoptosis indices were 15 and 30,respectively. Under same GCV concentration,continuous me-diation of GE7/pCMV-tk transfection into ovarian cancer cells had more significant inhibitory effect than one time mediation (P<0.05). Conclusion: Compared with one time mediation,continuous mediation of transfection with GE7 gene delivery system has higher efficiency. Continuous mediation of GE7/HSV1-tk/GCV therapeutic gene system has more powerful killing effect. | Xiaojun Liu Zhijun Jin Kangyun Xie Xiaoxi Huo Xinyan Zhang Yan Liu Congjian Xu | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，6： | 0 |
| 14 | Alterations in immune cell heterogeneities in the brain of aged zebrafish using single-cell resolution显示文摘Immunocytes,including the microglia,are crucial in the neurodegenerative process in old people.However,the understanding regarding microglia heterogeneity and other involved immunocytes remains elusive.We analyzed 26,456 immunocytes from 12-and 26-month-old zebrafish brains at single-cell resolution.Microglia and T lymphocytes were detected in the brain at both time points.Two types of microglia were annotated,namely,ac+microglia and xr+microglia,which were clustered into subsets 1,2,3,4,5,and subsets 6,7,8,9,respectively.Diversified microglia predominated the adult brains and cooperated with T cells to perform the functions of immune response and neuronal nutrition.We validated the specific microglia markers.The novel transgenic lines,Tg(lgals3bpb:e GFP)and Tg(apoc1:e GFP),were created,which faithfully labeled ac+microglia and served as valuable labeling tools.However,the microglia population reduced while T cells of six subtypes intriguingly increased to serve as the primary immune cells in aged brains.Unlike in 12-month-old brains,T cells,together with microglia,exhibited a coordinated signature of inflammation in the 26-month-old brains.Our findings revealed the immunocytes atlas in aged zebrafish brains.It implied the involvement of microglia and T cells in the progression of neurodegeneration in aging. | Jiangyong He Fangying Zhao Bingyue Chen Nianfei Cui Zhifan Li Jie Qin Lingfei Luo Congjian Zhao Li Li | 2023 | Science China(Life Sciences)2023，66，6： | 0 |
| 15 | CLINICAL EFFECTS ON 149 CASES OF INFANTILE DIARRHEA TREATED WITH RAPID-STICKING MOXATHERAPY Attaching 35 contrasted cases with western medicine显示文摘Of 149 cases.infantile diarrhea were treated with Zhou’s multiapplied rapid-sticking herbomoxa-pen.The main acupoints selected were Auriculoapex,Tianshu(ST 25),Zusanli(ST 36),Shenshu(BL 23),etc.TWO groups were observed,32 cases from the 149 cases as therapid-sticking moxatherapy(RSMT)group who suffered from the acute diarrhea without any thera-peutics before,and the other 35 cases with western medicine as the control group.Results showedthat the recovering rate and the average therapeutic course of healing in RSMT group were higher andshorter than that in control one(P<0.05;P<0.01),even without marked difference of the total ef-fective rates between the two groups(P>0.05).Of 149 cases with RSMT,the therapeutic effect onacute ones was better than those on delayed and chronic ones(P<0.05),yet the difference was notmarked in therapeutic effects between the etiological causes of infections and non-infections(P> 0.0.5).It is therefore worthy of popularizing RSMT due to its remarked curative results without anyside-effect,simply-manipulated and well-accepted features. | Zhou Ziyang Li Yangzheng* Wei Congjian, Affiliated Acupuncture Hospital, Anhui College of TCM, Anhui Prov. 230061, China *The Second Affiliated Hospital, Southern Anhui Medical College, Anhui Prov. 241000, China | 1993 | World Journal of Acupuncture-Moxibustion1993，3，3： | 0 |
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