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| 1 | Vedolizumab for ulcerative colitis: Real world outcomes from a multicenter observational cohort of Australia and Oxford显示文摘BACKGROUND Vedolizumab(VDZ),a humanised monoclonal antibody that selectively inhibits alpha4-beta7 integrins is approved for use in adult moderate to severe ulcerative colitis(UC)patients.AIM To assess the efficacy and safety of VDZ in the real-world management of UC in a large multicenter cohort involving two countries and to identify predictors of achieving remission.METHODS A retrospective review of Australian and Oxford,United Kingdom data for UC patients.Clinical response at 3 mo,endoscopic remission at 6 mo and clinical remission at 3,6 and 12 mo were assessed.Cox regression models and Kaplan Meier curves were performed to assess the time to remission,time to failure and the covariates influencing them.Safety outcomes were recorded.RESULTS Three hundred and three UC patients from 14 centres in Australia and United Kingdom,[60%n=182,anti-TNF naïve]were included.The clinical response was 79%at 3 mo with more Australian patients achieving clinical response compared to Oxford(83%vs 70%P=0.01).Clinical remission for all patients was 56%,62%and 60%at 3,6 and 12 mo respectively.Anti-TNF naive patients were more likely to achieve remission than exposed patients at all the time points(3 mo 66%vs 40%P<0.001,6 mo 73%vs 46%P<0.001,12 mo 66%vs 51%P=0.03).More Australian patients achieved endoscopic remission at 6 mo compared to Oxford(69%vs 43%P=0.01).On multi-variate analysis,anti-TNF naïve patients were 1.8(95%CI:1.3-2.3)times more likely to achieve remission than anti-TNF exposed(P<0.001).32 patients(11%)had colectomy by 12 mo.CONCLUSION VDZ was safe and effective with 60%of UC patients achieving clinical remission at 12 mo and prior anti-TNF exposure influenced this outcome. | Samba Siva Reddy Pulusu Ashish Srinivasan Krupa Krishnaprasad Daniel Cheng Jakob Begun CharlotteKeung Daniel Van Langenberg Lena Thin Tamara Mogilevski Peter De Cruz Graham Radford-Smith Emma Flanagan Sally Bell Soleiman Kashkooli Miles Sparrow Simon Ghaly Peter Bampton Elise Sawyer Susan Connor Quart-ul-ain Rizvi Jane M Andrews Gillian Mahy Paola Chivers Simon Travis Ian Craig Lawrance | 2020 | World Journal of Gastroenterology2020，26，30： | 2 |
| 2 | Laminin-binding integrins in rat lens morpho- genesis and their regulation during fibre differentiation显示文摘 | WedereU ED Brown H O' Connor M Chamberlain CG McAvoy JW de Iongh RU | 2005 | Exp Eye Res2005，81，3： | 1 |
| 3 | Diatom assemblages and their associated environmental factors in upland peat forest rivers显示文摘 | Connie O'Driscoll Elvira de Eyto Michael Rodgers Mark O'Connor Zaki-ul-Zaman Asam Liwen Xiao | 2012 | Ecological indicators2012，18，： | 1 |
| 4 | MOSFET optimization in deep submicron technology for charge amplifiers 显示文摘 | De Geronimo G O'Connor P | 2005 | IEEE Transactions on Nuclear Science2005，52，6： | 1 |
| 5 | Organizing for radicalinnovation:an exploratory study of the structural aspectsof RI management systems in large established firms显示文摘 | O'CONNOR G DE MARTINO R | 2006 | Journal of Product Innovation Management2006，23，6： | 1 |
| 6 | Leptin expression in human mammary epithelial cells and breast milk 显示文摘 | SMITHKIRWIN S M O'CONNOR D M DE JOHNSTON J | 1998 | J Clin Endocrinol Metab1998，83，5： | 1 |
| 7 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
| 8 | Analog CMOS peak detect and hold circuits 显示文摘 | Gianluigi De Geronimo Paul O' Connor | 2002 | Nuclear Instruments and Methods in Physics Research A2002，484，： | 1 |
| 9 | Leptin expression in human mammary epithelial cells and breast milk显示文摘 | SMITH - KIRWIN S M O'CONNOR D M DE JOHNSTON J | 1998 | J Clin Endocrinol Metab1998，83，5： | 1 |
| 10 | Epothilone biosynthesis:assembly of the methyl thiazolylcarboxy starter unit on the Epo Bsubunit显示文摘 | Chen H O'Connor S Cane DE | 2001 | Chem Biol2001，8，9： | 1 |
| 11 | Nucleus pulposus cellular longevity by telomerase gene therapy显示文摘 | Chung SA Wei AQ Connor DE | 2007 | Spine2007，32，11： | 1 |
| 12 | Development of transparent, conducting composites by surface infiltration of nanotubes into commercial polymer films 显示文摘 | O'CONNOR I DE S COLEMAN J N GUN'KO Y K | 2009 | Carbon2009，47，19： | 1 |
| 13 | inhibins in normal male physiology显示文摘 | O'Connor AE De Kretser DM | 2004 | Semin Reprod Med2004，22，3： | 1 |
| 14 | Leptin expression in human mammary epithelialcells and breast milk 显示文摘 | SMITH K S M CONNOR D M DE J J | 1998 | Clin Endocri- nol Meab1998，83，5： | 1 |
| 15 | FrontEnd ASIC for a GEM Based Time Projection Chamber显示文摘 | De Geronimo G ·Fried J O' connor | 2004 | IEEE TRANSACTIONS ON NUCLEAR SCIENCE2004，51，4： | 1 |
| 16 | Analysis of see- ondary Chromosomal alterations in 165 cases of follicular lymphoma with t ( 14 ; 18 ) 显示文摘 | Horsman DE Connors JM Pantzar T | 2001 | Genes Chromosomes Canc- er2001，30，4： | 1 |
| 17 | Ciprofioxacin - Resistant shigella sonnei associated with travel to India 显示文摘 | De Lappe N O' connor J Garvey P eta| | 2015 | Emerging Infectious Diseases2015，21，5： | 1 |
| 18 | Nucleus pulposus cellular longevity by telomerase gene therapy显示文摘 | Chung SA Wei AQ Connor DE | 2007 | Spine2007，32，11： | 1 |
| 19 | Myelin basic protein-reactive antoantibodies in the serum and eerebrospinal fluid of multiple selerosis patients are eharaeterized by low-affinity interaetions 显示文摘 | O'Connor KC Chitnis T Griffin DE | 2003 | J Neuroimmunol2003，136，2： | 1 |
| 20 | Role of subtyping indetecting Salmonella cross contamination in the laboratory 显示文摘 | De Lappe N Connor J O Doran G | 2009 | BMC Microbiol2009，9，1： | 1 |
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