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| 1 | Liver fat deposition and mitochondrial dysfunction in morbid obesity:An approach combining metabolomics with liver imaging and histology显示文摘AIM: To explore the usefulness of magnetic resonance imaging(MRI) and spectroscopy(MRS) for assessment of non-alcoholic fat liver disease(NAFLD) as compared with liver histological and metabolomics findings. METHODS: Patients undergoing bariatric surgery following procedures involved in laparoscopic sleeve gastrectomy were recruited as a model of obesityinduced NAFLD in an observational, prospective, singlesite, cross-sectional study with a pre-set duration of 1 year. Relevant data were obtained prospectively and surrogates for inflammation, oxidative stress and lipid and glucose metabolism were obtained through standard laboratory measurements. To provide reliable data from MRI and MRS, novel procedures were designed to limit sampling variability and other sources of error using a 1.5T Signa HDx scanner and protocols acquired from the 3D or 2D Fat SAT FIESTA prescription manager. We used our previously described 1H NMRbased metabolomics assays. Data were obtained immediately before surgery and after a 12-mo period including histology of the liver and measurement of metabolites. Values from 1H NMR spectra obtained after surgery were omitted due to technical limitations.RESULTS: MRI data showed excellent correlation with the concentration of liver triglycerides, other hepatic lipid components and the histological assessment, w h i c h e xc l u d e d t h e p r e s e n c e o f n o n-a l c o h o l i c steatohepatitis(NASH). MRI was sufficient to follow up NAFLD in obese patients undergoing bariatric surgery and data suggest usefulness in other clinical situations. The information provided by MRS replicated that obtained by MRI using the-CH3 peak(0.9 ppm), the-CH2- peak(1.3 ppm, mostly triglyceride) and the-CH=CH- peak(2.2 ppm). No patient depicted NASH. After surgery all patients significantly decreased their body weight and steatosis was virtually absent even in patients with previous severe disease. Improvement was also observed in the serum concentrations of selected variables. The most relevant findings using metabolomics indicate increased levels of triglyceride and monounsaturated fatty acids in severe steatosis but those results were accompanied by a significant depletion of diglycerides, polyunsaturated fatty acids, glucose-6-phosphate and the ATP/AMP ratio. Combined data indicated the coordinated action on mitochondrial fat oxidation and glucose transport activity and may support the consideration of NAFLD as a likely mitochondrial disease. This concept may helpto explain the dissociation between excess lipid storage in adipose tissue and NAFLD and may direct the search for plasma biomarkers and novel therapeutic strategies. A limitation of our study is that data were obtained in a relatively low number of patients.CONCLUSION: MRI is sufficient to stage NAFLD in obese patients and to assess the improvement after bariatric surgery. Other data were superfluous for this purpose. | Nahum Calvo Raúl Beltrán-Debón Esther Rodríguez-Gallego Anna Hernández-Aguilera Maria Guirro Roger Mariné-Casadó Lidón Millá Josep M Alegret Fàtima Sabench Daniel del Castillo María Vinaixa Miguelàngel Rodríguez Xavier Correig Roberto García-álvarez Javier A Menendez Jordi Camps Jorge Joven | 2015 | World Journal of Gastroenterology2015，21，24： | 2 |
| 2 | Correlation between electronic nose signals and fruit quality indicators on shelf - life measurements with pinklady apples 显示文摘 | J Brezmes E Llobet X Vilanova J Orts G Saiz and X Correig | 2001 | Sensors and Actuators B : Chemical2001，80，： | 1 |
| 3 | A Supervised feature extraction method for GC-MS data based on PLS application to olive oil adulteration detection显示文摘 | BURIAN C BREZMES J CORREIG X et a/ | 2011 | AIP Conference Proceedings2011，1362，： | 1 |
| 4 | Correlation between electronic nose signals and fruit quality indi- cators on shelf - life measurements with pinklady apples显示文摘 | J Brezmes E Llobet X Vilanova J Orts C Saiz and X Correig | 2001 | Sen- sors and Actuators B: Chemical2001，80，： | 1 |
| 5 | Fruit ripeness monitoring using an electronic nose显示文摘 | BREZMES J LLOBET E VILANOVA X SAIZ G CORREIG X | 2000 | Sensors and Actuators B-Chemical2000，69，3： | 1 |
| 6 | Building of a metal oxide gas sensor-based electronic nose to assess the freshness of sardines under cold storage显示文摘 | BARBRI N E AMARI A VINAIXA M BOUCHIKHI B CORREIG X LLOBET E | 2007 | Sensors and Actuators B-Chemical2007，128，1： | 1 |
| 7 | Analysis of conduction mechanisms in annealed n-Si1-xCx:H/pcrystalline Si heterojunetion diodes for different doping concentrations显示文摘 | Marsal L F Pallares J Correig X Orpella A Bardés D Alcubilla R | | 0，，02： | 1 |
| 8 | Thick film titania sensors for detecting traces of oxygen显示文摘 | E. Sotter X. Vilanova E. Llobet A. Vasiliev X. Correig | 2007 | Sensors & Actuators: B. Chemical2007，，： | 1 |
| 9 | Influence of the annealing and operating temperatures on the gas-sensing properties of rf sputtered WO3 thin-film sensors显示文摘 | STANKOVA M VILANOVA X LLOBET E CALDERER J BITTENCOURT C PIREAUX J J CORREIG X | 2005 | Sensors and Actuators B: Chemical2005，105，2： | 1 |
| 10 | Correlation between electronic nose signals and fruit quality indicators on shelf-life measurements with pinklady apples显示文摘 | J. Brezmes E. Llobet X. Vilanova J. Orts G. Saiz X. Correig | 2001 | Sensors & Actuators: B Chemical2001，，1： | 1 |
| 11 | Fruit ripeness monitoring using an Electronic Nose显示文摘 | J Brezmes E Llobet X Vilanova G Saiz X Correig | 2000 | Sensors & Actuators: B Chemical2000，，3： | 1 |
| 12 | ELectronic nose based on metal oxide semiconductor sensors as an alternative technique for the spoilage classification of red meat 显示文摘 | Barbri N E Llobet E Bari N E Correig X Bouchikhi B | 2008 | Sensors2008，8，1： | 1 |
| 13 | Analysis of seismic dynamical systems 显示文摘 | Urquizu M Correig A M | 1998 | Journal of Seismology1998，2，： | 1 |
| 14 | Building of a metal oxide gas sensor-based electronic nose to assess the freshness of sardines under cold storage 显示文摘 | Barbri N E I Amari A Vinaixa M Bouchikhi B Correig X Llobet E | 2007 | Sensors and Actuators B : Chemical2007，128，1： | 1 |
| 15 | Sub-ppm gas sensor detection via spiral μ-preconcentrator显示文摘 | I. Gràcia P. Ivanov F. Blanco N. Sabaté X. Vilanova X. Correig L. Fonseca E. Figueras J. Santander C. Cané | 2008 | Sensors & Actuators: B Chemical2008，，1： | 1 |
| 16 | Evaluation of an electronic nose to assess fruit ripeness 显示文摘 | Brezmes J Fructuoso Ma L L Llobet E Vilanova X Recasents I Orts J Saiz G Correig X | 2005 | IEEE Sens J2005，，5： | 1 |
| 17 | Correlation between electronic nose signals and fruit quality indicators on shelf - life measurements with pinklady apples 显示文摘 | J Brezmes E Llobet X Vilanova J Orts G Saiz and X Correig | 2001 | Sensors and Actuators B : Chemical2001，80，： | 1 |
| 18 | Building of a metal oxide gas sensor-based electronic nose to assess the freshness of sardines under cold storage显示文摘 | N. El Barbri A. Amari M. Vinaixa B. Bouchikhi X. Correig E. Llobet | 2007 | Chemical2007，，1： | 1 |
| 19 | Analysis of seismic dynamical systems显示文摘 | Urquizu M Correig A M | 1998 | Journal of Seismology1998，2，： | 1 |
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