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| 1 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 2 | IL-6 and IGF-1 are Independent Prognostic Factors of Liver Steatosis and Non-Alcoholic Steatohepatitis in Morbidly Obese Patients显示文摘 | David García-Galiano Miguel A. Sánchez-Garrido Isabel Espejo José Luis Montero Guadalupe Costán Trinidad Marchal Antonio Membrives José M. Gallardo-Valverde Juan R. Mu?oz-Casta?eda Eugenio Arévalo Manuel Mata Jordi Muntané | 2007 | Obesity Surgery2007，，： | 2 |
| 3 | Use of recombinant adenovirus for metabolic engineering of mammalian cells显示文摘 | Beeker T C Noel R J Costs W S | 1994 | Methods Cell Biol1994，43，： | 1 |
| 4 | Stomatal regulation of photosynthesis in apple leaves: evidence for different water-use strategies between two euhivars显示文摘 | Massonnet C Costes E Rambal S Dreyer E Regnard J L | 2007 | Annals of Botany2007，100，6： | 1 |
| 5 | Kinetic and Molecular Analysis of Nuclear Export Factor CRM1 Association with Its Cargo in vivo 显示文摘 | Daelemans D Costes SV Lockett S | 2005 | Mol Cell Biol2005，25，： | 1 |
| 6 | Tympanostomy tubesequelae in children with otitis media with effusion : a three - yearfollow - up study 显示文摘 | PEREIRA M B PEREIRA D R COST S S | 2005 | Braz J Otorhinolaryngol2005，71，4： | 1 |
| 7 | Mismatch repair ensures fidelity of replication andrecombination in the radio resistant organism Deinococcus radiodurans 显示文摘 | Mennecier S Coste G Servant P Mennecier S Coste G Servant P | 2004 | Molecular Genetics and Genomics2004，272，4： | 1 |
| 8 | A simple system for generating recombinant adenovirus显示文摘 | He TC Zhou S Da Costs LT | 1998 | Proc Natl Acad Sci USA1998，95，5： | 1 |
| 9 | Mechanics of granular materials at low effective stresses 显示文摘 | Sture S Costes N C Batiste S N Lankton M R Alshibli K A Jeremic B Swanson R A Frank M | 1998 | Journal of Aerospace Engineering1998，11，2： | 1 |
| 10 | β1-Integrin via NF-κB signaling is essential for acquisition of invasiveness in a model of radiation treated in situ breast cancer显示文摘 | Nam JM Ahmed KM Costes S | 2013 | Breast Cancer Res2013，15，4： | 1 |
| 11 | Predicting protein secondary structure with nearest-neighbor algorithm显示文摘 | Salzberg S Cost S | 1992 | J Mol Biol1992，22，2： | 1 |
| 12 | TRPM3 and miR-204 estab- lish a regulatory circuit that controls oncogenie autophagy in clear cell renal cell carcinoma显示文摘 | Hall DP Cost NG Hegde S | 2014 | Cancer Cell2014，26，5： | 1 |
| 13 | Quantification of RecA protein in Deinococcus radiodurans reveals involvement of RecA, but not LexA, in its regulation显示文摘 | Bonacossa de Almeida C Coste G Sommer S Bailone A | 2002 | Molecular Genetics and Genomics2002，268，1： | 1 |
| 14 | Assessing foliar chlorophyll contents with the SPAD -502 chlorophyll meter: a calibration test with thirteen tree species of tropical rainforest in French Guiana显示文摘 | Coste S Baraloto C Leroy C Marcon Renaud A Richardson A D Roggy J C Schimann H Uddling J H6rault B | 2010 | Annals of Forest Science2010，67，6： | 1 |
| 15 | Antifungal drug resistance mecha- nisms in fungal pathogens from the perspective of transcriptional gene regulation 显示文摘 | Sanglard D Coste A Ferrari S | 2009 | FEMS Yeast Res2009，9，7： | 1 |
| 16 | Lipoprotein-associ-ated phospholipase A2 activity and risk of recurrent stroke显示文摘 | Elkind M S Tai W Costes K | 2009 | Cerebrovasc Dis2009，27，1： | 1 |
| 17 | Expression and regulation of vascular:endothelial growth factor in human pulmonary epithelial cells显示文摘 | Boussat S Eddahibi S Coste A | 2000 | Am J Physiol Lung Cell Mol Physiol2000，279，2： | 1 |
| 18 | ITTALKS:A case study in DAML and the semantic Web显示文摘 | Cost R S Finin Tim Joshi Anupam | 2002 | IEEE Intelligent Systems2002，17，1： | 1 |
| 19 | Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2 显示文摘 | Coste S C Kesterson R A Heldwein K A | 2000 | Nat Genet2000，24，4： | 1 |
| 20 | 1 Well Bering Sea, Alaska 显示文摘 | Cao S Lerche I Geohistory thermal history and hydrocarbon genera- tion history of Navar in Basin Cost No | 1989 | Journal of Petroleum Geology1989，12，3： | 1 |
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