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| 1 | 液体过负荷,基础疾病及启动时机对接受连续性肾脏替代治疗危重症患儿的影响显示文摘目的:确定需要连续性肾脏替代(continuous renal replacement therapy,CRRT)治疗危重症患儿病死因素。设计基于前瞻性注册登记的回顾性观察性研究。场所拥有30张床位的三级、四级转诊PICU。对象接受CRRT的危重症患儿。干预连续性肾脏替代治疗。测量方法与主要结果研究期间接受CRRT治疗的161例患儿总体病死率为36%(n=58),接受体外膜肺氧合(extracorporeal membrane oxygenation,ECMO)治疗患儿病死率为47.5%(28/59),显着高于无需ECMO治疗者[28.4%(29/102),P=0.022]。根据入院诊断,血液肿瘤患儿病死率最高(77.8%),肾脏病患儿则最低(5.6%)。基于多元Logistic回归分析,入院时疾病严重程度评分较高(校正OR 1.49,95%CI 1.18~1.89,P<0.001),血液肿瘤疾病(OR 17.10,95%CI 4.10~72.17,P<0.001),液体过负荷10%~20%(OR 3.83,95%CI 1.33~11.07,P=0.013),>20%(OR 15.03,95%CI 4.03~56.05, P<0.001),及CRRT启动时机(OR 1.01,95%CI 1.00~1.01,P=0.040)与病死率独立相关。本研究人群中,从入住ICU起CRRT启动每延迟1 h,死亡几率增加1%。结论CRRT患儿病死率高,且与基础疾病,疾病严重程度和液体过负荷程度相关。在急性肾损伤及液体过负荷风险较高的危重症患儿中,早期启动CRRT可能降低病死率。 | Cortina G McRae R Hoq M 方伯梁(译者) 钱素云(审校者) | 2019 | 中国小儿急救医学2019，26，4： | 10 |
| 2 | Zn-Mg and Zn-Cu alloys for stenting applications:From nanoscale mechanical characterization to in vitro degradation and biocompatibility显示文摘In the recent decades,zinc(Zn)and its alloys have been drawing attention as promising candidates for bioresorbable cardiovascular stents due to its degradation rate more suitable than magnesium(Mg)and iron(Fe)alloys.However,its mechanical properties need to be improved in order to meet the criteria for vascular stents.This work investigates the mechanical properties,biodegradability and biocompatibility of Zn-Mg and Zn-Cu alloys in order to determine a proper alloy composition for optimal stent performance.Nanoindentation measurements are performed to characterize the mechanical properties at the nanoscale as a function of the Zn microstructure variations induced by alloying.The biodegradation mechanisms are discussed and correlated to microstructure,mechanical performance and bacterial/cell response.Addition of Mg or Cu alloying elements refined the microstructure of Zn and enhanced yield strength(YS)and ultimate tensile strength(UTS)proportional to the volume fraction of secondary phases.Zn-1Mg showed the higher YS and UTS and better performance in terms of degradation stability in Hanks’solution.Zn-Cu alloys presented an antibacterial effect for S.aureus controlled by diffusion mechanisms and by contact.Biocompatibility was dependent on the degradation rate and the nature of the corrosion products. | Claudia García-Mintegui Laura Catalina Córdoba Judit Buxadera-Palomero Andrea Marquina Emilio Jiménez-Piqué Maria-Pau Ginebra JoséLuis Cortina Marta Pegueroles | 2021 | Bioactive Materials2021，6，12： | 4 |
| 3 | Effects of asymmetric dimethylarginine on renal arteries in portal hypertension and cirrhosis显示文摘AIM To evaluate the effects of asymmetric dimethylarginine(ADMA) in renal arteries from portal hypertensive and cirrhotic rats.METHODS Rat renal arteries from Sham(n = 15), pre-hepatic portal hypertension(PPVL; n = 15) and bile duct ligation and excision-induced cirrhosis(BDL; n = 15) were precontracted with norepinephrine, and additional contractions were induced with ADMA(10-6-10-3 mol/L), an endogenous inhibitor of nitric oxide(NO) synthase. Concentration-response curves to acetylcholine(1 × 10-9^(-3) × 10^(-6) mol/L) were determined in precontractedrenal artery segments with norepinephrine in the absence and in the presence of ADMA. Kidneys were collected to determine the protein expression and activity of dimethylarginine dimethylaminohydrolase(DDAH), an enzyme that catabolizes ADMA. RESULTS In renal arteries precontracted with norepinephrine, ADMA caused endothelium-dependent contractions. The pD 2 values to ADMA were similar in the Sham and PPVL groups(4.20 ± 0.08 and 4.11 ± 0.09, P > 0.05, respectively), but were lower than those of the BDL group(4.79 ± 0.16, P < 0.05). Acetylcholine-induced endothelium-dependent relaxation that did not differ, in terms of p D2 and maximal relaxation, among the 3 groups studied. Treatment with ADMA(3 × 10^(-4) mol/L) inhibited acetylcholine-induced relaxation in the 3 groups, but the inhibition was higher(P < 0.05) in the BDL group compared with that for the Sham and PPVL groups. The m RNA and protein expression of DDAH-1 were similar in kidneys from the three groups. Conversely, DDAH-2 expression was increased(P < 0.05) in PPVL and further enhanced(P < 0.05) in the BDL group. However, renal DDAH activity was significantly decreased in the BDL group. CONCLUSION Cirrhosis increased the inhibitory effect of ADMA on basal- and induced-release of NO in renal arteries, and decreased DDAH activity in the kidney. | Gloria Segarra Belén Cortina María Dolores Mauricio Susana Novella Paloma Lluch Javier Navarrete-Navarro Inmaculada Noguera Pascual Medina | 2016 | World Journal of Gastroenterology2016，22，48： | 3 |
| 4 | 神经源素-3突变与先天吸收不良性腹泻的相关性 | Cortina G. M.G.Martín 程金湘 | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，0，12： | 2 |
| 5 | Small-scale spatial variation in soil CO 2 efflux in a Mediterranean semiarid steppe显示文摘 | Fernando T. Maestre Jordi Cortina | 2003 | Applied Soil Ecology2003，，3： | 2 |
| 6 | Accumulation of alpha-tocopherd in eggs enriched with omega3 and omega6 polyunsatured fatty acids 显示文摘 | Galobart J Barroeta A C Cortinas L | 2002 | Pouh Sci2002，81，12： | 1 |
| 7 | Acute frosted retinal periphleditis associated with cytomegalovirus retinitis in a heart transplant patient显示文摘 | Cortina P Diaz M Espana E | 1994 | Retina1994，14，5： | 1 |
| 8 | Narcotrend-assisted propofoVremifentanil anaesthesia vs clinical practice: does it make a difference 显示文摘 | Rundshagen I Hardt T Cortina K | 2007 | Br J Anaesth2007，99，5： | 1 |
| 9 | Genetic diversity in the Eucalyptus stem pathogen Teratosphaeria zuluensis显示文摘 | Cortinas M N Bames I Wingfield M J | 2010 | Australasian Plant Pathology2010，39，5： | 1 |
| 10 | Optimization of a-terpineol production by the biotransformation of R- ( + )-limonene and (-)-/3-pinene 显示文摘 | Rottava I Cortina P F Martello E | 2011 | Appl Siochem Biotechnol2011，164，4： | 1 |
| 11 | Sorption studies of Zn (Ⅱ) and Cu (Ⅱ) onto vegetal compost used on reactive mixtures for in situ treatment of acid mine drainage 显示文摘 | Gibert O De Pablo J Cortina J L | 2005 | Water Research2005，39，13： | 1 |
| 12 | Tomato abiotic stress enhanced tolerance by trehalose biosynthesis显示文摘 | Cortina C Culianez-Macia F A | 2005 | Plant Science2005，169，： | 1 |
| 13 | Polymorphic microsatellite markers for the Eucalyptus fungal pathogen Colletogloeopsis zuluensis显示文摘 | Cortinas M N Bames I Wingfield B D | 2006 | Molecular Ecology Notes2006，6，3： | 1 |
| 14 | Narcotrend-assisted pmpofol/remifentanil anaesthesia vs clinical practice:does it make a difference 显示文摘 | Rundshagen I Hardt T Cortina K | 2007 | Br J Anaesth2007，99，5： | 1 |
| 15 | Remnant shrubs in Mediterranean semiarid steppes:effect s of shrub size,abiotic factors and species identity on understory richness and occurrence显示文摘 | MAESTRE F T CORTINA J | 2005 | Acat Oecologica2005，27，： | 1 |
| 16 | Increased fibrin polymerization rate in patients with primary antiphospholipid syndrome and systemic lupus erythematosus显示文摘 | De Pablo P Ramirez A Cortina E | 2003 | Clin Appl Thrombo Hemost2003，9，3： | 1 |
| 17 | Multiparity increasestrophoblast invasion and vascular endothelial growth factor expressionat the matemal-fetal interface in mice 显示文摘 | Litwin S Cortina ME Barrientos GL | 2010 | J Reprod Immunol2010，85，2： | 1 |
| 18 | Reversible sple- nial lesion syndrome ( I!ESLES ) : what' s in a name? 显示文摘 | Garcia-Monco JC Cortina IE Ferreira E | 2011 | J Neuroimaging2011，21，2： | 1 |
| 19 | Narcotrend-assisted propofol/remifentanil anesthesia vs clinical practice:does it make a difference?显示文摘 | RUNDSHAGEN I HARDT T CORTINA K | 2007 | Br J Anaesth2007，99，5： | 1 |
| 20 | Determination of Mitoxantrone by Flow Injection Analysis Using an Amperometric Detector 显示文摘 | Juan Carlos Cortina Villar Agustin Costa Garcia Paulino Tunon Blanco | 1992 | Journal of Pharmaceutical and Biomedical Analysis1992，10，4： | 1 |
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