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| 1 | Ten cities cross-sectional questionnaire survey of children asthma and other allergies in China显示文摘Asthma,rhinitis and eczema(allergic or non-allergic)have increased throughout the world during the last decades,especially among children.Changes in the indoor environment are suspected to be important causes.China has experienced a dramatic change in indoor environmental exposures during the past two decades.However,such changes and their associations with children’s asthma and other health aspects have not been thoroughly studied.China,Children,Homes,Health(CCHH),Phase I,was a cross-sectional questionnaire survey of 48219 children 1–8 years old in 10 Chinese cities during 2010–2012.The questionnaire includes the International Study of Asthma and Allergies in Childhood(ISAAC)core health questions and additional questions regarding housing,life habits and outdoor environment.In health analyses,children aged 3–6 years old were included.The prevalences of doctor diagnosed asthma varied from 1.7%to 9.8%(mean 6.8%),a large increase from 0.91%in 1999 and 1.50%in2000.The prevalence of wheeze,rhinitis and atopic eczema(last 12 months)varied from 13.9%to 23.7%,24.0%to 50.8%and4.8%to 15.8%,respectively.Taiyuan had the lowest prevalences of all illnesses and Shanghai the highest,except for wheezewhere the highest value was for Urumqi.We found(1)no obvious association between disease prevalences and ambient PM10concentrations and(2)higher prevalences of disease in humid climates with hot summers and cold winters,but with no centrally heated buildings.Associations between the diseases and economic status as indexed by Gross Domestic Product(GDP)requires further study. | ZHANG YinPing LI BaiZhan HUANG Chen YANG Xu QIAN Hua DENG QiHong ZHAO ZhuoHui LI AnGui ZHAO JiaNing ZHANG Xin QU Fang HU Yu YANG Qin WANG Juan ZHANG Ming WANG Fang ZHENG XiaoHong LU Chan LIU ZhiJian SUN YueXia MO JinHan ZHAO YiLi LIU Wei WANG TingTing NORBCK Dan BORNEHAG Carl-Gustaf SUNDELL Jan | 2013 | Chinese Science Bulletin2013，58，34： | 22 |
| 2 | RNA-binding protein LIN28B inhibits apoptosis through regulation of the AKT2/FOXO3A/BIM axis in ovarian cancer cells显示文摘LIN28B is an evolutionarily conserved RNA-binding protein that regulates mRNA translation and miRNA let-7 maturation in embryonic stem cells and developing tissues.Increasing evidence demonstrates that LIN28B is activated in cancer and serves as a critical oncogene.However,the underlying molecular mechanisms of LIN28B function in tumorigenesis are still largely unknown.Here we report that LIN28B was expressed in over half of the patients with epithelial ovarian cancer who were examined(n=584).Functional experiments demonstrated that LIN28B inhibited ovarian cancer cell apoptosis.Furthermore,we showed that the proapoptotic factor BIM played an essential role in the antiapoptotic function of LIN28B.RNA-IP microarray analysis suggested that LIN28B binds to mRNAs that are associated with the DNA damage pathway,such as AKT2,in ovarian cancer cells.By binding to AKT2 mRNA and enhancing its protein expression,LIN28B regulated FOXO3A protein phosphorylation and decreased the transcriptional level of BIM,which antagonized the antiapoptosis activity of LIN28B.Taken together,these results mechanistically linked LIN28B and the AKT2/FOXO3A/BIM axis to the apoptosis pathway.The findings may have important implications in the diagnosis and therapeutics of ovarian cancer. | Xiaojuan Lin Jianfeng Shen Dan Peng Xinhong He Congjian Xu Xiaojun Chen Janos LTanyi Kathleen Montone Yi Fan Qihong Huang Lin Zhang Xiaomin Zhong | 2018 | Signal Transduction and Targeted Therapy2018，3，1： | 8 |
| 3 | A photocleavable low molecular weight hydrogel for light-triggered drug delivery显示文摘A photocleavable low-molecular-weight hydrogelator (LMWG) was synthesized based on coumarin derivative.~1H NMR and UV spectroscopy study suggested that the gelator had good gelling ability, and the driving force for the gelation were hydrogen bonding and π-π stacking. This molecular hydrogel exhibited satisfied photocleavage at C-N bond in 7-amino coumarin with the light irradiation (365 nm,77.5 mW/cm^2). The promising photo-triggered drug release of antineoplastics cytarabine hydrochloride has been obtained, due to the photocleavage motived gel-sol transition. | Qihong Liu Hao Wang Guotao Li Miaochang Liu Jinchang Ding Xiaobo Huang Wenxia Gao Huayue Wu | 2019 | Chinese Chemical Letters2019，30，2： | 4 |
| 4 | AP24534, a Pan-BCR-ABL Inhibitor for Chronic Myeloid Leukemia, Potently Inhibits the T315I Mutant and Overcomes Mutation-Based Resistance显示文摘 | Thomas O’Hare William C. Shakespeare Xiaotian Zhu Christopher A. Eide Victor M. Rivera Frank Wang Lauren T. Adrian Tianjun Zhou Wei-Sheng Huang Qihong Xu Chester A. Metcalf Jeffrey W. Tyner Marc M. Loriaux Amie S. Corbin Scott Wardwell Yaoyu Ning Jeffrey | 2009 | Cancer Cell2009，，5： | 1 |
| 5 | KIAP, a Novel Member of the Inhibitor of Apoptosis Protein Family显示文摘 | Jiing-Huey Lin Gary Deng Qihong Huang John Morser | 2000 | Biochemical and Biophysical Research Communications2000，，3： | 1 |
| 6 | KIAP, anovel member of the apotosis protein Family 显示文摘 | Jiing-Huey Lin Gary Deng Qihong Huang | 2000 | Biochemical and Biophysical Research Communications2000，279，： | 1 |
| 7 | FEM computation of groove ridge and Monte Carlo simulation in two-body abrasive wear显示文摘 | Liang Fang Qihong Cen Kun Sun Weimin Liu Xiaofeng Zhang Zhifu Huang | 2004 | Wear2004，，1： | 1 |
| 8 | Varia- tion in cooling load of a moving air-conditioned train compartment under the effects of ambient conditions and body thermal storage 显示文摘 | Liu Weiwei Deng Qihong Huang Wenjie | 2011 | Applied Thermal Engi- neering2011，，31： | 1 |
| 9 | The microRNAs miR-373 and miR-520e promote tumour invasion and metastasis显示文摘 | Qihong Huang Kiranmai Gumireddy Mariette Schrier et al | 2008 | Nature Cell Biol2008，10，2： | 1 |
| 10 | Discovery of 5-(arenethynyl) hetero-monocyclic derivatives as potent inhibitors of BCR–ABL including the T315I gatekeeper mutant显示文摘 | Mathew Thomas Wei-Sheng Huang David Wen Xiaotian Zhu Yihan Wang Chester A. Metcalf Shuangying Liu Ingrid Chen Jan Romero Dong Zou Raji Sundaramoorthi Feng Li Jiwei Qi Lisi Cai Tianjun Zhou Lois Commodore Qihong Xu Jeff Keats Frank Wang Scott Wardwell Yaoy | 2011 | Bioorganic & Medicinal Chemistry Letters2011，，12： | 1 |
| 11 | Long Noncoding RNAs with Enhancer-like Function in Human Cells显示文摘 | Ulf Andersson ?rom Thomas Derrien Malte Beringer Kiranmai Gumireddy Alessandro Gardini Giovanni Bussotti Fan Lai Matthias Zytnicki Cedric Notredame Qihong Huang Roderic Guigo Ramin Shiekhattar | 2010 | Cell2010，，1： | 1 |
| 12 | Cloning and characterization of an inhibitor of apoptosis protein (IAP)from Bombyx mori显示文摘 | Qihong Huang Quinn L Deveraux Susumu Maeda | 2001 | Biochimica Biophysica Acta2001，1499，： | 1 |
| 13 | KIAP, a Novel Member of the Inhibitor of Apoptosis Protein Family显示文摘 | Jiing-Huey Lin Gary Deng Qihong Huang John Morser | 2000 | Biochemical and Biophysical Research Communications2000，，3： | 1 |
| 14 | Effect of controlled-release urea on heavy metal mobility in a multimetal-contaminated soil显示文摘Controlled-release N fertilizers can affect the availability of heavy metals in the contaminated paddy soil.A soil incubation experiment was conducted to investigate the effects of prilled urea(PU),S-coated urea(SCU),and polymer-coated urea(PCU)on the solubility and availability of heavy metals Cd,Pb,Cu,and Zn in a multimetal-contaminated soil.The results showed that the application of different coated urea significantly affected the solubility and availability of heavy metals.At 5 d of incubation,the application of PU,SCU,and PCU had significantly decreased the concentrations of water-soluble and available Cd,Pb,Cu,and Zn,when compared with the control.At 60 d of incubation,the depletory effects of PU on water-soluble and available heavy metals had reduced,and the initial decrease in the concentrations of water-soluble Cd,Pb,Cu,and Zn caused by SCU had changed to an increase.The concentrations of water-soluble Pb,Cu,and Zn in the SCU-treated soil were higher than those in the control.Application with PCU led to a higher water-soluble Cu than that in the control,while the available Cd,Pb,and Zn were lower than those in the control.The effect of different coated urea was much stronger on the water solubility of the heavy metals than on their availability.The effects of controlled-release urea on the transformation of heavy metals resulted in changes in the concentrations of NH4^+,water-soluble SO4^2-,and soil p H.The results further suggested that PCU could be used in dry farming operations in multimetal-contaminated acid soils. | Chao XU Qian XIANG Qihong ZHU Hanhua ZHU Daoyou HUANG Yangzhu ZHANG | 2020 | Pedosphere2020，30，2： | 0 |
| 15 | Research Progress and Trends of Domestic Smart Learning Environment显示文摘In order to explore the main progress and current status of domestic research on smart learning environment, this paper takes 260 core and CSSCI journal papers included in the CNKI database as the research objects, and uses CiteSpace visual analysis software and uses bibliometrics and knowledge graph analysis as the main research methods, summarizes and analyzes the time distribution of the literature, the distribution of institutions and authors, co-occurrence and clustering of keywords, and research hotspots,etc. | Yaqiang Cui Qihong Gan Xiaoli Huang Qi Yu Chunyan Wang Jianlin Tian | 2019 | Review of Educational Theory2019，2，2： | 0 |
| 16 | The archaeal KEOPS complex possesses a functional Gon7 homolog and has an essential function independent of the cellular t^(6)A modification level显示文摘Kinase,putative Endopeptidase,and Other Proteins of Small size(KEOPS)is a multisubunit protein complex conserved in eukaryotes and archaea.It is composed of Pcc1,Kae1,Bud32,Cgi121,and Gon7 in eukaryotes and is primarily involved in N^(6)-threonylcarbamoyl adenosine(t^(6)A)modification of transfer RNAs(tRNAs).Recently,it was reported that KEOPS participates in homologous recombination(HR)repair in yeast.To characterize the KEOPS in archaea(aKEOPS),we conducted genetic and biochemical analyses of its encoding genes in the hyperthermophilic archaeon Saccharolobus islandicus.We show that aKEOPS also possesses five subunits,Pcc1,Kae1,Bud32,Cgi121,and Pcc1-like(or Gon7-like),just like eukaryotic KEOPS.Pcc1-like has physical interactions with Kae1 and Pcc1 and can mediate the monomerization of the dimeric subcomplex(Kae1-Pcc1-Pcc1-Kae1),suggesting that Pcc1-like is a functional homolog of the eukaryotic Gon7 subunit.Strikingly,none of the genes encoding aKEOPS subunits,including Pcc1 and Pcc1-like,can be deleted in the wild type and in a t^(6)A modification complementary strain named TsaKI,implying that the aKEOPS complex is essential for an additional cellular process in this archaeon.Knock-down of the Cgi121 subunit leads to severe growth retardance in the wild type that is partially rescued in TsaKI.These results suggest that aKEOPS plays an essential role independent of the cellular t^(6)A modification level.In addition,archaeal Cgi121 possesses dsDNA-binding activity that relies on its tRNA 3ʹCCA tail binding module.Our study clarifies the subunit organization of archaeal KEOPS and suggests an origin of eukaryotic Gon7.The study also reveals a possible link between the function in t^(6)A modification and the additional function,presumably HR. | Pengju Wu Qi Gan Xuemei Zhang Yunfeng Yang Yuanxi Xiao Qunxin She Jinfeng Ni Qihong Huang Yulong Shen | 2023 | mLife2023，2，1： | 0 |
| 17 | Identifying Transportation Modes from Raw GPS Data显示文摘Raw Global Positioning System (GPS) data can provide rich context information for behaviour understanding and transport planning. However, they are not yet fully understood, and fine-grained identification of transportation mode is required. In this paper, we present a robust framework without geographic information, which can effectively and automatically identify transportation modes including car, bus, bike and walk. Firstly, a trajectory segmentation algorithm is designed to divide raw GPS trajectory into single mode segments. Secondly, several modern features are proposed which are more discriminating than traditional features. At last, an additional postprocessing procedure is adopted with considering the wholeness of trajectory. Based on Random Forest classifier, our framework can achieve a promising accuracy by distance of 82.85% for identifying transportation modes and especially 91.44% for car mode. | Qiuhui Zhu Min Zhu Mingzhao Li Min Fu Zhibiao Huang Qihong Gan Zhenghao Zhou | 2016 | 国际计算机前沿大会会议论文集2016，，1： | 0 |
| 18 | Oxidative lactonization of C(sp^(3))–H bond in methyl aromatic alcohols enabled by proton-coupled electron transfer显示文摘Direct functionalization of inert C(sp^(3))–H bonds in pharmaceutically significant compounds is very important in modern synthetic organic chemistry.In this article,we disclose a practical and efficient method for the oxidative lactonization of benzylic C(sp^(3))–H bonds enabled by the synergistic interactions of organic dye-type rose bengal,n-Bu_(4)N∙Br,O_(2) and Na_(2)HPO_(4) under visible light irradiation.This reaction does not require transition metal catalysts or strong oxidants.A range of structurally diverse phthalides has been synthesized with excellent selectivity and high functional group compatibility.The late-stage application of this reaction to the preparation of structurally complex phthalides demonstrates its synthetic utility. | Shanyi Chen Qihong Lai Chao Liu Hui Liu Mingqiang Huang Shunyou Cai | 2022 | Science China Chemistry2022，65，8： | 0 |
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