|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Prognostic significance of tumor immune microenvironment and immunotherapy:Novel insights and future perspectives in gastric cancer显示文摘Despite a decrease in gastric cancer incidence, the development of novel biologic agents and combined therapeutic strategies, the prognosis of gastric cancer remains poor. Recently, the introduction of modern immunotherapy, especially using immune checkpoint inhibitors, led to an improved prognosis in many cancers. The use of immunotherapy was also associated with manageable adverse event profiles and promising results in the treatment of patients with gastric cancer, especially in heavily pretreated patients. These data have led to an accelerated approval of some checkpoint inhibitors in this setting. Understanding the complex relationship between the host immune microenvironment and tumor and the immune escape phenomenon leading to cancer occurrence and progression will subsequently lead to the identification of prognostic immune markers. Furthermore, this understanding will result in the discovery of both new mechanisms for blocking tumor immunosuppressive signals and pathways to stimulate the local immune response by targeting and modulating different subsets of immune cells. Due to the molecular heterogeneity of gastric cancers associated with differentclinico-biologic parameters, immune markers expression and prognosis, novel immunotherapy algorithms should be personalized and addressed to selected subsets of gastric tumors, which have been proven to elicit the best clinical responses. Future perspectives in the treatment of gastric cancer include tailored dual immunotherapies or a combination of immunotherapy with other targeted agents with synergistic antitumor effects. | Daniela Cornelia Lazǎr Mihaela Flavia Avram Ioan Romosan Mǎrioara Cornianu Sorina Tǎan Adrian Goldis | 2018 | World Journal of Gastroenterology2018，24，32： | 24 |
| 2 | Acoustic radiation force impulse imaging (ARFI) for non-invasive detection of liver fibrosis: examination standards and evaluation of interlobe differences in healthy subjects and chronic liver disease显示文摘 | Thomas Karlas Cornelia Pfrepper Johannes Wiegand Christian Wittekind Marie Neuschulz Joachim M?ssner Thomas Berg Michael Tr?ltzsch Volker Keim | 2011 | Scandinavian Journal of Gastroenterology2011，，12： | 4 |
| 3 | Value of a comprehensive geriatric assessment for predicting one-year outcomes in patients undergoing transcatheter aortic valve implantation: results from the CGA-TAVI multicentre registry显示文摘Background In a three-month report from the CGA-TAVI registry, we found the Multidimensional Prognostic Index (MPI) and Short Physical Performance Battery (SPPB) to be of value for predicting short-term outcomes in elderly patients undergoing transcatheter aortic valve implantation (TAVI). In the present analysis, we examined the association of these tools with outcomes up to one year post-TAVI. Methods CGA-TAVI is an international, observational registry of geriatric patients undergoing TAVI. Patients were assessed using the MPI and SPPB. Efficacy of baseline values and any postoperative change for predicting outcome were established using logistic regression. Kaplan- Meier analysis was carried out for each comprehensive geriatric assessment tool, with survival stratified by risk category. Results One year after TAVI, 14.1% of patients deceased, while 17.4% met the combined endpoint of death and/or non-fatal stroke, and 37.7% the combined endpoint of death and/or hospitalisation and/or non-fatal stroke. A high-risk MPI score was associated with an increased risk of all-cause mortality (aOR = 36.13, 95% CI: 2.77–470.78, P = 0.006) and death and/or non-fatal stroke (aOR = 10.10, 95% CI: 1.48–68.75, P = 0.018). No significant associations were found between a high-risk SPPB score and mortality or two main combined endpoints. In contrast to a worsening SPPB, an aggravating MPI score at three months post-TAVI was associated with an increased risk of death and/or non-fatal stoke at one year (aOR = 95.16, 95% CI: 3.41–2657.01). Conclusions The MPI showed value for predicting the likelihood of death and a combination of death and/or non-fatal stroke by one year after TAVI in elderly patients. | Martijn S.van Mourik Nathalie van der Velde Giulio Mannarino Marie-Pierre Thibodeau Jean-Bernard Masson Gennaro Santoro Jan Baan Sofie Jansen Jana Kurucova Martin Thoenes Cornelia Deutsch ANDreas W.Schoenenberger ANDrea Ungar Peter Bramlage M Marije Vis | 2019 | Journal of Geriatric Cardiology2019，16，6： | 3 |
| 4 | Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study显示文摘AIM To examine the associations between mental disorders and infectious, atopic, inflammatory diseases while adjusting for other risk factors.METHODS We used data from PsyC oL aus, a large Swiss Population Cohort Study(n = 3720; age range 35-66). Lifetime diagnoses of mental disorders were grouped into the following categories: Neurodevelopmental, anxiety(early and late onset), mood and substance disorders. They were regressed on infectious, atopic and other inflammatory diseases adjusting for sex, educational level, familial aggregation, childhood adversities and traumatic experiences in childhood. A multivariate logistic regression was applied to each group of disorders. In a complementary analysis interactions with sex were introduced via nested effects. RESULTS Associations with infectious, atopic and other chronic inflammatory diseases were observable together with consistent effects of childhood adversities and familial aggregation, and less consistent effects of trauma in each group of mental disorders. Streptococcal infections were associated with neurodevelopmental disorders(men), and measles/mumps/rubella-infections with early and late anxiety disorders(women). Gastric inflammatory diseases took effect in mood disorders(both sexes) and in early disorders(men). Similarly, irritable bowel syndrome was prominent in a sex-specific way in mood disorders in women, and, moreover, was associated with early and late anxiety disorders. Atopic diseases were associated with late anxiety disorders. Acne(associations with mood disorders in men) and psoriasis(associations with early anxiety disorders in men and mood disorders in women) contributed sex-specific results. Urinary tract infections were associated with mood disorders and, in addition, in a sex-specific way with late anxiety disorders(men), and neurodevelopmental and early anxiety disorders(women).CONCLUSION Infectious, atopic and inflammatory diseases areimportant risk factors for all groups of mental disorders. The sexual dimorphism of the associations is pronounced. | Vladeta Ajdacic-Gross Aleksandra Aleksandrowicz Stephanie Rodgers Margot Mutsch Anja Tesic Mario Müller Wolfram Kawohl Wulf R?ssler Erich Seifritz Enrique Castelao Marie-Pierre F Strippoli Caroline Vandeleur Roland von K?nel Rosa Paolicelli Markus A Landolt Cornelia Witthauer Roselind Lieb Martin Preisig | 2016 | World Journal of Psychiatry2016，6，4： | 2 |
| 5 | Developments in diagnosis and treatment of paediatric septic arthritis显示文摘Acute septic arthritis in children is an orthopaedic emergency.A delay in diagnosis and inappropriate treatment can result in devastating damage to the joint with lifelong disability as a consequence.The clinical presentation can be a diagnostic challenge,especially in young children.A recent systematic review showed that joint tenderness and fever are important signals of septic arthritis.Ultrasound is helpful in detecting the presence of a joint effusion.Plain radiographs may show bone changes but magnetic resonance imaging is the most reliable imaging study for detecting concomitant osteomyelitis.The diagnosis of acute septic arthritis is highly suggestive when pus is aspirated from the joint,in case of a positive culture or a positive gram stain of the joint fluid,or if there is a white blood-cell count in the joint fluid of more than 50000/mm3.Staphylococcus aureus is the most commonly cultured organism.Recent systematic reviews have identified the most effective drainage techniques,including needle aspiration,arthroscopy and arthrotomy,depending on the affected joint.After the drainage procedure it is important to monitor the clinical and laboratory outcomes.Additional drainage procedures may be necessary in select cases. | Cornelia M Donders Anne J Spaans Herbert van Wering Christiaan JA van Bergen | 2022 | World Journal of Orthopedics2022，13，2： | 2 |
| 6 | Polymers containing quaternary ammonium groups based on poly ( N- vinylimidazole) 显示文摘 | CORNELIA L SILVIA M MARCEL P | 2002 | European Polymer Journal2002，38，8： | 1 |
| 7 | Drug-gene interaction the insertion/deletion polymorphism of the angiotensin-converting enzyme gene and anti-hypertensive therapy显示文摘 | Klungel OH Schelleman H Cornelia M | 2006 | The Annals of Pharmacotherapy2006，40，2： | 1 |
| 8 | IGF-I bioactivity in an Elderly Population: Relation to Insulin Sensitivity, Insulin levels,and the Metabolic Syndrome显示文摘 | Michael P Brugts Cornelia M van Duijn Leo J Hofland | 2010 | Diabetes2010，59，2： | 1 |
| 9 | Management of diabetes mellitus complicating pregnancy 显示文摘 | Steven G Gabble M D Cornelia R | 2003 | Obstet Gynecol2003，102，4： | 1 |
| 10 | The effects of logistics capabilities on firm performance: customer-focused versus information -focused capabilities 显示文摘 | ZHAO M CORNELIA D THEODORE P S | 2001 | Journal of Business Logistics2001，22，2： | 1 |
| 11 | Challenges and solutions for the delivery of biotech drugs - a review of drug nanocrystal technology and lipid nanoparticles 显示文摘 | Rainer H Muller Cornelia M Keck | 2004 | J Biotechnol2004，113，13： | 1 |
| 12 | Effects of antibody concentration on the separation of human natural killer cells in a commercial immunomagnetic separation system 显示文摘 | Cornelia K Nakanmra M Melnik K | 2001 | Cytometry2001，45，4： | 1 |
| 13 | High-pressure solubility of 1 , 4-bis-( n-alkylamino ) -9,10-anthraquinones in near-and supercritical carbon dioxide显示文摘 | Cornelia B Kautz Bjorn Wagner Gerhard M Schneider | 1998 | Journal of Supercritical Fluids1998，13，： | 1 |
| 14 | Clinical re search 1 :advances in technology: tumor cell isolation,de tection,and clinical outeome显示文摘 | Schwalbe M Cornelia Klaus Hoeffken | 2005 | Clement Proc Amer As soc Cancer Res2005，46，： | 1 |
| 15 | Polymorphisms in DNA repair genes and associations with cancer risk显示文摘 | Ellen L Goode Cornelia M Ulrich John D Potter | 2002 | Cancer Epidemiology Biomarkers & Prevention2002，11，12： | 1 |
| 16 | noneonvulsive status epi- leptieus review article显示文摘 | Rama M Paula G Cornelia D | 2008 | Epilepsy & Behavior2008，12，4： | 1 |
| 17 | Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs显示文摘 | van de Steeg Evita Wagenaar Els van der Kruijssen Cornelia M M Burggraaff Johanna E C de Waart Dirk R Elferink Ronald P J Oude Kenworthy Kathryn E Schinkel Alfred H | 2010 | Journal of Clinical Investigation2010，，8： | 1 |
| 18 | Dual-regulated expression of C/ EBP-a and BMP-2 enables differential differentiation of C2C12 cells into adipocytes and osteoblasts 显示文摘 | Cornelia F Barbara M Beat P | 2004 | Nucleic Acids Res2004，32，1： | 1 |
| 19 | T-cell responses in rheumatoid arthritis: systemic abnormalities-local disease 显示文摘 | Weyand CM Schmidt D | 1999 | Curr Opin Rheumatol1999，11，： | 1 |
| 20 | Oxylipin profiling in pathogen-infected potato leaves显示文摘 | Cornelia G Feussner I Hamberg M 2002 | 2002 | Biochemica et Biophysica Acta2002，1584，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员