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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | Helicobacter pylori infection:How does age influence the inflammatory pattern?显示文摘The inflammatory pattern during Helicobacter pylori(H.pylori)infection is changeable and complex.During childhood,it is possible to observe a predominantly regulatory response,evidenced by high concentrations of key cytokines for the maintenance of Treg responses such as TGF-β1 and IL-10,in addition to high expression of the transcription factor FOXP3.On the other hand,there is a predominance of cytokines associated with the Th1 and Th17 responses among H.pylori-positive adults.In the last few years,the participation of the Th17 response in the gastric inflammation against H.pylori infection has been highlighted due to the high levels of TGF-β1 and IL-17 found in this infectious scenario,and growing evidence has supported a close relationship between this immune response profile and unfavorable outcomes related to the infection.Moreover,this cytokine profile might play a pivotal role in the effectiveness of anti-H.pylori vaccines.It is evident that age is one of the main factors influencing the gastric inflammatory pattern during the infection with H.pylori,and understanding the immune response against the bacterium can assist in the development of alternative prophylactic and therapeutic strategies against the infection as well as in the comprehension of the pathogenesis of the outcomes related to that microorganism. | Glauber Rocha Lima Araújo Hanna Santos Marques Maria Luísa Cordeiro Santos Filipe Antônio França daSilva Breno Bittencourt da Brito Gabriel Lima Correa Santos Fabrício Freire de Melo | 2022 | World Journal of Gastroenterology2022，28，4： | 2 |
| 3 | One-year follow-up of epithelial corneal cell sheet allografts mounted on platelet poor plasma in rabbits 显示文摘 | Luengo Gimeno F Lavigne V Gatto S Croxatto JO Correa L Gallo JE | 2009 | Mol Vis2009，15，： | 1 |
| 4 | A Vector Control Technique for Medium Voltage Multilevel Inverters显示文摘 | Rodriguez Jo se Moran Luis Correa Pablo | 2002 | IEEE Trans on Industrial Electronics2002，49，4： | 1 |
| 5 | A High Performance Vector Control of an 11-Level Inverter显示文摘 | Rodriguez Jo se Moran Luis Correa Pablo | 2003 | IEEE Trans on Industrial Electronics2003，50，1： | 1 |
| 6 | The interaction of encapsulated pharmaceutical drugs with a silica matrix显示文摘 | Everton C. Morais Gabriel G. Correa Rodrigo Brambilla Claudio Radtke Ione Maluf Baibich Jo?o Henrique Z. dos Santos | 2013 | Colloids and Surfaces B: Biointerfaces2013，，： | 1 |
| 7 | Effect of thalido- mide and pentoxifylline on experimental autoimmune en- cephalomyelitis(EAE)显示文摘 | Correa JO Aarestrup BJ Aarestrup FM | 2010 | Exp Neurol2010，226，1： | 1 |
| 8 | Effect of thalidomide and pentoxifylline on experimental autoimmune encephalomyelitis (EAE)显示文摘 | Correa JO Aarestrup BJ Aarestrup FM | | 0，，01： | 1 |
| 9 | Methadone patient-control ed analgesia for postoperative pain:a randomized,control ed,double-blind study显示文摘 | Neto JO Machado MD de Almeida Correa M | | 0，，： | 1 |
| 10 | Effect of thalidomide and pentoxifylline on experimental autoimmune encephalomyelitis ( EAE ) 显示文摘 | Correa JO Aarestrup B J Aarestrup FM | 2010 | Exp Neurol2010，226，1： | 1 |
| 11 | Association of polymorphisms of the tryptophan hydroxylase 2 gene with risk for bipolar disorder or suicidal behavior显示文摘 | Simone Becho Campos Débora Marques Miranda Bruno Rezende Souza Patricia Araújo Pereira Fernando Silva Neves Maria Aparecida Camargos Bicalho Paulo Henrique Casadei Melillo Juliana Tramontina Flávio Kapczinski Marco Aurélio Romano-Silva Humberto Correa | 2009 | Journal of Psychiatric Research2009，，5： | 1 |
| 12 | Methadone patient-controlled analgesia for postoperative pain:a randomized, controlled, double-blind study 显示文摘 | Neto JO Maehado MD de Almeida Correa M | 2014 | J Anesth2014，28，4： | 1 |
| 13 | Effect of thalidomide andpentoxifylline on experimental autoimmune encephalomyelitis ( EAE)显示文摘 | Correa JO Aarestrup BJ Aarestrup FM | 2010 | Exp Neurol2010，226，1： | 1 |
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